Hana ʻo AASraw i nā pauka NMN a me NRC i ka nui!

β-ʻO Nicotinamide Mononucleotide

Rating: Māhele:

Loaʻa iā AASraw ka manawa kūpono e hoʻolako i nā huahana anti-ʻelemakule-NMN Powder i ka nui me ka rula CGMP a me ka ʻōnaehana kaohi e like me ka hiki ke ʻike ʻia. Hiki i kā mākou hana hana mahina ke piʻi i 1500kg. Welina e kāhea me mākou no ka ʻike kūʻai hou aku:
Kūlana: i ka waihona

ʻĀpana pūʻolo: 1kg / ʻeke, 25kg / pahu

Product Description

Nā ʻano kikoʻī

Product Name Mon-Nicotinamide Mononucleotide (NMN)
Kāleka CAS 1094-61-7
Ka Lā Molecular C11H15N2O8P
Kaumaha Kaumaha 334.22
'O Synonyms NMN;

β-D-NMN;

BETA-NMN;

beta-D-NMN;

Pauma NMN;

NMN zwitterion;

NICOTINAMIDE RIBOTIDE;

Nicotinamide nucleotide;

Nicotimide mononucleotide.

Keʻano ʻO ka pauma
Ka mālama a me ka lima lima 2-8 ° C ma kahi maloʻo

Kuhi Nui:

♣ ʻO NAD + kahi coenzyme nui e pono ai no ke ola a me nā hana pūnaewele.

♣ Nā pae o ka NAD +, keu hoʻi i kona ʻano NAD +, hoʻemi maoli me ka makahiki i nā aʻa he nui.

Creates Hoʻokumu ke kino iā NMN ma ke ʻano he pae waena waena a i ʻole "precursor" iā NAD +. E kau maʻalahi: ʻoi aku ka kiʻekiʻe o ka NMN pae kiʻekiʻe ʻo NAD + kiʻekiʻe.

ʻIke ʻia: Ma nā ʻatikala aʻe, NMN i hoʻohana ma kahi o β-Nicotinamide Mononucleotide (NMN)


 

NMN Kaʻina - NAD + & NMN

ʻO NAD + kahi hui kū hoʻokahi, hana mau ʻia i loko o kā mākou kino a hoʻohana ʻia e nā enzyme kī he nui e kōkua i ka hoʻolauna ʻana i nā hana pūnaewele maikaʻi. Eia nō naʻe, no ka hoʻohana ʻia ʻana o NAD + i ke kaʻina hana o ka wahie i kēia ʻōnaehana ʻōnaehana, hoʻomaka mākou e komo i nā deficit NAD + i nā helu like ʻole i ko mākou ola, me ka hoʻonui pinepine ʻana i ko mākou mau makahiki. Ma muli o ka hana nui ʻana o kēia mau ʻenima mana NAD + i ka mālama ʻana i ka ikehu paʻa pūnaewele, a me ka paipai ʻana i ke olakino pūnaewele, hiki i ka emi ʻana o ka NAD + ke hoʻopōʻino nui i ko mākou olakino holoʻokoʻa.

Ma muli o kēia, ua hoʻomaka ʻia ka nui o ka noiʻi i ka hoʻolaha ʻana i nā pae NAD + i loko o ke kino. ʻO ke kumumanaʻo ma hope o ka paipai ʻana i nā pae ʻo NAD + he mea ia e kākoʻo nui i nā hana o ke kino koʻikoʻi, a ma ia mea hiki ke kōkua i ka hoʻolōʻihi i ka lōʻihi. ʻO ka mea nui loa nō naʻe, nā pae hoʻonui o NAD +, ʻaʻole pono e hoʻoliʻiliʻi wale i ka lōʻihi, hiki nō paha ke kōkua i ka hāpai i ka maikaʻi o ke ola i ko mākou mau makahiki.

No laila pehea mākou e hoʻokiʻekiʻe ai i nā pae NAD +? Me he mea paʻakikī loa kēia. Eia naʻe, ua wehe ʻia kahi noiʻi hou i kahi hui kū hoʻokahi i kapa ʻia ʻo Nicotinamide Mononucleotide (NMN), kahi e hiki ai i ke kino ke hoʻohana ma ke ʻano he mākaukau mua loa i ka NAD +. I ke kumumanaʻo, ʻo kēia ka mea e hoʻolaha i ka NMN i kahi ola lōʻihi a olakino hoʻi.

Eia nō naʻe, ʻaʻole ʻo NMN wale nō kahi lōʻihi lōʻihi e hāpai ana i ka pākuʻi. ʻO ka ʻoiaʻiʻo, he mea kōkua maikaʻi ʻo NMN no nā ʻōpio a me nā ʻelemākule, no ka mea, he hopena koʻikoʻi ia no nā makahiki o kou mau makahiki. Pono nā ʻōpio a me nā ʻelemākule i nā pae NAD + kiʻekiʻe no ko lākou mau kino a me nā noʻonoʻo e holo i ka hana kiʻekiʻe. ʻO ke kiʻekiʻe o kāu pae NAD +, ʻoi aku ka nui o ka ikehu pūnaewele āu e loaʻa ai, a ʻo ka maikaʻi e hiki ai i kou kino a me kou noʻonoʻo ke hana i nā hanana koi nui. Eʻoiaʻiʻo kākou, na wai i hiki ʻole ke hoʻohana iki i ka lihi ma kēia ao holo wikiwiki a koi hoʻi? No laila, inā makemake ʻoe e hoʻopihapiha i kāu mau pūnaewele, a pīhoihoi i ka mea e hiki ai i kou kino a me kou noʻonoʻo me kahi keu ʻo NAD + e keʻehi nei, a laila e paipai mākou iā ʻoe e hoʻomau i ka heluhelu ʻana ma o kēia blog ākea ākea i hoʻolālā ʻia e kōkua iā ʻoe e loaʻa ka hapanui mai loko mai o ka supplementation NMN!

 

He aha ka NMN?

ʻO NMN (Nicotinamide Mononucleotide) no ka ʻohana o nā nucleotides, i loaʻa nā moleolaola i loko o ka hapa nui o nā meaʻai a mākou e ʻai ai. E like me nā nucleotide āpau, haku ʻia ka NMN i nā ʻāpana he 3: kahi kumu nitrogenous, kahi kō, a me kahi hui phosphate.

ʻOiai ka hapanui o nā nucleotides i hoʻohana ʻia e kūkulu i ka DNA, hoʻohana ʻia ka NMN e hana i ka nicotinamide adenine dinucleotide (NAD +) a me ke kaulike kaulike maikaʻi. Hoʻokumu ke kino iā NMN ma ke ʻano he ʻanuʻu waena a i ʻole "precursor" iā NAD +. E kau maʻalahi: ʻoi aku ka kiʻekiʻe o ka NMN pae kiʻekiʻe ʻo NAD + kiʻekiʻe.

Hoʻonui ka NAD + i ke kālā ikehu nui o ke kino (ATP), kaulike i ke kaʻina o ka circadian, a hiki i nā haneli he ʻelima mau hopena enzymatic - ʻo ka hapa nui o lākou e hoʻopaneʻe i ka ʻelemakule Nā pae o ka NAD +, ʻo ia hoʻi kona ʻano NAD +, hoʻemi maoli me ka makahiki i nā aʻa he nui.

 

Pehea e hana ai ka NMN? / No ke aha e pono ai ka NMN kōkua?

He maikaʻi nā NR a me NMN no ka mea hoʻokiʻekiʻe lākou i nā pae o NAD +, e hoʻoliʻiliʻi me ka makahiki. He mea nui ka NAD + i ka metabolism pūnaewele, hoʻolilo i nā meaʻai i ka ikehu paʻa, a hoʻoulu ʻia hoʻi ia i nā sirtuins, kahi set o nā protein e hoʻoponopono i ke olakino pūnaewele. Loaʻa mākou āpau iā NAD + i loko o ko mākou kino mahalo i kā mākou papaʻai, ma ka ʻai ʻana i nā meaʻai me nā mea mua o NAD + i loko o lākou. ʻOiai ʻo NR a me NMN hiki ke loaʻa i nā helu kumulāʻau i nā meaʻai like ʻole, akā ʻaʻole hiki i kekahi ke ʻai i ka nui o nā mea āpau e hoʻonui ai i nā pae NAD +. A ʻo kahi hopena, hiki ke kōkua i ka hoʻopiha ʻana me ka precursor NAD i ka hoʻoliʻiliʻi.

 

Loaʻa nā NMN pono

  • Hoʻoikaika ʻo NMN i ka lako ikehu i nā pūnaewele ʻelemakule:

Lawe nā cell a hana i ka wahie e hana i kā lākou hana. I kou mau makahiki ua nalowale kēia hiki iā lākou, ke koi aku nei iā lākou i kahi kūlana i ʻike ʻia e like me ke kenekona kenela a i ʻole nā ​​ʻelemakule biolo e hele mai me nā hopena ʻino ʻē aʻe. ʻO NAD + kahi mea nui o ka lako wahie o ka cell i manaʻo ʻia ʻo ia wale nō ke ala e hiki ai iā NMN ke kōkua i ka ikehu paʻa pūnaewele. ʻO kēia ka hāʻawi ʻana me ka NMN i kāu mau pūnaewele i kahi ala wikiwiki e refuel a paipai i ka mahele o ka pūnaewele a me ka ulu ʻana.

 

  • Kōkua ʻo NMN i ka hakakā ʻana i nā maʻi metabolic:

Ke ʻelemakule nei ʻoe, ua laha ke ʻano o nā maʻi e like me ka maʻi diabetes, momona, dyslipidemia, a me nā maʻi ʻaʻa ʻole ʻona ʻona (NAFLD). Hoʻokumu ʻia lākou e ka hōʻemi o nā pae NAD +. Hana ʻo NMN ma o ke ala hoʻōla e hoʻoliʻiliʻi i nā pae o NAD + e hoʻonui ai i kēia mau maʻi maʻi ʻē aʻe.

 

  • Hoʻoulu hou ʻo NMN i ke kahe o ke kahe o ke kahe:

I ke kino o ke kino, ka helu a me nā hana o nā endothelial cells (ECs) e uhi ana i nā kīʻaha koko e emi. ʻO NAD + precursors e like me NMN a me nicotinamide riboside (NR) e hana nei ma o ke Sirtuin Pathway, hiki ke kōkua i ka hoʻihoʻi ʻana i ka hiki i nā pūnaewele endothelial e hana i ke koko hou. nā moku.

 

  • Hoʻopili ʻo NMN i ka waiwai e pili ana i ka makahiki:

I ka ʻelemakule o ka poʻe, loaʻa ke kaumaha. Ma kahi noi 2016, ua ʻike ʻia ua ʻike ʻia nā kumuhana i hāʻawi ʻia i ka NMN i ko lākou momona momona e hoʻemi ana a me ka hoʻonui nui ʻana o nā lean. Ma ke kākoʻo ʻana me NMN, hiki iā ʻoe ke lilo i kaupaona a kūkulu i nā mākala - ʻelua mau ala ikaika e hoʻomaikaʻi ai i ke olakino a nānā a ʻike ʻōpio.

 

  • Hoʻonui ka NMN i ka ikehu metabolism:

Ma ka hoʻopili ʻana i ka synthesity o NAD +, kōkua ka NMN i ka haki ʻana i nā meaola i ka ikehu, ka hana ʻana i nā hana o ka pūnaewele nui a me ka hoʻēmi ʻana i ke koʻikoʻi oxidative Hoʻoiho kēia mau hana biochemical a hoʻokū i ka hana ʻelemakule. ʻAʻole hoʻonui ʻo NMN i kou ikehu akā kōkua i ka hoʻoponopono ʻana i kāu mau pūnaewele.

 

NMN palekana a me nā ʻaoʻao ʻaoʻao

Manaʻo ʻia ʻo NMN palekana i nā holoholona, ​​a ke hoʻohiki nei nā hopena i ka hoʻomaka ʻana o nā hoʻokolokolo kanaka. Manaʻo nui ʻia kēia mole e palekana a ʻaʻole ʻawahia, ʻoiai ma nā kiʻekiʻe kiʻekiʻe i nāʻiole a me kahi noiʻi kanaka. ʻAʻohe hopena ʻino nā hopena o ka wā lōʻihi (hoʻokahi makahiki) i ka waha i nāʻiole. Ua pau ka hoʻokolohua hoʻokolohua mua loa i nā kānaka a kākoʻo nā hōʻike i ka manaʻo ʻaʻole ia he mea ʻawahia i hoʻokahi kaukana.

ʻOiai hoʻokahi noiʻi o nā kāne Kepanī i paʻi ʻia i Nowemapa 2019 i hōʻike ua hoʻonui nā kumuhana i nā kiʻekiʻe o ka bilirubin i loko o kā lākou koko ma hope o ka lawelawe ʻana o NMN, ua hoʻomau kēia mau pae i ka pae maʻamau. E nānā pono nā noiʻi e hiki mai ana i ka palekana lōʻihi a me ka pono o ka hoʻohana. ʻAʻole pili ʻo NMN i nā hopena ʻē aʻe i ʻike ʻia.

 

NMN ma ke ʻano he NAD + Pākuʻi-mahalo nui ʻia

Hoʻoemi nā noʻonoʻo intracellular o NAD + mai ka ʻelemakule e like me nā hana pūnaewele maʻamau hoʻopau i nā lako NAD + i ka manawa. Manaʻo ʻia e hoʻihoʻi ʻia nā pae olakino o NAD + e ka supplementation me NAD + precursors. Wahi a ka noiʻi, ua ʻike ʻia nā mea mua e like me NMN a me ka ribotide nikotinamide (NR) ma ke ʻano he kōkua o ka hana NAD +, e hoʻonui ana i ka noʻonoʻo o NAD +. ʻO David Sinclair, kahi mea noiʻi NAD + mai Harvard, i ʻōlelo, "ʻO ka hānai a lawelawe ʻana paha iā NAD + pololei i nā meaola ʻaʻole ia he koho kūpono. ʻAʻole hiki i ka NAD + mole keʻaʻa koke i nā membrane o ke kelepona e komo i nā hunaola, a no laila ʻaʻole hiki ke hoʻopili maikaʻi i ka metabolism. Akā, pono e hoʻohana i nā mole mua i NAD + e hoʻonui i nā pae bioavailable o NAD +. " ʻO kēia ʻaʻole hiki ke hoʻohana ʻia ʻo NAD + ma ke ʻano he hoʻopihapiha pololei, no ka mea ʻaʻole maʻalahi ia e komo. ʻOi aku ka maʻalahi o ka lawe ʻia o ka NAD + precursors ma mua o ka NAD + a ʻoi aku ka maikaʻi o nā mea hoʻohui.

 

Pono ʻoe e ʻike ma mua o ka kūʻai ʻana iā NMN Powder Online

 

▲ Kūlana paʻa ʻole.

ʻO ka hanauna mua o NMN me ka haʻahaʻa haʻahaʻa ʻaʻole i loaʻa ka wai maikaʻi maikaʻi. E hoʻoliʻiliʻi ka mana o AASraw o ka NMN i ke kumu kūʻai hana ma o ka kahe ʻana o ka pauka maikaʻi e alakaʻi ai i ka hoʻonui ʻana i ka hiki ke hana ʻoi aku ka maʻalahi o ka holo ʻana ma o nā mīkini. He aha hou aʻe, e alakaʻi kēia mana i kahi mea like o nā capsule e like me ka paʻakikī o ka mana haʻahaʻa haʻahaʻa e hui like. ʻO ka mea hope loa, hiki i ka NMN paukū haʻahaʻa i hoʻopili ʻia i ka papa papa ke lūlū maʻalahi i ka wā o ke kaʻa.

Hoao ka hapa nui o nā mea kūʻai aku e hoʻonā i kēia ma o nā mea hoʻohui hou aʻe akā alakaʻi ia i nā papa nui, ʻaʻole kūpono no nā mea kūʻai aku i ka lehulehu o ka pae. No laila, kūpono kūpono ʻo NMN haʻahaʻa haʻahaʻa wale nō no nā huahana huahana pauka.

 

▲ Hoʻokomo i nā mea NMN Adulterated Adulterated.

Ua hoʻopiha ʻia ka mākeke me NMN hoʻopunipuni a moe kolohe hoʻi. Ma hope o ka komo ʻana o NMN i ka mākeke i ka makahiki i hala aku nei ua kū nui nā mana hou NMN i hope o kekahi. He paʻakikī loa i nā mea hana a me kā mākou mea kūʻai aku e haʻi i ka mea kiʻekiʻe kiʻekiʻe maoli mai nā mea hoʻopunipuni a me ka maʻemaʻe haʻahaʻa i kūʻai ʻia ma ka pūnaewele.

Ua kūʻai aku kekahi mau huahana NMN ma lalo o 80% ka maʻemaʻe. ʻAʻole ʻike nā mea kūʻai aku a me nā mea kūʻai aku i nā mea hoʻopihapiha a me nā mea haumia i kahi 20% o ka huahana.

Ua ʻike maoli mākou i ka nui o nā mea hoʻolako NMN e kūʻai aku paha i ka nicotinamide (ʻo ka vitamin B3 maʻamau) a i ʻole ka nicotinamide riboside ma kahi o ka NMN. ʻOi aku ka nui o nā mea hoʻolako i ka palaoa e hoʻoheheʻe i ka NMN a hoʻopunipuni i kā lākou mea kūʻai aku. Kūleʻa pinepine kēia huahana akā ʻaʻohe hopena maikaʻi.

 

▲ Ka nele o ka palekana a me ka ʻikepili pono.

Lilo ka kaulana o ka NMN i ka US, ʻEulopa, Iapana a me Kina, a pēlā aku, akā nui ka palekana a me ka ʻike pono e hemahema nei. Nui ka poʻe hilinaʻi ʻole i kēia huahana, no laila kaupalena ʻia ka mākeke o NMN. ʻOiaʻiʻo ʻo NMN i ke kino o ke kanaka a me kekahi mau mea kanu e like me broccoli, no laila ʻaʻohe pilikia palekana. Akā he manawa kiʻekiʻe kēia no ka ʻikepili e hōʻoia hou ana i kona hopena.

 

[Reference]

[1] ʻO Tarragó MG, Chini CC, Kanamori KS, Warner GM, Caride A, de Oliveira GC, et al. (Mei 2018). "+ Hoʻoiho". Pūnaewele Metabolism. 27 (5): 1081-1095.e10. hana: 10.1016 / j.cmet.2018.03.016. PMC 5935140. PMID 29719225.

[2] Stipp D (Malaki 11, 2015). "Ma waho o Resveratrol: ʻO ka Anti-Aging NAD Fad". Pūnaewele Blog ʻAmelika ʻEpekema.

[3] Cambronne XA, Kraus WL (ʻOkakopa 2020). "+ Synthesis a me nā hana i nā Kelepona Mammalian". Nā hana i ka ʻepekema Biochemical. 45 (10): 858-873. hana: 10.1016 / j.tibs.2020.05.010. PMC 7502477. PMID 32595066.

[4] ʻO Bogan KL, Brenner C (2008). "ʻO ka Nicotinic acid, nikotinamide, a me ka ribotide nikotinamide: kahi loiloi molekole o ka NAD + precursor vitamins i ka meaʻai kanaka". ʻO ka loiloi makahiki o ka meaʻai. 28: 115-30. hana: 10.1146 / annurev.nutr.28.061807.155443. PMID 18429699.

[5] Yue Yang, Anthony A. Sauve. NAD + metabolism: Bioenergetics, hōʻailona a me ka manipula no ka lāʻau. ʻO Biochim Biophys Acta, 2016; DOI: 10.1016 / j.bbapap.2016.06.014.

[6] Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Hoʻolālā Kūlohelohe o Nicotinamide Mononucleotide Mitigates Hoʻololi ʻia ke olakino pili kino makahiki i nāʻiole. Pūnaewele Metab, 2016; DOI: 10.1016 / j.cmet.2016.09.013.

[7] Niels J. Connell, Riekelt H. Houtkooper, Patrick Schrauwen. ʻO NAD + metabolism ma ke ʻano he māka no ke olakino metabolic: ua loaʻa anei iā mākou ka pōkā kālā? Diabetologia, 2019; DOI: 10.1007 / s00125-019-4831-3.

[8] Ann Katrin-Hopp, Patrick Grüter, Michael O. Hottiger. Hoʻoponopono o ka Glucose Metabolism e NAD + a me ADP-Ribosylala. Nā Kelepona, 2019; ʻOI: 10.3390 / cells8080890.

[9] Shuang Zhou, Xiaoqiang Tang, Hou-Zao Chen. ʻO Sirtuins a me Insulin Resistence. Front Endocrinol (Lausanne), 2018; DOI: 10.3389 / fendo.2018.00748.


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