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ʻO Cortexolone 17α-propionate kalo

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SKU: 19608-29-8. Māhele:

ʻO ka AASraw me ka hōʻano a me ka hana hana mai ka gram a ka papa helu nui o Cortexolone 17α-propionate pauna (19608-29-8), ma lalo o ke kānāwai CGMP a me ke kikowaena o ka mana.

Product Description

ʻO Cortexolone 17α-propionate powder video


ʻO Cortexolone 17α-propionate kalo nā Pūʻulu Pūʻulu

Name: ʻO Cortexolone 17α-propionate kalo
CAS: 19608-29-8
Nā Kaulike Molecular: C24H34O5
Molecular Weight: 402.52
Wahi Manaʻo:
Hōʻoia Kōkua: ʻO ke anawela
kala like 'ole: ʻO ka'ōmaʻomaʻo keʻokeʻo


ʻO Cortexolone 17α-propionate ka hoʻokele

Nā inoa

CAS: 19608-29-8
Nā inoa inoa: cortexolone-17α-propionate,
Nā inoa'ē aʻe: CB-03-01, Winlevi kaola, Breezula kaola, 11-deoxycortisol 17α-propionate, Cortexolone 17α-propionate kaheʻe

ʻO Cortexolone 17α-propionate hoʻohana

Cortexolone 17α-propionate he anuandrogen steroidal aniandrogen - ma keʻano, he antagonist a me ka'enerogenehana -ʻo ke kāohiʻia e Cassiopea a me Intrepid Therapeutics no ka hoʻohanaʻana i nā lāʻau lapaʻau ma ka mālamaʻana i nā kumu hoʻohālike e hoʻohālike me ka haneko vulgaris a me ke alopecia orogenic (male-pattern ka lauoho lauoho).

He aha keʻano o Cortexolone 17α-propionate

ʻO Cortexolone 17α-propionate 1% kaomi, kahi mana houʻoihana antiandrogen no ka hanaʻana o kaʻeha vulgaris. ʻO kahi papahana kūkoko, uaʻike pālua makapō me ka placebo a me ka 0 · 05% cream.

KĀWAI

ʻO ka'ānela vulgaris he maʻi ia o ka pūnaewele pilote e hāʻawi ai nā'ōnelo i kona hopena a hoʻomau. ʻO ka hoʻohanaʻana i nā antiandrogens he mea pono loa ia; Eia naʻe,ʻaʻole i loaʻa nā māmā no ka hoʻohanaʻana i ka papahana ma ka mākeke. ʻO Cortexolone 17α-propionate kahi meaʻoihana hou iʻoi aku ka pono i ka'āneu vulgaris.

NĀ'ĀINA

No ka loiloi i ka pono a me ka pono o ka Cortexolone 17α-propionate 1% cream ma ka'ānela vulgaris ma ka hoʻohālikeʻia me placebo a me ka 0 · 05% cream tretinoin.

METHOD

Hiki i nā kānaka he kanahikukumamāhiku iʻike i ka 2-3 e like me ka'IGA (Investigator's Global Assessment (IGA) i loaʻa kahi placebo i (n = 15), aiʻole Cortexolone 17α-propionate 1% cream (n = 30), aiʻole 0 05 tretinoin % cream (n = 32) i hoʻokahi manawa i ka lā ma kahi hoʻomaha no nā hola 8. Ua hoʻonuiʻia ka pono o ka lawelaweʻana ma nāʻano 2 a pau me nā helu helu liona (TLC), helu helu liona inflammatory (ILC), ka hō'ālua o ka'eneki (ASI) a me IGA. ʻO ka papa hana palekana e komo ana i ka heluʻana o ka hanu, kahi hoʻolālā lapaʻau, hoʻokolohua kino, nā hōʻailona koʻikoʻi a me ka hoʻopaʻaʻana i nā hanana kū'ē.

Nā Hua

Uaʻae maikaʻi loaʻia ka CB-03-01 kaomi, a uaʻoi aku ka maikaʻi ma mua o placebo e pili ana i ka TLC (P = 0 · 0017), ILC (P = 0 · 0134) a me ASI (P = 0 · 0090), aʻoi aku ka maikaʻi. ma mua o ke kūkākūkā. Ua hoʻokomoʻia ka huahana i ka wikiwiki o ka loaʻaʻana o ka 50% i ka hoʻololiʻana i nā mea hoʻohālikelike i luna. CB-03-01

KE KULA

Ke kākoʻo nei kēia haʻawina pilot i ke kumu no ka hoʻohanaʻana i nā antiandrogens topical i ka mālamaʻana i kaʻeha vulgaris. ʻO Cortexolone 17α-propionate 1% cream ka mea kūpono me kaʻike o kahi antiandrogen kūpono no ka hoʻohanaʻana i ka loiloi.

Pehea e hana aiʻo Cortexolone 17α-propionate

Cortexolone 17α-propionate (CAS 19608-29-8), aiʻole 11-deoxycortisol 17α-propionate, he meaʻonika steroidal antiandrogen -ʻoiaʻiʻo, he antagonist e loaʻa ana i nā kumuhana Androgene - ke hoʻomōhalaʻia nei e Cassiopea a me Intrepid Therapeutics no ke hoʻohanaʻana i lāʻau lapaʻau ma ʻo ka hoʻomaluʻana i nā kumu hoʻohālike o ka androgene me kaʻene vulgaris a me ka androgenic alopecia (pale male). ʻO C17α propionate ester o 11-deoxycortisol (cortexolone); Loaʻa ka loaʻaʻana o nā esters o C17a o 11-deoxycortisol i ka loaʻaʻana o ka hana antiandrogen, a ua kohoʻia ka cortexolone 17α-propionate no ka hoʻonuiʻana ma muli o konaʻike lāʻau maikaʻi loa.

Ma nāʻiole, ua loaʻa ka lāʻau lapaʻau no ka loaʻaʻana o ka hanaʻoihana antiandrogen i ka'āpana, akā,ʻoiʻole kaʻoihana antiandrogen pūnaewele i ka lawelaweʻiaʻana ma keʻano o nā inikopa. Eia kekahi, o ka cortexolone 17α-propionateʻaʻole he progonadotropic, e'ōlelo ana he mea maʻamau ke koho. I ka mea kanu, uaʻoi aku ka nui o kaʻoihana o ka lāʻau lapaʻau ma mua o ka progeterone, flutamide, a me finasteride a he like me ka cyproterone acetate.

Ua ho'āʻoʻia kahi ho'āʻo uila ma 2011 o nā kāne i hanaʻia me ka XTUMX% cortexolone topicine-propionate 17% o ka'ekene i loaʻa ka maikaʻi o ka lāʻau a hōʻemi nuiʻia nā hōʻailona o kaʻeha. Eia kekahi, uaʻoi aku ka nui o kona kūpono ma mua o ka mea hoʻokūkū hana,ʻo 1% cream. No 0.05, hiki i ka lāʻau lapaʻau i loko o ka hui III mau ho'āʻo hoʻokolohua no nā'ākena vulgaris a me ka hoʻolālā o ke kau II no ka alopecia androgenic.

'Ōlelo Aʻo

ʻO Cortexolone 17a-proprionate, Breezula kaola i kona mau polymorphic:ʻo kaʻohana mua o ka patent, e pau ana i United States ma 2022 / 23 a me ka 2022 i ke koena o ke ao, e uhi i ka hoʻohanaʻana i ka lāʻau no ka hoʻomaʻemaʻeʻana i ka hakihaki, alopecia a me nā maʻi'ē aʻe; ʻO ka lua o nā palapala hōʻaia ka uhiʻana i nā'ōpoki crystalline a pau o ka API, nā mele e like me ka API like a me ka hoʻohanaʻana i kaʻele, AGA a me nā maʻi'ē aʻe: ua hoʻopukaʻia kēiaʻohana hoʻokele i United States, Europe, Canada, Japan and nā 'āina'ē aʻe, e pau i ka 2030 ma United States a me 2028 i ke koena o ke ao.Breezula lūlū

Cortexolone 17α-propionate Kaheʻe Laua

ʻOiwi kauohaʻo 10grams.
Hiki ke hoʻouna i ka nīnau no ka mea maʻamau (Ma waena o 1kg) i nā hola 12 ma hope o ka uku.
No ke kauoha nui aku hiki ke hoʻokuʻuʻia i ka 3 mau lā hana ma hope o ka uku.

ʻO Cortexolone 17α-propionate Nā meaʻono

No ka nīnauʻana i ko mākou mea hōʻailona kōkua (CSR) no nā kiko kiko'ī, no kāu reference.Winlevi paula

Cortexolone 17α-propionate Kakihi

E hoʻolakoʻia i ka wā e hiki mai ana.

He Cortexolone 17α-propionate kekahi i loaʻa i kekahiʻaoʻao

Cortexolone 17α-propionate he steroidal-ester hou, he androgen-antagonist maʻamau, i hoʻolakoʻia me ka hana'āpana hana'aloʻula,ʻaʻohe mea kūpono no ka hōʻailona o kaʻeha vulgaris. Hanaʻo CB-03-01 i ke kūlana o kaʻenehana-androgen-receptor āpau me kaʻole o ka hoʻonāukiʻana i ka 5α-reductase i loko o kaʻili. Hiki i ka mea hoʻokele ke komo i loko o kaʻili o ke kanaka a ua hoʻokomo kokeʻia i ka makualepa makuaʻole i nele i nā hopena pūnaewele. ʻO ka mea nui, i kēia lā,ʻaʻole ia i hōʻike i kahi hopena o ka hopena pūnaewele pūnaewele aʻoihana paha.


Pehea e kūʻai aku ai i ka Cortexolone 17α-propionate pauna mai AASraw

1.E hōʻike mai iā mākou ma o mākou leka uila pūnaewele noiʻi, aiʻole skype pūnaeweleka hoʻonohonoho hoʻonohonoho kanaka (CSR).
2.Ke hāʻawi mai i kāu helu a me kāu helu wahi.
3.OUR CSR e hāʻawi iāʻoe i ka helu, ka manawa uku, helu helu, nā puka puka a me ka lā i hōʻea muaʻia (ETA).
4.E ukuʻia a hoʻokuʻuʻia nā waiwai i nā hola 12 (No ke kauoha ma loko o 10kg).
Ua loaʻaʻo 5.Goods a hāʻawi i nā manaʻo.


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COA

HNMR

ideas

ʻO Cortexolone 17α-propionate Nā meaʻala maʻemaʻe:

No ka nīnauʻana i ko mākou mea hōʻailona kōkua (CSR) no nā kiko kiko'ī, no kāu reference.Winlevi paula

Nāʻike & nā hua'ōlelo huahana

Nā Hana Loss maikaʻi loa no nā kāne: Cortexolone 17α-propionate pauna (CB-03-01)