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ʻO Cabozantinib

Rating: Māhele:

ʻO Cabozantinib Powder, kūʻai ʻia ma lalo o nā inoa inoa ʻo Cometriq a me Cabometyx, kahi lāʻau i hoʻohana ʻia e mālama ai i ka maʻi ʻaʻai thyroid medullary, carcinoma pūnaʻi pūpū, a me ka maʻi heposis. He mea pāpā liʻiliʻi ia o ka tyrosine kinases c-Met a me VEGFR2, a pāpā pū kekahi iā AXL a me RET. Ua ʻike ʻia a hoʻomohala ʻia e Exelixis Inc.

Product Description

Nā ʻano kikoʻī

Product Name Paukū Cabozantinib
Kāleka CAS 849217-68-1
Ka Lā Molecular C28H24FN3O5
Papale ʻaʻa 501.514
'O Synonyms XL184, BMS907351;

Cabometyx;

ʻO Cometriq;

ʻO Cabozanix.

Keʻano ʻO kaʻeleʻele'alaʻula
Ka mālama a me ka lima lima E mālama iā ia i ka mahana wela a mamao aku mai ka wela a me ka momona.

 

Pauka CabozantinibDescription

ʻO Cabozantinib Powder, kūʻai ʻia ma lalo o nā inoa inoa ʻo Cometriq a me Cabometyx, kahi lāʻau i hoʻohana ʻia e mālama ai i ka maʻi ʻaʻai thyroid medullary, carcinoma pūnaʻi pūpū, a me ka maʻi heposis. He mea pāpā liʻiliʻi ia o ka tyrosine kinases c-Met a me VEGFR2, a pāpā pū kekahi iā AXL a me RET. Ua ʻike ʻia a hoʻomohala ʻia e Exelixis Inc.

I Nowemapa 2012, ʻae ʻia ka cabozantinib paukū (Cometriq) i kāna formule capsule e ka US Food and Drug Administration (FDA) ma lalo o ka inoa ʻo Cometriq no ka mālama ʻana i nā mea maʻi me ka maʻi ʻaʻaiid medullary Ua ʻae ʻia ka pepa capsule i ka European Union no ke kumu like ma 2014.

I ʻApelila 2016, ua ʻae ka FDA no ke kūʻai aku ʻana i ka papa papa (Cabometyx) ma ke ʻano he laina ʻelua no ka maʻi ʻaʻai puʻupaʻa [8] [9] a ua ʻae ʻia ka mea like i ka European Union i Kepakemapa o kēlā makahiki. loaʻa nā formulate ʻokoʻa a ʻaʻole hiki ke loli.

 

ʻO Cabozantinib Powder Mekanika o ka Hana

Hoʻopili ka Cabozantinib Powder i kēia mau receptor tyrosine kinases: MET (ka ulu ʻana o ka hepatositte factor receptor protein) a me VEGFR, RET, GAS6 receptor (AXL), KIT), a me Fms-like tyrosine kinase-3 (FLT3).

 

Pauka Cabozantinib noi

Hoʻohana ʻia ka pauka Cabozantinib i nā ʻano ʻelua. Hoʻohana ʻia kahi palapala capsule mai ka makahiki 2012 e mālama ai i ka maʻi ʻaʻai thyroid medullary a hoʻohana ʻia kahi palapala papa mai ka makahiki 2016 ma ke ʻano he lālani lua no ka maʻi puʻuwai puʻuwai.

 

Pauka Cabozantinib Nā ʻaoʻao a me nā ʻōlelo aʻoaʻo

ʻAʻole i ho'āʻo ʻia ka pauka Cabozantinib i nā wahine hāpai; kumu ia i ka pōʻino i nā fetus i ke koʻokoʻo. ʻAʻole pono nā wahine hāpai e lawe i kēia lāʻau, a ʻaʻole hāpai nā wahine i ka wā e lawe ana. ʻAʻole ʻike ʻia inā cabozantinib ka pauka e excreted i ka waiū umauma. Pono e hoʻohana ʻia ka lāʻau me ke akahele i ka poʻe me ka moʻolelo o nā pilikia puʻuwai puʻuwai, e like me ka wā QT lōʻihi.

I ka US, lawe ka capsule formulate (Cometriq) i kahi pahu ʻeleʻele e pili ana i ka makaʻu o nā puka e hana ana i loko o ka ʻōpū a i ʻole nā ​​ʻōpū a me ke kūkulu ʻia ʻana o nā fistula (nā tunnels ma waena o ka GI tract a me ka ʻili). Hoʻomaopopo pū ka pahu ʻeleʻele i ka makaʻu o ke kahe ʻole o ke kahe. Hoʻomaopopo pū ka papa papa (Cabometyx) i kēia mau hopena.

Hoʻomaopopo pū nā lepili i ka makaʻu o nā clots e hoʻokumu a hana i nā puʻuwai puʻuwai a i ʻole nā ​​hahau, ke koko kiʻekiʻe me ka pilikia hypertensive, osteonecrosis o ka iwi ā, ka maʻi diarrhea nui, ka ʻili e haki ana i nā pālima a me nā kapuwaʻi, kahi maʻi maʻi me ka headache, huikau, nalo o ka ʻike , a me ka hopu ʻana, a me ka protein i hōʻike ʻia i ka mimi

ʻO nā hopena maikaʻi ʻole maʻamau (ʻoi aku ma mua o 10% o ka poʻe) komo i ka hōʻemi ʻana i ka makemake; haʻahaʻa pae pālolo, potassium, phosphate, a me nā pae magnesium; nā pae bilirubin kiʻekiʻe; ʻino hewa o ka ʻono, ʻeha poʻo, a me ka dizziness; ke koko kiʻekiʻe; ʻano hewa o ka lohe, pepeiao a me ka ʻāʻī ʻeha; diarrhea, nausea, constipation, ka luaʻi, ʻeha o ka ʻōpū a me ka ʻōpū huhū, a me ka mumū o ka waha a me nā lehelehe a me ke ahi wela i loko o ka waha; ʻoki ka ʻili i nā poho lima a me nā kapuwaʻi, hoʻololi ke kala o ka lauoho a me ka nalo ʻana o ka lauoho, ka ʻehu, ka ʻili maloʻo, a me ka ʻulaʻula; ʻeha puʻupuʻu a me nā spasms muscle; ka luhi a me ka nāwaliwali; ka pohō kaumaha, nā transaminase kiʻekiʻe, nā kiʻekiʻe kolesterol kiʻekiʻe, a me ka nalo ʻana o nā ʻulaʻula a me ke keʻokeʻo.

 

Reference

[1] "Cabozantinib kaola e hoʻohana ai i ka wā o ka hāpai ʻana". ʻO Drugs.com. 30 Malaki 2020. Ua kiʻi ʻia 23 Kepakemapa 2020.

[2] "Cabometyx- cabozantinib pauka pauka". DailyMed. 21 Iulai 2020. Ua kiʻi ʻia 23 Kepakemapa 2020.

[3] "Cometriq- cabozantinib pauka kit Cometriq- cabozantinib pauka capsule". DailyMed. 11 Pepeluali 2020. Ua kiʻi ʻia 23 Kepakemapa 2020.

[4] "Cometriq EPAR". ʻOihana Lapaʻau ʻEulopa (EMA). Ua kiʻi ʻia 23 Kepakemapa 2020.

[5] "Cabometyx EPAR". ʻOihana Lapaʻau ʻEulopa. 17 Kepakemapa 2018. Loaʻa iā 23 Kepakemapa 2020.

[6] "ʻĀpono ʻo FDA iā Cometriq e mālama i nā ʻano ʻano like ʻole o ka maʻi ʻaʻai thyroid" (Press release). ʻO ka US Food and Drug Administration (FDA). 29 Nowemapa 2012. Archive from the original on July 7, 2014.


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