ʻO ka Punawai o nā ʻōpio: NAD + & NMN ma ke ʻano he kumukanawai
Hana ʻo AASraw i ka paukū Cannabidiol (CBD) a me ka Hemp Essential Oil i ka nui!

NAD + & NMN

 

ʻO ka hoʻokuʻu ʻia ʻana o nā ʻike ʻepekema e pili ana i ka hoʻonui ʻana o ka NMN i ka NAD i loko o nā kino o nā ʻiole i kuʻi i ka nūpepa a me nā poʻo nui o ka makasina, e kāhea nei i ka loaʻa.ka pūnāwai o ka ʻōpio. "

Ua hōʻike ka noiʻi ua lilo nāʻiole ʻelemakule i ʻōpio, ikaika, a lahilahi ke hāʻawi ʻia i ka hui. No laila, hiki iā ʻoe ke hoʻohuli i kāu hana ʻelemakule ma o ka lawe ʻana i ka supplement. ʻOiai ʻoe e kūkā kamaʻilio i ka lawe ʻana i nā mea hoʻohui me kāu kauka.

 

Hismoʻolelo o NMN a me NAD +

ʻO Nicotinamide adenine dinucleotide, a i ʻole NAD no ka pōkole, kekahi o nā mole nui a koʻikoʻi hoʻi i ke kino. Ma muli o ke kikowaena o ka hāʻawi ʻana i nā hunaola me ka ikehu, ʻaʻohe kokoke i ke kaʻina koiola i koi ʻole iā NAD. A ʻo kahi hopena o kēia, ʻo NAD ke kiko o ka noiʻiolaolaola ākea.

I ka makahiki 1906, ua ʻike ʻo Arthur Harden lāua ʻo William John Young i kahi “mea” i lawe ʻia mai loko mai o ka hū a ka brewer e hoʻonui ai i ke kō o ke kō i loko o ka waiʻona. ʻO kēlā "mea", i kapa ʻia he "coferment" i kēlā manawa, ua lilo ʻo NAD.

ʻO Harden, me Hans von Euler-Chelpin, hoʻomau i ka ʻili ʻana i nā mea pohihihi o ka fermentation. Ua hāʻawi ʻia lākou i ka Nobel Prize ma 1929 no ka hoʻomohala ʻana i kahi ʻike kikoʻī i kēia mau kaʻina hana, me ke ʻano kemika a me nā waiwai o ka mea e ʻike koke ʻia ʻo NAD.

Ua hoʻonui ʻia ka moʻolelo o NAD i ka makahiki 1930, ma lalo o ke alakaʻi a Otto Warburg, kekahi Nobel laureate, ka mea i ʻike i ke kuleana nui o NAD i ka hana maʻalahi ʻana i nā hopena biochemical. Ua ʻike ʻo Warburg he lawelawe ʻo NAD ma ke ʻano he relay biological no nā electrons. ʻO ka hoʻoili ʻana o nā electrons mai kekahi mole i kekahi ʻē aʻe, lilo ia i kumu no ka ikehu e pono ai e hana i nā hopena biochemical āpau.

I ka makahiki 1937, ua ʻike ʻo Conrad Elvehjem a me nā hoa hana ma ke Kulanui o Wisconsin, Madison, ua hōʻola ka NAD + supplementation i nā ʻīlio pellagra, a i ʻole "ʻ Tonglelo ʻEleʻele". I ke kanaka, pellagra ke kumu o kahi hōʻailona o nā ʻōuli, e like me ka maʻi diarrhea, dementia, a me nā ʻeha ma ka waha. Hoʻokumu ʻia ia mai ka hemahema o ka niacin a mālama pinepine ʻia me nicotinamide, kekahi o nā mea mua i NMN.

ʻO kā Arthur Kornberg noiʻi e pili ana iā NAD + ma waena o 40 a 50 paha he mea kōkua i ke alakaʻi ʻana iā ia e ʻike i nā loina ma hope o ka hoʻopili ʻana o DNA a me ka palapala RNA, ʻelua mau hana e pono ai ke ola. I ka makahiki 1958, ua wehe ʻo Jack Preiss lāua ʻo Philip Handler i nā ʻanuʻu biochemical ʻekolu, kahi e hoʻohuli ʻia ai ka waikawa nikotinic i NAD. ʻO kēia kaʻina o nā ʻanuʻu, i kapa ʻia he ala, i kēia lā ʻo Preiss-Handler Pathway.

I ka makahiki 1963, ua hōʻike ʻo Chambon, Weill, a me Mandel i ka hāʻawi ʻana o ka nicotinamide mononucleotide (NMN) i ka ikehu e pono ai e hoʻoulu i kahi enzyme nukelea koʻikoʻi. Ua wehe ʻia kēia ʻike i kahi ala no nā ʻike kupaianaha ma kahi ʻano protein i kapa ʻia ʻo PARP. He kūlana koʻikoʻi nā PARP i ka hoʻoponopono ʻana i ka hōʻino ʻana o DNA, ka hoʻoponopono ʻana i ka make o ke kelepona, a ʻo ka mea e pili ana ka hana me nā loli i ke ola.

I ka makahiki 1976, ua ʻike ʻo Rechsteiner a me kāna mau hoapili i nā hōʻike hōʻoiaʻiʻo ʻo NAD + me he mea lā he "hana nui ʻē aʻe" i loko o nā hunaola mammalian, ma ʻō aku o kāna kūlana biochemical kahiko ma ke ʻano he moleka hoʻoili ikehu.

ʻO kēia ʻike i hiki ai iā Leonard Guarente a me kāna mau hoa hana ke ʻike i nā protein i kapa ʻia he sirtuins e hoʻohana i ka NAD e hoʻolōʻihi i ke ola ma ka mālama ʻokoʻa ʻana i kekahi mau ʻāpana. Mai ia manawa, ua ulu ka hoihoi i NAD a me kāna mau waena, NMN a me NR, no ko lākou hiki ke hoʻonui i kekahi mau pilikia olakino pili i ka makahiki.

NAD + & NMN

Wpāpale ʻAiʻai i loko o NMN?

Kūlohelohe ka NMN i ka meaʻai e like me ka avocado, broccoli, cabbage, a me nā ʻōmato. I kēia manawa, e noʻonoʻo paha ʻoe: "Inā loaʻa ka NMN i ka meaʻai, ʻaʻole hiki iaʻu ke hoʻonui i kaʻu mau pae o NAD + e ka ʻai ʻana i ka nui o kēlā mau meaʻai? “He nīnau maikaʻi kēlā a paipai mākou iā ʻoe e ʻai i ka papaʻai olakino. Akā, eia ka pilikia:

ʻOiai ʻo NMN i kēia mau meaʻai, ʻoi aku ka liʻiliʻi o nā konsentration ma mua o 1 mg no kg o ka meaʻai. I nā huaʻōlelo ʻē aʻe, e kiʻi ma kahi o 1mg o NMN, pono ʻoe e ʻai e pili ana i 1kg o broccoli!

Ua ʻike ʻia e hoʻonui i nā pae o NAD + i loko o ke kanaka, aia nā pae o ka NMN i nā haneli milligrams i kēlā me kēia kau. ʻOi aku kēia kiʻekiʻe ma mua o ka mea hiki ke loaʻa mai kā mākou papaʻai, no ka nui o ka broccoli a mākou e ʻai ai.

ʻO AASraw ka mea hana ʻoihana o NAD + & NMN i mea hoʻohui.

E ʻoluʻolu e kaomi ma aneʻi no ka ʻike ʻōlelo. Hana iā mākou

 

No ke aha e hoʻohui me NMN?

E like me kā mākou i hōʻike ai, hana nui ʻo NMN i ka hana ʻana iā NAD +. Ke loaʻa iā mākou nā pae kiʻekiʻe o NAD + i loko o ko mākou mau kino, hoʻonui ka ikehu cellular i lilo i wahie o ke ola-ka mana ʻana i kēlā me kēia meaola a me nā pūnaewele i loko o ko mākou kino a pale iā mākou mai ka hōʻino ʻia o DNA. Hoʻokomo pū ʻo NAD + iā Sirtuins i mea nui i ka hoʻonui ʻana i ko mākou ola a hoʻolōʻihi i ke kaʻina ʻelemakule.

Hoʻonui pololei ka hoʻopili ʻana me NMN i nā pae o NAD + i loko o kā mākou kino, kahi e pale ai i ka hāʻule kūlohelohe e kū nei i ko mākou mau makahiki. Ua hōʻike ʻia ka noiʻi ma o ke kākoʻo ʻana me NMN, ka Nā pae NAD + i nā poʻe mākua hiki ke hāpai ʻia i kahi 20 mau makahiki!

 

(1) He aha ka Nicotinamide Adenine Dinucleotide (NAD +) a me kāna mau Hana?

ʻO NAD + kahi coenzyme nui e pono ai no ke ola a me nā hana pūnaewele. ʻO nā enzymes nā mea catalist e hiki ke hana i nā hopena biochemical. ʻO nā mole he "kōkua" Coenzymes e pono ai nā enzyme i mea e holo pono ai.

ʻO NAD + ka mole mole nui loa i ke kino ma waho o ka wai, a me ka ʻole o ia, e make ana kahi meaola. Hoʻohana ʻia ʻo NAD + e nā protein i loko o ke kino, e like me nā sirtuins, ka mea e hoʻoponopono ai i ka DNA i hōʻino ʻia. He mea nui ia no ka mitochondria, ʻo ia nā powerhouse o ka pūnaewele a hoʻoulu i ka ikehu kemika a kā mākou kino e hoʻohana ai.

 

(2) Nā hana e hoʻonui ai i nā pae NAD +

ʻO ka hoʻokēʻai a hoʻēmi paha i ka lawe ʻana o ka calorie, ʻoi aku ka maikaʻi i ʻike ʻia me ka palena ʻana o ka calorie, ua hōʻike ʻia e hoʻonui i nā pae NAD + a me ka hana sirtuin I nāʻiole, ʻo ka hoʻonui ʻia o ka NAD + a me ka hana sirtuin mai ke kaohi calorie i hōʻike ʻia e lohi i ke kaʻina ʻelemakule. ʻOiai aia ʻo NAD + i kekahi mau meaʻai, haʻahaʻa loa ka hoʻopili ʻana i mea e hoʻopili ai i nā intracellular concentrations. Lawe ʻia kekahi mau mea hoʻopihapiha, e like me NMN, ua hōʻike ʻia e hoʻonui i nā pae NAD +.

 

(3) NAD+ Pākuʻi e like me NMN

Hoʻoemi nā noʻonoʻo intracellular o NAD + mai ka ʻelemakule e like me nā hana pūnaewele maʻamau hoʻopau i nā lako NAD + i ka manawa. Manaʻo ʻia e hoʻihoʻi ʻia nā pae olakino o NAD + e ka supplementation me NAD + precursors. Wahi a ka noiʻi, nā mea mua e like me NMN a nicosinamide riboside (NR) ʻike ʻia ma ke ʻano he kōkua o ka hana NAD +, e hoʻonui nei i ka noʻonoʻo o NAD +. ʻO David Sinclair, kahi mea noiʻi NAD + mai Harvard, i ʻōlelo, "ʻO ka hānai a lawelawe ʻana paha iā NAD + pololei i nā meaola ʻaʻole ia he koho kūpono. ʻAʻole hiki i ka NAD + mole keʻaʻa koke i nā membrane o ke kelepona e komo i nā hunaola, a no laila ʻaʻole hiki ke hoʻopili maikaʻi i ka metabolism. Akā, pono e hoʻohana i nā mole mua i NAD + e hoʻonui i nā pae bioavailable o NAD +. " ʻO kēia ʻaʻole hiki ke hoʻohana ʻia ʻo NAD + ma ke ʻano he kuhikuhi hoʻoponopono hou, no ka mea ʻaʻole maʻalahi ke komo. ʻOi aku ka maʻalahi o ka lawe ʻia o ka NAD + precursors ma mua o ka NAD + a ʻoi aku ka maikaʻi o nā mea hoʻohui.

 

He aha ia o Nicotinamide Mononucleotide (NMN)?

ʻO Nicotinamide Mononucleotide (CAS:1094-61-7), i kapa ʻia ʻo NMN, kahi hui kūlohelohe i kū liʻiliʻi i loko o ke kino o ke kanaka a me kekahi mau meaʻai. He bioavailable waha ʻo NMN, a ke lawe waha ʻia hiki ke kākoʻo i nā pae NAD + i loko o ka akepaʻa a me nā mākala puʻupuʻu.

Ua hōʻike ʻia kahi noiʻi hou e hiki i ka NMN ke kākoʻo i ke olakino cardiovascular, ka hana ʻana i ka ikehu, ke olakino noʻonoʻo, a me ke olakino retinal a iwi. ʻO kahi mea hoihoi loa i ka noiʻi NMN ka mea hiki ke hāpai i ka hoʻomaikaʻi ʻana o DNA a kākoʻo i ka hoʻoulu ʻana o nā genes SIRTUIN i manaʻo ʻia he mea nui i ka ʻelemakule olakino.

 

 Pehea e hoʻopili ʻia ai ka NMN i ke Kino?

Hana ʻia ʻo NMN mai nā huaʻai B i loko o ke kino. ʻO ka enzyme kuleana no ka hana NMN i ke kino i kapa ʻia ʻo nicotinamide phosphoribosyltransferase (NAMPT). Hoʻopili ka NAMPT i ka nicotinamide (kahi huaʻai B3) i kahi kō kōkoʻomaʻa i kapa ʻia ʻo PRPP (5'-phosphoribosyl-1-pyrophosphate). Hiki ke hana ʻia ka NMN mai ka 'nikotinamide riboside' (NR) ma o ka hoʻohui ʻana o kahi hui phosphate.

ʻO 'NAMPT' ka ʻenemi palena palena palena palena i ka hana o NAD +. ʻO kēia ke kumu o nā pae haʻahaʻa o NAMPT e hoʻemi i ka hana NMN, e hopena ana i nā pae NAD + i hōʻemi ʻia. Hiki ke hoʻohui i nā mole mua e like me NMN hiki ke wikiwiki i ka hana NAD +.

NAD + & NMN

Nā Pōmaikaʻi kūpono o NMN

I ka manawa i loko o nā keena holoholona, ​​hānai ʻo NMN i ka hana ʻana o NAD +, kahi e hāʻawi ai i nā hunaola me ka ikehu e pono ai a manaʻo ʻia he koʻikoʻi no ka ʻelemakule olakino. Hoʻokani pū ʻo NAD + i kahi hana nui i ka hoʻoulu ʻana i nā protein e mālama i ka pono o kā mākou DNA. Hāʻawi ʻia i kāna kuleana nui i loko o nā hana cellular he nui, nā pōmaikaʻi kūpono o ka NMN e hoʻolōʻihi i nā ʻōnaehana o ke kino. Ma lalo iho nei kekahi o nā laʻana kaulana loa.

 

 Paipai i ke olakino Vascular a me ke kahe koko

Hilinaʻi mākou i ko mākou mau mākala iwi no ka neʻe, kūpaʻa a me ka ikaika. I mau ai ka ikaika a me ke kūlana maikaʻi, pono e hoʻopau kēia mau mākala i nā nui o nā molaki ikehu kī, e like me ka glucose a me nā waikawa momona. No ka mea e koi ʻia ʻo NAD + e hoʻopili i kēia mau mole, pono i ko mākou mākala i kahi lako mau o kāna mau hale kūkulu, e like me NMN.

Ua hōʻike ʻia nā noiʻi i nāʻiole i ka pale ʻana o ka NMN i nā hāʻule e pili ana i ka ʻelemakule i ke olakino, e like me ke ʻoʻoleʻa ʻana o nā kīʻaha koko, ke koʻikoʻi oxidative, ka hiki i kā mākou mau pūnaewele ke hoʻokaʻawale, a me nā loli i ka hana a kā mākou genes. hōʻike manaʻo.

 

 Hoʻonui i ka hoʻomanawanui ʻana i ka mākala a me ka ikaika

Ua hōʻike nā noiʻi ua hānai nāʻiole iā NMN no nā manawa lōʻihi i ʻoi aku ka maikaʻi o ka ikehu me ka ʻike ʻole i nā hopena ʻaoʻao. ʻOi aku ka nui o ke olakino o ko mākou mau mākala i ko mākou mau makahiki a me kā mākou pono ponoʻī o NAD + e hōʻole.

 

 Pale aku i ka maʻi puʻuwai

ʻO ka liʻiliʻi e hoʻomaha i kou mau mākala iwi. ʻAʻole hiki i kou puʻuwai ke hoʻomaha wale, ʻaʻole hiki ke hoʻolōʻihi i kāna wikiwiki me ka ʻole o nā pilikia koʻikoʻi. No laila, ikaika ka ikaika o ka ikaika o ka puʻuwai. A no ka hoʻomau ʻana i ke kikoke, pono ia e hana i nā NAD + āpau i hiki. ʻO kēia ke kumu e pono ai i nā hunaola puʻuwai e lako mau i ka NMN.

 

 Nā hoʻohaʻahaʻa haʻahaʻa o ka momona

Hoʻopili ʻia ʻo Obesity i kahi ākea o nā kūlana olakino a hiki ke lilo i mea paʻakikī loa e mālama. ʻAʻohe ala maʻalahi no ka momona a me nā kūlana e pili ana e like me ka maʻi kō a me ka maʻi maʻi metabolic. ʻOiai ʻo nā hoʻoponopono nohona e like me ka hoʻoikaika mau a me ka papaʻai olakino ka mea nui, kōkua kēlā me kēia mea liʻiliʻi.

I nā noi iole, hōʻike ka NMN i kahi hopena e hoʻohālikelike i nā ʻaoʻao o ka palena kalepona (CR). ʻOiai ua hōʻike ʻia ʻo CR e hāʻawi i nā pono he nui i ka ʻelemakule a me ke olakino, he aupuni paʻakikī ia e mālama i kahi manawa lōʻihi. ʻO ka mimicking ʻana i kāna mau pono me ka pili ʻole i ka papaʻai nui loa e lilo ia i mea maikaʻi loa.

ʻO AASraw ka mea hana ʻoihana o NAD + & NMN i mea hoʻohui.

E ʻoluʻolu e kaomi ma aneʻi no ka ʻike ʻōlelo. Hana iā mākou

 

 Hoʻonui i ka mālama ʻana o ka hoʻoponopono ʻana iā DNA

Hana ka NAD + mai NMN i kahi hui o nā protein i kapa ʻia sirtuins. ʻO Sirtuins, i kekahi manawa i manaʻo ʻia he kiaʻi no ko mākou ola olakino, he kuleana nui i ka mālama ʻana i ka pono DNA. I kēlā me kēia manawa ke kaʻawale o kā mākou mau pūnaewele, ulu ka DNA ma nā wēlau o kā mākou chromosome i kahi liʻiliʻi liʻiliʻi. Ma kekahi kiko, hoʻomaka kēia e hōʻino i ko mākou mau gen. Hoʻolohi ʻo Sirtuins i kēia kaʻina hana i ka hoʻokūpaʻa ʻana i kēlā mau ʻāpana hopena, i ʻike ʻepekema ʻia me he telomeres. I mea e holo ai, akā naʻe, hilinaʻi nā sirtuins iā NAD +. Ua hōʻike ʻia nā noiʻi hou ʻana i ka hanai ʻana i nā ʻiole NMN i nā sirtuins a ua alakaʻi ʻia i nā telomeres paʻa hou aʻe.

 

 Hoʻonui i ka Hana Mitochondrial

Ma ka waiho wale, ʻaʻole hiki iā mākou ke noho me ka ʻole o kā mākou mitochondria. ʻIke ʻia kēia mau ʻano kūkulu ʻokoʻa e like me ka powerhouse o ke kolamu. Hoʻololi lākou i nā molekiola mai ka meaʻai a mākou e ʻai ai i ka ikehu e hoʻohana ai kā mākou pūnaewele. ʻO NAD + ke kikowaena o kēia kaʻina. ʻO ka ʻoiaʻiʻo, nā anomalies mitochondrial i hoʻokumu ʻia e ka nalo ʻana o NAD + a ʻoi paha e hoʻopili i nā maʻi neurological e like me Alzheimer. Ua hōʻike ʻia nā noiʻi i hana ʻia i nāʻiole i hoʻopakele ka hoʻōla NMN i kekahi mau hana mitochondrial.

 

How Long Does It Take To See Ehelehelena Of NMN?

KANAKAHoʻonui ka NMN pauma i ka pae o NMN i kou kino i loko o nā minuke, ʻoiai ua hoʻonui ʻia nā pae NAD + i loko o 60 mau minuke. Eia nō naʻe, no ka NAD + e hoʻomaka i ka hoʻoulu hou ʻana i kāu mau pūnaewele, he mau pule ka lōʻihi.

Hōʻike ka hapa nui o nā mea hoʻohana ʻike lākou i ka ʻōpio a me ke olakino ma waena o 2 a 3 mau pule. Hiki ke ʻike ʻia nā keu piha o ka NMN ma hope o kekahi mau mahina o ka hoʻohana ʻana - akā e ʻike mua ʻoe i ka ʻokoʻa i loko o kekahi mau pule!

No laila inā makemake ʻoe e ʻike i nā hopena hoʻololi o ka AASraw's NMN, loaʻa iā ʻoe kahi manawa kū hoʻokahi e hana pēlā. A ʻo ka ʻāpana ʻoi loa? ʻAʻole pono ʻoe e lawe i kahi makaʻu. Uhi ʻia ka NMN o AASraw e kahi ʻōlelo hoʻohiwahiwa. ʻO kēia ka mea no ka mea maopopo lākou e aloha ʻoe i kā lākou NMN, ʻae lākou e hāʻawi iā ʻoe i kahi hōʻoia.

NAD + & NMN

Nā ʻaoʻao ʻaoʻao o ka NMN supplement

Me kekahi mea hou paha hoʻoponopono hou, aia nā hopohopo e pili ana i nā hopena. I kēia manawa, ʻaʻole hōʻike nā ʻepekema ʻepekema i nā hopena weliweli a hopena paha e pili ana me ka hoʻohana ʻana i kēia waihona.

ʻO ka hoʻopiʻi ikaika wale e pili ana i ka monotucleamide nicotinamide ʻo ia ke kūlike ʻole i ka pono, akā hana ʻia ia i nā hanana ulu o kahi waihona hou. ʻOiaʻiʻo, pono ʻoe e nīnau i kāu kauka e pili ana i ka lawe ʻana i kēia waihona, ʻoiai inā he hāpai ʻoe a hānai waiu paha.

 

Is NMN BʻOi THAN NAD +?

No nā makahiki he nui, ua manaʻo ʻia he nui loa nā mole o NAD + e lawe pololei ʻia a pono e hāpai ʻia e hoʻohana ana i kahi mea mua e like me NMN. I kēia mau lā, ua ʻike ʻia ua hiki i ka NAD + keʻaʻa i ka pale o ka lolo a hiki i ka hypothalamus inā i lawe ʻia i sublingually. Hiki iā ia ke hoʻonui i nā pae NAD + i kēia gland e pōmaikaʻi ai ke kino holoʻokoʻa no ka mea kaohi ia i ka metabolism. Hiki iā ia ke lilo i hiki hoʻoponopono hou e kōkua i ka poʻe i loaʻa i nā maʻi metabolic ma muli o ka emi o nā pae NAD + i ka hypothalamus.

ʻO NMN, ma ka ʻaoʻao ʻē aʻe, hoʻokiʻekiʻe aʻe i nā pae NAD + i loko o nā pūnaewele i loko o ke kino a he mea kōkua ʻoi aku ka maikaʻi e lawe ai e hoʻonui i kāu pae NAD + āpau a lohi i ka ʻelemakule.

 

Hoʻopau

ʻO Nicotinamide mononucleotide (NMN) kahi mea kūlohelohe i kou kino e hoʻoulu ai i ka hana o kahi mea ʻē aʻe i kapa ʻia ʻo nicotinamide adenine dinucleotide. He mea nui ko NMN a me NAD i ka pale ʻana i ka hana ʻelemakule. No ka mea nui ʻo NAD, mai kou ʻelemakule a nui, ʻo ka liʻiliʻi o ka hiki i kou kino ke hana iā NAD. Ma laila kahi e kōkua ai ka waihona NMN ma hope, ke hoʻopau ʻia e nāʻiole, hoʻonāukiuki koke ia i ka NAD i nā ʻōpū o lalo.

A ʻo kahi hopena, ua kāpili ʻia ka waihona ma ka “punawai o ka wā ʻōpio”, a ke lohi nei ke kaʻina o ke kino a hoʻohuli iā ia iho. ʻAʻole wale i hōʻike ʻia nā noiʻi i ka pono o ke kaʻina anti-kūnewa, akā hiki i ka waihona NMN ke kōkua i ka pale a mālama ʻana i nā maʻi ʻē aʻe e like me ka maʻi ʻaʻai, puʻuwai a me ka maʻi kō. I ka 2016, ua hoʻomaka kahi hui o nā ʻepekema i ka hoʻopaʻa haʻawina lapaʻau mua me nā kānaka ma nā hopena maikaʻi o lawe i nā mea hoʻopiha NMN. ʻOiai ka maikaʻi o ka NMN i nā wā mua, ʻoi aku ka nui o nā hōʻike e hōʻoia i ka hopena o ka waihona.

Ke hoʻoholo ʻoe e kūʻai i ka waihona NMN ma ka pūnaewele, e ʻoluʻolu e heluhelu hou aku i nā ʻatikala e pili ana iā NMN a me NAD +. Pono ʻoe e ʻike inā maikaʻi ia i kou kino, pehea e hana ai i kou kino, ke lawe ʻoe iā ia a me nā ana o NMN, nā pilikia ʻē aʻe iā ʻoe. Weclome e hāhai iā mākou no nā mea hou e pili ana i ka NMN i ka wā e hiki mai ana.

ʻO AASraw ka mea hana ʻoihana o NAD + & NMN i mea hoʻohui.

E ʻoluʻolu e kaomi ma aneʻi no ka ʻike ʻōlelo. Hana iā mākou

 

Reference No ka ʻatikala

[1] Lautrup S, Sinclair D et al. 2019. NAD + ma nā Brain Aging a me nā maʻi Neurodegenerative. Pūnaewele Metabolism 30,630-655.

[2] Zhang, H., 2016. Hoʻomaikaʻi ʻo NAD + pani i ka mitochondrial a me ka hana o ka cell stem a hoʻonui i ke ola i nāʻiole. ʻEpekema 352, 1436-1443.

[3] "NMN vs NR: Nā ʻokoʻa ma waena o kēia 2 NAD + Precursors". www.nmn.com. Ua kiʻi ʻia 2021-01-11.

[4] Imai, S., & Guarente, L. 2014. NAD a me nā sirtuins i ka ʻelemakule a me nā maʻi. Nā hana i ka Biology Pūnaewele, 24 (8), 464-471.

[5] Braidy, CK Lim, R.Grant, BJ Brew, a me GJ Guillemin. 2013. Nā pae Nicotinamide Adenine Dinucleotide pae ma o ka papa maʻi ma Multiple Sclerosis. ʻO Brain Res 1537: 267-272.

[6] Stipp D (Malaki 11, 2015). "Ma waho o Resveratrol: ʻO ka Anti-Aging NAD Fad". Pūnaewele Blog ʻAmelika ʻEpekema.

[7] Prolla, T., Denu, J. 2014. NAD ka nele i nā hana Mitochondrial pili i ka makahiki. Pūnaewele Metabolism, 19 (2), 178-180.

[8] Fletcher RS, Lavery GG (ʻOkakopa 2018). "Ke kū ʻana o nā kinotope ribotide nikotinamide i ka hoʻoponopono o NAD + metabolism". Ka Nūpepa o Molecular Endocrinology. 61 (3): R107 – R121. hana: 10.1530 / JME-18-0085. PMC 6145238. PMID 30307159.

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