Product Description
Alpha GPC Powder Video-AASraw
Nā Kiʻi Kūʻai Kūʻai ʻo Alpha GPC Powder
| Name: | ʻO Alpha GPC uila |
| CAS: | 28319-77-9 |
| Kaulike Molecular: | C8H20NO6P |
| Kaumaha Molecular: | 257.22 |
| Wahi Manaʻo: | 142.5-143 ° |
| Hōʻoia Kōkua: | -20 ° C |
| kala like 'ole: | ʻO ka pauma |
He aha ka Alpha GPC Powder?
ʻO Alpha GPC, i kapa ʻia ʻo Alpha-glycerophosphocholine (aGPC), he phospholipid i loaʻa i ka choline i loaʻa mai ka soy. ʻO nā haʻawina like ʻole e pili ana i kēia kemika e hōʻike ana i kahi kuleana i ka hoʻomaikaʻi ʻana i ka hana cognitive, hoʻoikaika i ka ikaika, a me ka hoʻoulu ʻana i ka ulu ʻana o ka hormone ulu.
ʻO AASraw's Alpha GPC Powder he mea hana maikaʻi loa no ka hoʻonuiʻana i ka hoʻomanaʻo a me ke aʻoʻana, a me ka hakakāʻana i ka emiʻana o ka naʻau a me nā hōʻailona maʻi o Alzheimer. Ke hōʻike ka mea maʻi i nā hōʻailona o ka emi ʻana o ka hana naʻau, ʻike ʻia i kekahi manawa ʻo "Brain Fog," kōkua ʻo Alpha GPC supplementation e hiki ai i ka noʻonoʻo maʻalahi a ʻoi aku ka ʻoi. Hiki ke hoʻohana ʻia kēia kumu maikaʻi o ka choline e nā poʻe olakino e hoʻonui i ka hana cognitive. ʻO ke akepaʻa a me nā ʻiʻo ʻōkana ʻē aʻe, ʻaʻole ia he mea nui i ka ʻai ʻana o ʻAmelika ʻĀkau, ʻo ia ka meaʻai nui loa i ka choline. ʻO ka hopena, ua ʻike mākou he nui ka poʻe i hemahema a hiki ke pōmaikaʻi nui mai ka hoʻohui ʻana me Alpha GPC. He kumu wahie maikaʻi ia no nā hana noʻonoʻo o ka lolo. I ka lā holoʻokoʻa, pilikia ka hapa nui o ka poʻe i ka ikaika a me ka nānā ʻana. ʻO ka hopena, nui ka poʻe e ʻimi nei i kahi hoʻonā i ka hāʻule ʻana o ke ahiahi i mea e hoʻomaikaʻi ai i kā lākou noʻonoʻo. ʻO ka pauka Alpha GPC mai AASraw he mea hoʻohui e kōkua me ka noʻonoʻo a me ka hana.
E hoʻomau i ka heluhelu e aʻo i ka hana ʻana o Alpha GPC, kona mau pōmaikaʻi a me nā pilikia e hiki mai ana, me ka dosage.
Pehea e hana ai ka Alpha GPC Powder i ke kino?
Hana ʻia ka pauka Alpha GPC ma ka hoʻonui ʻana i nā pae acetylcholine (ACh) i ka lolo. ʻO ka Acetylcholine kahi neurotransmitter e pili ana i ka hoʻokumu ʻana i ka hoʻomanaʻo a me ke aʻo ʻana, a me ka hoʻopaʻapaʻa muscular.
Hana ko mākou kino i ka liʻiliʻi a emiʻole ka acetylcholine i ko mākou mau makahiki. Hiki i kēia ke hopena i nā pilikia hoʻomanaʻo a me ka hōʻino ʻia o ka naʻau. Manaʻo ʻia ka pauka Alpha GPC e kōkua i ka pale ʻana i ka hoʻohaʻahaʻa cognitive e pili ana i ka makahiki ma o ka hoʻonui ʻana i nā pae acetylcholine i ka lolo a lawelawe ʻia ma ke ʻano he lāʻau nootropic pro-cholinergic. ʻO kēia ka mea e kōkua ai i ka hana ʻana o ka acetylcholine, hiki ke kōkua i ka hoʻonui ʻana i ka hana cognitive.
ʻO Phosphatidylcholine (PC), kahi mea nui o nā membrane cell, he mea mua hoʻi ia i ka pauka Alpha GPC. Pono ka PC no ke olakino a me ka maʻalahi o nā membrane cell. Hāʻawi pū ia i ka hoʻokumu ʻana i ka pū myelin, kahi uhi momona e uhi a pale i nā neurons. Hana ʻia ka lolo i nā piliona neurons e hoʻouna a loaʻa i nā mana uila i nā manawa āpau. I mea e hana pono ai ko mākou lolo, pono e wikiwiki a maikaʻi kēia mau leka. Hana ʻia ka myelin coating ma ke ʻano he insulator, pale i nā aʻalolo a me ka ʻae ʻana i nā hōʻailona uila e neʻe wikiwiki a maikaʻi.
Eia kahi Phosphatidylcholine (PC) e pāʻani ai. Pono ʻia ʻo PC no ka mālama ʻana i nā membrane cell olakino a no ka hoʻomohala ʻana i ka sheath myelin.
Hoʻololi ʻia i Alpha GPC ma o ʻelua ala ʻokoʻa:
Ke Alanui Kennedy
He Alanui Methylation
ʻO ka Kennedy Pathway he pūʻulu o nā kaʻina hana e hoʻolako pū i kekahi o kā mākou ala nui loa no ka hoʻomalu ʻana i ka hoʻomohala ʻana o ke kelepona. Hoʻololi ʻia ka choline manuahi i cytidine diphosphate (CDP), i hoʻopili ʻia me ka diacylglycerol e hana i ka PC. Hoʻololi ke kaʻina hana methylation i ka PC, ka mea i haku ʻia me ka phosphatidylethanolamine a me ka choline, i mea waiwai nui no ka hoʻokumu ʻana i ka insulation myelin i kou lolo. Me ka hana a Phospholipase D, hoʻololi ʻia ʻo PC i 1-acyl-GPC a laila iā Alpha GPC. Lawe ʻia ka Alpha GPC ma waena o ka pale koko-lolo, kahi e hoʻonui ai i nā pae acetylcholine i ka lolo.
He aha nā pono olakino o Alpha GPC?
· Alpha GPC ma ke ʻano he nootropic.
Nui ka poʻe e hoʻohana iā Alpha GPC no ka hoʻomanaʻo ʻana mai ka hōʻike ʻana o nā haʻawina mua e kōkua paha ia i ke aʻo ʻana. Hoʻonui ka AASraw Alpha GPC i ka hoʻokumu ʻana o ka acetylcholine, he mea nui ia no ka hoʻomanaʻo a me ka hoʻoponopono naʻauao. ʻO kekahi noiʻi ʻē aʻe i nānā iā Alpha GPC no ka nānā ʻana a ʻike ʻia he mea maikaʻi. ʻO ka hopena, hiki ke hoʻohana ʻia ka pauka Alpha GPC i ka hoʻonui ʻana i ka nānā.
· Alpha GPC a me ke olakino naʻau.
Piʻi ka pae homocysteine ke ʻai ʻoe i ka nui o ka ʻiʻo. Hiki i nā pae homocysteine ke kiʻekiʻe loa ke loaʻa ka hopena maikaʻi i ke olakino naʻau. Kōkua ʻo Choline i ka hoʻololi ʻana o ka homocysteine i ka methionine, kahi amino acid nui e kōkua i ka biosynthesis protein. Eia kekahi, ua ʻike ʻia kahi noiʻi ʻo ka lawe ʻana i ka choline lōʻihi e kōkua i ka hoʻohaʻahaʻa ʻana i ka mumū a me nā pōʻino ʻē aʻe e hōʻeha i ke olakino naʻau. ʻOiai e pono ai ka noiʻi hou, hiki i ka Alpha GPC ke pōmaikaʻi i ke olakino cardiovascular.
· Alpha GPC a me ke kaumaha.
Ke ʻai nui ʻoe i ka ʻiʻo, piʻi aʻe kou pae homocysteine. ʻO kahi pae homocysteine maikaʻi ʻole e hōʻino paha i ke olakino naʻau. Hoʻololi ʻia ka Homocysteine e ka choline i loko o ka amino acid methionine koʻikoʻi, pono ia no ka synthesis protein. Eia kekahi, ua ʻike ʻia kahi noiʻi ʻo ka hoʻohana ʻana i ka choline maʻamau e hōʻemi i ka mumū a me nā pilikia ʻē aʻe i ke olakino naʻau. Hiki i ka Alpha GPC ke hoʻomaikaʻi i ke olakino cardiovascular, akā pono ka noiʻi hou aku.
· Alpha GPC a me hana kino.
Wahi a ka noiʻi, ʻo Alpha GPC kahi ala maikaʻi loa e hoʻomaikaʻi ai i ka mana o ka mana muscular a me nā hormones e paipai i ka ulu ʻana o ka ʻiʻo. Wahi a kahi noiʻi 2015, ʻike ka poʻe i lawe i ka pauka Alpha GPC i kēlā me kēia manawa i ka hoʻonui nui ʻana i ka ikaika muscular ma hope o nā lā 6. Ma kahi noiʻi hou, ua ʻike ʻia ka pauka Alpha GPC e hoʻonui i ka ulu ʻana o ka hormone ulu a me ka momona momona i nā ʻōpio olakino. Hoʻoikaika ka hormone ulu kanaka (HGH) i ka ulu ʻana o ka ʻiʻo, ka hoʻemi ʻana i ka momona, a me ka hoʻoponopono wikiwiki ʻana i ka ʻiʻo.
(Ke kaʻina hana o Alpha GPC hoʻoponopono i ka ʻiʻo)
Aia kekahi pilikia no ka pōʻino lōʻihi mai ka lawe ʻana iā Alpha GPC?
Ua hōʻike ʻia nā haʻawina ʻaʻohe hopena koʻikoʻi o Alpha GPC i nā ʻāpana koko e like me ke kahe koko a i ʻole ka puʻuwai puʻuwai. ʻO nā mea kiʻekiʻe o Alpha GPC (1000 mg a ʻoi aʻe paha) hiki ke hōʻeha i ke poʻo o kekahi poʻe a hiki i ka hoʻokumu ʻia ʻana o ko lākou ʻae ʻana i ka mea hoʻohui. ʻO ka haʻahaʻa haʻahaʻa haʻahaʻa no kēia poʻe e hoʻomaka me 300 mg i kēlā me kēia lā.
Pehea ʻoe e lawe ai i ka Alpha GPC Powder?
No ka mea aia ʻo Alpha GPC ma kahi o 40% choline ma ke kaupaona, 1,000 mg o ka pauka Alpha GPC mai AASraw e hāʻawi i kahi 400 mg o ka choline meaʻai. Wahi a nā koina lepili pinepine, he 300-600 mg ka maʻamau maʻamau o Alpha GPC. ʻO kēia nui ka mea kūpono e lawe ai no nā mea pāʻani, no ka mea e hahai ana i ka noiʻi e hoʻohana ana iā Alpha GPC e hoʻomaikaʻi i ka mana (600 mg) a me nā haʻawina ʻelua e hōʻike ana i ka piʻi ʻana o ka ulu ʻana o ka hormone ulu.
Ma kahi kokoke i nā haʻawina a pau e hoʻohana i kahi ʻano o 1,200 mg i kēlā me kēia lā, hoʻokaʻawale ʻia i ʻekolu mau kau o 400 mg, e hoʻēmi i nā hōʻailona o ka naʻau. ʻAʻole maopopo i ke ʻano o ka liʻiliʻi liʻiliʻi e kōkua i ka cognition, akā ʻo ka pae i ʻike ʻia e pili mau ana me ka pōmaikaʻi ʻo 1,200 mg. Wahi a nā noiʻi ʻiole, ʻo ka hopena o ka Alpha GPC oral intake peak ma kahi o 300-600 mg/kg, e pili ana i kahi helu kanaka i manaʻo ʻia o 48-96 mg/kg (a no ke kanaka 150lb, 3,272-6,545 mg i kēlā me kēia lā).
No ka hoʻohana ʻana i ka nootropic stack, manaʻo mākou e hoʻomaka me 300-600 mg a hoʻonui mālie inā manaʻo ʻoe e pōmaikaʻi ʻoe i nā mea hou aʻe. Hoʻomanawanui maikaʻi ʻia ʻo Alpha GPC ke lawe ʻia ma nā pae i kuhikuhi ʻia. ʻOi aku ka nui o ke ʻano o ka dosage kūpono no ka hapa nui o nā kānaka; he 300-1200 mg o kēlā me kēia lā, i hoʻohana ʻia i hoʻokahi a ʻelua paha, palekana a maikaʻi.
E like me nā mea hoʻohui, ʻoi aku ka maikaʻi o ka hoʻomaka me ka haʻahaʻa haʻahaʻa haʻahaʻa e hiki ai a hoʻonui mālie e like me ka mea e pono ai.
Alpha GPC vs. CDP Choline
E hoʻomaka kākou me nā kumu. Kālā ʻo CDP, i ʻike ʻia ʻo citicoline, ua haku ʻia me ka choline (ʻelua pūʻulu phosphate) a me ka cytidine, ʻoiai ʻo Alpha GPC ka choline (hoʻokahi hui phosphate) a me ka glycerol. Ua like paha kēia, akā hoʻopuka ia i kekahi mau hana hoihoi a ʻokoʻa i ke kino.
No ka mea hoʻokahi, hoʻokiʻekiʻe ʻo Alpha GPC i nā pae koho koko ma mua o CDP choline. ʻO ka hopena, ʻoi aku ka ikaika o ka hoʻohaʻahaʻa cognitive pili i ka makahiki a me ka hana kino. ʻO ka lua, hiki i ka Alpha GPC ke hoʻonui i ka momona momona a me ka hanauna o ka hormone ulu, e hāʻawi iā ia i mea maikaʻi ma mua o ka CDP choline i nā bodybuilders.
ʻO ka CDP choline, ma kekahiʻaoʻao, koiʻia no ka hoʻokumuʻana i ka phosphatidylcholine. He ʻoi aku ka nui o nā metabolites ikaika a loaʻa paha i nā pono olakino noʻonoʻo.
Ma hea e kūʻai ai i ka Alpha GPC Powder?
He maʻalahi ke poina i ka hana ʻana o kou kino e like me ka mīkini. I ka holo ʻana i ka mīkini, pono ia i ka wahie kūpono, ʻo ia ka mea nui inā ʻoe e hoʻoikaika kino. He aha nā meaʻai āu e ʻai ai i mea e hoʻonui ai i kāu mau hana? A i ka manawa hea kēia e hana ai?
E ʻoluʻolu e hoʻomanaʻo ʻaʻole pono nā kānaka a pau mai ka Alpha GPC Powder. Ua kūʻai paha ʻoe i kahi Alpha GPC Powder maikaʻi ʻole ka manaʻo mua, pehea e ʻike ai i kahi mea hana Alpha GPC Powder maoli, pono ʻoe e hoʻolei i kāu mau hana ma luna. Inā kūʻaiʻoe i ka pauka Alpha GPC mai AASraw, e loaʻa iāʻoe ke kumukūʻai maikaʻi Alpha GPC Powder.
Hanaʻia a ho'āʻoʻia nā mea hoʻopihapiha a pau mai ka mea kūʻai AASraw no ka palekana a me ka maikaʻi, e hōʻoia ana i ka hāʻawiʻiaʻana o nā mea kiʻekiʻe loa iāʻoe. Hiki ke kiʻi ʻia ka pauka Alpha GPC ma AASraw no nā mea kūʻai nui.
Hōʻike hoʻāʻo ʻo Raw Alpha GPC Powder-HNMR
He aha ka HNMR a He aha ka HNMR spectrum e haʻi aku iā ʻoe? ʻO H Nuclear Magnetic Resonance (NMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā hui pū ʻia i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR e hoʻohālikelike i nā hale waihona puke spectral a i ʻole e kuhi pololei i ke ʻano kumu. Ke ʻike ʻia ke ʻano kumu, hiki ke hoʻohana ʻia ka NMR no ka hoʻoholo ʻana i ka conformation molecular i ka hopena a me ke aʻo ʻana i nā waiwai kino ma ka pae molekala e like me ka hoʻololi conformational, nā hoʻololi ʻana, ka solubility, a me ka diffusion.
Alpha-GPC(28319-77-9)-COA
Pehea e kūʻai ai i ka Alpha GPC Powder mai AASraw?
❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu whatsapp iā mākou, e hoʻopili aku kā mākou mea kūʻai aku (CSR) me ʻoe i 12 mau hola.
❷E hāʻawi mai iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.
❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala hoʻouna a me ka lā i manaʻo ʻia (ETA).
❹E uku ʻia a hoʻouna ʻia nā waiwai i loko o 12 mau hola.
❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.
Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine
Mea kākau moʻolelo puke moʻolelo ʻepekema:
1. Ling Sun
Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, Kina
2. Antonia Di Mola
Mahele Di Chimica a me Biologia “A. Zambelli", Università degli study di Salerno, Via Giovanni Paolo II, 84084, Fisciano, SA, Italia
3. Mele Hee Lee
Keʻena o Neurology, Hallym University, College of Medicine, Chuncheon, Republic of Korea
4. Lacomba C.
Institute of Pharmacology, Kulanui o Bari, Italia
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.
Reference
[1] De Jesus Moreno Moreno M (Ianuali 2003). "ʻO ka hoʻomaikaʻi ʻana i ka cognitive i ka maʻi dementia o Alzheimer ma hope o ka mālama ʻana me ka acetylcholine precursor choline alfoscerate: kahi multicenter, pālua-makapō, randomized, placebo-controlled trial". Nā lāʻau lapaʻau lapaʻau. 25 (1): 178–93. PMID 12637119.
[2] Parnetti L, Mignini F, Tomassoni D, Traini E, Amenta F (Iune 2007). "Cholinergic precursors i ka mālama ʻana i ka cognitive impairment o vascular origin: inffective approaches or need for re-valuation?". Ka Nupepa o ka Neurological Sciences. 257 (1–2): 264–9. PMID 17331541.
[3] Doggrell SA, Evans S (ʻOkakopa 2003). "Ka mālama ʻana i ka dementia me ka modulation neurotransmission". Manaʻo Kuʻuna ma luna o nā lāʻau noiʻi. 12 (10): 1633–54. PMID 14519085.
[4] Wallace, TC et al. (2019). Choline: ʻO ka Neurocognitive Essential Nutrient of Interest to Obstetricians and Gynecologists. Journal of Dietary Supplements, 17(6), pp.733–752.
[5] Moreno, M. (2003). ʻO ka hoʻomaikaʻi ʻana i ka noʻonoʻo i ka dementia ʻo Alzheimer haʻahaʻa a haʻahaʻa ma hope o ka mālama ʻana me ka acetylcholine precursor choline alfoscerate: kahi multicenter, double-blind, randomized, placebo-controlled trial. ʻO nā lāʻau lapaʻau, [online] 25(1), pp.178–193.
