Mai Reddit & Quora: Nā Nīnau 12 (hoʻopaʻapaʻa nui ʻia) No NMN - AASraw
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ʻO Nicotinamide Mononucleotide NMN

 

  1. He aha ka pauka NMN?
  2. He aha ka hana a NAD + me NMN?
  3. Pākuʻi palekana ʻo NMN Powder?
  4. He aha nā pono i hiki i ka NMN Powder ke lawe mai i koʻu kino?
  5. Hiki iaʻu ke lawa NMN mai ka meaʻai a i ka anti-ʻelemakule?
  6. Pehea e lawe ai i ka NMN Powder?
  7. E lawe pū paha wau i nā mea hoʻohui ʻē aʻe me NMN?
  8. He kōkua maikaʻi anei ka NMN e kūʻē iā COVID-2019?
  9. NMN VS. NR: ʻO wai ka mea ʻoi aku ka maikaʻi?
  10. Pehea e hiki ai iaʻu ke ʻike i ka pauka NMN maikaʻi loa?
  11. Pehea e mālama ai iā NMN Powder?
  12. Aia kekahi mau loiloi maoli ma ka NMN Powder?
  13. hōʻuluʻulu manaʻo

 

E like me mākou āpau, anti-ʻelemakule nā ​​huahana kahi kumuhana paʻa a he nui ka poʻe e hoʻopaʻa haʻawina i kēia kahua no ka manawa lōʻihi, I ka makahiki 2018, aia kekahi lāʻau hou no ka ʻelemakule kūpikipiki a hoʻonāukiuki i nā huahana anti-ʻelemakule, ua kapa ʻia kēia huahana hou " NMN ”. NMN (β-Nicotinamide Mononucleotide) ma ke ʻano he mea hou o nā mea hoʻohui anti-ʻelemakule i kaulana loa. ʻO ka lawe ʻana i nā mea hoʻopihapiha NMN a i ʻole ka hoʻohui ʻana i kekahi pauka NMN i ka ʻaina kakahiaka ua ʻike nui ʻia nā mea mai ka makahiki 2020. He aha ka ʻike e ʻike ai mākou e pili ana i ka NMN a pehea e kūʻai ai i ka pauma NMN ma ka pūnaewele, hopohopo nā nīnau āpau e ka hapa nui o ka poʻe e mākaukau ana e hoʻohana i ka pauka NMN a i ʻole nā ​​mea hoʻohui. I kēia lā, ua ʻohiʻohi mākou i nā kumuhana e kūkā nui ʻia ma ka pūnaewele mai reddit a me quora ma NMN, lana ka manaʻo e hiki i kēia mau pane ke kōkua iā ʻoe e ʻike iā NMN a kūʻai i ka pauma NMN maoli ma ka pūnaewele.

 

He aha ka pauka NMN? 

Pōkole ka NMN no ka monotucleotide nicotinamide (CAS: 1094-61-7), kahi mole kūlohelohe maoli i kū i nā ʻano āpau. Ma ka pae mole, he ribonucleotide ia, kahi anakahi paʻa o ka RNA acid acid. I ke ʻano he lālā nicotinamide ia, kahi hui ribose a me kahi hui phosphate. ʻO NMN kahi huaʻai Vitamin B3 (niacin). Kūlohelohe ia a hiki ke hana ʻia mai nā kumuwaiwai e like me nā huaʻai, ka waiū, a me nā mea kanu. I ke kino, hoʻohana ʻia ka NMN e hana nikotinamide adenine dinucleotide (NAD +), kahi mole moleka ikaika a pono e ʻike ʻia i kēlā me kēia keena o ke kino. No laila, ʻo ka lawe ʻana i ka pauma NMN kahi ala e hoʻonui ai i nā pae o NAD +, a laila hoʻokō i ke kumu o ka ʻelemakule kūpuna.

I kēia manawa, nui a hewahewa nā ʻano hana e hana i nā mea hana NMN i ka hale hana, i kapa ʻia hoʻi ka pauka NMN. I koʻu ʻike, ua ʻike wau i ʻelua mau ala mai ka hale hana e hana ana i ka pauka NMN:

Nā huaolelo 1 no ka hana ʻana i ka pauma NMN: Kaʻina catalyst (Papa Hana)

ʻO kēia huahana hana wale ʻia no ka hoʻohana ʻana i nā hana kemika Industrial, kūpono ʻole no ke kanaka, ʻaʻole pono lākou e ʻike i ka mea kaumaha, nā anakuhi microbiological i loko o ka pauka, weliweli ia.

Nā huaolelo 2 no ka hana ʻana i ka pauma NMN: ʻano hana Enzymatic (Papa Papa Meaʻai)

Ma kēia hana, palekana ka pauma NMN no ka poʻe e hoʻohana nei, a ʻaʻohe koena Reagent, e hoʻohana ana i ka hana maʻamau i waho e hoʻāʻo i ka maikaʻi, ʻo ka hopena ʻaʻole i emi iho ka 98% maʻemaʻe. (aia kekahi mau huahana e hoʻomaloʻo wale i ka wai makuahine e kiʻi i ka pauka, a hoʻohana i ka hana HPLC e hoʻāʻo ai i ka maʻemaʻe, ʻaʻole ia i emi ma lalo o 98%, akā ke hoʻohana ia i nā ʻano maʻamau o waho e ana, a laila maopopo leʻa. .

ʻO AASraw kahi hale hana hana e hana i ka pauma NMN ma Kina a me ke ʻano hana a mākou i hoʻohana ai me ka hana enzymatic, e hoʻāʻo ʻia kēlā me kēia puʻupuʻu NMN ma mua o ke kūʻai aku ʻana a hōʻike ka maʻemaʻe 99% min, kūpaʻa ka maikaʻi. Ua hana mākou i nā ʻaelike me kekahi ʻoihana hui hoʻohui nui a hoʻolako i ka pauma NMN no lākou i ka wā lōʻihi. ʻAʻohe kānalua he koho maikaʻi ka hana Enzymatic no ka hapa nui o nā hale hana. No laila, e ʻoluʻolu e hōʻoia i kēia me kāu mea hoʻolako i ka pauma NMN ma mua ou kūʻai i ka nui NMN ka lehu.

 

He aha ka hana a NAD + me NMN?

Kū ʻo NAD i ka nikotinamide adenine dinucleotide. Mai nā koʻohune i nā primates, ʻo ia kekahi o nā mole momona a koʻikoʻi loa i ka metabolism pūnaeho. Ma kekahi ʻano ʻē aʻe, he waiwai ko nā KAD āpau, make paha mākou i 30 kekona me ka loaʻa ʻole o NAD +. ʻO kēlā e haʻi iā mākou ʻo NAD + mea waiwai nui ia no ko mākou kino, hiki iā ia ke kākoʻo i ka hana o ke kino e like me ka maʻamau i kēlā me kēia lā.

Hana ʻo NAD + ma ke ʻano he kaʻa kaʻa kaʻa, hoʻololi i nā electron ma o kahi mole molaola i kekahi mole. Kōkua ia i ka hoʻohuli i nā meaola i ka ikehu ma ke ʻano he mea pāʻani nui i ka metabolism a me ka hana ʻana ma ke ʻano he molekope kōkua no nā proteins e hoʻoponopono i nā hana pūnaewele ʻē aʻe. He mea kupaianaha loa kēia mau kaʻina hana. ʻO nā hana ʻē aʻe o NAD + me ka hoʻoponopono ʻana i ka pōpō hiamoe / ala. Hoʻokomo ʻo NAD + i nā sirtuins e hoʻoponopono i ka metabolism a mālama i nā chromosome paʻa. Kōkua pū ka mole mole i ka hoʻoponopono hou ʻana i ka DNA ʻino.

ʻO Nicotinamide Mononucleotide 04

 

No laila, he mea nui ia e mālama i ka pae NAD + o ko mākou kino. Ua haʻi ʻia iā mākou he ʻōpio mākou ma ka hoʻonui ʻana i ka pae NAD +, kōkua iā mākou e hakakā i ka ʻelemakule. A laila he aha kā mākou e hoʻonui ai i kā mākou pae NAD +?

E like me ka ʻōlelo a nā ʻepekema, ʻekolu ala e hoʻonui ai i ka pae NAD +:

Hoʻoponopono i nā papaʻai papaʻai. ʻO nā papaʻai kiʻekiʻe i loko o nā momona a haʻahaʻa i nā huaʻalea, e like me ka keto a i ʻole ka Atkins-style diet, paipai i ka mokuʻāina o ketosis. Ke komo kou kino i ketosis, hoʻohana ʻoe i ka momona no ka ikehu ma kahi o ka glucose. Hoʻonui kēia ʻenehana i ka lakio o NAD + iā NADH, no laila ke pale nei i kou kino mai ka hoʻohaʻahaʻa.

NAD + Pākuʻi. He hiki i kou kino ke hana i ka NAD +, no laila ke ʻimi nei i kahi mea hoʻopihapiha mai kahi mea hana kaulana e hāʻawi i nā hōʻoiaʻiʻo no ka hoʻomaʻemaʻe he ala ʻeha ʻole ia e hoʻonui ai i kēia mau pae i kou kino. Hoʻopili kēia mau mea hoʻopiha i ka nicotinamide, ka waikawa nikotinic, ka mononucleotide nikotinamide (NMN), a me ka ribotide nikotinamide (NR). Conver hoʻololi ʻo Nicotinic acid i NAD + ma o ʻekolu mau ʻanuʻu. I ka hana mua, hoʻololi ka ʻenima NAPRT i ka waikawa nicotinic i ka monatucleotide acid nicotinic (NAMN). I ka lua o ka anu u, ua hoʻololi ka enzyme, NMNAT i ka NAMN i ka nicotinic acid adenine dinucleotide (NAAD). Hoʻololi ka enzyme, NAD + synthetase (NADS) iā NAAD i NAD +. ʻO NAD + biosynthesis i ke ala hoʻopakele e pili ana i ka huli ʻana o nicotinamide i NMN ma o kahi enzyme, phosphoribosyltransferase, NMNAT. Hoʻololi ka enzyme iā NMN i NAD +.】

Hoʻomaʻamaʻa i ka hoʻokē ʻai liʻliʻi. ʻOiai ʻaʻohe koi ʻia ka palena kalena nui a i ʻole nā ​​wā lōʻihi o ka hoʻokēʻai ʻana no ka hapanui o nā mākua, hiki i ka hoʻokēʻai pōkole a intermittent paha ke hōʻike i nā hopena like. ʻO ka hoʻokē ʻai wā waena kahi ala hoʻomau ʻoi aku i ka hoʻolauna ʻana i kou kino i nā wā lōʻihi me ka ʻole o ka ʻai ʻana, e hāpai ana i kāu pae NAD + ma ke ʻano like me ka ketosis.

Minamina, ʻaʻole kūpono paha kahi papaʻai momona kiʻekiʻe inā loaʻa ʻoe i ka maʻi diabetes, maʻi maʻi puʻuwai, a i ʻole hoʻonui ʻia ka LDL kolesterol. Pēlā nō, ʻaʻole kūpono paha ka hoʻokēʻai ʻana no ka poʻe me nā kūlana olakino a paʻakikī pinepine e hoʻomau i ka hala ʻana o ka manawa. Pēlā, hoʻonui ʻia me nā pauka NMN a i ʻole nā ​​mea ʻē aʻe Pākuʻi NAD ʻo ia ka ala palekana loa a maʻalahi hoʻi e paipai i ka hoʻonui ʻia o ka hana o NAD.

Ma hope o kā mākou ʻike iā NAD + a pehea e holo ai, manaʻo wau e ʻike ʻoe i ke kumu e pono ai iā mākou e lawe i ka pauka NMN? Pehea e hana ai ke hele ka NMN pauka i loko o ko mākou kino. Ma kahi ala maʻalahi, ʻo NMN ka mua o NAD + ma mua o ke komo ʻana i kā mākou kino. Lawe i ka pauma NMN hiki ke hoʻonui i ka pae NAD + a kōkua iā mākou e paʻi i ka wikiwiki o ka ʻelemakule.

 

Pākuʻi palekana ʻo NMN Powder? 

ʻO ka hapa nui o nā ʻikepili a hiki i kēia manawa no nā holoholona, ​​ʻaʻole i hōʻike i nā hopena ʻaoʻao. ʻAʻole i hōʻike ʻia kahi noiʻi ʻiole wā lōʻihi i kahi mea ʻino, nā hopena ʻino hoʻi, a i ʻole ka hoʻonui ʻia ʻana o ka make ma loko o ka manawa o ka manawa he 12 mau makahiki. E like me kā mākou ʻike, ua hoʻokolokolo ʻia nei kahi hoʻokolokolo kanaka ma waho o Iapana. ʻO ke kumu o ka hoʻokolokolo ʻana e hoʻoholo inā palekana ka lawe ʻana o ka pauka NMN. Ua lawelawe ʻia ʻo NMN i 10 mau kāne olakino. Hāʻawi ʻia nā hana o 100, 250, a me 500 mg NMN. ʻAʻole i hoʻokumu ʻia nā lawelawe waha hoʻokahi o NMN i kekahi hōʻailona koʻikoʻi a i ʻole nā ​​loli i nā biomarkers nui e like me ka nui o ka puʻuwai, ke kahe o ke koko, ka oxygen oxygen, a me ka mahana o ke kino. Kōkua ka hoʻokolokolo e hōʻoia i, ma ka laulā, palekana a ʻae maikaʻi ʻia ka pauka NMN; i kēlā hopena, hiki i ka hoʻokolokolo ke noʻonoʻo ʻia he kūleʻa. Ua ana kēia hoʻopaʻa ʻana i ka maikaʻi o ka hiamoe, a loaʻa ʻole nā ​​ʻokoʻa ma mua a ma hope hoʻi o ka hoʻohana ʻana o NMN.

Ma muli o ka palena o nā hoʻokolohua kanaka, hoʻomau ka ʻepekema i ka ʻimi ʻana i nā hopena ʻaoʻao o ka NMN, e ʻimi nei e loaʻa i ka ʻikepili hou aʻe mai nā hoʻokolohua kanaka, i mea e hōʻoia ai i kēia huahana anti-kūnewa hou.

I ka manawa like, pono mākou e kamaʻilio e pili ana iā Kauka David Sinclair ʻo ia kekahi o nā poʻe koʻikoʻi 100 o ka honua e Time Magazine, e lawe nei i nā mea hoʻopihapiha NMN no nā makahiki me nā hoaaloha i ka ʻoihana ʻelemakule. Ua kaʻanalike mai ʻo ia i ka ʻike iā mākou ma hope o kona lawe ʻana i ka pauma NMN no ka manawa lōʻihi. Ua ʻōlelo ʻo ia: "Lawe mau wau i ka 1 gram o NMN i kēlā me kēia lā, me nā mea hoʻopihapiha ʻē aʻe e like me resveratrol, metformin, a me aspirin. ʻAʻole wau i ʻike i kekahi mea ʻē aʻe ma mua o ka huhū o ka ʻōpū. ” Hoʻomaopopo pū ʻo ia e mālama mākou i ka pauma NMN i kahi ani anuanu a i ʻole maikaʻi i loko o ka pahu hau, no ka mea, hoʻohaʻahaʻa ʻo NMN iā Nicotinamide i kou kino ke mālama ʻia ʻo NMN i nā mahana wela / mahana.

 

He aha nā pono i hiki i ka NMN Powder ke lawe mai i koʻu kino? 

ʻO NMN (Nicotinamide Mononuleotide) kahi mea kū i mua o NAD +. Hāpai ʻo NMN supplementation iā DAN + no ke olakino kūpono a me ka lōʻihi i waena o ka hāʻawi ʻana i nā pono olakino ʻē aʻe. I kēia lā, ʻaʻohe hōʻike o nā hopena maikaʻi ʻole, ʻoiai ma nā koina kiʻekiʻe ma kahi o ka lōʻihi o ka manawa. Ua hōʻike ʻia hoʻi nā pono olakino i nā hihia o ʻAno II Diabetes a ʻO ka maʻi o Alzheimer. Ma lalo nā 10 o nā pono kiʻekiʻe o ka pauka NMN:

Ka hopena anti-Aging

♦ Hoʻonui i ka momona o nā wahine

♦ Hoʻonui i ka maka a me ka hihiʻo

♦ Hoʻonā ikaika

♦ Hoʻonohonoho pono i ka hoʻoponopono ʻana o nā kaula DNA haki

♦ Hoʻonui i ka hana o ka hakuʻala & ke kahe o ke koko

♦ Hoʻohaʻahaʻa kolesterol & triglycerides

♦ Hoʻonui i ka hana ʻōnaehana pale maʻi

♦ Paipai i ka olakino puʻuwai & hana

♦ Hoʻonui i ka hana mitochondrial e ka hōʻemi ʻana i ka neuroinflammation

 

Hiki iaʻu ke lawa NMN mai ka meaʻai a i ka anti-ʻelemakule? 

ʻO ka pane "ʻoiaʻiʻo ʻaʻole". Ma muli o ka loaʻa maʻamau o ka NMN i nā meaʻai he nui a hiki iā ʻoe ke maʻalahi e loaʻa iā lākou i ko mākou ola. Ma lalo nā meaʻai ʻeono kiʻekiʻe i NMN:

▪ Brokoli

▪ Kāpeti

▪ Kukama

▪ ʻEdamame

▪ ʻAukake

▪ ʻO Tomato

 

ʻO Nicotinamide Mononucleotide

I kēia manawa, pono ʻoe e noʻonoʻo: "Inā loaʻa ka NMN i ka meaʻai, ʻaʻole hiki iaʻu ke hoʻonui i kaʻu mau pae o NAD + ma ka ʻai ʻana i nā mea ʻai he nui?" He nīnau maikaʻi kēlā. Eia nō naʻe, pono wau e kuhikuhi inā makemake ʻoe e hoʻohuli i ka ʻelemakule me NMN, pono ʻoe e ʻai i ka nui o kēlā me kēia meaʻai. Minamina, ʻaʻohe lawa ka NMN i kekahi mau koʻokoʻo o ka broccoli e hoʻomaka ai e hoʻonui i nā pae NMN. ʻOiai ʻo NMN i kēia mau meaʻai, ʻoi aku ka liʻiliʻi o nā kikowaena ma mua o 1 mg i kēlā me kēia kg o ka meaʻai. I nā huaʻōlelo ʻē aʻe, e kiʻi e pili ana i 1mg o NMN, pono ʻoe e ʻai e pili ana i 1kg o broccoli! ʻIke ʻia e hoʻonui ai i nā pae o NAD + i loko o nā kānaka, aia nā pae o NMN i nā haneli haneli milligrams no ka mahele lāʻau. ʻOi aku kēia kiʻekiʻe ma mua o ka mea hiki ke loaʻa mai kā mākou papaʻai, no ka nui o ka broccoli a mākou e ʻai ai. No laila, pono mākou e noʻonoʻo e pili ana i ka lawe ʻana i ka pauma NMN i mea hoʻohui i ka anti-kūnewa i ko mākou ola, hiki iā ia ke kōkua i ko mākou kino e hoʻonui i ka NAD +, e hakakā ana i ka ʻelemakule.

 

Pehea e lawe ai i ka NMN Powder? 

I ka nīnau i hala, ua ʻōlelo mākou iā Dr. David Sinclair nāna i lawe ka 1g NMN i kēlā me kēia lā. A laila ʻo 1g ka mea hana kūpono loa no mākou e loaʻa ai nā pono o NMN, ʻeā? "ʻAʻole loa ia!" Ke hana nei i ka nui āu e pono ai, he mea nui e noʻonoʻo pehea ka lawelawe ʻana o ka NMN a me kona bioavailability. He aha hou aʻe, ke kino ʻokoʻa me nā ʻano ʻokoʻa. Pono mākou e hana i ka wā maikaʻi e lawe i ka NMN, pehea e lawe ai a pehea ka nui o nā mahele e lawe ai mākou ke mākaukau ʻoe e lawe i ka pauka NMN.

 

E kamaʻilio mākou i ka nīnau mua: Pehea e lawe ai i ka pauka NMN? 

Mālama ʻia ʻo NMN i nā koho ʻehā e pili ana i ka nui o ka NMN e hana ai i loko o kāu ʻōnaehana koko: ka pauka, ka pauka sublingual, nā capsule maʻamau, a me nā capsule kūpaʻa gastric.

E hoʻomaopopo i ka bioavailability, pono i kekahi e hoʻomaopopo i ka First Pass Effect (pili ia i ka nui o kahi mea i luku ʻia a i hana ʻia e ke akepaʻa ma mua o ka hele maoli ʻana i loko o ka ʻōnaehana koko). ʻO kēia ka manaʻo paʻakikī, manaʻo wau hiki i kēia wikiō ke kōkua iā mākou e hoʻomaopopo pehea e hana ai a no ke aha he mea nui ia no mākou e ʻike ai ma mua o ka lawe ʻana i ka pauma NMN. Ma muli o ka metabolism mua loa, ʻoi aku ka maikaʻi o ka hoʻohana waha o NMN ma mua o nā capsule sublingual a i ʻole gastro-resistant. Ke lawe waha ʻia ka NMN pauka (i ka wā e ʻai ʻia a hui ʻia paha me kahi wai) e luku ʻia ka hapa nui o ia e ka ʻōpū o ka ʻōpū. Hoʻopili ʻia ke koena NMN e ke ake. Pehea e hoʻopili ai ka ate i ka NMN i ka hopena nui ma ka bioavailability. ʻO ia wale nō paha kahi hapa o NMN e hana iā ia i kāu ʻōnaehana. I mea e hoʻomaikaʻi ai i kāu pae NAD +, hiki iā ʻoe ke lawe i nā capsule NMN hoʻolohi ʻia me kahi Sirtuin Activator e like me Resveratrol me kahi yogurt momona piha e kōkua ai i ka bioavailability o Resveratrol.

Akā ke lawe ʻia ʻo NMN (a i ʻole kekahi lāʻau lapaʻau a i ʻole hoʻopihapiha) sublingally, lawe ʻia ia ma nā ʻāpana mucous (ma lalo o ke alelo) a hele pololei i ke kahe o ke koko. Mai laila e hele pololei i ka lolo a me nā mea ʻē aʻe, e kāpae ana i ka "hopena pass mua" mai ke ake. No kēia kumu, manaʻoʻiʻo mākou i ka lawe ʻana i ka NMN sublingual a i ʻole i ka capsule kūpaʻa gastric ka mea pono a maikaʻi loa. Pono paha ia i nā lāʻau ma lalo o ka lawe ʻana i ka pauka NMN ma ka waha a i ʻole ma ka palapala capsule maʻamau.

  1. He aha ka pauka NMN?
  2. He aha ka hana a NAD + me NMN?
  3. Pākuʻi palekana ʻo NMN Powder?
  4. He aha nā pono i hiki i ka NMN Powder ke lawe mai i koʻu kino?
  5. Hiki iaʻu ke lawa NMN mai ka meaʻai a i ka anti-ʻelemakule?
  6. Pehea e lawe ai i ka NMN Powder?
  7. E lawe pū paha wau i nā mea hoʻohui ʻē aʻe me NMN?
  8. He kōkua maikaʻi anei ka NMN e kūʻē iā COVID-2019?
  9. NMN VS. NR: ʻO wai ka mea ʻoi aku ka maikaʻi?
  10. Pehea e hiki ai iaʻu ke ʻike i ka pauka NMN maikaʻi loa?
  11. Pehea e mālama ai iā NMN Powder?
  12. Aia kekahi mau loiloi maoli ma ka NMN Powder?
  13. hōʻuluʻulu manaʻo

 

ʻO ka nīnau aʻe: I ka manawa kūpono e lawe i ka pauka NMN? 

ʻO ka ʻelemakule kahi maʻi i hiki ke hakakā me nā hui kūpono o nā mea hoʻopihapiha a me nā lawena, e like me ka noiʻi hou mai ke Kulanui o Waterloo. i ko lākou makahiki. Pono e lawe i kekahi mau mea hoʻopihapiha anti-kūnewa e ka poʻe ʻōpio i ka pō, ʻoiai e lawe ka poʻe kahiko i ke awakea no ka pono nui loa. e hoʻopili i kou kino, pehea kou makahiki a pehea kou noho ʻana, "wahi a ka mea noiʻi Layton. "E noʻonoʻo ka poʻe i ka wā a lākou e ʻai ai a hōʻoia hoʻi i ke kūlike me nā mea ʻē aʻe i ko lākou kaiapuni e hoʻopili i kā lākou hiamoe / ala uila a i ʻole ka uaki o ke kino.

No laila, i ka manawa kūpono e lawe i ka pauka NMN? ʻo ka makahiki ka mea nui ma mua o ka hoʻoholo ʻana i ka nui o mākou e lawe ai i ka pauka NMN. ʻO kahi laʻana, ua aʻo ʻia ʻoi aku ka waiwai o nā mea hoʻopihapiha NMN no ka poʻe ʻōpio e lawe i ʻeono mau hola ma hope o ke ala ʻana. Ma ka ʻaoʻao ʻē aʻe, hōʻike nā noiʻi e hana maikaʻi nā mea hoʻopihapiha Resveratrol inā lawe ka poʻe ʻōpio iā lākou i ke awakea. No nā mākua ʻelemakule, he mea nui e lawe i kēia mau mea hoʻopiha i ke awakea.

 

ʻO ka nīnau hope loa: ʻEhia kā mākou e lawe ai i ka pauka NMN? 

Ma hope o kā mākou heluhelu ʻana i nā nīnau i luna, pono mākou e ʻike pono i kēlā me kēia mea e loaʻa i nā ana ponoʻī no ka pauka NMN, ʻaʻole kahi mahele kikoʻī e like me ka ʻōlelo. A laila pehea e hiki ai iā mākou ke hoʻomaulia i ke ana NMN no mākou iho? E like me nā noi hou loa, pili ia me ko mākou kaupaona. Mai ke aʻo ʻana: "Hāʻawi ʻia i hiki i ka 100 mg / kg / lā o NMN ke hoʻoemi i ka nui o nā makahiki e pili ana i nā makahiki i hōʻemi ʻia i loko o nāʻiole, kahi like like o ka ʻāpana o ka nui o nā kānaka ~ 8 mg / kg / lā, e hāʻawi ana i ka manaʻolana e unuhi i kā mākou nā hopena i nā kānaka. " Wahi a nā mea kākau o kahi noiʻi noiʻi hou, e lawe i ka palena iki o 8 mg o NMN no ka kg o ke kaumaha o ke kino i kēlā me kēia lā. Inā pololei ke aʻo ʻana, a laila e ʻike i ka nui o ka NMN āu e pono ai ma ka liʻiliʻi, pono ʻoe e ʻike i kou kaupaona i kg, a laila e hoʻonui ʻia e 8. Eia kekahi laʻana, inā 50kg kou kaupaona, 400% ka paona o ka paona.

Inā ʻoe e lawe i kahi hoʻopihapiha kiʻekiʻe kiʻekiʻe me ka bioavailability maikaʻi, e like me AASraw's ʻO ka pauma NMN, a laila paipai mākou i nā ʻaoʻao aʻe e pili ana i ka manaʻo o ka poʻe kūʻai:

 

Weight Nā Hana No Ke Kuhikuhi (i kēlā me kēia lā)
45kg 45kg * 8mg = 360mg
50kg 50kg * 8mg = 400mg
60kg 60kg * 8mg = 480mg
70kg 70kg * 8mg = 560mg
90kg 90kg * 8mg = 720mg
ʻO kēia mau ana he refence wale nō. Ehia mau mea āu e lawe ai? Aia iā 'oe. Akā inā ʻoe e ʻike i kēia noi ʻana e hōʻoiaʻiʻo ana, hoʻomaka paha ʻoe i kāu helu ʻana ma 8 mg i kēlā me kēia kg o ke kaumaha o ke kino i kēlā me kēia lā.

 

E lawe pū paha wau i nā mea hoʻohui ʻē aʻe me NMN? 

Inā ʻoe he mea nānā pono, ʻike paha ʻoe e lawe ʻo Kauka David Sinclair i nā mea hoʻohui anti-ʻelemakule i kēlā me kēia lā, ʻaʻole wale ka pauka NMN wale nō, a ʻo nā mea ʻē aʻe kekahi, e like me resveratrol, metformin, a me aspirin ... Pono paha ia e lawe i nā mea hoʻohui ʻē aʻe me ka pauka NMN pū? No ke aha mai?

ʻO ke kumu ma nā noiʻi a Kauka David Sinclair a me kāna hui, ke lawe nei i ka pauka NMN he mea kōkua ʻē aʻe no ka anti-ʻelemakule. I kēia manawa, e māhele wau i nā mea hoʻopihapiha 3 ke lawe mākou i ka pauka NMN. 2 mau hoʻopiha i resveratrol a me pterostilbene. ʻO Resveratrol kahi stilbenoid i loaʻa i ka ʻili o nā hua waina i nā mea haʻahaʻa. Ua hōʻike nā noiʻi e hiki i ka resveratrol ke hōʻemi i ka makaʻu o ka maʻi puʻuwai, ka maʻi ʻaʻai a me ka neurodegeneration. Pono ʻo Resveratrol e hoʻāʻo i nā gene sirtuin (ka mea e pale ai i kā mākou DNA a me ka epigenome), ʻoiai ʻo NMN e pono ai e hoʻā i nā sirtuins. Eia nō naʻe, paʻakikī ka lawe ʻia o resveratrol e ka ʻōpū, a ua haki ka resveratrol liʻiliʻi i pau i ke kino. iho wikiwiki loa. No laila, ʻoi aku ka maikaʻi o ka pterostilbene. ʻO Pterostilbene kahi mole e like like me ka resveratrol, akā lawe ʻia ʻoi aku ka maikaʻi a ʻoi aku ka paʻa o ke kino o ke kanaka.

ʻO kekahi mea kōkua he trimethylglycine (TMG), ke lawe mākou i ka pauka NMN no ka manawa lōʻihi, hoʻopau ka NMN i nā hui methyl i loko o ko mākou kino, ma ke ʻano he makaʻala, manaʻo ʻia he mea nui e lawe iā TMG (kahi amino acid i kapa ʻia ʻo betaine) e hāʻawi i nā hui methyl. Ke hoʻololi ʻia ʻo NMN i NAD +, hoʻokumu ʻia ʻo nicotinamide (NAM). ʻAʻole maikaʻi nā nikotinamide kiʻekiʻe no ko mākou mau kino a i mea e hemo ai kā mākou kino i ka nicotinamide pono ia e methylated i loko o ka N-methyl nicotinamide i hoʻopuka ʻia i loko o kā mākou mimi. I mea e methylate NAM, huki ke kino i ka manaʻo mai kā mākou mālama o nā hui methyl. ʻO ke kumumanaʻo ʻo ka nui o ka NMN āu e lawe ai, ʻo ka nui o nā hui methyl e koi ʻia e kāpae i ka NAM.

I loko o ka podcast ma lalo me Dr. Mercola, ua ʻōlelo ʻo Kauka David Sinclair ua lawe ʻo ia i TMG ma ke ʻano he mea e pale aku ai i kēia mai ka hiki ʻana, hiki iā mākou ke aʻo hou aʻe i ka ʻike mai kēia wikiō a Dr. David Sinclair.

ʻOiai ʻo ka hapa nui o nā mea hoʻopihapiha i ʻōlelo ʻia palekana a maikaʻi i ko mākou mau kino, ʻoi aku ka maikaʻi e nānā me kāu kauka olakino ma mua o ka hoʻomaka ʻana e lawe ia, keu hoʻi inā he olakino kou a ke hoʻohana nei ʻoe i ka lāʻau hoʻomau. E hāhai mau i nā lāʻau i koi ʻia.

 

He kōkua maikaʻi anei ka NMN e kūʻē iā COVID-2019? 

ʻO ka pane mua o ke kino i kahi hoʻoweliweli maʻi e like me COVID-19, i ʻike ʻia ma ke ʻano he immune immune activation, ma muli o NAD +. Hoʻopau nā maʻi Viral i ka NAD + no ka mea ʻo nā maʻi e hoʻonāukiuki i kahi cascade pale cellular i hopena i ka hoʻonui ʻia ʻana o ka hoʻohaʻahaʻa NAD + e pale aku i ka maʻi mai ka lawe ʻana i ka pūnaewele. Ua hōʻike nui ʻia ka hoʻoliʻiliʻi NAD + i COVID-19 a manaʻo kekahi mau kānaka noiʻi he kumu nui kēia no ke kumu o ka make loa ʻana o kēia maʻi, ʻo ia hoʻi i ka poʻe me ka waihona ʻo NAD + pau. Ua noi ʻo Kauka Zhavoronkov e hoʻāʻo i ka rapamycin haʻahaʻa haʻahaʻa ma ka pākahi a i ʻole me ka metformin, a me nā mea hoʻouluulu NAD + e like me nicosinamide riboside (NR), a i ʻole nicotinamide mononucleotide (NMN) hiki ke kōkua i ka pale ʻana i ka poʻe ʻelemākule mai ka maʻi gerolavic i kēia lā a hoʻonui paha i ka hoʻōla waiwai ke pau ka pandemia honua.

Hoʻohui ʻia, ua hōʻike ʻia nā noiʻi e hiki i ka NAD + ke hoʻoulu i kahi pane o ka pale pale e pale ai i ke kino mai kahi coronavirus e like me COVID-19. ʻO kahi loiloi i paʻi ʻia ma Malaki 23, 2020 na ka University of Medical Science ʻo Isfahan e hōʻike nei i nā pae haʻahaʻa NAD + hiki ke nakinaki ʻia i ke kiʻekiʻe kiʻekiʻe a me nā helu maʻi i ka maʻi maʻi COVID-19. Wahi a nā hoʻokolohua hoʻokolohua, hoʻonui nā NMN i ka NAD + i nā pae ʻōpio. Ke hoʻolako nei i ka mole NAD + i nā genes SIRT1 e hoʻonui i ko lākou hiki ke pale i ke kino i ka maʻi a me ka hōʻino. Ke mālama ʻia nei nā noiʻi hou aʻe, ke ʻike nei nā mea noiʻi he kuleana nui kā ka NAD + i ka hoʻoponopono ʻana i nā ʻōnaehana paleʻea.

Ua ʻike pū lākou i nā macrophages (kahi ʻano o ke aʻa koko keʻokeʻo e ʻai i nā mea hiki ke komo e like me bacteria, fungi, parasites, a me nā virus) e hoʻohana i kahi ala i synthesize ʻia e NAD + e hōʻoia i ke ola ʻana o ka pūnaewele a me ka mālama ʻana i ka mumū. Ma nā mea āpau, ke hōʻike nei nā noiʻi e hiki i ka NMN a me nā hopena i hoʻonui ʻia o ka NAD + ke hana nui i ke kōkua ʻana i ko mākou kino e hakakā i nā maʻi a me nā bacteria. I nā huaʻōlelo ʻē aʻe, hiki iā ia ke hoʻoikaika i kā mākou ʻōnaehana pale a kōkua iā lākou i nā manawa o ka maʻi a me nā maʻi.

Ua paʻi ʻia kahi hihia hihia ma ka lā 22 ʻApelila 2020 e Kauka Robert Huizenga MD ma ke Kulanui o Chicago e hōʻike ana i kāna pane i kahi wahine 55 makahiki i loaʻa i ka haukapila me COVID-19 ma Malaki 16. 13 ua loaʻa ʻo ia i ka pulumonia, ka cytokine ʻino a me ka hsCRP kiʻekiʻe kiʻekiʻe, kahi marker inflammatory non-kikoʻī. Ua mālama ʻo Kauka Huizenga iā ia me ka NMN waha, betaine a me NaCl (ʻike ʻia e hōʻemi i ka IL-6) a hoʻomau i ka lāʻau zinc i hāʻawi ʻia iā ia ma mua. I ka lā 15, ua hōʻemi ʻia kona kuni a hoʻomaikaʻi maikaʻi ʻia nā ʻōuli. I ka lā 17 ua hoʻokuʻu ʻia ʻo ia e hoʻi i ka home. I ka lā 23, ua asymptomat ʻo ia. Ua mālama ʻia ʻelua mau mea ʻelemākule ʻē aʻe me ka "cocktail" like a ua ʻike like nā like ʻelua.

 

NMN VS. NR: ʻO wai ka mea ʻoi aku ka maikaʻi? 

ʻO Nicotinamide mononucleotide (NMN) a me ka nikotinamide riboside (NR) he mea mua i ka mole molemole no ka metabolism - nicotinamide adenine dinucleotide (NAD +). Kūlike like nā ʻōnaehana mole o NMN a me NR, koe wale nō ka NMN i hoʻohui ʻia i kahi hui phosphate. Hana kēia hui phosphate i ka NMN i kahi mole mika nui aʻe ma mua o NR. Hoʻohui pinepine ʻia ʻo NR (nicotinamide riboside) a me NMN (nicotinamide mononucleotide) ma ke ʻano he ʻelua o nā mea hoʻopuka hoʻohiki e hoʻohālua i ka ʻelemakule. Mālama nā kiʻekiʻe ʻo NAD + kiʻekiʻe i kā mākou epigenome a me DNA. ʻO ka hoʻonui ʻana i nā pae NAD + e alakaʻi aku ai i nā pono olakino he nui i nā mea like ʻole, e like me ka lolo, ka ʻōnaehana maʻi, a me nā mākala.

Hāʻawi ʻia ʻo NR a me NMN e hoʻonui i nā pae NAD +, kāhea pinepine ʻia lākou ʻo NAD boosters. Hōʻike nā noiʻi he nui i hiki i ka NR a me ka NMN ke hoʻomaikaʻi i nā hiʻohiʻona ʻelemakule, e like me ka epigenome disregulated, DNA hōʻino, hōʻiliʻili ʻana i ka protein, inflammaging (ka hoʻoweliweli pili ʻelemakule) a me nā ʻano ʻelemakule ʻē aʻe.

Akā ʻo ka nīnau nui o ka papa: ʻo wai ka mea ʻoi aku ka maikaʻi, NMN pauka a NR pauka paha?

I kēia manawa, ʻaʻohe noiʻi e hoʻohālikelike ana iā NMN a me NR poʻo e pili ana i nā hopena olakino a me nā hopena ola. E hoʻohālikelike mākou iā NMN a me NR:

NMN vs. NR

Pehea e hiki ai iaʻu ke ʻike i ka pauka NMN maikaʻi loa? 

Manaʻo wau ua ʻike ʻoe i nā mea hoʻolako i ka wā e kau ai ʻoe i ka "NMN pauka" ma Google, i ʻole ʻoe e ʻike i kahi ʻoi aku ka maikaʻi a kūpono paha iā ʻoe iho. Pono mākou e noʻonoʻo i ka mea a mākou e nānā ai ke kamaʻilio pū me kahi mea hoʻolako NMN paukū. No ka hana ʻana i kēia pilikia, ua kamaʻilio wau me nā mea hoʻolako he nui o ka pauma NMN ma ka pūnaewele a hoʻokaʻawale i kahi papa inoa no nā kūmole:

 

(1) Nīnau Hunahuna

Pono ʻoe e nānā i kā lākou pūnaewele a i ʻole nā ​​hale kūʻai ma ka pūnaewele, e ʻike pono he mea hoʻolako hilinaʻi lākou, ʻaʻole hoʻopunipuni. E hele i kā lākou pūnaewele a i ʻole nā ​​hale kūʻai, e kamaʻilio pū me lākou, e nīnau i nā nīnau āu e makemake ai. ke pane lākou i kāu mau nīnau, hiki iā ʻoe ke manaʻo inā hilinaʻi ia, e like me kā mākou e ʻike nei, ʻo ka ʻoiaʻiʻo ke kumu o ke alu like ʻana. Ke nīnau ʻoe i kā lākou nīnau, hiki iā ʻoe ke kamaʻilio e pili ana i kēia ʻano: NMM pauka hana, palapala NMN pauka, hiki ke hāʻawi i ka pauma NMN….

 

(2)Ka hōʻoia maikaʻi

ʻO ka lepo NMN maikaʻi loa e loaʻa ka 99% maʻemaʻe a ʻoi paha. ʻAʻole ia e hoʻopihapiha i nā mea hoʻopihapiha a huahana paha e like me GMO, waiū, hua manu, soy, gluten, chemicals chemicals, heavy metals, a solvents paha i hoʻohana ʻia i ka hana maoli o ka huahana. ʻO ka hapa nui o ka NMN pauma e hoʻohana i nā mea hoʻopihapiha a i ʻole stimulants e hana i ka hapa nui o ka huahana. Hiki i kēia ke hoʻokau i kou olakino i ka makaʻu nui no ka mea ʻaʻole ʻoe ʻike i ka mea āu e lawe nei. Inā kūʻai ʻoe i kāu NMN mai kahi hui e kūʻai wale aku nei i nā capsule NMN, he mea paha kēlā.

 

(3)Nā Palapala Pili - Nā hōʻike hōʻike hoʻāʻo

Ma ke ʻano he hale hana NMN pauka, e puka mai nā palapala e pili ana (COA, HPLC, HNMR, MS) ma hope o ka hana ʻana i kahi huahana batch, pono lākou e hōʻoia i kona ʻano, e hoʻouna iā 3-labs e hoʻāʻo (ʻo kēia pū me ka maʻemaʻe, nā mea haumia, a me nā metala kaumaha.), e ʻike ia aia i ka pae maʻamau a hiki ke kūʻai aku iā ia i ka mākeke. Ma ke ʻano he mea kūʻai, hiki iā ʻoe ke noi e ʻike i kēia mau hōʻike, no COA a me HPLC. Hiki iā ʻoe ke nānā i ka pūnaewele o ka mea hoʻolako no ka ʻike hoʻokolohua ʻaoʻao ʻekolu, a i ʻole e kelepona pololei i kā lākou lawelawe mea kūʻai aku. ʻO ka hōʻoia o ka hoʻāʻo ʻaoʻao ʻaoʻao he ala maʻalahi ia e hōʻoiaʻiʻo ai e kūʻai mai ana ʻoe mai kahi kumu kaulana. E hauʻoli paha kēlā me kēia ʻoihana e hoʻohana nei i nā hōʻike ʻaoʻao ʻekolu e kaʻana like i kēlā ʻike me ʻoe.

 

(4)Hoʻohālikelike i ke kumukūʻai ma waena o nā mea hoʻolako

ʻO NMN Price kekahi metric i hiki iā ʻoe ke hoʻohana no ke ana ʻana i ka pono o ka mea hoʻolako, ma ka nānā ʻana i kahi helu o nā mea hoʻolako NMN no nā paukū a me nā capsule e loaʻa ai iā ʻoe ka manaʻo o ke kumukūʻai maʻamau no ka gram. Inā ʻoe e noʻonoʻo e pili ana i ke kumukūʻai ma ka mākeke, pono ʻoe akahele He mea hoʻowalewale mau ka makemake e mālama i ke kālā inā loaʻa iā ʻoe, akā me NMN kikoʻī, loaʻa iā ʻoe ka mea āu e uku ai. He papa ʻai paha ka NMN kumu kūʻai haʻahaʻa, ʻaʻole papa lāʻau lapaʻau, ʻo ia hoʻi ʻaʻole like ka nui o nā pōmaikaʻi NMN. I ka ʻoiaʻiʻo, aia kekahi manawa ma mua o 10% NMN i ka papaʻai meaʻai NMN. E hoʻāʻo i kēia, he papaʻai kā mākou Laʻana NMN ua hoʻāʻo a ua hoʻi mai me 8% NMN. He mea nui ka noʻonoʻo ʻana i kāu moʻohelu kālā, akā pau paha ʻoe i ka uku ʻana i ka wā lōʻihi ke koho ʻana no nā huahana NMN haʻahaʻa haʻahaʻa inā ʻaʻole ʻoe e ʻike i nā pono olakino mai iā lākou.

 

(5)ʻO ka mea lawelawe maikaʻi loa

Loaʻa ka maikaʻi NMN mai nā mea hoʻolako maikaʻi, pono i ka mea hoʻolako pono i kahi lawelawe lawelawe maikaʻi. Ke kamaʻilio pū ʻoe me ka poʻe kūʻai aku, hoʻouna i nā nīnau āpau iā lākou a pane koke lākou iā ʻoe. Eia kekahi, e ʻike iā ʻoe i ke kaʻina kūʻai holoʻokoʻa, pehea e hana ai a ʻike iā ʻoe i kāu mea e hana ai no ke kaʻina hou aʻe. e alualu iā ʻoe iho. E ʻoluʻolu e hoʻomanaʻo i kahi lawelawe mea kūʻai aku maikaʻi kekahi mea ʻoluʻolu e kamaʻilio pū kekahi me kekahi i kēlā me kēia manawa.

 

(6)Nā manaʻo loiloi mai nā mea kūʻai aku ʻē aʻe

Ma ke ʻano he laulā, hiki iā mākou ke ʻike i kekahi mau loiloi e pili ana i kēlā ʻoihana inā hāʻawi kahi ʻoihana i ka pauma NMN no ka manawa lōʻihi, a i ʻole hiki iā lākou ke hāʻawi i kekahi manaʻo mai nā mea kūʻai aku ʻē aʻe. Ma hope o nā mea āpau, hiki iā mākou ke ʻike he ʻoiaʻiʻo inā aia lākou i kā lākou moʻolelo kūʻai a me nā pane maoli o nā mea kūʻai aku. ʻOiaʻiʻo, pono mākou e ʻike i nā loiloi mai nā mea kūʻai aku ʻē aʻe ma ke ʻano he kūmole ke hoʻoholo mākou e kūʻai i ka pauma NMN, hilinaʻi ia iā ʻoe ma ka hopena.

ʻO AASraw ka ʻoihana i hōʻoia i ka hale hana, hiki ke hana nui i ka pauma NMN a me nā mea hoʻohui anti-ʻelemakule, paʻa ka lako. Hele ʻoe i kā lākou pūnaewele-www.aasraw.com i kēlā me kēia manawa a nīnau i kā lākou lawelawe lawelawe, e noi i ka palapala hōʻoia maikaʻi a me nā hōʻike hoʻāʻo ma 3rd-e ka lab, e hōʻoia i kā lākou NMN pauka he 99% ka hoʻomaʻemaʻe i nā lāʻau lapaʻau a ʻo ia ka mea kiʻekiʻe. Ma kaʻu ʻike, hiki iā lākou ke hoʻouna i ka huahana āu i kauoha ai i nā lā hana he 1-3, ʻoiai he 12 mau hola ma hope o ka hōʻoia ʻana o ke kauoha, kiʻekiʻe loa ka hana, pono wau e hāʻawi iā lākou i nā manamana nui no kēlā. E kiʻi ʻoe i ka NMN paukū kiʻi a me ka helu huli mai iā lākou ma hope o ke kauoha, a laila hiki iā ʻoe ke hoʻohana i ka nānā ʻana i ka ʻāpana ma ka pūnaewele a ʻike i hea ia, pehea ka mamao mai kou home. E aʻo hou aʻe e pili ana iā AASraw i kēia manawa

Pehea e mālama ai iā NMN Powder? 

Ua hōʻike ʻia ʻo Nicotinamide riboside (NR) a me nicotinamide mononucleotide (NMN) e hoʻonui i nā maʻi e pili ana i nā makahiki i nā holoholona. Hoʻolālā maikaʻi ʻia lākou ma nā kiʻekiʻena kiʻekiʻe a hoʻonui pono i nā pae NAD +. ʻAʻole paʻa paʻa kēia mau mole i nā mahana wela a i ʻole nā ​​kūlana kiʻekiʻe o ka wai. Hoʻohaʻahaʻa koke lākou i loko o ka nicotinamide, ka mea e kāohi i ka hana o sirtuins a me PARP, kahi enzyme hoʻomaikaʻi DNA. No nā hopena maikaʻi loa, pono e mālama ʻia ka pauma NMN i loko o kā lākou ipu kumu a mamao aku i nā kumu wai. ʻAʻole iʻai ʻia ka pauka NMN no 3 mau mahina a ʻoi aku paha i loko o ka pahu hau e hōʻoia e mālama lākou i ka ikaika piha. Ma ke ʻano he alakaʻi ma ka honua holoʻokoʻa, hāʻawi mau ʻo AASraw i ke kiʻekiʻe kiʻekiʻe loa a me ka maikaʻi loa ʻo NAD + a me NMN pauka i loaʻa.

 

Aia kekahi mau loiloi maoli ma ka NMN Powder? 

ʻO Tom mai UK: Ua hoʻomaka wau me kaʻu wahine e lawe i ka pauka NMN i mau mahina i hala aku nei a ua pūʻiwa mākou ua kū wau i ka hū ʻana a ua hoʻomaka ka emi ʻana o nā pilikia ʻili o kaʻu wahine. ʻIke wale mākou i ka mālamalama o ka noʻonoʻo a me ka nui o ka ikaika, ʻaʻole wau i lawe i kahi hoʻopihapiha i loaʻa iaʻu kahi hopena i ʻike wau e lawe ʻoe i nā huaora he nui a me nā mea hoʻopihapiha akā ʻaʻole ʻike maoli i nā hopena. ʻO kēia nā mea hoʻopiha kupaianaha loa i ʻike ʻia e ke ʻano kanaka a ʻo ka hiki wale nō paha o ka hoʻihoʻi ʻana i nā miliona o nā hunaola i loko o ke kino o ke kanaka kahi mea kupaianaha loa no ka hana ʻelemakule! Manaʻo wau e ʻike ka poʻe āpau i kēia pila i ka wā e hiki mai ana a e ʻike pū ʻia ka noiʻi ʻana o ka maʻi ʻaʻai. ʻO wai ka mea makemake ʻole e noʻonoʻo i ke olakino e hoʻohui nei i kēia i kāu mea hoʻopiha anti-kūnewa e hoʻololi i kou ola no ka mea ʻoi aku ka hilinaʻi iaʻu !!!

liMei mai Kina: Ua koho wau i ka pauka NMN no ka mea ua heluhelu wau he kōkua ia i ka oxygenate i ke koko a hāʻawi i ka oxygen i koʻu mau kino. Ke kāhea nei koʻu kino i kēia huahana, luhi wau a ʻaʻole hiki ke noʻonoʻo. ʻO wau nō lawe ana i ka pauka NMN no ʻelua pule i kēia manawa. Ua ʻike wau i ka hoʻonui ʻana o ka ikehu, hiki iaʻu ke komo i loko o kahi papahana hoʻoikaika kino cardio ma hope o ka hana ʻana i ka lā holoʻokoʻa. Maopopo koʻu mau manaʻo, ʻaʻole wau e hiamoe i nā hālāwai. Nui koʻu hauʻoli me nā mea hoʻopihapiha NMN ke kiʻi nei wau i nā hopena aʻu e ʻimi nei. Eia hou, pono wau e ʻōlelo: kiʻekiʻe iki ke kumukūʻai NMN akā makemake wau e koi e lawe, no ka mea makemake wau e ʻōpio hou aku, haha ​​...

ʻO Gary mai Australia: He mea hoʻopiha anti-kūnewa nui kēia. ʻIke wau i ka hoʻonui ʻana o ka ikehu, ʻaʻole i loaʻa iaʻu ke anuanu o kaʻu makahiki 4, a ʻaʻole wau luhi maʻalahi. ʻOkoʻa ke ʻano o ka ikehu aʻu e ʻike ai mai kahi kiʻekiʻe o ka caffeine. ʻAʻole wau hopohopo a hoʻonāukiuki nui paha, makaʻala maoli a hou. ʻOiai ka makaʻala, ua hoʻomaikaʻi koʻu hiamoe. ʻAʻohe oʻu pilikia e hiamoe ana, akā hiki iaʻu ke ala nui i ka pō. Me ka pauka NMN ke hiamoe lōʻihi nei au i kahi kīʻaha. Manaʻo wau ke hoʻopōmaikaʻi nei ʻo NMN iaʻu i nā ʻano he nui a ʻaʻole hiki iaʻu ke ʻōlelo nui e pili ana iā ia.

ʻO Steven mai USA: Ma hope o ke aʻo ʻana e pili ana i ka pauma NMN a he hopena paha ia mai ka Harvard Study i alakaʻi ʻia e Dr. David Sinclair, ua hoʻoholo wau e hoʻāʻo. Mai ka lā mua wau i hoʻāʻo ai, ua ʻike wau i kahi ʻokoʻa i koʻu pae ikehu. He 57 koʻu mau makahiki, a ke hoʻololi nei paha kaʻu metabolism no ka ʻoi aku. ʻAʻole wau i loli i kaʻu ʻano papaʻai, eia naʻe ke emi nei koʻu kaumaha, 14 lbs i 4 mau pule. ʻO kēlā manawa ke kuhikuhi nei i ka nalo mau. Ua lilo kaʻu wahine i 9 lbs, a ua ʻeha ʻo ia i kahi maʻi laha ʻole i kapa ʻia ʻo Erythromelalgia, ka mea e wela ai nā piko me nā ʻeha neuropathic, a kūlike ia. ʻO ka ʻāpana Niacin o ka hui, me ka hoʻohui i kāna mau lāʻau, ua hoʻēmi iki ka ʻeha, a hiki i ka hana hou aku. Ma hope o koʻu holo mua ʻana i ka manawa mua - ua hoʻāʻo wau i ka mea mai kekahi mea hoʻolako i ka pauka NMN. He ʻokoʻa ka hui ʻana, a ua hoʻopau ʻia ka ikehu. ʻO ia ke kumu i hoʻi ai wau i MAAC10, a i kēia manawa hoʻi wau i ke ala. ʻIke ʻoe, manaʻoʻiʻo wau ua pouli kekahi o koʻu lauoho ākea ākea me ka wai ʻole. Hana ia ʻike ʻoe - ʻaʻole wau i manaʻo e nānā hou wau iā 57. Eia nō naʻe, mahalo no kēia hana mana hoʻopihapiha-NMN kaola a mahalo no ka aasraw.

 

hōʻuluʻulu manaʻo

ʻOiai ʻo ka Punawai o nā ʻōpio ke waiho nei i kahi kaʻao kupanaha ʻaʻole hiki ke hoʻokō ʻia i kēlā me kēia manawa koke, ke hoʻomau nei ka ʻepekema ma hope o ka lāʻau kūpuna. Malia paha i kekahi lā, hiki iā ʻoe ke inu i kahi pill kupaianaha a ʻike hou i ke ola ma ke ʻano he ʻōpio makua. Ua hōʻike nā noiʻi i nā holoholona i nā waiwai hoʻohiki a NMN ma NAD + -e hoʻonui a me ka ʻelemakule kūnewa. I kēia manawa, ʻoiai ke neʻe nei nā mea noiʻi me nā hoʻokolohua hoʻokolohua e noiʻi i ka palekana a me ka pono o ka mole i nā kānaka. A hiki i kēlā manawa, Pākuʻi NAD a me NMN hāʻawi i nā pono maoli e hoʻolohi i nā hopena koʻikoʻi o ka ʻelemakule o ke kelepona ma ke kino o ke kanaka. Manaʻo wau he mea kōkua ia inā kōkua lākou i ko mākou kino, e hui ʻōpio hou kākou.

 

Reference

[1] ʻAkau, BJ, Rosenberg, MA, Jeganathan, KB, Hafner, AV, Michan, S., Dai, J.,… & van Deursen, JM (2014). Hoʻokomo ʻo SIRT2 i ka wahi huli kinase BubR1 e hoʻonui i ke ola. ʻO ka puke pai EMBO, e201386907.

[2] Honi, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A.,… & Ungvari, Z. (2020). Hoʻonui ka Nicotinamide mononucleotide (NMN) i ka hoʻohou hou ʻana o ka neuro i nā ʻiole ʻelemakule: ka palapala transcriptal o ka hoʻoulu ʻana o SIRT1, ka pale mitochondrial, anti-inflammatory, a me nā hopena anti-apoptotic. ʻO GeroScience, 1-20.

[3] Grozio, A., Mills, KF, Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K.,… & Imai, SI (2019). ʻO Slc12a8 kahi mea lawe i mononucleotide nikotinamide. ʻO ka metabolism kūlohelohe, 1 (1), 47-57.

[4] Li, J., Bonkowski, MS, Moniot, S., Zhang, D., Hubbard, BP, Ling, AJ,… & Sinclair, DA (2017). Mālama ʻia kahi ʻeke hoʻopaʻa paʻa ʻo NAD + i kaohi i nā pilina protein-protein i ka wā ʻelemakule. ʻEpekema, 355 (6331), 1312-1317.

[5] Stipp D. Beyond Resveratrol: ʻO ka Anti-Aging NAD Fad. Pūnaewele Blog ʻAmelika ʻEpekema. 11 Malaki 2015.

[6] ʻO Tarragó MG, Chini CC, Kanamori KS, Warner GM, Caride A, de Oliveira GC. + Hoʻole. Pūnaewele Metabolism. Mei 2018, 27 (5): 1081-1095.e10. PMC 5935140. PMID 29719225. doi: 10.1016 / j.cmet.2018.03.016.

[7] ʻO Bogan KL, Brenner C. Nicotinic acid, nicotinamide, a me ka nicotinamide riboside: kahi loiloi molekole o ka NAD + precursor vitamins i ka meaʻai kanaka. ʻO ka loiloi makahiki o ka meaʻai. 2008, 28: 115-30. PMID 18429699.

[8] Fletcher RS, Lavery GG (ʻOkakopa 2018). "Ke kū ʻana o nā kinotope ribotide nikotinamide i ka hoʻoponopono o NAD + metabolism". Ka Nūpepa o Molecular Endocrinology. 61 (3): R107 – R121. hana: 10.1530 / JME-18-0085. PMC 6145238. PMID 30307159.

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