CMS121

Nā Kiʻi Kuleana CMS121 Pauda Maka

He aha ka CMS121 pauda?

ʻO ka CMS121 ka pauka he mea hoʻohui e hana ma ke ʻano he mea hoʻoheheʻe synthase acid fatty. ʻO ka fatty acid synthase kahi enzyme i komo i ka synthesis o nā momona momona, he mau mea pono ia o nā membrane cell a pāʻani i kahi hana i nā kaʻina hana kelepona. Hiki i ke kaohi ʻana i ka fatty acid synthase ke hoʻopilikia i ka metabolism lipid a loaʻa nā hopena i nā maʻi e like me ka maʻi o Alzheimer.

Hoʻohui ʻia, hōʻike ʻo CMS121 i nā hopena anti-inflammatory, ʻo ia ka mea hiki ke kōkua i ka hōʻemi ʻana i ka mumū i loko o ke kino. Hoʻopili ʻia ka ʻāʻī maʻamau me kekahi mau kūlana olakino, me nā maʻi autoimmune, nā maʻi cardiovascular, a me kekahi mau ʻano o ka maʻi kanesa. Ma ka ho'ēmiʻana i ka mumū, hiki i ka CMS121 ke loaʻa nā noi kūpono i ka mālamaʻana i kēia mau maʻi pili i ka mumū.

ʻO kekahi waiwai kaulana o CMS121 ʻo kāna hana antioxidative. ʻO ke koʻikoʻi oxidative, ma muli o ke kaulike ʻole ma waena o ka hana ʻana o nā ʻano oxygen reactive (ROS) a me ka ʻōnaehana pale antioxidant o ke kino, hiki ke alakaʻi i ka pōʻino o ke kelepona a kōkua i ka ulu ʻana o nā maʻi like ʻole, me nā maʻi neurodegenerative a me nā maʻi cardiovascular. e pale aku i kēia koʻikoʻi oxidative, hiki ke pale aku i nā cell mai ka pōʻino.

Eia kekahi, ua hōʻike ʻo CMS121 i nā hopena renoprotective, e hōʻike ana i kona hiki ke pale i nā puʻupaʻa mai ka hōʻeha a i ʻole ka hana ʻino. ʻO nā maʻi kīpē, e like me ka maʻi maʻi maʻi maʻi a i ʻole ka hōʻeha ʻeha ʻeha, hiki ke loaʻa i nā hopena koʻikoʻi no ke olakino holoʻokoʻa. Ma ka hoʻohana ʻana i nā hopena renoprotective, paʻa ʻo CMS121 i ka ʻōlelo hoʻohiki ma ke ʻano he lāʻau lapaʻau kūpono no nā kūlana pili i ke kīkī.

Pehea ka hana ʻana o CMS121?

ʻO ka maʻi o Alzheimer kahi maʻi neurodegenerative i hōʻike ʻia e ka hōʻiliʻili ʻana o nā plaque beta-amyloid a me nā neurofibrillary tangles i loko o ka lolo. Hoʻopili ʻia ia me ka emi ʻana o ka cognitive, ka mumū, a me ke kaumaha oxidative. ʻO ka hoʻomohala ʻana i nā hoʻolālā therapeutic e hoʻopaʻa i kēia mau hiʻohiʻona pathological kahi wahi ikaika o ka noiʻi.

I loko o ka pōʻaiapili o ka maʻi o Alzheimer, ua noiʻi nā haʻawina i nā pono kūpono o ka fatty acid synthase inhibition me ka hoʻohana ʻana i nā pūhui e like me CMS121. Ua hōʻike ʻia nā haʻawina preclinical me ka hoʻohana ʻana i nā kiʻi ʻiole transgenic o ka maʻi o Alzheimer e hiki i ka CMS121 ke pale aku i ka nui o ka lipid peroxidation, hoʻemi i ka mumū, a hoʻēmi i ka nalo naʻau.

ʻO ka nui o ka lipid peroxidation e pili ana i ka pōʻino i hana ʻia e nā ʻano oxygen reactive i nā lipid i loko o nā membrane cell. Hiki i kēia kaʻina hana ke alakaʻi i ka cellular dysfunction a kōkua i ka holomua o nā maʻi neurodegenerative. Ma ke kāohi ʻana i ka fatty acid synthase, hiki i ka CMS121 ke kōkua i ka hoʻihoʻi ʻana i ka homeostasis lipid a hoʻemi i ka lipid peroxidation.

Eia kekahi, ʻike ʻia ka ʻāʻī e pāʻani nui i ka holomua o ka maʻi o Alzheimer. Hiki i nā hana inflammatory i loko o ka lolo ke kōkua i ka pōʻino neuronal a me ka emi ʻana o ka cognitive. Ua hōʻike nā haʻawina he hopena anti-inflammatory ka CMS121, hiki ke kōkua i ka hoʻēmi ʻana i ka pane ʻeha e pili ana i ka maʻi o Alzheimer.

ʻO nā pono o ka pauka CMS121

ʻO ka pauka CMS121 kahi hui quinoline i hoʻololi ʻia i loaʻa nā waiwai pono. Ua ʻike ʻia e hōʻike i nā hana neuroprotective, anti-inflammatory, antioxidative, a me renoprotective. Eia kekahi mau hopena a me nā hana a CMS121:

Neuroprotection: Ua hōʻike ʻia ʻo CMS121 i ka pale ʻana i nā cell hippocampal mouse HT22 mai ka pōʻino i hoʻokomo ʻia i ka glutamate in vitro. Kōkua ia i ka mālama ʻana i nā pae o ka glutathione (GSH), he antioxidant koʻikoʻi, i loko o kēia mau cell. Hoʻohui hou, hōʻike ʻo CMS121 i ka pale ʻana i ka ischemia a me ka oxytocin (glutamate-induced cell death) ma HT22 cell.

Anati-hoʻoʻino: Hōʻike ʻo CMS121 i nā hopena anti-inflammatory ma ka pale ʻana i ka hoʻāla ʻana o N9 microglia, kahi ʻano o ka cell immune i loko o ka lolo. Ma ke alo o lipopolysaccharide (LPS), CMS121 ho'ēmi i ka microglial activation e 82% ma N9 microglia. Hiki i kēia waiwai anti-inflammatory ke kōkua i nā ʻano neuroinflammatory like ʻole.

Antioxidant: Hoʻopau ʻo CMS121 i nā radical manuahi, e like me ka mea i hōʻike ʻia ma kahi Trolox equivalent activity concentration (TEAC) assay. ʻO nā radical manuahi he mau molekole reactive hiki ke hoʻopōʻino i ke kelepona a kōkua i nā maʻi like ʻole. Ma ka ʻoki ʻana i nā radical manuahi, hana ʻo CMS121 ma ke ʻano he antioxidant a kōkua i ka pale ʻana i nā cell mai ke kaumaha oxidative.

Induction of differentiation: Hoʻokomo ʻo CMS121 i ka ʻokoʻa o nā cell PC12. Hoʻohana pinepine ʻia nā cell PC12 ma ke ʻano he kumu hoʻohālike no ke aʻo ʻana i ka ʻokoʻa neuronal a me ka hana. ʻO ka hiki i ka CMS121 ke hoʻoulu i ka ʻokoʻa i loko o kēia mau cell e hōʻike ana i kāna kuleana kūpono i ka hoʻoikaika ʻana i ka hoʻomohala ʻana a me ka hoʻoponopono ʻana.

Hoʻomalu hou: Hōʻike ʻo CMS121 i nā hopena renoprotective, ʻoi aku ka nui o kahi kiʻi kiʻi SAMP8 o ka maʻi maʻi maʻi e pili ana me ka ʻelemakule wikiwiki. Ke hoʻohana ʻia ma kahi maʻa o 10 mg/kg i kēlā me kēia lā e hoʻomaka ana i ka ʻeiwa mahina, hoʻemi ʻo CMS121 i ka pohō kaumaha o ke kīkī a hoʻemi i ka hōʻike ʻana o TNF-α, caspase-1, a me ka inducible nitric oxide synthase (iNOS). Hōʻike kēia mau hopena i kahi hana therapeutic kūpono no CMS121 i ka pale ʻana i nā puʻupaʻa mai ka pōʻino e pili ana i ka maʻi maʻi maʻi maʻi.

I ka hōʻuluʻulu ʻana, ʻo CMS121 kahi hui hoʻohiki me nā waiwai pono he nui, me ka neuroprotection, nā hopena anti-inflammatory, ka hana antioxidative, a me ka renoprotection. ʻO kāna mau hana like ʻole e lilo ia i moho kūpono no ka mālama ʻana i nā maʻi neurological like ʻole, nā kūlana pili i ka mumū, a me nā maʻi kīkī.

Ma hea e kūʻai ai i ka pauka CMS121?

ʻO AASraw kahi maikaʻi loa e kūʻai ai i ka CMS121 kūʻai nui. Hele mai kā mākou huahana āpau me kahi palapala hōʻoia kūʻokoʻa kūʻokoʻa i hāʻawi ʻia e nā ʻaoʻao ʻekolu no ka ʻike, ka maʻemaʻe, a me ka noʻonoʻo. A loaʻa iā mākou ka nui CMS121 no ke kūʻai ʻana ma ka waihona!

ʻO AASraw kahi mea hoʻolako CMS121 a me ka mea hana CMS121 i loaʻa kahi lab kūʻokoʻa a me kahi hale hana nui e like me ke kākoʻo, e hana ʻia nā hana āpau ma lalo o ke kānāwai CGMP a me kahi ʻōnaehana mālama maikaʻi. Paʻa ka ʻōnaehana lako CMS121, a ua ʻae ʻia nā kauoha kūʻai a me nā mea kūʻai nui. Inā makemake ʻoe e kūʻai i ka CMS121 ma ka pūnaewele, e kipa mai i kā mākou pūnaewele (aasraw.com).

CMS121 Hōʻike Hōʻike-HNMR

He aha ka HNMR a he aha ka HNMR spectrum e haʻi iā ʻoe? ʻO H Nuclear Magnetic Resonance (NMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā huila i loaʻa nā pūhui i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR e hoʻohālikelike i nā hale waihona puke spectral a i ʻole e kuhi pololei i ke ʻano kumu. Ke ʻike ʻia ke ʻano kumu, hiki ke hoʻohana ʻia ka NMR no ka hoʻoholo ʻana i ka conformation molecular i ka hopena a me ke aʻo ʻana i nā waiwai kino ma ka pae molekala e like me ka hoʻololi conformational, nā hoʻololi ʻana, ka solubility, a me ka diffusion.

Pehea e kūʻai ai iā CMS121 mai AASraw?

❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu WhatsApp iā mākou, e hoʻopili aku kā mākou mea kūʻai aku (CSR) iā ʻoe i loko o 12 mau hola.

❷E hāʻawi iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.

❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala lawe, a me ka lā i manaʻo ʻia e hiki mai ai (ETA).

❹E uku ʻia a hoʻouna ʻia nā waiwai i loko o 12 mau hola.

❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.

Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine

Mea kākau moʻolelo puke moʻolelo ʻepekema:
1.Gamze Ates
Kelepona Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA
2.Sveinn Olafsson
Kumu o ka ʻepekema kino, Kulanui o Iceland, Reykjavik, ʻIceland
3.Diana Garibo
Ke Kula Nui ʻo Tomsk Polytechnic, Lenin Ave.No 30,6634050 Tomsk, Lusia
4.Rodrick Wallace
ʻO ka New York State Psychiatric Institute, ʻAmelika Hui Pū ʻIa
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.

Reference

[1] Schneider LS, Mangialasche F., Andreasen N., Feldman H., Giacobini E., Jones R. Nā hoʻokolohua lapaʻau a me ka hoʻomohala ʻana i ka lāʻau lapaʻau hope loa no ka maʻi o Alzheimer: kahi loiloi mai 1984 a 2014.J.Intern.Med. 2014;275: 251–283.doi: 10.1111/joim.12191.

[2] Ashraf A., Jeanriens J., Parkes HG, So P.-W.Iron dyshomeostasis, lipid peroxidation a me ka haʻi haʻalulu o ka cystine/glutamate antiporter i ka maʻi o Alzheimer: nā hōʻike o ferroptosis.Redox Biol.2020;32: 101494. doi: 10.1016/J.REDOX.2020.101494.

[3] Trares K., Gào X., Perna L., Rujescu D., Stocker H., Möllers T. Nā hui o nā pae mimi 8-iso-prostaglandin F2α me nā kumu dementia a pau, ka maʻi Alzheimer, a me ka maʻi dementia vascular: nā hualoaʻa mai kahi haʻawina koho koho.Alzheimers Dement.2020;16(5): 804–813.doi: 10.1002/alz.12081.

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