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Wehe i ka hiki o Coluracetam: Hoʻonui i ka hana Cognitive a me ka mālama ʻana i ka hopohopo

/Blog/Gallery/Wehe i ka hiki o Coluracetam: Hoʻonui i ka hana Cognitive a me ka mālama ʻana i ka hopohopo

Posted on by kākauʻo ia i loko Gallery.
ʻO Coluracetam
" ʻO Coluracetam (BCI-540, i ʻike ʻia ʻo MKC-231) he nootropic momona momona. ʻOi aku ka ikaika o Coluracetam ma mua o Piracetam, ka racetam mua. ʻO ka Mitsubishi Tanabe Pharma o Iapana i hoʻopaʻa i ka coluracetam i ka makahiki 2005. ʻO ia kekahi o nā nootropics hou loa. "

ʻO ka ʻohana Racetam o Nootropic- Coluracetam

ʻO Coluracetam (BCI-540, a i ʻole MKC-231) kahi nootropic hiki ke hoʻoheheʻe ʻia i ka momona i ka papa racetam-papa o nā hui. ʻOi aku ka ikaika o Coluracetam ma mua o ka racetam kumu, Palekana. Ua ʻae ʻia ʻo Coluracetam e Mitsubishi Tanabe Pharma o Iapana i ka makahiki 2005. Ke hoʻolilo nei i kekahi o nā nootropics i hoʻokumu ʻia ma ka racetam hou.

Ua kūʻai lilo ʻia ka palapala hoʻohoka no Coluracetam iā BrainCells, Inc. ma San Diego, Kaleponi. He hui liʻiliʻi ʻo BrainCells, pilikino pilikino paʻa ʻia i ka hoʻomohala ʻana i nā mea hoʻohui no ka mālama ʻana i kahi maʻi depressive nui (MDD), depress depression depress (TRD), a me ka maʻi ʻo Alzheimer

ʻO Coluracetam kahi ʻano like me Piracetam. A e like me nā nootropics racetam āpau, loaʻa kahi pyrrolidone nucleus ma kāna kumu. Hōʻike ka noiʻi noiʻi hou loa i ka hiki no ka mālama ʻana i nā maʻi depressive, a me ka retinal a me ka nerve optic nerve.

He ikaika nui ʻo Coluracetam choline e kuhikuhi ana i nā supplement. Hoʻonui ia i ka hoʻohuli koho ʻana o kou lolo i acetylcholine (ACh) ma o ke kaʻina choline uptake (HACU) kiʻekiʻe. ʻO ka mea e hoʻonui ai i ka makaʻala, ka nānā ʻana i nā kikoʻī a me ka hoʻomanaʻo.

Ke hōʻike nei kekahi mau noiʻi, a me nā ʻike pilikino iā Coluracetam i ka hopena o ka AMPA. Ke hoʻolilo nei i mea nootropic ampakine hiki. ʻO ka mea hiki ke wehewehe i nā hopena stimulant-like me ka ʻole o nā hopena ʻaoʻao o nā stimulants kuʻuna. Hōʻike pū ʻo Coluracetam i kekahi mau ʻano ʻano kūpilikiʻi (anti-hopohopo) e kōkua ana i ka hoʻomaikaʻi ʻana i ka naʻau a me ka hoʻomake ʻana i ka hopohopo.

Pehea e hana ai ka Coluracetam (Mechanism of Action)

E like me ka nui o nā hui racetam, coluracetam (CAS:135463-81-9) hana nui ma ka hoʻonui ʻana i nā pae o ka neurotransmitter acetylcholine, i pili ikaika me ke aʻo ʻana, ka hoʻomanaʻo ʻana, a me ka ʻike.

Eia nō naʻe, ʻano ʻokoʻa ka coluracetam e hoʻololi ai i nā pae acetylcholine. ʻO ka maʻamau, hoʻonāukiuki nā racetams i ka hana acetylcholine e ka hoʻoulu ʻana i nā mea loaʻa kūpono, akā hana ʻo coluracetam ma o ka hoʻonui ʻana i ka choline kiʻekiʻe-affinity choline, a i ʻole HACU. Hoʻoholo ka ʻōnaehana HACU i ka helu i kahakaha ʻia ai ka choline i loko o nā neurons no ka hoʻololi ʻana i acetylcholine.

Ma ka hoʻonui ʻana i ka helu i huki ʻia ai ka choline i loko o nā hunaola nerve, hoʻolaha ka coluracetam i ka hana acetylcholine a kumu e piʻi ai nā kiʻekiʻe o ka lolo o kēia neurotransmitter koʻikoʻi. i ka loaʻa wikiwiki o choline no ka lawe ʻana.

Hoʻohui pū kēia mau hana i nā pae kiʻekiʻe o acetylcholine, i pili me ka hoʻonui i ka ʻike a me ka hoʻomanaʻo.

ʻO Coluracetam

Nā pōmaikaʻi a me nā hopena o Coluracetam

❶ Hoʻonui ʻo Coluracetam i ka hoʻomanaʻo a me ke aʻo ʻana

Hoʻomaopopo ka maikaʻi o Coluracetam i ka hoʻokō ʻana i ka hana noʻonoʻo a hoʻomanaʻo i nāʻiole a me nā hopena like i nā kānaka. Ua alakaʻi ʻo Brain Cells Inc. i kahi noiʻi e hōʻike ana i ka hoʻomaikaʻi o ka noʻonoʻo i nāʻiole ma hope o ka loaʻa ʻana iā AF64A no ʻewalu mau lā. Ua hoʻomau ʻia ka hoʻomohala ʻana ma ʻō aku o ka lāʻau. Alzheimer ka maʻi hiki i nā pae haʻahaʻa o acetylcholine. Ma ka ulu ʻana i ka acetylcholine i ka hippocampus, e hoʻonui ka coluracetam i nā ʻōuli o ka maʻi o Alzheimer e like me nā maʻi aʻo a me ka hoʻomanaʻo maikaʻi ʻole.

❷ Hoʻoemi ʻo Coluracetam i ke kūpikipiki-pale kūpale

I ke aʻo ʻana o 101 mau kānaka me ke kaumaha, ʻaʻole i loaʻa ka hopena me ka antidepressants, he hopena kūkulu ia i ka hoʻomaikaʻi hou ʻia o ka maikaʻi o ke ola ma 80 mg 3 manawa i ka lā. Eia naʻe, ʻo kēia wale nō ke aʻo ʻana i nā kānaka. ʻO ka hiki iā ia ke hoʻoliʻiliʻi i ka noxiousness glutamate e pili no kāna hopena maikaʻi i ka mālama ʻana i ke kaumaha.

❸ Hoʻoemi ʻo Coluracetam i ka pīhoihoi

I loko o kahi noi iole, hōʻike ʻia nā lā ma 21 mau lā o coluracetam i kahi 20% hoʻomaikaʻi i ka hopohopo, ʻoi aku ka kiʻekiʻe ma mua o ka hopena o ka 12% hopena valium i hoʻokahi mahele like i ka hoʻopaʻa like ʻana.

❹ ʻO Coluracetam Paipai iā Neurogenesis

ʻ mentionlelo kekahi mau noiʻi e kōkua ia me ka neurogenesis. ʻAʻole maopopo ka ʻōnaehana mua, akā pili ia i ka lawelawe ʻana iā ia i mau pule he nui, kahi e hoʻonui ai i ka acetylcholine ma ka wahi hippocampus. ʻAʻole ʻike ʻia ke ʻano, akā manaʻo ʻia e pili ana i ka hoʻonui ʻana o ka acetylcholine hippocampal ke hana ʻia ka coluracetam i kēlā me kēia lā no kekahi mau pule. "

❺ ʻO Coluracetam Kōkua me Schizophrenia

Hoʻonui ka Coluracetam i ka hana o ChAT i nāʻiole me ka hōʻino ʻana o ke aʻa nerve. Hōʻike kēia hoʻonui ʻana e pōmaikaʻi paha i nā mea maʻi me schizophrenia ma o kēia enzyme like. Ke hana nei nā noiʻi hou aʻe e pili ana i ka poʻe me ka schizophrenia.

❻ ʻO Coluracetam Hoʻonui i ka maka maka

Ua hōʻike ʻo Coluracetam i kāna mau optic ikaika e like me ka hoʻomaikaʻi ʻana i ke kala, ʻike, a me ka vividness. ʻO ke kikoʻī, paipai ia i ka ulu ʻana o ke aʻalolo no ka maʻi retinal degenerative. Hōʻike nā noiʻi he nui i ka ʻike kala maikaʻi a me ka ʻoi o ka maka, akā ʻaʻohe noiʻi ʻepekema i hōʻoia i kēia mau hopena.

Pehea e hana ai ʻo Coluracetam i ka lolo?

Hoʻoikaika ʻo Coluracetam i ke olakino lolo a hana i nā ʻano like ʻole. Akā kū ʻokoʻa ʻelua.

Hoʻoikaika ʻo Coluracetam i kou lolo's koho choline i ka hopu ʻana a me ka hana ʻana me ke kaʻina choline uptake kiʻekiʻe (HACU) i loko o nā neurons o ka lolo.

Hana ʻia ʻo Acetylcholine (ACh) o choline a me acetate. Pono e loaʻa i kēia mau mea i ka maʻi neuron i nā manawa āpau. Pēlā i hiki ai ke synthesize i ka ACh ke pono ia.

ʻO ka choline manuahi e kahe ana i ke koko keʻa i ka pale o ka lolo. A lawe ʻia e nā cholinergic neuron terminal. Lawe ʻia i loko o ka neuron e ke ʻano kiʻekiʻe choline uptake (HACU) ʻōnaehana. Hana ʻia ka synthesi o ACh i ka synaptic cleft. ʻO ka hakahaka ma waena o nā neurons ke hele ia i loko o ka neurona.

ʻO ka ʻōnaehana HACU ka wela, ka ikehu, a me ka paʻakai. ʻO kēia ʻōnaehana ke ala mua e pono ai ka choline e pono ai no ka synthes o ACh i lawe ʻia i loko o ka neuron. A ʻo ia ka ʻanuʻu palena palena palena i ka hana ʻana o kēia neurotransmitter koʻikoʻi. Ke wāwahi paha kēia ʻōnaehana a hana ʻole paha e like me ka maikaʻi e like me ia i hoʻolālā ʻia ai, ʻike ʻoe i nā pilikia me ka hoʻomanaʻo, ke aʻo ʻana, a me ka noe o ka lolo.

Hoʻopili ʻo Coluracetam i kēia kaʻina hana a kōkua iā ia e hana me ka maikaʻi. I ka ʻoiaʻiʻo, me he mea lā e hoʻonui ana i ke kaʻina HACU. ʻOiai i nā neurons poino. Hoʻonui ka acetylcholine i nā neurons i mea e hoʻomaikaʻi ai i ka hoʻomanaʻo. hoʻonui i ka ʻike a hāʻawi i nā koho hoʻoholo maikaʻi aʻe.

ʻO Coluracetam kahi e hoʻomaikaʻi ai i ka AMPA potentiation. Hoʻopili ʻia nā mea loaʻa AMPA e glutamate. Hana i ka lolo a me ka ʻōnaehana waena e hoʻomaikaʻi i ka makaʻala a me ka ʻike.

Hana ʻo Coluracetam me ka AMPA potentiation a me ka choline hāpai ʻana i ka hoʻonui. Kōkua kēia hui ʻana i mea e hoʻomaikaʻi ai i nā ʻano maʻi me ka loli ʻole ʻana i nā pae serotonin.

ʻO Serotonin Selective Reuptake Inhibitors (SSRIs) ke ʻano olakino i makemake nui ʻia i kēia manawa no ka hana ʻana i nā ʻano maʻi a me ke kaumaha. Hele mai lākou me ka papa inoa o nā hopena maikaʻi ʻole. A mai hana i kēlā me kēia mea hoʻomanawanui kaumaha.

Ua hōʻike nā kānaka noiʻi ua maikaʻi ʻo Coluracetam i ka mālama ʻana i ke kaumaha nui a me nā maʻi pīhoihoi. Me ka hoʻololi ʻole i nā pae serotonin i ka lolo. A me ka ʻole o nā hopena ʻē aʻe e hele pū me ka hoʻohaunaele serotonin.

ʻO Coluracetam

Hoʻohana ʻia ʻo Coluracetam: Dosage and Stack No Reference Only

ʻO Coluracetam kahi hui i loaʻa ʻole i loko o nā meaʻai a hiki ʻole i ko mākou kino ke hana. No laila, ʻo ke ala wale nō e hāʻawi ai i nā pono o kēia mole ma o ka supplementation.

Kūʻai maʻamau ʻo Coluracetam i ka pauka a i ʻole ke ʻano capsule a hiki ke lawe ʻia ma ka waha. Hiki ke lawe ʻia nā hana sublingally (ma lalo o ke alelo) no ka wikiwiki a me ka maikaʻi o ka lawe ʻana.

ʻOiai ʻo coluracetam kahi agena ikaika loa, pono e hoʻomaka me ka hopena hopena haʻahaʻa. Inā ʻike ʻoe he pono e hoʻonui i ka lāʻau e ʻike ai i nā pōmaikaʻi, pono e hana mālie i kēia a ʻaʻole i ʻoi aku i ka 80mg.

ʻAʻole ʻona ʻo Coluracetam a manaʻo ʻia he palekana a hoʻomanawanui maikaʻi ʻia. Aia kekahi mau hopena ʻē aʻe e pili pū me ka pūhui, e like me ka hopohopo, ʻeha poʻo, luhi a me ka nausea. He kakaikahi kēia mau ʻaoʻao a ke hana wale ia ke loaʻa ʻole kahi lawa mua o ka waihona choline e hoʻohana ʻia no ka acetylcholine synthes. ʻO kēia ke kumu e paipai ai iā mākou e hoʻomaka i ka synthese-hoʻonui i ka coluracetam me kahi enhancer pae choline e like me citicoline.

Hiki i ka Coluracetam ke launa pū me kekahi mau lāʻau, keu hoʻi nā mea e launa pū me ka mea loaʻa nā NMDA. Hoʻopili pū kēia me nā suppressants ʻūhū a me nā anesthetics. ʻO nā mea ʻē aʻe e launa pū me ka ʻōnaehana cholinergic, e like me ka lāʻau glaucoma a me ka nikotine, hiki ke launa pū me nā hopena o coluracetam. Hiki iā Coluracetam ke pale aku i nā hopena o nā lāʻau anti-cholinergic (e like me kekahi Benadryl, kekahi antipsychotics a me nā lāʻau a Parkinson).

E like me nā mea kōkua, inā ʻoe i ka lāʻau a i ʻole loaʻa kahi olakino olakino, kūpono paha ʻoe e ʻōlelo i kāu kauka ma mua o ka hoʻomaka ʻana i kekahi. hoʻoponopono hou hoʻomalu.

※ How To Kākoʻo We With Nā lāʻau ʻē aʻe

♦ ʻO Coluracetam kahi mole molemona hiki ke hoʻoheheʻe ʻia, no laila ʻoi aku ka maikaʻi me ka momona momona e like me ka niu a me ka aila MCT.

♦ E hoʻopili pū ʻia ʻo Coluracetam me ka koho koho e like me citicoline. Hoʻonui ʻo Citicoline i ka loko o nā choline i loaʻa no ka synthes. Hiki i ka stack ke hana i nā hopena ikaika ma o ka hoʻonui ʻana i ka choline (citicoline) a me ka hiki ke synthesise iā ia i acetylcholine (coluracetam).

※ Hana Kūpono: 5-80mg i kēlā me kēia lā

Paipai mākou ma waena o 5-80mg o coluracetam i kēlā me kēia lā.

ʻO ka palena kiʻekiʻe o ka palekana no coluracetam ʻo 80mg i kēlā me kēia lā. Eia naʻe, paipai mākou e noho me 35mg i kēlā me kēia lā no ka mea ʻaʻole i nānā piha ʻia nā hopena o nā lāʻau kiʻekiʻe i nā kānaka.

ʻOi aku ka maikaʻi o ka hoʻokaʻawale ʻana i kēia mau kaha i loko o ke kakahiaka a i ʻole ke awakea. ʻO kahi laʻana, kahi 20mg mahele lāʻau o 10mg i ke kakahiaka a me 10mg hou aʻe i ke awakea.

E like me ka mea i ʻōlelo ʻia ma mua, pono ʻoe e hoʻomaka ma ka palena haʻahaʻa o ka pae ʻana o ka hana. ʻO ka hoʻomaka ʻana o ka mahele lāʻau haahaa e hoʻoliʻiliʻi i ka likelike o ka ʻike i nā hopena ʻaoʻao maikaʻi ʻole.

Nā ʻaoʻao ʻaoʻao ʻo Coluracetam

He mea ʻawaʻawa ʻole ʻo Coluracetam. Pēlā nō i manaʻo ʻia he ʻae maikaʻi ʻia a palekana hoʻi. Hōʻike ka hapa nui o nā mea hoʻohana manawa mua o Coluracetam ka luhi ʻo ka hopena ia o ka hoʻomaka ʻana me kahi lāʻau kiʻekiʻe loa.

E hoʻomanaʻo, hana ʻo Coluracetam i ka hoʻonui ʻana i ka lawe choline i kou lolo. ʻO Choline kahi mea mua i ka hana o acetylcholine. Inā ʻaʻole lawa ka choline i loaʻa i kāu ʻōnaehana, ʻike ʻoe i nā hopena ʻaoʻao.

Heʻole nā ​​hopena iʻole e hiki ke komo i ka manaʻo nui, nāwaliwali, nā maka'āinana, ka nervousness a me ka nausea. Eia hou, o nā hopena o ka hopena he hopena pinepine ia o nā lāʻau kūikawā kūikawā o ka nootropic.

Kū pinepine nā poʻo hina mai ka hoʻohana ʻana iā Coluracetam ke poina iā ʻoe e hoʻohui iā ia me kahi waihona choline maikaʻi. ʻO ka maʻi poʻo ke poʻo pinepine o kahi choline deficit i kou lolo.

Nānā nui- Coluracetam

ʻO Coluracetam kekahi o nā lālā hou a liʻiliʻi o ka papa racetam o nootropics, akā punahele ia me nā mea hoʻohana he nui.

Hoʻonui ia i nā pae o ka '' aʻo neurotransmitter '' acetylcholine, kahi e hoʻonui ai i ka noʻonoʻo, a me nā noiʻi holoholona e hōʻike ana hiki iā ia ke hoʻopau i nā hemahema hoʻomanaʻo me ka ʻole o nā hopena koʻikoʻi. ʻOiai aia kahi noiʻi kanaka liʻiliʻi liʻiliʻi e pili ana i ka coluracetam, ʻo nā noiʻi e kū nei e hōʻike ana he lapaʻau maikaʻi paha ia no ka hopohopo a me ke kaumaha.

Helu ka hapa nui o nā mea hoʻohana ma luna he mea hāpai pono i ka naʻau a me ka mea hoʻonui hoʻomanaʻo e hāʻawi iā lākou i ka noʻonoʻo a me ka noʻonoʻo maikaʻi. Wahi a haʻi e hāʻawi iā lākou i ka like o "HD hihiʻo", e hoʻomālamalama ana i nā kala, ʻokoʻa iʻoi aku ka ikaika, a me nā kukui e ʻā hou.

He hui ikaika ʻo Coluracetam, no laila haʻahaʻa nā helu o nā ana, a ʻike ʻia he hana wikiwiki. Kūʻai ʻia ia ma ke ʻano he papaʻai hoʻoponopono hou i ka US a hiki ke lawe 'ia ma ke kānāwai i Kanada a me UK i nā liʻiliʻi.

Nui aʻe nā mea e aʻo ʻia e pili ana i ka coluracetam, akā ʻike ʻia he palekana ia no ka hapa nui o nā mea hoʻohana ke lawe ʻia me ke kuleana. Inā hoihoi ʻoe i ka hoʻohui ʻana i kahi mea hou a ʻokoʻa i kāu nootropic hoʻokō, coluracetam hiki ke lilo i mea e noʻonoʻo ai.

ʻAʻohe nui o ka noiʻi a Coluracetam, nā hōʻike i loaʻa e hōʻike i kahi hiki ke hoʻohana ʻia. ʻO ia kekahi o nā heihei mainstream hou loa, e pili ana me Papakurukama. Eia nō naʻe, i kēia mau lā, ua ʻae ʻo FDA i kahi ʻano "hoʻonui" o Fasoracetam no ka mālama ʻana iā ADHD.

ʻO AASraw ka mea hana loea o Coluracetam (BCI-540, a i ʻole MKC-231) nona ka lab kūʻokoʻa a me ka hale hana nui e like me ke kākoʻo, e hoʻokō ʻia nā hana āpau ma lalo o ke kānāwai CGMP a me ka ʻōnaehana mālama maikaʻi. Paʻa ka ʻōnaehana hoʻolako, ʻae ʻia nā kauoha kūʻai a me nā mea kūʻai.

E kiʻi mai iaʻu i kēia manawa

Mea kākau o kēia ʻatikala:

Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine 

Mea kākau moʻolelo puke moʻolelo ʻepekema:

1.Yukihiko Shirayama
Ke Keʻena ʻOihana Hoʻonaʻauao, Ke Kula Nui ʻo Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8677, Iapana. 

2.Akinori Akaike
Keʻena ʻOihana Lapaʻau, Kula Puke Lapaʻau ʻepekema, Ke Kulanui ʻo Kyoto, Kyoto 606-01, Iapana

3. Shigeo Murai
Keena o Pharmacology. Kula o na niho. Ke Kulanui Lapaʻau ʻo Iwate. Morioka. 020, Iapana.

4.Tomoko Bessho

Lapaʻau Lapaʻau Lapaʻau 1, Yokohama Research Center, Mitsubishi Chemical Corporation, Yokohama 227, IAPANA.

5.Ken Takashina

Lapaʻau Lapaʻau. I, Mitsubishi Chemical Co., Yokohama 227, Iapana

6.Uemura Kazumasa

ʻOihana ʻekolu o ka Lapaʻau Kuloko, 65 Tsuruma-cho, Showa-ku, Nagoya 466–8550, Iapana

ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.

E hoʻomaopopo '

[1] Shirayama Y, Yamamoto A, Nishimura T, Katayama S, Kawahara R (September 2007). "Ma hope o ka hoʻolaha ʻana i ka choline uptake enhancer MKC-231 antagonizes phencyclidine-induced behavioral deficits and reduction in septal cholinergic neurons i nā ʻiole". ʻEulopa Neuropsychopharmacology. 17 (9): 616–26.

[2] Hoʻolaha ʻo BrainCells Inc. i nā hopena mai ka Exploratory Phase 2a Trial of BCI-540 Archived November 21, 2011, ma ka Wayback Machine.

[3] Uemura K, Yoshioka S, Ueda M, Tamaya N, Iguchi A, Hotta N.' 247 Ian;231(1999):79-1. doi: 113/jjp.5.PMID: 10.1254.

[4] Takashina K., Bessho T., Mori R., Eguchi J., Saito K. "MKC-231, he mea hoʻonui choline uptake enhancer: (2) Ka hopena i ka synthesis a me ka hoʻokuʻuʻana o ka acetylcholine i nāʻiole i mālamaʻia e AF64A." Nūpepa no ka Neural Transmission (Vienna). 2008 Iulai;115(7):1027-35.

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