Nā lāʻau lapaʻau o Alzheimer (AD drug) nā moho: J147, CMS121, CAD31

I kēia lā, ʻo Alzheimer ka mua o ka noiʻi biomedical. Ke hana nei nā mea noiʻi e wehe i nā ʻano o ka maʻi o Alzheimer a me nā dementias ʻē aʻe i hiki. ʻO kekahi o ka holomua nui loa i hoʻomālamalama i ka hopena o Alzheimer i ka lolo. ʻO ka manaʻolana kēia ʻike maikaʻi aʻe e alakaʻi i nā lāʻau hou. Ke hoʻokolokolo ʻia nei nā ʻano hiki i kēia manawa a puni ka honua.

ʻO ka 2,4-Dinitrophenol (DNP) lāʻau paʻakikī maikaʻi loa i loko o bodybuilding

Ua hoʻomaka ka papahana neurobiologyʻo Salk me nā kinikonaʻelua i loaʻa i loko o nā mea kanu i hōʻike i nā mea lapaʻau: iʻa, kahi hua maoli i huaʻia mai nā hua a me nā huaʻai, a me curcumin, mai ka'āpana kukui. Mai kēia mau mea, ua hui pūʻia ka huiʻekolu AD lāʻau lāʻau ʻo nā moho e pili ana i ko lākou hiki ke pale i nā neurones mai nā maʻi he nui e pili ana i ka loloʻelemakule. Ua hōʻike ka hana i kēia mau mea kohoʻekolu (ʻikeʻiaʻo CMS121, CAD31 a me J147), a me ka iʻa a me curcumin, hoʻemiʻia nā'ōmumu mole o kaʻelemakule, a me ka dementia, a hoʻonui i ka laulā o waena o nāʻiole a me nā nalo.

ʻO ka mea nui, ua hōʻikeʻia e ka huiʻo nā alapili'ulaʻi e hanaʻia e kēia mau mea noiʻi lāʻau maʻamau e like like meʻelua mau pūnaehana hōʻano houʻia iʻikeʻia e hoʻonui i ke ola o nā holoholona he nui. No kēia kumu, a ma muli o ka hopena o kā lākou aʻo muaʻana, ua'ōlelo ka hui i ka iʻa, curcumin a meʻekolu mau mea noiʻi lāʻau maʻamau a pau e pili ana i keʻano o ka geroneuroprotectors.

ʻO nā haʻawina'ē aʻe i loko o ka laikini e hoʻoholo ana inā he hopena kēia mau mea ma nāʻano o waho ma ka lolo. "Inā loaʻa kēia mau lāʻau lapaʻau no nā'ōnaehana'ē aʻe, e like me ka mālamaʻana i ka hana'ōkiko a me ka olakino olakino, hiki ke hoʻohanaʻia i nā ala'ē aʻe e mālama ai a paleʻana i nā maʻi o kaʻelemakule," e'ōlelo anaʻo Schubert.

- ʻO nā moho Alzheimer (drug AD) moho: J147

Curcumin, ka mea nui o ka turmeric spry Indian, he hui multitarget ia e hoʻemi ana i ka hoʻolālā, ka hana ROS, ka'awaʻahu amyloid, a me ka excitotoxicity, a he kūpono loa ma nāʻano o ke kola o AD. Eia naʻe,ʻo ka curcumin ka hana haʻahaʻa liʻiliʻi loa, ka maikaʻiʻole o ka biovavailability, a me ka lolo o ka lolo. No ka hoʻomaikaʻiʻana i ka hana neurotropic a me ka paʻa o ka holomua o ka curcumin, ua hoʻohana mākou i ka hoʻomehana hoʻoikaikaʻike SAR no ka hoʻomaikaʻiʻana i nā mea pharmacological ma ka manawa hoʻokahi e hoʻonui i kona ikaika a me nāʻano o kāna mau hana ola. I ka hoʻomaka mua, ua hoʻololiʻia keʻano o ka'āpana o ka curgone a me ka pyrazole e hana i ka CNB-001, me ka hoʻonuiʻana i ke kūlana a me ka neuroprotectiveʻoihana ma luna o ka curcumin. Uaʻikeʻia nā'ōnaehana o nā hui maʻekolu o nā'āpana phenyl o CNB-001 e ponoʻole nā ​​hui hydroxl no kaʻoihana i nā hananaʻikeʻehiku. ʻO ka hoʻohuiʻana oʻelua mau methyl i ka pyrazole i hoʻohuiʻia me ka pyrazole i alakaʻiʻia i CNB-023 me ka manaʻoi aʻe ma luna o CNB-001. Eia nō naʻe,ʻo CNB-023 he lipophilic kiʻekiʻe (cLogP = 7.66), a he mau pūʻona me ka lipophilicity kiʻekiʻe. No ka hoʻohaʻahaʻaʻana i ka lipophilicity a ho'ākāka i nā kumumalima o nā koi no kaʻoihana, ua weheʻia kekahi o nā hui cinnamylʻelua a uaʻoi aku ka hoʻonuiʻana i ka hoʻomanaʻoʻana i kahi mole mole nui loa. J147. ʻO J147 ka 5-10 manawa iʻoi aku kaʻoi aku o ka pahuhopu i nā koi a pau loa e like me CNB-001, oiai he nui aʻoiʻole ka hana o curcumin i kekahi hopena. ʻAʻoleʻo J147 wale nō ka mana loa akā he maikaʻi nāʻano physicchemical (MW = 350, cLogP = 4.5, tPSA = 42). J147 (1146963-51-0) ua aʻo nuiʻia i nā hiʻona maʻamau a me nā hiʻohiʻona AD i kahi o kona kūlana maikaʻi loa.