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Alfaxalone

Rating: Māhele:

ʻO Alfaxalone kahi neuroactive steroid mole me nā waiwai o kahi anesthetic āpau. Ua ho'ākāka 'ia' o Alfaxalone e like me 3-α-hydroxy-5-α-hapuu-11, 20-dione, a he 332.5 ka paona molekike.

Product Description

Nā ʻano kikoʻī

Product Name Alfaxalone
Kāleka CAS 23930-19-0
Ka Lā Molecular C21H32O3
Kaumaha Kaumaha 332.48
'O Synonyms Alphaxalone;

Alfaxalone;

23930-19-0;

5alpha-Pregnan-3alpha-ol-11,20-dione;

Alfaxalonum.

Keʻano ʻO ka pauma
Ka mālama a me ka lima lima Hale kūʻai ma ke keʻena wela -20 ° C

 

Hōʻike Alfaxalone

ʻO Alfaxalone kahi neuroactive steroid mole me nā waiwai o kahi anesthetic āpau. Ua hōʻike kemikal ʻo Alfaxalone ma ke ʻano he 3-α-hydroxy-5-α-hāpai a-11, 20-dione, a he 332.5 ka paona o ka molakeke. ʻO ka papa hana mua no ka hana anesthetic o alfaxalone ka hoʻololi ʻana i ka lawe ʻia o ka cell neurone cell membrane chloride ion, i hoʻokomo ʻia e ka paʻa ʻana o alfaxalone i nā GABAA (gamma-aminobutyric acid) nā ʻenekia ʻili o ka ʻili.

 

ʻO Alfaxalone Mechanism o ka hana

Hoʻokumu ʻo Alfaxalone i ka noʻonoʻo ʻole ma o ka hana ʻana i nā gamma aminobutyric acid subtype A (GABAA) mau loaʻa ma ke kikowaena ʻōnaehana (CNS). ʻO kēia mau receptor he mau kaha lika-gated ionotropic, a ʻo GABA ko lākou lāhui endogenous. ʻO GABA ka neurotransmitter kaohi nui i ka CNS. Ma hope o ka hoʻoulu ʻia ʻana o ka receptor, wehe a hoʻoliʻiliʻi ke kahawai i ka lawe ʻia ʻana o ka chloride i loko o ke keʻena, e hana ana i ka hyperpolarization o ka membrane postsynaptic. I nā hoʻohaʻahaʻa haʻahaʻa, hoʻololi pono ʻo alfaxalone i ke au o ka chloride ma o ke kahawai chloride; akā i nā kiʻekiʻe kiʻekiʻe, hana ia ma ke ʻano he agonist GABA, ma ke ala like me barbiturates. ʻO ka hopena hopena he sedation hohonu a i ʻole induction o anesthesia, kaukaʻi ʻia i ka mahele lāʻau a me ke ala o ka hoʻokele.

 

Noi Alfaxalone

ʻO Alfaxalone, i ʻike ʻia ma ke ʻano alphaxolone a i ʻole alphaxalone a hoʻohana ʻia ma lalo o ka inoa kalepa ʻo Alfaxan, kahi neuroactive steroid a me nā lāʻau lapaʻau anesthetic āpau i hoʻohana ʻia i nā ʻīlio a me nā pōpoki. Hiki ke hoʻohana ʻia ma ke ʻano he mea hoʻokomo a i ʻole no ka anesthesia ākea.

 

Nā Alfaxalone Pōmaikaʻi & Nā Kūpono ʻole

  • pono:

Hana ʻo Alfaxalone i ka loli liʻiliʻi i ka hopena o ka naʻau a i ʻole ke kahe o ke koko ke hāʻawi ʻia nā lāʻau e pili ana i ka lāʻau i nā maʻi olakino. He papa kuhikuhi therapeutic kiʻekiʻe ʻo Alfaxalone, he hana pōkole, a noncumulative. Hana kēia mau ʻano i alfaxalone kūpono no ka hoʻohana ʻana ma ke ʻano he agena hoʻokomo a i ʻole no ka hāʻawi ʻana i ka anesthesia injectable.

Hiki ke lawelawe pū ʻia ʻo Alfaxalone i ka intramuscularly, no laila hiki ke hoʻohana ʻia e hoʻohiamoe i nā mea maʻi uncooperative. Ke hoʻohana ʻia ka alfaxalone e hoʻohiamoe i kahi mea maʻi ma ka mahele lāʻau he 1-3mg / kg IM a lawelawe pinepine ʻia ia me kahi opioid no ka hoʻohiamoe maikaʻi loa.

Ke hoʻohana ʻia ka alfaxalone no nā ʻāpana caesarean e ʻoi aku ka makaʻala a me ke ola o nā ʻīlio me ka hoʻomaikaʻi ʻia o nā helu AGPAR i ka propofol.

 

  • keakea:

ʻO Alfaxalone ke kumu o ke kaumaha o ka hanu e pili ana i ka maʻi, me ka apnea e kū ana ma hope o ka wikiwiki IV injection. Hoʻomākaukau e intubate, hāʻawi i ke kākoʻo oxygen, a me ka ea i ka hoʻohana ʻana i ka alfaxalone no ka hoʻokomo a i ʻole ka sedation.

Hiki i ka lawelawe nui ʻana o ka alfaxalone ke kumu o ke kaumaha o ka maʻi maʻi i loko o ka maʻi, me ka nui o ka hoʻoliʻiliʻi o ka hopena o ka naʻau a me ke koko. Pono e mālama pono ʻia ka mahele lāʻau alfaxalone i nā mea maʻi i hōʻemi i nā mālama maʻi maʻi a i ʻole hemodynamically paʻa ʻole.

ʻAʻole hāʻawi ʻo Alfaxalone i kekahi analgesia, no laila pono ia e hoʻohana pū ʻia me kahi opioid kūpono no nā kaʻina hana ʻeha.

Ke lawelawe ʻia ʻo alfaxalone i ka intramuscularly hiki ke nui ka nui o ke kiʻina, hiki ke ʻeha i ka pahu kui. Hiki i ka nui nui ke hana i ka hoʻokūkū paʻakikī i ka wā he window kaupalena ʻia no ka hoʻopili ʻana ma muli o ke ʻano hoʻomanawanui. Hiki i ka hoʻomalu Alfaxalone ke hopena i ka loaʻa hou ʻana o kahi maikaʻi ʻole e hōʻike ʻia e nā kekelē ʻokoʻa o ka hoe, ka leo, a me / a i ʻole myoclonus.

 

Reference

[1] Whittem T, Pasloske KS, Heit MV et al. (2008) ʻO nā pharmacokinetics a me nā pharmacodynamics o alfaxalone i nā pōpoki ma hope o ka lawelawe hoʻokahi a nui o Alfaxan ma nā kauka lāʻau a me nā supraclinical. ʻO J Vet Pharmacol Ther 31 (6), 571-579.

[2] Ferre PJ, Pasloske K, Whittem T et al. (2006) Plasma pharmacokinetics o alfaxalone i nā ʻīlio ma hope o ka bolus intravenous o Alfaxan-CD. ʻO Vet Anaesth Analg 33, 229-236.

[3] Muir W, Lerche P, Wiese A et al. (2009) ka cardiorespiratory a me nā hopena anesthetic o nā lāʻau lapaʻau a me nā supraclinical o ka alfaxalone i nā pōpoki. ʻO Vet Anaesth Analg 36, 42-54.

[4] Clarke KW, Trim CM, Hall LW, eds. (2014). "Mokuna 15: Anesthesia o ka ʻīlio". Anesthesia Kauka (11th ed.). Oxford: WB Saunders. pp. 135-153.

[5] Varga M (2014). "Mokuna 4: Anesthesia a me Analgesia". Puke puke o Rabbit Medicine (2nd ed.). ʻO Butterworth-Heinemann. pp. 178–202.

[6] Nieuwendijk H (Malaki 2011). "Alfaxalone". Pūʻulu Kākoʻo ʻAteteria & ʻAnalgesia Kākoʻo Pūʻulu. Ua kiʻi ʻia Iulai 14, 2017.

[7] Zeltzman P (Nowemapa 17, 2014). "No ke aha e hoʻokele ai i ka Alfaxalone e koi ai i kahi aʻo o ke aʻo". Nūhou Hana Lapaʻau. Ua kiʻi ʻia Iulai 14, 2017.


 

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