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Pākī Crizotinib (877399-52-5)

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SKU: 877399-52-5. Māhele:

ʻO ka AASraw me ka hōʻano a me ka hana hana mai ka gram a ka papa hana nui o ka pauku Crizotinib (877399-52-5), ma lalo o ke kānāwai CGMP a me ka'ōnaehana mālama maikaʻi.

Product Description

ʻO ka wikiō kalawī


Pākī ka pahu nā Pūʻulu Pūʻulu

Name: Pākī ka pahu
CAS: 877399-52-5
Nā Kaulike Molecular: C21H22Cl2FN5O
Molecular Weight: 450.343
Wahi Manaʻo: 197-203 ° C
Hōʻoia Kōkua: RT
kala like 'ole: keʻokeʻo i ka pale pale-kōma


Crizotinib ka pauka i ka hoʻohanaʻana i ka lāʻau maʻi

Nā inoa

Crizotinib ka pauka, ka pauka Xalkori

Ka hoʻohanaʻiaʻana o ka paukū

ʻO ka'elepa Crizotinib he lāʻau maʻi lapaʻau e pale i ka ulu a me ka hoʻolahaʻana o nā pūnaeho maʻi maʻi i loko o ke kino. Hoʻopiliʻia ka māmā Crizotinib no ka mālamaʻana i ka maʻi kanulau liʻiliʻi liʻiliʻi.

ʻO ka'elepa Crizotinib ka mea hana'ākau tyrosine kinase. Hana ia ma ke kāohiʻana i kahi enzyme i kapaʻiaʻo anaplastic lymphoma kinase (ALK). ʻO ka pauma Crizotinib wale nō ka hana i loko o nā puʻukua maʻiʻeleʻele e loaʻa kahi overactive o ALK. Ma 5 ma 100 poʻe (5%) me NSCLC ka mea. Kapaʻiaʻo ia ka maʻi ALK.

Hiki i kāu kauka ke'ōlelo iāʻoe e loaʻa iā Crizotinib ka pauka inā loaʻaʻoe i kahi maʻiʻeleʻele liʻiliʻi liʻiliʻi e pono aiʻo ALK.

Hoʻopihaʻia nā capsulesʻeleʻele e like me nā capsules ulu pa'ū i kākauʻia me ka 250 mg a me ka 200 mg o Crizotinib pauka me ka silica dioxide, ka cellulose microcrystalline, ka waipika konupomi calipate phosphate, ka waileka sodium sodium, ka konupora stearate, a me nā pūpū capella ka malole paʻakikī e like me nā mea hanaʻole.

ʻO nā kinikini o ka poli opaque mālū na gelatin, ka hao dioxide, a me ka'opae hao hao. Aia nā gelatin a me ka dioxide o kaʻaila o kaʻaila opaque keʻokeʻo. ʻO ka pulina paipalapala ka loaʻaʻana o ka shellac, ka propylene glycol, ka hopena ammonia ikaika, ka potassium hydroxide, a me kaʻeleʻele hao hao.

ʻO ka paumaʻepa ka capsule. Pauʻoe ia mea me kahi aniani wai. Hiki iāʻoe ke loaʻa me kaʻaiʻole.

Ponoʻoe e lawe i nā capsules e like me ke kuhikuhi a kāu kauka a kauka lāʻau hāʻawi iāʻoe.
Ponoʻoe e lawe i ka hōʻailona kūpono,ʻaʻole nui a emiʻole.

Mai haʻalele i ka laweʻana i ka lāʻau lapaʻau me ka'ōleloʻole aku i kāu kauka.

Hoʻoluaʻoe i ka lā - hoʻokahi kakahiaka a hoʻokahi manawa i ke ahiahi.

Hoʻomaopopo mauʻoe no ka lōʻihi o ka hanaʻana, koe naʻe kaʻinoʻole o nāʻaoʻaoʻaoʻao.

Loaʻa iāʻoe nā hoʻokolohua koko ma mua o ka hoʻomakaʻana i ka lapaʻau a me kāu kauka. Hoʻopili lākou i kāu mauʻokoʻa koko a me nā mea'ē aʻe i loko o ke koko. ʻIke lākou i ka hana o kou ate a me nā puʻupaʻa.

Pākuʻi iā Adrafinil

Hiki ke hoʻohana i nā lāʻau lapaʻau me kekahi mau lāʻau lapaʻau a me nā mea kanu. E haʻi i kāu kauka a mea kauka lāʻau paha e pili ana i nā lāʻau a pau āu e lawe nei. Hoʻopili kēia i nā huaʻai, nā mea kanu āpau a me nā mea hōʻailona.

E mālama i ka huaʻala a me ka waiʻona no ka mea hiki iā lākou ke hoʻonui i nā hopena o kaʻaoʻao.

ʻO ka hāpaiʻana a me ka hihia
Hiki ke hōʻeha kēia lāʻau i kahi pēpē e ulu ana i ka'ōpū. He mea nui eʻoleʻoe e hāpai aiʻole e hānau i ke keiki i ka wā e hanaʻia aiʻoe me kēia lāʻau lapaʻau a no nā mahina 3 ma hope iho. E kūkākūkā i kāu kauka a kahu maʻi paha e pili ana i nā hoʻokepeka kūpono ma mua o ka hoʻomakaʻana i ka hoʻomalu

Māmā
ʻAʻoleʻike mākou i ka hikiʻana i kēia maʻamau ke hoʻololi i ka momona. ʻAʻole hiki iāʻoe ke hāpai a makua paha i ke keiki ma hope o ka mālamaʻana i kēia lāʻau lapaʻau. E kūkākūkā i kāu kauka ma mua o ka hoʻomakaʻana i nā hana hoʻomalu inā manaʻoʻoe e makemake pahaʻoe e loaʻa i ke keiki i ka wā e hiki mai ana.

Hiki i kekahi poʻe ke mālama i ka sperm ma mua o ka hoʻomakaʻana i ka lapaʻau. Hiki i kekahi mau wahine ke mālama i nā hua a me nā hōʻailona ma mua o ka hoʻokuʻuʻana.

Ka hānaiʻana
Mai hānai i ka umauma i loko o kēia maʻamau no ka hikiʻana o ke kaukō i loko o kou waiu waiū.

Hana no nā kumu'ē aʻe
E haʻi pinepine i nā kauka, nā kahu hānai, nā kauka lāʻau a lāʻau paha e loaʻa iāʻoe kēia hana inā e ponoʻoe e lapaʻau no kekahi mea'ē aʻe, e like me nā pilikia o ka niho.

ʻO nā maʻi lapaʻau
ʻAʻohe o nā lāʻau lapaʻau me nā ola ola olala ma kāu hanaʻana a no nā manawa keu 6 ma hope.

Hiki iā ʻoe:

ʻO nā lāʻau'ē aʻe'ē aʻe, akāʻaʻole lākou e hāʻawi iāʻoe i ka pale nui e like me ka mea maʻamau
ʻO ka maʻi o ka maʻi
-e hoʻokaʻaʻike aku i nā kānaka'ē aʻe i ola i nā lāʻau lapaʻau e like me nā injections

E hōʻalo i ka pilina me nā poʻe i ola i nā lāʻau lapaʻau i laweʻia e ka waha (nā lāʻau āpau waha). ʻO kēia keʻano o ka lapaʻau rotavirus i hāʻawiʻia i nā keiki. ʻO ka maʻi i loko o ka'ōmene pēpē no nā wiki 2 a hiki iā ia ke hōʻeha iāʻoe. No laila, e hōʻole i ka hoʻololiʻana i kā lākou napies no nā 2 mau hebedoma ma hope o ka hōʻailonaʻana inā hiki. A iʻole eʻaʻahu i nā mīkina lima a holoi i kou mau lima ma hope.

Ponoʻoe e pale i kekahi mea i loaʻa i ka maʻi polio a iʻole typhoid i kēia manawa.

Nā kuhikuhi hou aku

ʻO ka paukū XALKORI (Crizotinib lulupa) he mea hōʻailona o ka tyraline receptor tyrosine kinase. ʻO ke kinikōmololo no ka pauma Crizotinib ka C21H22Cl2FN5O. ʻO ke kaumaha kaumaha ka 450.34 pahuhopu. Crizotinib pauka ua ho'ākāka 'ia ma chemically like (R) -3- [1- (2,6-Dichloro-3-fluorophenyl) ethoxy] -5- [1- (piperidin-4-yl) -1H-pyrazol-4-yl] pyridin- 2-amine.

Crizotinib he lepo lā o ka keʻokeʻo i ka haikea-yellow ka pauka me ka pKa o 9.4 (piperidinium cation) a me 5.6 (pyridinium cation). Ke solubility o Crizotinib he lepo lā i loko o koʻana koko Media emi ma ka laulā pH 1.6 i pH 8.2 mai iʻoi aku ma mua o 10 mg / ML i emi ma mua o 0.1 mg / ML. ʻO ka log o ka helu helu hoʻohui (octanol / wai) ma ka pH 7.4 ka 1.65.

Loaʻa i ke kōkua lapaʻau kūikawā inā loaʻa iāʻoe kekahi o kēia mau hōʻailona o ka hopena maʻi: hives; ka hanu pilikia; ka pehu o kou mau maka, kou lehelehe, kou lehelehe, a me kou puʻu.

Mai ka hoʻohanaʻana i ke kalapona Crizotinib a kelepona i kāu kauka i ka manawa hoʻokahi inā loaʻa iāʻoe kekahi hopena koʻikoʻi koʻikoʻi e like me:

nā nūnū nui, nāwaliwali, nā wikiwiki a me nā'ōpū o ka puʻuwai;
nā pilikia o ka hihiʻo e like me ka nānā i ka hihiʻo, hoʻonui i kaʻike o kou mau maka i ka mālamalama, aiʻole eʻike ana i nā kukui o ka mālamalama aiʻole nā ​​"floaters";
ka eha o ka maʻi, ka maloʻo maloʻo a me ka ulua me ke kīkino, ka uila, ka manaʻoʻole i ka hanu, kaʻehaʻeha, ke koko ...

Pākīpika māmā Pāpaʻi

ʻOiwi kauohaʻo 10grams.
Hiki ke hoʻouna i ka nīnau no ka mea maʻamau (Ma waena o 1kg) i nā hola 12 ma hope o ka uku.
No ka hoʻonohonoho nui (Ma waena o 1kg) hiki ke hoʻounaʻia i ka 3 workingdays ma hope o ka uku.

Crizotinib pauhana Marketing

E hoʻolakoʻia i ka wā e hiki mai ana.


Pehea e kūʻai ai i ka Crizotinib pauku mai AASraw

1.E hōʻike mai iā mākou ma o mākou leka uila pūnaewele noiʻi, aiʻole skype pūnaeweleka hoʻonohonoho hoʻonohonoho kanaka (CSR).
2.Ke hāʻawi mai i kāu helu a me kāu helu wahi.
3.OUR CSR e hāʻawi iāʻoe i ka helu, ka manawa uku, helu helu, nā puka puka a me ka lā i hōʻea muaʻia (ETA).
4.E ukuʻia a hoʻokuʻuʻia nā waiwai i nā hola 12 (No ke kauoha ma loko o 10kg).
Ua loaʻaʻo 5.Goods a hāʻawi i nā manaʻo.

NA HALO A E HOOLAHA:

E kūʻai ʻia ana kēia ʻano mea no ka noiʻi noiʻi wale nō. Wahi a ke kūʻai aku. ʻAʻole no ka loiloi kanaka, ʻaʻole lāʻau lapaʻau, manu hoʻāno, a i ʻole e kōkua ʻia nā mea hale.


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COA

HNMR

Kalepa Crizotinib (877399-52-5) AASRAW HNMR

ideas

Kāpena Crizotinib Pākī Pālolo Manua

No ka nīnauʻana i ko mākou mea hōʻailona kōkua (CSR) no nā kiko'ī, no kāu'ōlelo.

Nāʻike & nā hua'ōlelo huahana

ʻO ka pauku'āpana (877399-52-5) he mea hōʻailona hōʻailona hana kino