ʻO Pregabalin ka lepo

Pregabalin Powder Video-AAsraw

Nā Kiʻi Kumu

He aha Pregabalin pʻona anei?

ʻO Pregabalin kahi lāʻau lapaʻau i hoʻohana ʻia e hoʻomaha i ka ʻeha neuropathic, me ka ʻeha mai ka hōʻeha ʻana o ke aʻalolo maʻi ma nā lima, nā lima, nā wāwae, nā wāwae, a me nā manamana wāwae, a me ka neuralgia postherpetic (ʻeha ma hope o ka shingles). Hoʻohana ʻia e mālama i ka fibromyalgia, ka ʻeha neuropathic ma hope o ka hōʻeha ʻana i ke kuamoʻo, a ma ke ʻano he lapaʻau adjuvant no kekahi ʻano o ka hopu ʻana i nā pākeke a me nā keiki. Eia kekahi, he lāʻau anticonvulsant ka pregabalin e hana ana ma ka hoʻohaʻahaʻa ʻana i nā hōʻailona ʻeha mai nā aʻalolo ʻeha. Ua ʻae mua ʻia i ka makahiki 2004 no ka mālama ʻana i ka epilepsy, akā pili pū kekahi i nā kemika lolo e pili ana i ka hōʻailona ʻeha.

How does Pregabalin wma ke kino?

ʻO Pregabalin kahi lāʻau lapaʻau maʻalahi e hiki ke mālama i nā pilikia olakino. Hiki iā ia ke pale i nā hōʻailona ʻeha i ka ʻeha neuropathic, hoʻoponopono i ka hoʻokuʻu ʻana o ka neurotransmitter e pale aku i ka hopu ʻana, a hiki ke kōkua i ka hoʻohaʻahaʻa ʻana i ka hopohopo ma ke kāohi ʻana i ka hoʻokuʻu neurotransmitter.

Kāohi a hoʻopaʻa i nā hōʻailona ʻeha:

ʻO ka neuralgia, ka mea i kapa ʻia ʻo ka ʻeha neuropathic, ke kumu pinepine ʻia e ka ʻeha aʻalolo, e hopena i nā hōʻailona ʻeha aberrant. Hoʻopilikia ʻo Pregabalin i kēia kaʻina hana ma ke kāohi ʻana a i ʻole ka hoʻopaʻa ʻana i nā leka ʻeha, ma ka lolo a me ke kuamoʻo, kahi e hana ʻia ai a hāʻawi ʻia i ke koena o ke kino. Hiki i ka Pregabalin ke kōkua i ka poʻe me nā maʻi e like me ka neuropathy diabetic, post-herpetic neuralgia, a me ka fibromyalgia e hoʻomaha i ka ʻeha hoʻomau a me ka hoʻoluhi pinepine ʻana i ka hoʻouna ʻana i nā hōʻailona ʻeha.

Hoʻololi i ka hana uila maʻamau i loko o ka lolo:

Hōʻike ʻia ka maʻi maʻi ma muli o ka hana uila ʻino a keu loa i loko o ka lolo, e alakaʻi ana i ka hopu ʻana. Hana ʻo Pregabalin ma ka hoʻoponopono ʻana i ka hana uila aberrant i loko o ka lolo e kāohi ai i ka epileptic seizures. Hoʻemi ʻo Pregabalin i ka excitability o nā neurons lolo, kahi e hōʻemi ai i ka hopena o ka hoʻokuʻu aberrant. Hiki i ka Pregabalin ke kōkua i ka poʻe me ka epilepsy e hoʻoponopono maikaʻi i ko lākou kūlana a hoʻemi i ka pinepine a me ka paʻakikī o ka hopu ʻana ma o ka hoʻoponopono ʻana i ka hana uila i loko o ka lolo.

Hoʻopaʻa i nā ʻōnaehana neurotransmitter:

Hoʻokumu ʻia nā maʻi hopohopo ma muli o ke kaulike kemika i loko o ka lolo, kahi e hoʻoulu ai i nā manaʻo o ka ʻoluʻolu, ka hopohopo, a me ka makaʻu. Hoʻopili ʻia nā hopena sedative o Pregabalin ma o kēia mau ʻōnaehana neurotransmitter. ʻO ka Pregabalin, ʻo ia hoʻi, ke kāohi nei i ka hoʻokuʻu ʻana o nā kemika o ka lolo e hoʻopuka ai i ka hopohopo. ʻOiai ʻaʻole hoʻohana mau ʻia ka pregabalin ma ke ʻano he lāʻau lapaʻau mua no nā maʻi hopohopo, hiki ke hoʻohana ʻia i kekahi mau hihia kahi i hōʻike ʻia ai nā lāʻau lapaʻau ʻē aʻe i ʻoi aku ka maikaʻi.

ʻOiai ua loaʻa ākea ka pauka pregabalin ma ka honua holoʻokoʻa, he mea nui ia e hoʻomaʻamaʻa i ka wā e noʻonoʻo ai e kūʻai a kūʻai wale mai ia mai nā kumu kaulana. He nui nā mea hana pregabalin a me nā mea hoʻolako e ʻōlelo nei e hāʻawi lākou i ka pregabalin o ke ʻano kiʻekiʻe, akā ʻaʻole pono nā pauka pregabalin āpau. ʻO ke kūʻai ʻana i nā lāʻau lapaʻau mai nā kumu i hōʻoia ʻole ʻia a i ʻole nā ​​mākeke pūnaewele hiki ke pilikia a hiki ke hopena i ka loaʻa ʻana o nā huahana hoʻopunipuni.

ʻO ka bpono o ʻO Pregabalin ka lepo 

ʻO ka pauka Pregabalin kahi lāʻau lapaʻau maʻalahi e hiki ke kōkua i nā poʻe me nā pilikia olakino. ʻO ka neuropathy diabetic peripheral, postherpetic neuralgia, partial epilepsy, fibromyalgia, neuropathic pain, a me ka maʻi hopohopo nui kekahi o nā maʻi maʻamau e hiki ke pōmaikaʻi ma ka hoʻohana ʻana i ka pauka AASraw pregabalin.

①ʻO ka maʻi maʻi maʻi neuropathy (DPN)

ʻO ka neuropathy maʻi diabetic (DPN) kahi hopena maʻamau o ka maʻi diabetes type 1 a me ke ʻano 2 e pili ana i ka 30-40% o nā maʻi. ʻO ka ʻeha, nāwaliwali, a me ka nalowale ʻana o ka naʻau he hōʻailona ia o kēia maʻi aʻalolo ma nā lima a me nā wāwae. ʻO ka pauka Pregabalin ka lāʻau lapaʻau mua no DPN, a hāʻawi ia i ka hoʻomaha ʻeha nui.

②ʻO Postherpetic Neuralgia (PHN)

ʻO ka postherpetic neuralgia (PHN) kahi maʻi ʻeha mau loa e hiki mai ana ma hope o ka puka ʻana o ka herpes zoster a ulu nui aʻe i ka wā e ulu aʻe ai nā maʻi. He paʻakikī ke mālama ʻana i ka PHN a koi pinepine i ka hoʻohana ʻana i nā lāʻau lapaʻau he nui e hāʻawi i ka hoʻomaha ʻeha. ʻO ka lāʻau lapaʻau hou loa i laikini ʻia no PHN ʻo ka pauka pregabalin. Hōʻike ka ʻikepili i ka maikaʻi o ka hōʻeha ʻana i ka ʻeha a me ka hoʻopau ʻana i ka hiamoe i hana ʻia e PHN i nā maʻi i hoʻopilikia ʻia.

③Epilepsy hapa

ʻO ka pauka Pregabalin kahi lāʻau antiepileptic i ʻae ʻia a kūʻai ʻia no ka hoʻohana ʻana ma ke ʻano he lāʻau lapaʻau no ka epilepsy hapa. Hoʻololi ia i ka hoʻokuʻu neurotransmitter i ka CNS ma ka hana ʻana i nā kahawai calcium presynaptic. ʻEkolu multi-center randomized, double-blind, placebo-controlled trials e pili ana i ka poʻe maʻi me ka refractory partial epilepsy i ʻike ʻia he hopena antiepileptic ka pregabalin ke hoʻohālikelike ʻia me ka placebo ma ke ʻano he supplementary therapy, me 31-51% o nā maʻi e loaʻa ana he 50% hoʻemi i ka pinepine hopu. .

④Fibromyalgia

Manaʻo ʻia ka pauka Pregabalin e hōʻoluʻolu i ka ʻeha fibromyalgia ma ke kāohi ʻana i ka hoʻolaha sensory o ka nociception a me ka hoʻokuʻu ʻana o ka neurotransmitter ma ke ala e piʻi ai i ka ʻeha ma o ka hoʻopaʻa ʻana i ke kahawai calcium. Ua hōʻike pū ʻia ʻo Pregabalin e hōʻemi i ka pae glutamate a me ka glutamine i ka insula hope o ka poʻe maʻi fibromyalgia, ke keʻakeʻa nei i kāna pili hana i ka pūnaewele mode default.

Hōʻike nā noiʻi ʻana i ka hoʻoulu ʻana o ke aʻalolo occipital (ONS) i nā poʻe maʻi fibromyalgia e hoʻemi ʻia ka hoʻoponopono ʻana i ka ʻeha. Ua hōʻike ʻia ʻo Pregabalin i nā ʻiole i hōʻeha i ke aʻalolo e loaʻa nā hopena i ka iho ʻana o ka ʻeha ʻeha; no laila, hiki i nā hana koʻikoʻi o pregabalin ke kōkua i kona kūleʻa i ka mālama ʻana i ka fibromyalgia.

⑤ʻEha ʻO Neuropathic

ʻO ka Pregabalin podwer kahi mea kūʻē i ke kahawai Ca2+ i loaʻa i nā hopena analgesic ma o ka hoʻopaʻa ʻana i ka subunit alpha-2-delta. Hoʻomaʻamaʻa maikaʻi ia i nā hōʻailona o nā ʻano like ʻole o ka ʻeha neuropathic a ua ulu aʻe i kahi lāʻau lapaʻau lapaʻau mua me kahi kiʻekiʻe o ka palekana a me ka pono. Ua hōʻike ʻia ka maikaʻi i ka mālama ʻana i nā hōʻailona e like me allodynia a me hyperalgesia i ka preclinical study i kekahi mau ʻano holoholona o ka ʻeha neuropathic.

 ⑥ʻO ka maʻi kūpilikiʻi maʻamau (GAD)

Ua ʻike ʻia ʻo Pregabalin i loko o nā haʻawina e hana mau i ka mālama ʻana i ka maʻi hopohopo nui (GAD). Ua ʻike ʻia kahi loiloi koʻikoʻi he ʻehiku o ʻewalu mau hoʻokolohua randomized a hoʻomalu ʻia me ka pregabalin powder doses mai ka 150 a hiki i ka 600mg i hōʻike i nā hōʻemi koʻikoʻi i ka Hamilton Anxiety Rating Scale scores. ʻO ka nui o nā hōʻailona haʻalele a me ka hopohopo hou ma hope o ka hoʻopau ʻana he mea liʻiliʻi i kahi noiʻi ʻokoʻa e pili ana i nā maʻi GAD i loaʻa i ka pregabalin powder therapy no nā wiki 12-24. Hiki i ka pauka Pregabalin ke lilo i koho lapaʻau maikaʻi no nā maʻi GAD i pane maikaʻi ʻole i ka lāʻau antidepressant.

'Ōlelo Aʻo: No ka mea ua nakinaki ʻia ka pono maoli o pregabalin i ka maikaʻi o ka huahana, he mea koʻikoʻi ke kiʻi ʻana i ka pauka pregabalin kiʻekiʻe mai kahi mea hoʻolako pregabalin pauka hilinaʻi. Hana ʻo AASraw a hoʻolako i ka pregabalin raw pauka e like me nā koi hana koʻikoʻi. Inā makemake ʻoe, ʻo ka pauka pregabalin AASraw kahi koho maikaʻi loa.

He aha nā hopena ʻaoʻao o Pregabalin?

ʻO nā hopena ʻaoʻao o ka pauka pregabalin e like me nā mea ʻē aʻe o ke kikowaena pūnaeho depressants. ʻO nā hopena lāʻau maikaʻi ʻole e pili ana i ka hoʻohana ʻana i ka pregabalin penei:

Maʻa mau loa (>10%):

Hoʻoponopono

Ka maikaʻi

Maʻamau (1-10%):

ʻO ka hihiʻo pōʻino

ʻO Diplopia

Euphoria

Kū'ē

Hoʻonui i ka ʻai a me ke kaumaha ma hope

ʻAʻole maʻamau (0. 1-1%):

Hypoglycemia

Hāmeʻa

ʻO ka māmā

ʻO Myalgia

ʻO Arthralgia

ʻO ka Thrombocytopenia

ʻO nā koki koki

E mālama: Inā ʻaʻole e emi a nalo paha nā hopena ʻaoʻao, e ʻimi koke i ka lāʻau lapaʻau. Ma waho aʻe, e ʻoluʻolu e kūʻai i nā huahana kūpono e hōʻemi i nā hopena ʻaoʻao.

Dosage a me ka lawelawe ʻana o ka pauka Pregabalin no ka ʻike

Hōʻike ka papa ma lalo nei i ka manaʻo i manaʻo ʻia o ka pauka pregabalin no nā ʻano olakino like ʻole no ka kuhikuhi ʻana:

'Ōlelo Aʻo: Pono e hoʻomaopopo ʻia he mau ʻōlelo aʻoaʻo wale nō kēia mau dosage a hiki ke hoʻololi ʻia ma muli o nā ʻano pilikino e like me ka makahiki, ke kaumaha, a me ka mōʻaukala olakino. Eia kekahi, pono e hoʻololi ʻia ka dosage i ka manawa ma muli o ka pane ʻana o kēlā me kēia i ka lāʻau lapaʻau a me nā hopena ʻaoʻao. No ka hoʻokumu ʻana i ka dosage maikaʻi loa no kēlā me kēia kūlana olakino kūʻokoʻa, e hoʻopili me kahi loea mālama ola.

Ma hea e kūʻai ai i ka pauka Pregabalin?

Nui nā hale kūʻai pūnaewele a me nā mea kūʻai aku e kūʻai aku i nā peptides a me nā mea pili. Loaʻa paha ka Pregabalin no ke kūʻai ʻana ma kēia mau pūnaewele. Ke kūʻai aku nei i kahi kūʻai pūnaewele, he mea nui e koho i kahi mea kūʻai aku i ʻike ʻia a hilinaʻi. E heluhelu i nā loiloi mea hoʻohana, e ʻimi i nā palapala hōʻoia, a e hōʻoia i ka pono a me ka maikaʻi o ka huahana.

KANAKA He mea hana hanohano a mākaukau a me ka mea hoʻolako kūikawā i ka hāʻawi ʻana i ka pauka pregabalin. Me kā mākou ʻoihana loea a me kā mākou ʻike, hāʻawi mākou i nā huahana kiʻekiʻe i nā mea noiʻi, nā hui lāʻau lapaʻau, a me nā poʻe e hana ana i ka pregabalin synthesis a me ka hoʻomohala ʻana. Inā ʻoe e ʻimi nei i kahi mea hoʻolako pregabalin hilinaʻi, ʻo AASraw kahi koho maikaʻi loa.

FAQs

ʻO ka pregabalin kahi mea hōʻeha ʻeha ikaika?

Ua ho'ēmiʻia kaʻeha e ka hapakolu aʻoi aʻe paha no ka 5 o ka 10 poʻe i lawe i ka pregabalin 300 mg a iʻole 600 mg i kēlā me kēia lā, ke hoʻohālikelikeʻia me 3 o ka 10 i lawe i ka placebo. ʻO Pregabalin 300 mg a i ʻole 600 mg i kēlā me kēia lā i hōʻemi i ka ʻeha e 50% a ʻoi aʻe i loko o 3 a 4 paha o 10 mau kānaka me ka ʻeha diabetes, a me 2 a 3 paha o ka 10 me kahi placebo.

Hoʻopilikia anei ka pregabalin i ka hiamoe?

He kūpono a palekana ʻo Pregabalin i ka mālama ʻana i nā pilikia hiamoe i nā poʻe maʻi fibromyalgia ʻoiai e hoʻemi ana i ka helu o nā ala ala ʻoiai e hoʻonui ana i ka lōʻihi o ka hiamoe.

Pehea ka lōʻihi e lawe pono ʻia ai ka pregabalin?

Pehea ka lōʻihi e lawe ai au i ka pregabalin? Pono e hoʻohana ʻia ʻo Pregabalin no ka lōʻihi e pono ai ʻoe e hōʻemi i ka ʻeha ʻeha. Pono e nānā ʻia i kēlā me kēia ʻeono a ʻumikūmālua mahina. Inā ua lawe kekahi i ka pregabalin no ka manawa lōʻihi, ʻaʻole hiki ke hana hou a pono paha.

ʻO ka manawa hea ka manawa kūpono e lawe ai i ka pregabalin?

ʻOi aku ka maikaʻi o ka lawe ʻana i ka maʻi mua i ka pō. ʻO ka 300-450 mg i kēlā me kēia lā (e laʻa, 150 mg ʻelua a ʻekolu mau manawa i kēlā me kēia lā). ʻO ka palena kiʻekiʻe loa o Pregabalin i kēlā me kēia lā he 600 mg. He palekana ke lawe me ka ʻai ʻole.

He mea make ka pregabalin i ke ake?

ʻO Pregabalin kahi mea hoʻopaneʻe hana neuronal i hoʻohana ʻia e mālama i ka neuropathy ʻeha a ma ke ʻano he anticonvulsant. ʻAʻole pili ka piʻi ʻana o ka serum aminotransferase me ka lāʻau pregabalin, a ua kākau ʻia ka hōʻino ʻana o ka ate mai ka pregabalin akā ʻike ʻia he kakaikahi.

Pili ka pregabalin me ka nalo iwi?

Ua ʻike ʻo Akin a me nā hoa hana ʻo ka lawelawe ʻana i ka pregabalin (Lyrica) i kāna ʻano lāʻau lapaʻau no ʻeono mahina ʻaʻohe hopena i ka metabolism iwi, me ka nānā ʻole i ke kāne, ma kahi noiʻi o 40 mau maʻi, 27 wahine a me 13 kāne.

Pehea e kūʻai pregabalin powder mai AASraw?

❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu WhatsApp iā mākou, e hoʻopili aku kā mākou mea kūʻai aku (CSR) iā ʻoe i loko o 12 mau hola.

❷E hāʻawi iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.

❸Na kā mākou CRS e hāʻawi iā ʻoe i ka ʻōlelo ʻōlelo, ka manawa uku, ka helu huli, nā ala hoʻouna, a me ka lā i manaʻo ʻia e hiki mai ai (ETA).

❹E uku ʻia a hoʻouna ʻia nā waiwai i loko o 12 mau hola.

❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.

Pregabalin Powder(148553-50-8)-COA

Pregabalin Powder(148553-50-8)-COA

Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine

Mea kākau moʻolelo puke moʻolelo ʻepekema:
1. Alexandra M. Stein
ʻOihana Orthopedic, Hôpital Cochin Paris, 27, rue du Faubourg Saint-Jacques, 75014 Paris, Farani
2. Tomoya Akashi
Kumu o ka lāʻau lapaʻau, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Iapana
3. HR Martínez
Tecnologico de Monterrey, Escuela de Medicina a me Ciencias de la Salud, Monterrey NL, Mexico
4. Markus Dold
4.Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.

Reference

[1] MC Walker, JW Sander. Paʻakikī i ka extrapolating mai ka ʻikepili hoʻokolohua lapaʻau i ka hana lapaʻau: ka hihia o nā lāʻau antiepileptic. Neurology, 49 (1997), pp. 333-337

[2] MJ Field, RJ Oles, L. Singh. Pregabalin hiki ke hōʻike i kahi papa hou o nā mea anxiolytic me kahi ākea ākea o ka hana. Br J Pharmacol, 132 (2001), pp. 1-4

[3] Hong JS, Atkinson LZ, Al-Juffali N, Awad A, Geddes JR, Tunbridge EM, et al. (Malaki 2022). "Gabapentin a me ka pregabalin i ka maʻi bipolar, nā kūlana hopohopo, a me ka insomnia: Systematic review, meta-analysis, and rationale". Molecular Psychiatry. 27 (3): 1339–1349.

[4] Freynhagen R, Baron R, Kawaguchi Y, Malik RA, Martire DL, Parsons B, et al. (Ianuali 2021). "Pregabalin no ka ʻeha neuropathic i nā hoʻonohonoho mālama mua: nā ʻōlelo aʻoaʻo no ka dosing a me ka titration". Lapaʻau Postgraduate. Informa UK Limited. 133 (1): 1–9.

E kiʻi i kahi hōʻaiʻē nui