CAD031 Pauka

ʻO CAD031 Paʻa Kūʻai Kūlohelohe

Nootropics no ka maʻi o Alzheimer (AD)

ʻO nā Nootropics, ka mea i ʻike ʻia he cognitive enhancers a i ʻole nā ​​​​lāʻau lapaʻau akamai, he mau mea i manaʻoʻiʻo ʻia e hoʻomaikaʻi i ka hana cognitive, hoʻomanaʻo, hoʻomohala, a me ka hana holoʻokoʻa o ka lolo. Hiki iā lākou ke hoʻokomo i nā pūhui kūlohelohe, nā lāʻau synthetic, a i ʻole nā ​​mea hoʻohui meaʻai. Hoʻohana pinepine ʻia nā Nootropics e kākoʻo i nā mana cognitive e like me ka hoʻomanaʻo, ka nānā ʻana, a me ka noʻonoʻo noʻonoʻo.

Ma ke kahua o ka hoʻomohala ʻana i ka lāʻau lapaʻau AD, aia kekahi mau moho hoʻohiki i hōʻike i ka hiki i nā haʻawina preclinical. ʻO kekahi o ia moho ʻo J-147, he lāʻau hoʻokolohua i hōʻike i nā hopena kūʻē i ka AD a me ka ʻelemakule i nā kiʻi kiʻi. ʻO ka maʻi maʻi AD.

ʻO kekahi moho ʻē aʻe ʻo CMS121, kahi pūhui e hana nei ma ke ʻano he mea hoʻopaneʻe synthase waikawa momona. Ua hōʻike nā haʻawina e hiki i ka CMS121 ke pale aku i ka lipid peroxidation, hoʻemi i ka mumū, a hoʻohaʻahaʻa i ka nalo cognitive i nā kiʻi kiʻi transgenic o AD. Ma ka huli ʻana i ka lipid metabolism, mālama ʻo CMS121 i ka ʻōlelo hoʻohiki i ka hoʻoponopono ʻana i nā kaʻina lipid dysregulated e pili ana me ka holomua AD.

Ma waho aʻe o J-147 a me CMS121, aia kekahi mau moho lāʻau AD ʻē aʻe ma lalo o ka hoʻokolokolo. Ua hōʻike ʻia i ka hoʻololi ʻana i ka mumū, ke olakino synaptic, a me ka metabolism lipid. Ua hōʻike pū ʻo CAD031 i ka maikaʻi i ka hōʻemi ʻana i nā hemahema o ka hoʻomanaʻo a me ka ʻeha o ka lolo i nā kiʻi ʻiole o AD.

ʻO ka holoʻokoʻa, ʻo ka hoʻomohala ʻana o nā moho lāʻau AD i loko o ke kahua o nā nootropics e paʻa i ka ʻōlelo hoʻohiki no ka hoʻoponopono ʻana i ka emi ʻana o ka cognitive a me nā kaʻina neurodegenerative e pili ana i ka maʻi. Hāʻawi kēia mau ala hou i nā mea hou no ka hoʻomaikaʻi ʻana i ke ola o nā poʻe i hoʻopilikia ʻia e AD. Inā pono ʻoe e kūʻai i ka pauka CAD031 no ka noiʻi, e ʻoluʻolu e koho i kahi mea hoʻolako hilinaʻi ma ka pūnaewele.

He aha ka CAD031?

ʻO CAD031, i kapa ʻia ʻo CAD-31. ʻO CAD-31 kahi mea i loaʻa i ka lāʻau hoʻokolohua J147. He pūhui hou ia i hoʻomohala ʻia ma ke ʻano he koho therapeutic kūpono no ka maʻi o Alzheimer (AD). Hōʻike ʻo CAD-31 i ka hana neurogenic i hoʻonui ʻia ma luna o J147 i loko o nā pūnaewele neural precursor kanaka, ʻo ia hoʻi he ikaika ikaika e hoʻoulu i ka replication o kēia mau cell. Hoʻohui ʻia, ua ʻike ʻia ʻo CAD-31 e paipai i ka hoʻohana ʻana i nā ʻakika momona manuahi no ka hoʻoulu ʻana o ka ikehu ma o ka hoʻololi ʻana i ka profile metabolic o nā momona momona i ka hana ʻana i nā kino ketone. Hoʻohana nā kino Ketone i kumu ʻē aʻe o ka ikehu i ka lolo ke haʻahaʻa ka pae glucose.

ʻO ka mole mole o CAD-31 ka ATP synthase, he protein i loaʻa i ka mitochondria. Ma ka huli ʻana i ka ATP synthase, CAD-31 manaʻo e hoʻololi i ka hana mitochondrial a me ka metabolism ikehu i ka lolo. ʻO kēia modulation o ka ikehu metabolism hiki ke loaʻa i nā hopena kūpono no nā maʻi neurodegenerative e like me ka maʻi o Alzheimer.

He mea nui e hoʻomaopopo i ka CAD-31 ke hoʻokolokolo ʻia nei a pono e noiʻi hou ʻia e hoʻomaopopo piha i kona pono, ʻike palekana, a me ka hiki ke lilo i mea lapaʻau no AD. ʻAʻole nui ka lako o ka pauka CAD031 ma ka mākeke. Hiki i nā hui liʻiliʻi ke synthesize i kēia material.CAD031 mea hoʻolako AASRAW hiki ke hāʻawi i ka pauka CAD031 maʻemaʻe kiʻekiʻe. Me kā mākou lab kūʻokoʻa a me ka hui R&D ʻoihana, ʻaʻole pilikia ka lako kūʻai nui CAD031.

Pehea e hana ai ka CAD031?

Hana ʻo CAD031 ma ka huli ʻana i ka ATP synthase, he protein i loaʻa i loko o ka mitochondria o nā cell. ʻO ATP synthase ke kuleana no ka hana ʻana i ka adenosine triphosphate (ATP), ʻo ia ke kālā ikehu mua o nā cell. Ma ka hoʻololi ʻana i ka hana o ATP synthase, CAD031 manaʻo e hoʻohuli i ka hana mitochondrial a me ka metabolism ikehu i ka lolo.

Ua hōʻike ʻia ʻo CAD031 e hoʻonui i ka hana neurogenic i nā cell neural precursor kanaka, ʻo ia ka mea e hoʻoulu ai i ka hana hou ʻana o kēia mau cell. Hoʻoikaika pū ia i ka hoʻohana ʻana i nā ʻakika momona manuahi no ka hana ʻana i ka ikehu ma o ka hoʻololi ʻana i ka ʻike metabolic o nā momona momona i ka hana ʻana i nā kino ketone. Hoʻohana nā kino Ketone i kumu ʻē aʻe o ka ikehu i ka lolo ke haʻahaʻa ka pae glucose.

Ma ka hoʻololi ʻana i ka metabolism ikehu a me ka hoʻoikaika ʻana i ka neurogenesis, hiki i ka CAD031 ke loaʻa nā hopena neuroprotective. Manaʻo ʻia e kōkua i ke kākoʻo ʻana i ke ola a me ka hana o nā neurons a hiki ke pale aku i kekahi o nā hanana ʻona e pili ana i nā maʻi neurodegenerative, e like me ka maʻi o Alzheimer.

Eia nō naʻe, he mea nui e hoʻomaopopo ʻia ke aʻo ʻia a hoʻomaopopo ʻia nā ʻano hana pololei o ka hana a CAD031 a me kona hopena piha. Pono nā noiʻi hou aʻe e hoʻoholo i kāna ʻano hana pololei a me kona hiki ke lilo i mea lapaʻau no nā maʻi neurological.

He aha nā pōmaikaʻi o CAD031?

ʻO CAD031, ma ke ʻano he moho lāʻau lapaʻau maʻi Alzheimer (AD), ua hōʻike i kekahi mau pono kūpono e pili ana i ka noiʻi i loaʻa:

Nā Neuroprotective Properties: Ua ʻike ʻia ʻo CAD031 e loaʻa i nā waiwai neuroprotective ikaika i loko o nā hōʻike aʻoaʻo nerve he nui e hoʻohālike i nā mea ʻawaʻawa i ʻike ʻia i ka lolo ʻelemakule. Hōʻike kēia i ka CAD031 hiki ke pale i nā neurons mai ka pōʻino a me ka degeneration.

Hoemi i na hemahema hoomanao: Ma kahi kiʻi ʻiole o AD, ua hōʻike ʻo CAD031 i ka pono therapeutic ma o ka hoʻemi ʻana i nā hemahema hoʻomanaʻo. I ka lawelawe ʻana i nā ʻiole AD kahiko, symptomatic, CAD031 alakaʻi i ka emi ʻana o ka hōʻino hoʻomanaʻo, e hōʻike ana i kona hiki ke hoʻomaikaʻi i ka hana cognitive.

Hoʻemi ʻia ka ʻā o ka lolo: Ua ʻike ʻia ʻo CAD031 e hōʻemi i ka ʻeha o ka lolo i nā mice AD. Ma ka ho'ēmiʻana i nā pane inflammatory i ka lolo, hiki i ka CAD031 ke kōkua i ka hoʻohaʻahaʻa i nā hopenaʻino e pili ana i nā maʻi neurodegenerative.

Hoʻonui i ka Synaptic Protein Expression: Ua hōʻike ʻia ka lapaʻau CAD031 e hoʻonui i ka hōʻike o nā protein synaptic i ka lolo. Pono nā protein synaptic no ka mālama ʻana i nā pilina olakino ma waena o nā neurons a hana koʻikoʻi i ka hana cognitive. ʻO ka hoʻonui ʻana i ka ʻōlelo protein synaptic e hōʻike ana i kahi hiki no CAD031 ke kākoʻo i ke olakino synaptic.

Nā hopena ma luna o ka Fatty Acid Metabolism a me ka Inflammation: Ua ʻike ʻia ʻo CAD031 he hopena koʻikoʻi i ka metabolism o ka waikawa momona a me nā ala ʻā. Hōʻike kēia i ka CAD031 hiki ke hoʻololi i kēia mau kaʻina hana, hiki ke alakaʻi i kahi hopena maikaʻi i ke olakino lolo a me nā kūlana neurodegenerative.

Ma hea e kūʻai ai i ka pauka CAD031?

I ka hopena, hōʻike ʻo CAD031 i ka hiki ke hoʻohiki e like me ka lāʻau nootropic no ka hoʻonui cognitive. Pono nā noiʻi hou aʻe e hoʻomaopopo pono i ka pono, nā hopena lōʻihi, a me ka hoʻohana maikaʻi ʻana o CAD031.CAD031 a me nā pūhui like e paʻa i ka hiki ke kōkua nui i ke kākoʻo ʻana i ka maikaʻi noʻonoʻo a me ka wehe ʻana i ka hiki ke kanaka. ʻO ka hoʻomau ʻana i ka noiʻi a me ka ʻimi kuleana e koʻikoʻi i ka hoʻohana ʻana i nā pono o CAD031 no ka hoʻonui ʻana i ka naʻau a me ka hoʻoponopono ʻana i nā pilikia e pili ana i ka emi ʻana o ka cognitive a me nā maʻi neurodegenerative. I ka hōʻoia ʻana i ka palekana o ia mau mea, he mea nui e kūʻai i ka pauka CAD031 kiʻekiʻe mai kahi mea hana kaulana. Nui nā pauka CAD031 no ke kūʻai aku ma ka pūnaewele. He koho paha ke kūʻai ʻana ma ka pūnaewele. No ka hoʻomaʻemaʻe ʻana, e ʻoluʻolu e ʻoluʻolu e loaʻa iā lākou nā hōʻike hoʻāʻo kūʻokoʻa e like me COA, HPLC, etc.

CAD031 Hōʻike Hōʻike Hōʻike Pahu-HNMR

He aha ka HNMR a he aha ka HNMR spectrum e haʻi iā ʻoe? ʻO H Nuclear Magnetic Resonance (NMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā huila i loaʻa nā pūhui i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR e hoʻohālikelike i nā hale waihona puke spectral a i ʻole e kuhi pololei i ke ʻano kumu. Ke ʻike ʻia ke ʻano kumu, hiki ke hoʻohana ʻia ka NMR no ka hoʻoholo ʻana i ka conformation molecular i ka hopena a me ke aʻo ʻana i nā waiwai kino ma ka pae molekala e like me ka hoʻololi conformational, nā hoʻololi ʻana, ka solubility, a me ka diffusion.

Pehea e kūʻai ai i ka CAD031 Powder mai AASraw?

❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu WhatsApp iā mākou, e hoʻopili aku kā mākou mea kūʻai aku (CSR) iā ʻoe i loko o 12 mau hola.

❷E hāʻawi iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.

❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala lawe, a me ka lā i manaʻo ʻia e hiki mai ai (ETA).

❹E uku ʻia a hoʻouna ʻia nā waiwai i loko o 12 mau hola.

❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.

Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine

Mea kākau moʻolelo puke moʻolelo ʻepekema:
1.Trieu-Duc Vu
Laboratory of Genomics for Health and Longevity, School of Pharmacy, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Iapana
2.Naoki Ito
Ke Keʻena ʻImi ʻImi Lapaʻau Hikina, Ke Kulanui ʻo Kitasato, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Iapana
3.Devin Kepchia
Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA
4.Marguerite Mamua
ʻO ka Salk Institute for Biological Studies, Cellular Neurobiology, La Jolla, CA, USA.
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.

Reference

[1] Currais A, Huang L, Petrascheck M, Maher P, Schubert D. "He hana biology kemika no ka ʻike ʻana i nā ala molekala e pili ana me ka ʻelemakule." Geroscience.2021 Feb;43(1):353-365.doi: 10.1007/ s11357-020-00238-5.Epub 2020 Jul 23.PMID: 32705410

[2] Ma mua o M, Goldberg J, Chiruta C, Farrokhi C, Kopynets M, Roberts AJ, Schubert D. 2016-12.doi: 6/j.jalz.678.Epub 86 Mei 10.1016.PMID: 2016.03.016

[3] ʻO Ruth Beckervordersandforth, Chiara Rolando. https://doi.org/10.1016/j.coph.2019.12.002

[4] David Schubert, Antonio Currais, Joshua Goldberg, Kim Finley, Michael Petrascheck, Pamela Maher.

E kiʻi i kahi hōʻaiʻē nui