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ʻO Nicotinamide riboside chloride

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Product Description

Nā ʻano kikoʻī

Product Name ʻO Nicotinamide riboside chloride
Kāleka CAS 23111-00-4
Ka Lā Molecular C11H15ClN2O5
Kaumaha Kaumaha 290.7
'O Synonyms 23111-00-4

ʻO Nicotinamide riboside chloride

ʻO Nicotinamide riboside (chloride)

3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride

ʻO Nicotinamide ribose chloride

Keʻano ʻO ka pauma
Ka mālama a me ka lima lima 0 - 4 C no ka wā pōkole (mau lā a i mau pule), a i ʻole -20 C no ka wā lōʻihi (mau mahina).

 

Hōʻike Nicotinamide riboside chloride

ʻO Nicotinamide Riboside Chloride (NIAGEN) ke ʻano paʻakai paʻakai o ka nikotinamide riboside (NR). ʻO ka NR kahi ʻano hou pyridine-nucleoside o ka huaora B3 e hana ma ke ʻano he precursor i ka nicotinamide adenine dinucleotide (NAD) a i ʻole NAD +. (GRAS) ma ʻAmelika Hui Pū ʻIa no ka hoʻohana ʻana i nā huahana meaʻai. ʻO Nicotinamide riboside chloride kahi ʻano aniani o Nicotinamide riboside (NR) chloride. Hoʻonui ka Nicotinamide riboside chloride i nā pae NAD [+] a hoʻoheheʻe iā SIRT1 a me SIRT3, e hoʻopau ana i ka hoʻonui ʻana i ka metabolism oxidative a me ka pale ʻana i nā kino momona i hoʻopili ʻia i ka papaʻai momona. Hoʻohana ʻia ʻo Nicotinamide riboside chloride pauka i loko o nā mea hoʻopihapihaʻai.

 

ʻO Nicotinamide riboside chloride ʻOihana o ka Hana

ʻO Nicotinamide Riboside Chloride (NIAGEN) ke ʻano paʻakai paʻakai o ka nikotinamide riboside (NR). ʻO NR kahi ʻano pyridine-nucleoside o ka huaola B3 e hana ma ke ʻano he prekursor i ka nikotinamide adenine dinucleotide a i ʻole NAD +. Paʻa ka NR i ka hoʻohaʻahaʻa o nā ʻoki lāʻau i hoʻokiʻi ʻia i nā neurons ex vivo a pale aku i ka nalo ʻana o ka leo i loko o nāʻiole ola. ʻO ka paukū ribotide Nicotinamide e pale aku ai i ka mākala, neural a me ka melanocyte stem cell senescence. ʻO ka hoʻonui ʻia ʻana o ka muscular regeneration i nāʻiole i ʻike ʻia ma hope o ka mālama ʻia ʻana me ka ribotide nikotinamide, e alakaʻi ana i ke kuhi manaʻo e hoʻomaikaʻi paha ia i ka hoʻoliʻiliʻi o nā meaola e like me ke akepaʻa, ka puʻuwai, a me ka puʻuwai. Hoʻohaʻahaʻa hoʻi ʻo Nicotinamide riboside i ke kō glucose a me ke ake momona i ka prediabetic a me nā ʻano diabetic type 2 me ka pale ʻana i ka ulu ʻana o ka neuropathy diabetic peripheral. Nānā: ʻO Nicotinamide Riboside chloride kahi hui α / β.

 

Noi Nicotinamide riboside chloride

Ua hoʻopaʻa inoa ʻia ka Nicotinamide riboside chloride pauka me ka helu CAS 23111‐00‐4 a me ka helu EC 807-820-5. ʻO IUPAC kona inoa ʻo 1 - [(2R, 3R, 4S, 5R) -3,4 dihydroxy ‐ 5‐ (hydroxymethyl) oxolan ‐ 2 ‐ yl] pyridin ‐ 1 ‐ ium ‐ 3 ‐ carboxamide; chloride. ʻO ka mole molekiola o ka nicotinamide riboside chloride ʻo C11H15N2O5Cl, a me kona kaupaona mole 290.7 g / mol. ʻO Nicotinamide Riboside Chloride (NIAGEN) ke ʻano paʻakai paʻakai o ka nikotinamide riboside (NR). ʻO ka NR kahi ʻano hou pyridine-nucleoside o ka huaora B3 i hana ma ke ʻano he precursor i ka nicotinamide adenine dinucleotide (NAD) a me NAD + Pono ke kino iā NAD + e hana maʻamau. Hiki i nā pae haʻahaʻa o NAD + ke kumu i nā pilikia olakino. Hiki i ka lawe ʻana i ka riboside nikotinamide ke kōkua i ka hāpai ʻana i kēia pae haʻahaʻa NAD +.

 

pomaikai o ʻO Nicotinamide riboside chloride

ʻO Nicotinamide riboside Chloride, kahi NAD + precursor waha, hoʻonui i nā pae NAD + a hoʻoulu iā SIRT1 a me SIRT3. ʻO Nicotinamide riboside Chloride pauka kahi kumu o ka huaʻai B3 (niacin) a hoʻohana i ka Nicotinamide riboside Chloride pauka hiki ke hoʻonui i ka metabolism oxidative, pale i ka momona momona i hoʻopili ʻia i nā meaola metabolic. ʻO ka Nicotinamide riboside Chloride e hōʻemi i ka hōʻino o ka naʻau ma ke ʻano o ka iole transgenic o ka maʻi ʻo Alzheimer.

 

Reference

[1] Chi Y, Sauve AA. ʻO Nikotinamide riboside, kahi mea moʻomeheu o nā mea ʻai i nā meaʻai, he vitamin B3 me nā hopena i ke kaola metabolism a me ka neuroprotection. ʻO Ke Kulanui ʻO Curr Opin Clin Nutr Metab. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Hoʻopau ʻana. PubMed PMID: 24071780.

[2] ʻO Bogan KL, Brenner C. Nicotinic acid, nikotinamide, a me ka nicotinamide riboside: kahi loiloi molekole o nā huaʻai mua NAD + i ka meaʻai kanaka. ʻO Annu Rev Nutr. 2008; 28: 115-30. hana: 10.1146 / annurev.nutr.28.061807.155443. Loiloi. ʻO PubMed PMID: 18429699.

[3] ʻO Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation ma ke ʻano he cell-intrinsic, hoʻokele evolutionary o ka mālama ʻana i ka momona: kemika a me ka noʻonoʻo metabolic o ka acetyl-lysine hoʻololi. ʻO Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. hana: 10.3109 / 10409238.2013.838204. Loiloi. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.

[4] Yang Y, Sauve AA. NAD (+) metabolism: Bioenergetics, hōʻailona a me ka manipula no ka lāʻau. ʻO Biochim Biophys Acta. 2016 Dec; 1864 (12): 1787-1800. hana: 10.1016 / j.bbapap.2016.06.014. Loiloi. ʻO PubMed PMID: 27374990.

[5] Kūʻai AA. NAD + a me ka wikamina B3: mai ka metabolism i nā therapies. ʻO J Pharmacol Exp Ther. 2008 Malaki; 324 (3): 883-93. hana: 10.1124 / jpet.107.120758. Loiloi. ʻO PubMed PMID: 18165311.

[6] Kato M, Lin SJ. Hoʻonohonoho i ka NAD + metabolism, hōʻailona a me ka compartalization i ka hū Saccharomyces cerevisiae. Hoʻoponopono DNA (Amst). 2014 Nov; 23: 49-58. hana: 10.1016 / j.dnarep.2014.07.009. Loiloi. PubMed PMID: 25096760; PubMed Central PMCID: PMC4254062.

[7] ʻO Cantó C, et al. Hoʻonui ka NAD (+) i ka mua o ka nikotinamide riboside i ka metabolism oxidative a me ka pale ʻana i ka momona momona. Pūnaewele Metab. 2012 Jun 6; 15 (6): 838-47.

[8] Bing Gong, et al. Hoʻomaikaʻi ʻo Nicotinamide Riboside i ka ʻike ma o ka hoʻonui ʻana o Proliferator-Activated Receptor-γ Coactivator 1α i hoʻoponopono ʻia Secret-Secretase 1 Degradation a me ka Mitochondrial Gene Expression i nā Model Mouse a Alzheimer. ʻO Neurobiol Aging. 2013 Iune; 34 (6): 1581-8.

[9] Collin D Heer, et al. Hoʻopau ka Coronavirus a me ka PARP Expression i ka Metabolome NAD: kahi mea hiki ke hana ʻia no ka Immunity Innate. bioRohana 2020 Apr 30; 2020.04.17.047480.