N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

ʻO ka AASraw me ka hōʻano a me ka hana hana mai ka gram i ka papahu nui o N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-Xboxic acid (CAS 681136-29-8), ma lalo o nā kānāwai CGMP a me ke kālepa maikaʻi.

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder he piperazinyl phenylurea ka mea i likeʻole konaʻano me nā'āpana carbamates a me ka'āpana heterocyclic alpha-keto a he mea kaha a hoʻololi i kaʻaila momona amide hydrolase (FAAH) (IC50s = 34 a me 33 nM ma ka'īlio a me ke kanaka,) e hiki iā ia e hele i ke kālepa o ka lolo.1 Ma 20 mg / kg, pili mau i ka pūnaeweleʻoihana o FAAH ma o ka paʻiʻana o ka hana hana Urea no ka hāʻawiʻana i aniline a me ka FAAH-poperazinyl carbamate.

Pākuhi AASRAW PDF

Product Description

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video


I.N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters:

Name: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Purity: ≥99% (HPLC)
Hōʻuluʻulu Manaʻo: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Nā Kaulike Molecular: C19H19N5OS
Molecular Weight: 365.459
ʻO ka helu kuhi: 240.48
Ka paila kohu: 559.69 ° C ma 760 mmHg
'Aiha: ~ 1.3 g / cm3
Hōʻoia Kōkua: E kūʻai i ka + 4 ° C
Palekana: DMSO: ≥28mg / mL
Kōmike hoʻohālike: N20D 1.68
kala like 'ole: He pōhakuʻeleʻele
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChI Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N


II. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Ka hoʻohanaʻana o ka mana i ka'ōlena:

1.Name:

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid paukū, JNJ 166101 Powder

2.How ka hana ma ka N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Ka hoʻohanaʻana i ka mana?

Hoʻomākaukauʻo FAAH me JNJ-1661010 i ka hoʻololi wikiwiki o ka pilina ma waena o ka JNJ1661010 a me ka pae hana, i hoʻonuiʻia i nā kiʻekiʻe kiʻekiʻe. ʻO JNJ-1661010 ka mea hana pāʻani paʻa, e like me ka nānāʻia e LC-ESI-MS. Ka hanana JNJ-1661010 me ka phenylthiadiazole ma ka pūkuʻu hydrophobic a me ka phenylurea i loko o ka apo hydrophilic o FAAH, JNJ-1661010 (20 mg / kg ip) ka mea e hoʻoneʻe ai i ka FAAH ma o 85% no ka hiki i ka 4 h ma hope o ka dosing, ka hopena o ka lipid ethanolamides ma ka lolo. Ke hoʻololi neiʻo JNJ-1661010 i ka hoʻohālike o ka allodynia me kaʻoiʻoi aku o ka 90% ma 30 min ma hope o ka Mice Māmā Mice (MTI) a me ka'ōleʻa. ʻO JNJ-1661010 (20 mg / kg) hoʻohuli i ka'āpana allodynia e 60.8% ma ka 30 min ma ka hōʻailona hōʻino o ke kino. Hōʻike ka JNJ-1661010 (50 mg / kg ip) i kahi hōʻailona nui o ka hyperalgesia i ka 30 min e kau nei i keʻano o kaʻumeke a me kaʻeha o ka maʻi.
ʻO nā kuʻi me JNJ-1661010 (20 mg / kg ip) kahi Cmax plasma o 26.9 μM ma ka Tmax o 0.75 h a me kahi Cmax ma ka lolo o 6.04 μM ma ka Tmax o 2 h. Hana ka JNJ-1661010 (20 mg / kg ip) i ka brain FAAH a hoʻokiʻekiʻe i ke kūlana AEA i loko o ka lolo i loko o ka iole.

3.Warning ma N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid paukū

4.Further kuhikuhi:

5. N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder:

ʻOiwi kauohaʻo 10grams.
Hiki ke hoʻouna i ka nīnau no ka mea maʻamau (Ma waena o 1kg) i nā hola 12 ma hope o ka uku.
No ka hoʻonohonoho nui (Ma waena o 1kg) hiki ke hoʻounaʻia i ka 3 workingdays ma hope o ka uku.

6. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Pūnaewele Powder:

No ka nīnauʻana i ko mākou mea hōʻailona kōkua (CSR) no nā kiko'ī, no kāu'ōlelo.

7. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid kaheʻe Kānana:

E hoʻolakoʻia i ka wā e hiki mai ana.


III. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-Carboxamide Lulu HNMR

ʻO mākou nā mea e hoʻopiliʻia ai ka momona, ka momona'āpana kūʻai, Raw Aprepitant Powder (170729-80-3) hplc≥98% | Nā R & D Hoʻokiʻekiʻe AASraw


IV. Pehea e kūʻai ai i ka N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide pele mai AASraw?

1.E hōʻike mai iā mākou ma o mākou leka uilapūnaewele noiʻi, aiʻole skype pūnaeweleka hoʻonohonoho hoʻonohonoho kanaka (CSR).
2.Ke hāʻawi mai i kāu helu a me kāu helu wahi.
3.OUR CSR e hāʻawi iāʻoe i ka helu, ka manawa uku, helu helu, nā puka puka a me ka lā i hōʻea muaʻia (ETA).
4.E ukuʻia a hoʻokuʻuʻia nā waiwai i nā hola 12 (No ke kauoha ma loko o 10kg).
Ua loaʻaʻo 5.Goods a hāʻawi i nā manaʻo.


Eʻike i kāu moʻomanaʻo pūnaewele punahele:

  Pehea e hoʻohana ai i ka Clenbuterol no ka pohō kaumaha He aha ka nandrolone kalo e hoʻohanaʻia no nā koina nandrolone?


Nāʻike hou aku e pili ana i nā huahana kūpono,pōmaikaʻi e kaomi maʻaneʻi.


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