ʻO nā lāʻau lapaʻau 7 kiʻekiʻe loa no ka mālama ʻana i ka maʻi ʻaʻai maʻi-ʻāpono ʻia e FDA
Hana ʻo AASraw i ka paukū Cannabidiol (CBD) a me ka Hemp Essential Oil i ka nui!

Lung Cancer

    1. He aha ka maʻi ʻaʻai puʻu?
    2. He aha nā ʻano o ka maʻi ʻaʻai ʻōpū?
    3. He aha nā hōʻailona ke loaʻa ʻoe i ka maʻi ʻaʻai maʻi?
    4. Pehea e hiki ai iaʻu ke ʻike inā loaʻa wau i ka maʻi ʻaʻa maʻi?
    5. He aha nā pae o kaʻu maʻi ʻōpū paru?
    6. No ke aha e loaʻa ai wau i ka maʻi ʻaʻa maʻi?
    7. Pehea e mālama ai i kāu maʻi ʻōpū?

 

He aha ka maʻi ʻaʻai puʻu?

Hiki i ka maʻi ʻaʻai ke hoʻomaka i kekahi wahi i ke kino. Kapa ʻia ka maʻi ʻaʻa e hoʻomaka i ka akemāmā i kapa maʻi ʻaʻa. Hoʻomaka ia ke ulu aʻe nā hunaola i loko o ka akemāmā a hoʻohemo i nā pūnaewele maʻamau. He mea paʻakikī kēia i ke kino e hana i ke ʻano e pono ai.

Hiki i nā hunaola maʻi ʻaʻai ke hoʻolaha aku i nā ʻāpana ʻē aʻe o ke kino. Hiki i nā hunaola maʻi ʻaʻai i loko o ka māmā ke hele i kekahi manawa i ka lolo a ulu ma laila. Ke hana kēia i nā hunaola maʻi ʻaʻai, kapa ʻia ʻo metastasis. I nā kauka, like nā pūnana maʻi ʻaʻai i ka wahi hou e like me nā mea o ka akemāmā.

Kapa ʻia ka maʻi ʻaʻai no ka wahi e hoʻomaka ai. No laila ke pālahalaha ka maʻi ʻaʻai māmā i ka lolo (a i ʻole nā ​​wahi ʻē aʻe), ua kapa ʻia ia he maʻi ʻaʻa maʻi. ʻAʻole ia i kapa ʻia he maʻi ʻaʻai lolo ke hoʻomaka ʻole ia mai nā pūnaewele i ka lolo.

ʻIke ʻia: ʻO nā māmā he 2 mau ʻāpana sponge-like i loaʻa i ka umauma. ʻO nā māmā akau he 3 mau ʻāpana i kapa ʻia he lobes. ʻO ka māmā hema he 2 lobes. Lawe ka māmā i ka ea i loko a i waho o ke kino. Lawe lākou i ka oxygen a kāpae i ke kalapona kalapona, kahi huahana neoneo.

Lawe ka puka makani, a i ʻole trachea, i ka ea i loko o nā akemāmā. Māhele ʻia i ʻelua mau paipu i kapa ʻia ʻo bronchi (kapa ʻia kahi paipu he bronchus).

 

Lung Cancer

He aha nā ʻano o ka maʻi ʻaʻai ʻōpū?

Kāhea ʻia ka maʻi ʻaʻai e hoʻomaka i loko o nā akemāmā ʻo ka maʻi ʻaʻa maʻi nui. Ua ʻike ʻia ka maʻi ʻaʻai i hohola aʻe i nā akemāmā mai kahi wahi ʻē aʻe o ke kino. ʻO kēia ʻaoʻao e pili ana i ka maʻi ʻaʻai maʻi maʻi mua.

Aia he ʻano nui ʻelua o ka maʻi ʻaʻai nui ma mua. Hoʻokaʻawale ʻia kēia mau mea e ke ʻano o nā hunaola kahi e hoʻomaka ai ka ulu ʻana o ka maʻi ʻaʻai. O lākou:

ʻO ka maʻi ʻaʻai liʻiliʻi liʻiliʻi ʻole (NSCLC) - ka palapala maʻamau, e helu ana ma mua o 87% o nā hihia. Hiki iā ia ke lilo i hoʻokahi o nā ʻano ʻekolu: carcinoma cell squamous, adenocarcinoma a i ʻole carcinoma nui pūnaewele.

Ka maʻi ʻaʻa maʻi liʻiliʻi liʻiliʻi (SCLC) - kahiʻano liʻiliʻi e hoʻolaha pinepine aku ma mua o ka maʻi ʻaʻai liʻiliʻi liʻiliʻi ʻole.

ʻO ke ʻano o ka maʻi ʻaʻaʻa āu e hoʻoholo ai i nā ʻano lāʻau e koi ʻia ai.

 

He aha nā hōʻailona ke loaʻa ʻoe i ka maʻi ʻaʻai maʻi?

ʻAʻole hiki i nā poʻe me ka maʻi ʻaʻai puʻupuʻu ke loaʻa kekahi mau hōʻailona a hiki i kahi pae hope. Inā ʻike ʻia nā ʻōuli, hiki iā lākou ke hoʻohālikelike i nā maʻi o ka hanu.

 

ʻO kekahi o nā hōʻailona kūpono

▪ hoʻololi i ka leo o ke kanaka, e like me ka uē

▪ nā maʻi o ka umauma pinepine, e like me ka bronchitis a i ʻole ka niumonia

▪ ka ʻōhū ʻana i nā lymph node ma waenakonu o ka umauma

▪ kahi kūmū lohi e hoʻomaka paha e ʻino

▪ ʻehaʻeha o ka umauma

▪ ka pōkole o ka hanu a me ke kō

 

I ka manawa, hiki i kekahi kanaka ke ʻike i nā hōʻailona ʻoi loa, e like me:

▪ ʻeha ʻeha nui

▪ ʻeha iwi a me nā iwi haʻi

▪ ʻeha poʻo poʻo

▪ ʻūkū i ke koko

▪ kahe koko

▪ lilo ka makemake a me ka pohō kaumaha

▪ luhi

 

Lung Cancer

 

Pehea e hiki ai iaʻu ke ʻike inā loaʻa wau i ka maʻi ʻaʻa maʻi?

Nīnau ka kauka iā ʻoe i nā nīnau e pili ana i kou olakino a hana i kahi hōʻike kino. Inā ke kuhikuhi nei nā ʻōuli i ka maʻi ʻaʻai māmā, e hana ʻia nā hōʻike hou aku.

Eia kekahi o nā hoʻokolohua āu e pono ai:

Kānana x-ray: ʻO kēia ka hōʻike mua loa e hana ai e nānā i nā kiko ma kou mau māmā. Inā ʻike ʻia kahi loli, pono ʻoe i nā hoʻāʻo hou.

C scan: Kāhea ʻia kēia he scan CAT. He ʻano x-ray kūikawā ia e lawe i nā kiʻi kikoʻī o kāu ʻaoʻao o loko. Hiki ke hoʻohana ʻia ka CT scans e kōkua i ka hana ʻana i kahi biopsy (e ʻike ma lalo).

Pākuʻi PET: I kēia hoʻāʻo, hāʻawi ʻia ʻoe i kahi ʻano kō i hiki ke ʻike ʻia i loko o kou kino me kahi kāmela kūikawā. Inā loaʻa ka maʻi ʻaʻai, hōʻike ʻia ke kō ma ke ʻano he “wahi wela” kahi e loaʻa ai ka maʻi ʻaʻai. Hiki iā ia ke kōkua ke noʻonoʻo kāu kauka ua pālahalaha ka maʻi ʻaʻai, akā ʻaʻole ʻike i hea.

ʻO ka Bronchoscopy: Hoʻomoe ʻia kahi Tube lahilahi, māmā, maʻalahi i loko o kou waha i loko o ka bronchi. Hiki i ke kauka ke nānā i loko o ka pahu e loaʻa ai i nā tumors. Hiki ke hoʻohana ʻia ka paipu e hana i kahi biopsy.

Nā ho'āʻo koko: ʻAʻole hoʻohana ʻia nā hoʻokolohua koko e ʻike i ka maʻi ʻaʻaʻa, akā hana ʻia ia e haʻi hou aku i ke kauka e pili ana i kou olakino.

 

Lung Cancer

 

He aha nā pae o kaʻu maʻi ʻōpū paru?

Inā loaʻa iā ʻoe ka maʻi ʻaʻai liʻiliʻi liʻiliʻi liʻiliʻi, makemake ka kauka e ʻike pehea ka laha ʻana. Kāhea ʻia kēia. Ua lohe paha ʻoe i nā poʻe ʻē aʻe e ʻōlelo ana ʻo kā lākou maʻi ʻaʻai ka "pae 2" a i ʻole "pae 3." E makemake ana kāu kauka e ʻike i ke kahua o kou maʻi ʻaʻai e kōkua ai i ka hoʻoholo ʻana i ke ʻano o ka hoʻomaʻamaʻa maikaʻi loa nāu.

Hōʻike ka paepae i ka hoʻolaha ʻana o ka maʻi ʻaʻai ma o ka māmā. Hōʻike pū kekahi inā ua pālahalaha ka maʻi ʻaʻai i nā lālā kokoke a i ʻole nā ​​mea kino i mamao loa aku.

Hiki i kāu pae ke pae 1, 2, 3, a i ʻole 4. ʻO ka haʻahaʻa o ka helu, ʻo ka liʻiliʻi o ka pā ʻana o ka maʻi ʻaʻai. ʻO ka helu kiʻekiʻe, e like me ka pae 4, ʻo ia hoʻi kahi maʻi ʻaʻai ʻoi loa i pālahalaha ʻia ma waho o kou mau māmā. E nīnau pono i ke kauka e pili ana i ka pae o kou maʻi ʻaʻai a me ke ʻano o ia.

ʻO AASraw ka mea hana ʻoihana o nā lāʻau ʻino ʻo Lung.

E ʻoluʻolu e kaomi ma aneʻi no ka ʻike ʻōlelo. Hana iā mākou

 

(1) Nā pae o ka maʻi ʻaʻai liʻiliʻi liʻiliʻi liʻiliʻi

Hoʻohana maʻamau ka poʻe ʻoihana olakino i ka nui o ka tumo a pāhola e wehewehe i nā pae o ka maʻi ʻaʻai liʻiliʻi liʻiliʻi liʻiliʻi, penei:

Hoʻokupu, a i ʻole hūnā ʻia: ʻAʻole hōʻike ʻia ke kanesa ma nā kiʻi paʻi kiʻi, akā ʻike ʻia nā hunaola maʻi ʻaʻai i ka phlegm a i ʻole ka mucus.

Hana 0: Aia nā pūnaewele ʻokoʻa wale i nā papa luna o nā hunaola e kau ana i nā alaloa.

Hana 1: Aia kahi tumo i loko o ka akemāmā, akā he 4 kenimika (knm) a ma lalo a ʻaʻole pālahalaha ʻia i nā ʻāpana ʻē aʻe o ke kino.

 Hana 2: He 7 knm a ma lalo paha ka tumo a ua pālahalaha paha i nā mea kokoke a me nā pūnana lymph.

Hana 3: Ua pālahalaha ka maʻi ʻaʻai i nā lymph node a hōʻea i nā ʻāpana ʻē aʻe o ka akemā a me nā wahi e pili ana.

Hana 4: Ua pālahalaha ka maʻi ʻaʻai i nā ʻāpana o ke kino i mamao loa, e like me nā iwi a me ka lolo.

 

(2) Nā Kūlana Of Small kulai Ce Lung Cancer

Loaʻa i kāna maʻi ponoʻī ka maʻi ʻaʻai puʻupuʻu liʻiliʻi. ʻIke ʻia nā pae ma ke ʻano he palena a ākea hoʻi, a kuhikuhi lākou inā ua pālahalaha ka maʻi ʻaʻai i loko a i ʻole ma waho o nā māmā.

I ka pae kaupalena, hoʻopili ka maʻi ʻaʻai i hoʻokahi ʻaoʻao o ka umauma, ʻoiai aia paha ia i kekahi o nā lymph node e pili ana. Ma kahi o ka hapakolu o ka poʻe me kēia ʻano e ʻike he maʻi ʻaʻai kā lākou i ka manawa o ka pae palena. Hiki i nā ʻoihana ola kino ke mālama iā ia me ka radiation therapy ma ke ʻano he wahi hoʻokahi.

I ka pae nui, ua pālahalaha ka maʻi ʻaʻai ma ʻō aku o ka ʻaoʻao o ka umauma. Hoʻopili paha ia i ka lung a i ʻole nā ​​ʻāpana ʻē aʻe o ke kino. Ma kahi o ʻelua hapakolu o ka poʻe me ka maʻi ʻaʻai liʻiliʻi liʻiliʻi e loaʻa iā lākou ke loaʻa ia i ka wā nui.

 

No ke aha e loaʻa ai wau i ka maʻi ʻaʻa maʻi? 

Hoʻomohala ka maʻi ʻaʻai ma hope o ka hōʻino ʻana o ka genetika i ka DNA a me nā loli epigenetic. Hoʻopili kēlā mau hoʻololi i nā hana maʻamau o ka cell, e like me ka hoʻonui ʻana o ka cell, ka make ʻana o ka cell (apoptosis), a me ka hoʻoponopono ʻana iā DNA. Ke piʻi aʻe ka nui o nā pōʻino, piʻi ka makaʻu no ka maʻi ʻaʻai.

ʻO kēia mau kumu ke alakaʻi i ka maʻi ʻaʻai maʻi māmā:

No ke aha e loaʻa ai wau i ka maʻi ʻaʻai pūpū

 

 

▲ Paka

ʻAʻole loaʻa i nā mea puhipaka nā maʻi ʻaʻaiā āpau, a ʻaʻole nā ​​kānaka āpau i loaʻa i ka maʻi ʻaʻa maʻi he puhipaka. Akā ʻaʻohe kānalua ʻo ka puhipaka ka mea nui makaʻu nui loa, e kumu ana 9 mai loko mai o 10. Ma waho aʻe o ka puhipaka, pili pū ka pika a me ka puhipaka ʻana i ka maʻi ʻaʻai māmā. ʻO ka nui o kou puhi a ʻo ka lōʻihi o kou puhi, ʻo ka nui o kou manawa o ka ulu ʻana i ka maʻi ʻaʻai māmā

ʻAʻole pono ʻoe e puhipaka e hoʻopilikia ʻia. ʻO ka hanu ʻana i ka uahi a nā poʻe ʻē aʻe e hoʻonui ai i ka makaʻu o ka maʻi ʻaʻai māmā. Wahi a nā Centers for Disease Control and Prevent CDC) Source Trusted, ʻo ka uahi lua ke kuleana no ka make ʻana o ka maʻi ʻaʻai pūhaka ma kahi o 7,300 i kēlā me kēia makahiki ma United States.

Loaʻa nā huahana paka i ka 7,000 mau kemikō, a ma ka liʻiliʻi he 70 i ʻike ʻia e lilo i ka maʻi ʻaʻai.

Ke hanu ʻoe i ka uahi paka, hāʻawi pololei ʻia kēia hui ʻana o nā kemika i kou mau māmā, kahi e hoʻomaka koke ai e hōʻino.

Hiki i nā māmā ke hoʻoponopono hou i nā mea hōʻino i ka wā mua, akā ʻo ka hopena hoʻomau i kaʻiʻo māmā e lilo i paʻakikī e hoʻokele. ʻO ia ka manawa e hiki ai i nā hunaola ke hoʻololi a ulu i waho o ka kaohi. Komo pū nā kemikū āu e huki ai i kou kahe o ke koko a halihali ʻia i loko o kou kino, e hoʻonui ana i ka makaʻu o nā ʻano ʻē aʻe. Hiki i nā mea puhipaka ke hopohopo nei i ka ulu ʻana i ka maʻi ʻaʻai māmā, akā ʻo ka haʻalele ʻana hiki ke hoʻohaʻahaʻa loa i kēlā pilikia. Ma waena o 10 mau makahiki o ka haʻalele ʻana, hāʻule ka makaʻu o ka make ʻana i ka maʻi ʻaʻai māmā i ka hapalua.

 

ʻEnekini Radon

ʻO Radon kahi kinoea kala ʻole a ʻaʻala ʻole i hoʻokumu ʻia e ka haki ʻana o ka radium radioactive, a ʻo ia ka hua popopo o ka uranium, i loaʻa i ka pā o ka Honua. Hoʻopili nā huahana palaho radiation i nā mea kūlohelohe, e hoʻoulu ana i nā mutation i lilo i cancerous i kekahi manawa. ʻO Radon ka lua o nā kumu maʻamau o ka maʻi ʻaʻai puʻupuʻu ma ka US, e hoʻouka ana ma kahi o 21,000 mau make i kēlā me kēia makahiki. Hoʻonui ka pilikia i 8-16% no kēlā me kēia 100 Bq / m³ hoʻonui i ka nui o ka radon. o ka lepo ma lalo a me nā pōhaku. Ma kahi o 15 mau home i ka US i loaʻa nā pae radon ma luna o ka papa kuhikuhi i kau ʻia o 4 picocury i kēlā me kēia lita (pCi / l) (148 Bq / m³).

 

ʻo Asbestos

Hiki i ka asbestos ke hana i nā ʻano maʻi like ʻole e like me ka maʻi ʻaʻa maʻi. ʻO ka puhipaka paka a me nā asbestos he ʻelua synergistic nā hopena i ka ulu ʻana o ka maʻi ʻaʻa maʻi. Ma nā mea puhipaka e hana pū ana me asbusa, hoʻonui ʻia ka makaʻu o ka maʻi ʻaʻai pūhā he 45 paona i ka hoʻohālikelike ʻia me ka heluna lehulehu. Hiki pū i ʻAsbestos ke kumu o ke kanesa o ka pleura, i kapa ʻia ʻo mesothelioma - ʻokoʻa ʻokoʻa ia i ka maʻi ʻaʻaʻa.

 

Pau kaʻino

ʻO nā mea haumia o ka lewa i waho, ʻo ia hoʻi nā mea kemika i hoʻokuʻu ʻia mai ka puhi ʻana i nā wahie fossil, e hoʻonui i ka makaʻu o ka maʻi ʻaʻaʻa. ʻO nā particulate maikaʻi (PM2.5) a me nā sulfate aerosol, i hoʻokuʻu ʻia i nā ʻāpau kāhea o nā kaʻa, e pili pū me kahi pilikia i hoʻonui iki ʻia. No ka nitrogen dioxide, kahi hoʻonui hoʻonui o 10 mau ʻāpana i kēlā me kēia piliona e hoʻonui ai i ka makaʻu o ka maʻi ʻaʻai māmā e 14%. Hoʻohālikelike ʻia ka haumia o ka ea ma waho i ka 1-2% o nā maʻi ʻaʻai.

Kākoʻo ʻia nā hōʻike tentative i ka hoʻonui ʻia o ka makaʻu o ka maʻi ʻaʻaiakū mai ka haumia ea o loko e pili ana i ka puhi ʻana i ka wahie, nā lanahu, ka lepo, a me nā koena o nā mea kanu no ke kuke ʻana a me ka hoʻomehana ʻana. ʻike ʻia nā huahana e pili ana i ka biomass kuni ʻia a i ʻole kanalua paha carcinogens. Hoʻopilikia kēia pilikia ma kahi o 2.4 biliona mau kānaka ma ka honua holoʻokoʻa, a manaʻo ʻia ʻo ia ka hopena o 1.5% o ka make ʻana o ka maʻi ʻaʻa maʻi.

 

Nā Genetics

Ma kahi o 8% o ka maʻi ʻaʻa maʻi i hoʻokumu ʻia e nā mea hoʻoilina. Ma nā ʻohana o ka poʻe i ʻike ʻia me ka maʻi ʻaʻaʻa, ua pāpālua ʻia ka makaʻi, ma muli paha o ka hui pū ʻana o nā gen. pilikia o ka maʻi ʻaʻai māmā. ʻO nā polymorphism single-nucleotide (SNPs) o nā ʻāpana e hoʻopili ana i ka receptor nicotinic acetylcholine (nAChR) - CHRNA5, CHRNA6, a me CHRNB15 - kekahi o nā mea e pili pū ana me ka hoʻonui ʻia o ka makaʻu o ka maʻi ʻaʻai, a ʻo RGS5 - kahi moʻokūʻauhau. ke hoʻoponopono nei i ka hōʻailona G-protein.

 

Other kumu

Nui nā ʻano mea ʻē aʻe, nā hana, a me nā hōʻike ʻana o ke kaiapuni i hoʻopili ʻia i ka maʻi ʻaʻai māmā. Ua ʻōlelo ka International Agency for Research on Cancer (IARC) aia kekahi mau "hōʻike kūpono" e hōʻike ai i kēia mau mea he carcinogenic i nā akemāmā:

ʻO kekahi mau metala (hana aluminika, cadmium a me cadmium compound, chromium (VI) hui pū, beryllium a me beryllium compound, hao a me nā kila i hoʻokumu ʻia, nā nickel compound, arsenic a me inorganic arsenic compound, a me nā mining hematite i lalo o ka honua.

ʻO kekahi mau huahana o ka puhi ʻana (hoʻopau ʻole i ke ahi, lānahu (nā mea i hoʻoluhi ʻia i loko o ka hale mai ka hoʻā ʻana o nā lānahu kūloko), ka hoʻomāhuahua ʻana o ka lānahu, ka pitch-tar pitch, ka hana coke, ka ʻili, a me ka hoʻopau ʻenekini diesel

ʻO radiation radiation (X-ray a me gamma).

ʻO kekahi mau kinoea ʻawahia (methyl ether (grade loea), a me bis- (chloromethyl) ether, sulfur mustard, MOPP (vincristine-prednisone-nitrogen mustard-procarbazine hoʻohuihui) a me nā fume mai ka pena ʻana)

ʻO ka hana Rubber a me ka lepo silica crystalline.

Aia kahi hoʻonui iki o ka makaʻu o ka maʻi ʻaʻai lung i ka poʻe i hoʻopilikia ʻia e ka sclerosis ʻōnaehana.

ʻO AASraw ka mea hana ʻoihana o nā lāʻau ʻino ʻo Lung.

E ʻoluʻolu e kaomi ma aneʻi no ka ʻike ʻōlelo. Hana iā mākou

 

Pehea e mālama ai i kāu maʻi ʻōpū? 

Nui a hewahewa nā ala e mālama ai i ka maʻi ʻaʻai māmā. Hoʻohana ʻia ke kaha a me ka radiation e mālama ai i ka maʻi ʻaʻai wale nō. ʻAʻole lākou e hoʻopili i ke koena o ke kino. ʻO nā lāʻau Chemo, hoʻomōhala ʻia, a me nā immunotherapy hele ma waena o ke kino holoʻokoʻa. Hiki iā lākou ke kiʻi i nā hunaola maʻi ʻea kokoke i nā wahi āpau o ke kino.

 

ʻO ka mālama ʻana no ka maʻi ʻaʻai māmā e hiki ke komo i ke kahakaha, ka pāhawewe, ka chemotherapy, ka lāʻau hoʻomōhala, a me ka immunotherapy ʻO ka papa hana lapaʻau e ʻoi aku ka maikaʻi iā ʻoe e kaukaʻi ʻia:

▪ Ke kahua o ka maʻi ʻaʻai

▪ ʻO ka manawa kūpono e kōkua ai kahi ʻano lapaʻau

▪ kou mau makahiki

▪ Nā pilikia olakino ʻē aʻe āu

▪ kou mau manaʻo e pili ana i ka mālama ʻana a me nā hopena ʻē aʻe e hiki mai ana.

 

Lung Cancer

 

Koho ka poʻe maʻi he nui me ka maʻi ʻaʻa puʻupuʻu ke lāʻau lapaʻau i ka wā mua, no ka mea ʻo ia ke ala pololei a maʻalahi hoʻi e kaohi i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai. Hoʻohana pinepine ʻia nā lāʻau aʻe e mālama ai i ka maʻi ʻaʻa maʻi (SCLC a me NSCLC):

 

❶ AZD-3759 (CAS: 1626387-80-1)

AZD-3759 kahi mea ulu epidermal factor factor receptor (EGFR) mea kāohi, me ka hana antineoplastic hiki. Hoʻopili a paʻa ka AZD-3759 i ka hana o EGFR a me kekahi ʻano mutant o EGFR. Pale kēia i ka hōʻailona waena waena o ka EGFR, a e alakaʻi ʻia i ka induction o ke cell cell a me ka pāpā ʻana i ka ulu ulu ulu ma nā ʻaoʻao e hōʻike ana iā EGFR.

Nā lāʻau lapaʻau maʻi maʻi AZD 3759

 

❷ Gefitinib (CAS: 184475-35-2)

ʻO Gefitinib kahi mea kāpae tyrosine kinase i hoʻohana ʻia e like me ka laina laina mua e mālama ai i ka maʻi liʻiliʻi liʻiliʻi liʻiliʻi (NSCLC) e kū ana i kekahi pae hoʻohālikelike kūlohelohe.

ʻO Gefitinib kahi mea kāohi o ka mea ulu epidermal factor receptor (EGFR) tyrosine kinase e hoʻopaʻa ai i ka adenosine triphosphate (ATP) -e hoʻopaʻa ana i ka pūnaewele. Hōʻike pinepine ʻia ʻo EGFR e hōʻike ākea ʻia i loko o kekahi mau hunaola kino kanaka kanaka, e like me nā hunaola maʻi ʻaʻai a me nā umauma umauma. Alakaʻi ʻo Overexpression i ka hoʻonui ʻana o ka anti-apoptotic Ras hōʻailona transcuction cascades, a laila hopena i ka hoʻonui ʻana i ke ola ʻana o nā hunaola maʻi ʻaʻai a me ka hoʻonui ʻana o ka cell i ka ʻole. ʻO Gefitinib ka mea kāohi koho mua o ka EGFR tyrosine kinase i kapa ʻia ʻo Her1 a i ʻole ErbB-1. Ma ke kāpae ʻana i ka EGFR tyrosine kinase, ua kāohi ʻia hoʻi nā cascades hōʻailona o lalo, a ua hopena ʻia i ka hoʻonui ʻia ʻana o ka cell malignant.

 

AZD-9291(CAS: 1421373-65-0)

Ua kapa ʻia ʻo AZD-9291 ʻo Osimertinib kahi mea kāohi kinetona i hoʻohana ʻia i ka mālama ʻana i kekahi ʻano o ka maʻi liʻiliʻi liʻiliʻi liʻiliʻi liʻiliʻi.

AZD-9291 kahi mea ulu epidermal factor factor receptor (EGFR) tyrosine kinase inhibitor (TKI) e pili ana i kekahi ʻano mutant o EGFR (T790M, L858R, a me exon 19 holoi ʻia) i predominate i nā tumors liʻiliʻi liʻiliʻi liʻiliʻi (NSCLC) ma hope o ka mālama ʻana me ka mua -lalani EGFR-TKI. Ma ke ʻano he hanauna tyrosine kinase inhibitor ʻekolu, he kikoʻī ʻo AZD-9291 no ka mutation o ka mea kiaʻi puka ʻo T790M e hoʻonui ai i ka hana paʻa ATP i ka EGFR a me nā hopena i ka wānana maikaʻi ʻole no ka maʻi o ka pae hope. Eia kekahi, ua hōʻike ʻia ʻo AZD-9291 i kahi EGFR ʻano hihiu i ka manawa o ka therapy, a laila e hoʻemi ana i ka hoʻopaʻa ʻana ʻaʻole kikoʻī a me ka kaohi ʻana i nā mea ʻino.

Nā lāʻau lapaʻau maʻi maʻi AZD 9291

 

❹ Dacomitinib (CAS: 1110813-31-4)

ʻO Dacomitinib kahi lāʻau i hoʻohana ʻia e mālama ai i ka maʻi ʻaʻai liʻiliʻi liʻiliʻi liʻiliʻi me ka EGFR exon 19 kāpae ʻana o exon 21 L858R pani. ʻO Dacomitinib, hoʻolālā ʻia e like me (2E) -N-16-4- (piperidin-1-yl) akā-2-enamide, kahi ʻāpana quinazalone koho nui waha o ka lua o ka hanauna tyrosine kinase inhibitors i ʻano e ka paʻa hiki ʻole ke hoʻololi ʻia ma ka ʻĀina ATP o nā ʻāpana ulu ʻohana epidermal receptor kinase domains. ʻO Dacomitinib kahi lāʻau no ka mālama ʻana i ka maʻi liʻiliʻi liʻiliʻi liʻiliʻi (NSCLC). He mea koho a koho ʻole hiki ʻole ke hoʻihoʻi ʻia o EGFR.

 

❺ Ceritinib (CAS: 1032900-25-6)

Kapa ʻia ʻo Ceritinib ʻo LDK378 kahi mea antineoplastic kinase inhibitor i hoʻohana ʻia e mālama i ka anaplastic lymphoma kinase (ALK) -positive metastatic non-liʻiliʻi cell cancer cancer (NSCLC) i nā mea maʻi me ka lawa ʻole o ka pane olakino a i ʻole ka hoʻomanawanui ʻole i ka crizotinib.

Hoʻohana ʻia ʻo Ceritinib no ka mālama ʻana i nā mākua me ka anaplastic lymphoma kinase (ALK) -positive metastatic non-liʻiliʻi cell cancer cancer (NSCLC) ma hope o ka holo pono ʻole (lua i ke kūʻē ʻana a i ʻole intolerance) o ka crizotinib therapy mua. Ma kahi o 4% o nā mea maʻi me ka NSCLC i kahi hoʻoponopono hou chromosomal e hana i kahi fusion fusion ma waena o EML4 (echinoderm microtubule-e pili ana i ka protein like 4) a me ALK (anaplastic lymphoma kinase), nā hopena i ka hana kinase Constutive e hāʻawi i ka carcinogenesis a me he mea lā e holo ka phenotype malignant. Hana ʻo Ceritinib i kāna hopena therapeutic e ka pāpā ʻana i ka autophosphorylation o ALK, ALK-mediated phosphorylation o ka pūlima hōʻailona STAT3 i lalo, a me ka hoʻonui ʻana o nā hunaola maʻi kūpē ALK. Ma hope o ka mālama ʻana me crizotinib (kahi hanauna ALK hanauna mua), hoʻomohala ka hapanui o nā tumors i ka lāʻau kūpaʻa ma muli o ka hoʻololi ʻana i nā koena "kiaʻi puka" nui o ka ʻenemika. ʻO kēia hanana i alakaʻi ʻia i ka hoʻomohala ʻana i nā mea hanauna ALK hanauna ʻelua e like me ceritinib e lanakila i ke kūʻē ʻana o crizotinib. Ua ʻae ʻo FDA i ka ceritinib i ʻApelila 2014 ma muli o ke kuhi pane pane kiʻekiʻe (56%) i mua crizotinib-o nā kūpale kūpale a ua koho ʻia me ke kūlana lāʻau makua ʻole.

 

❻ Afatinib (CAS: 439081-18-2)

ʻO Afatinib kahi mea hoʻohana antineoplastic i hoʻohana ʻia no ka mālama ʻana i ka maʻi ʻaʻa liʻiliʻi liʻiliʻi kūloko a metastatic ʻole (NSCLC) me nā kūpaʻa EGFR ʻole kūʻē a kūʻē paha i ka chemotherapy kahua platinum.

ʻO Afatinib kahi 4-anilinoquinazoline tyrosine kinase mea kāohi i ke ʻano o ka paʻakai dimaleate i loaʻa e like me kā Boehringer Ingelheim inoa inoa Gilotrif. No ka hoʻohana waha, ʻo nā papapa afatinib kahi laina mua (hoʻomaka) no nā mea maʻi me ka maʻi ʻaʻai liʻiliʻi liʻiliʻi metastatic (NSCLC) me nā hoʻololi o ka mea ulu epidermal (EGFR) e like me ka mea i ʻike ʻia e kahi hōʻike i ʻāpono ʻia e ka FDA 4. Gilotrif ( afatinib) ʻo ia ka huahana oncology i ʻae ʻia e FDA mai Boehringer Ingelheim.

 

❼ Erlotinib (CAS: 183321-74-6)

ʻO Erlotinib kahi ʻO ka mea kāohi ʻo EGFR tyrosine kinase hoʻohana ʻia e mālama i kekahi mau maʻi ʻaʻai liʻiliʻi liʻiliʻi a i ʻole nā ​​maʻi maʻi pancreatic holomua. Pili ia i kahi papa o nā lāʻau i ʻike ʻia me nā mea kāohi ʻo tyrosine kinase. Hana ia ma ke kāpae ʻana i ka hana o kahi protein i kapa ʻia ʻo ka ʻepepermal factor factor receptor (EGFR). ʻIke ʻia ka EGFR ma ka ʻili o nā hunaola maʻi ʻaʻai e like me nā hunaola maʻamau. Mālama ʻia ia me he "antenna," ke loaʻa nei nā hōʻailona mai nā pūnaewele ʻē aʻe a me ke kaiapuni e haʻi i ka cell e ulu a māhele. He mea nui ka EGFR i ka ulu a me ka hoʻomohala prenatally a i ka wā kamaliʻi a kōkua i ka mālama ʻana i ka hoʻololi maʻamau o nā hunaola kahiko a ʻino hoʻi i nā mākua. Eia nō naʻe, nui nā hunaola maʻi 'aʻai i nui nā nui o ka EGFR ma ko lākou ʻili, a i ʻole ua hoʻololi ʻia ko lākou EGFR e ka hoʻololi ʻana o ka DNA e hāpai ana i ka code genetika no ka protein. ʻO ka hopena ʻo ia nā hōʻailona e hele mai ana mai ka EGFR ikaika loa, e alakaʻi ana i ka ulu nui ʻana o ka cell a me ka mahele, kahi hiʻohiʻona o ka maʻi ʻaʻai.

Hiki ke hāʻawi ʻia kēia mau lāʻau āpau e aasraw i ka pauka pauka maoli, no ka noiʻi wale nō. Welina e launa pū me aasraw inā makemake ʻoe e ʻike i ka ʻike hou aku e pili ana i ke kūʻai ʻana i nā lāʻau ʻaʻai maʻi ʻaʻā aganist!

ʻO AASraw ka mea hana ʻoihana o nā lāʻau ʻino ʻo Lung.

E ʻoluʻolu e kaomi ma aneʻi no ka ʻike ʻōlelo. Hana iā mākou

 

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