Enclomiphene Citrate Pauda

ʻO Enclomiphene Citrate Paʻa Kūʻai Kūʻai

He aha ka Encomiphene Citrate Powder?

ʻO Encomiphene Citrate ka trans-isomer hoʻomaʻemaʻe o clomiphene citrate. ʻO ia ka mea koho estrogen receptor modulator (SERM) a me ka non-steroidal estrogen receptor antagonist. Hoʻohana ʻia ia ma ke ʻano he lapaʻau no ka infertility i nā kāne me nā haʻahaʻa testosterone haʻahaʻa, kahi kūlana i kapa ʻia ʻo hypogonadism.

ʻO nā SERM e like me Encomiphene Citrate Powder a me ka clomiphene citrate e hana ma ke ʻano he estrogen antagonists ma o ka hoʻopaʻa ʻana i ka hypothalamic estrogen receptors i ka lolo. Hoʻopunipuni kēia i ke kino i ka noʻonoʻo ʻana ʻaʻole lawa ka estrogen, no laila e hoʻoulu ai i ka hana ʻana o nā hormones luteinizing hormone (LH) a me ka follicle-stimulating hormone (FSH). Ua hōʻike ʻia ʻo Encomiphene Citrate Powder i ka liʻiliʻi o nā hopena ʻaoʻao ma mua o ka clomiphene citrate.

ʻO ka Encomiphene Citrate Powder ka mea maʻamau e lawe waha ʻia a loaʻa i kahi ʻano Powder i hiki ke hui ʻia me ka wai a i ʻole nā ​​wai ʻē aʻe. ʻOiai ke kūʻai wale nei ʻoe i ka Encomiphene Citrate Powder, he mea nui e hahai i nā ʻōlelo aʻoaʻo i hāʻawi ʻia e kāu mea mālama ola i ka wā e lawe ai i kēia lāʻau lapaʻau.

ʻO ka hana o ka Encomiphene Citrate Powder?

ʻO Encomiphene Citrate ka mea koho estrogen receptor modulator (SERM),ʻo ia hoʻi ka mea hiki ke hoʻopaʻa i ka estrogen receptors i nāʻokoʻa likeʻole o ke kino, e hana ana ma keʻano he estrogen agonist a iʻole ka mea kū'ē ma muli o ke kino. I loko o ka hypothalamus, Encomiphene Citrate e hana ma ke ʻano he estrogen antagonist, e alakaʻi ana i ka hoʻonui ʻana i ka hana o ka gonadotropin-releasing hormone (GnRH) e hoʻoulu ai i ka hoʻokuʻu ʻana o ka follicle-stimulating hormone (FSH) a me ka luteinizing hormone (LH) mai ka pituitary gland. ʻO kēia ka mea e hoʻoulu ai i ka ovulation a me ka hana ʻana o ka progesterone mai nā ovaries.

Hoʻohana ʻia ʻo Encomiphene Citrate i ka mālama ʻana i ka maʻi ovulatory dysfunction i nā wahine me ka infertility, a kōkua ia i ka hoʻihoʻi ʻana i nā pōʻai ovulation maʻamau ma ke kāohi ʻana i nā manaʻo maikaʻi ʻole o ka estrogen ma ka hypothalamus. Ma ka hanaʻana pēlā, hoʻonui ia i ka hoʻokuʻuʻana o GnRH, kahi e hoʻoulu ai i ka hoʻokuʻuʻana o FSH a me LH, e alakaʻi ana i ka ulu a me ka uluʻana o nā follicles ovarian a me ka hoʻokuʻuʻana i kahi hua manu.

I nā kāne, hiki i ka Encomiphene Citrate ke hoʻonui i ka hana o ka testosterone ma ke kāohi ʻana i ka manaʻo maikaʻi ʻole o ka estrogen ma ka hypothalamus a me ka pituitary gland. ʻO kēia, ke alakaʻi nei i ka hoʻonui ʻana i ka hoʻokuʻu ʻana o ka hormone luteinizing (LH) a me ka follicle-stimulating hormone (FSH), ka mea e hoʻoulu ai i nā testes e hoʻonui i ka testosterone.

Ma keʻano holoʻokoʻa, ʻo ka hana o ka Encomiphene Citrate e pili ana i ka hoʻoponopono ʻana i ka hana a me ka hoʻokuʻu ʻana o nā hormones i pili i ka ovulation a me ka hana testosterone, hiki ke kōkua i ka hoʻomaikaʻi ʻana i ka momona i nā kāne a me nā wahine.

He aha nā pōmaikaʻi o ka lawe ʻana i ka Encomiphene Citrate Powder?

Hiki ke hoʻololi ʻia nā hopena o ka lawe ʻana i ka Enclomiphene Citrate Powder ma muli o kēlā me kēia kanaka a me ka nui o ka lāʻau lapaʻau, akā kekahi mau pono maʻamau:

Hoʻomaikaʻi ʻia ka maikaʻi o nā hua manu: Hiki i ka Enclomiphene Citrate Powder ke hoʻonui i ka maikaʻi o ka sperm i nā kāne me ka hypogonadism, e alakaʻi ana i ka hoʻonuiʻana i ka momona a me ka hiki ke hāpai i kahi keiki.

Hoʻonui ʻia ʻo Testosterone Production: Hana ka Enclomiphene Citrate Powder ma ka hoʻouluʻana i ka hanaʻana o ka hormone luteinizing (LH) a me ka hormone hoʻouluʻana i ka follicle (FSH), aʻo ia hoʻi ka hoʻouluʻana i nā hōʻailona e hoʻonui i ka testosterone.

ʻO nā pono ʻē aʻe o ka lawe ʻana i ka Enclomiphene Citrate Powder

ʻOiai ʻo ka hoʻonui ʻana i kāu testosterone a me ka helu sperm hiki ke kōkua i ka hoʻomaikaʻi ʻana i kou momona holoʻokoʻa, aia kekahi mau pono ʻē aʻe i ka lawe ʻana i ka Enclomiphene Citrate Powder.

Ua hoʻopili ʻia ka testosterone maikaʻi i:

ʻOi aku ka lean mass: Hōʻike nā haʻawina e kōkua ka testosterone i ke kākoʻo ʻana i ke kaumaha o ke kaumaha ma o ka hoʻonui ʻana i kāu metabolism.

ʻOi aku ka nui o ka moekolohe: Ua pili pono ka Testosterone i ka libido, me na pae ki'eki'e e pili ana me ka ho'okalakupua ki'eki'e. Aia kekahi mau hōʻike e hiki ai i ka testosterone optimized ke hoʻomaikaʻi i ka erectile dysfunction (ED).

Hoʻonui i ka manaʻo: Mai ka noe lolo a hiki i ka hopohopo, hiki i ka testosterone haʻahaʻa ke hoʻopilikia i ke ʻano o ke kanaka a me ka hana naʻau. Hōʻike nā noiʻi e pili ana ka hoʻonui ʻana i nā pae testosterone me ka hoʻomaikaʻi ʻana i ka maikaʻi o ke ola, me ka ʻoi aku o ka sociability, ka noʻonoʻo, a me ka hilinaʻi iā ia iho.

Pehea e hoʻohālikelike ai ʻo Encomiphene Citrate Powder i ka testosterone replacement therapy (TRT)?

ʻElua ʻano hypogonadism - hypogonadism kumu a me ka hypogonadism lua.

• I ka hypogonadism mua, hypothalamus a me ka hana pituitary he mea maʻamau, ʻo ia hoʻi ke hōʻailona maikaʻi nei kēia mau ʻeleʻele i nā testicles e hana i ka testosterone-akā ʻaʻole hiki i nā testicles ke hana i ka nui o ka testosterone. ʻIke ʻia kēia ma ke ʻano he testicular failure mua.
• I ka hypogonadism lua, hoʻohuli ʻia ke kūlana. Loaʻa i ke kanaka nā testicles maʻamau e hiki ke hana i ka testosterone, akā ʻaʻole hoʻouna ka hypothalamus a me ka pituitary i ka hōʻailona e hoʻonui i ka hana testosterone.

ʻO ka hapa nui o nā kāne me "Low T" e loaʻa i ka hypogonadism lua.

I ka hihia o ka hypogonadism mua, testosterone replacement treatment (TRT), e pili ana i ka hoʻolako ʻana i ke kino me ka testosterone exogenous, ʻo ia wale nō kāu koho.

Akā i  tuarua  hypogonadism, ʻoi aku ka paʻakikī o ke kiʻi. I kēia mau hihia, ʻo ka lawe wale ʻana i ka testosterone ʻaʻole paha ka manaʻo maikaʻi loa.

ʻAʻole maikaʻi ka TRT no ka hypogonadism lua.

ʻO ka mea pōʻino, ua hoʻololi ʻia ka nui o ka testosterone hou i hana ʻia e TRT i estradiol, kahi ʻano estrogen. Ke hoʻopaʻa ʻia ka estradiol hou aku i nā mea hoʻokipa estrogen cellular i loko o ka lolo a me nā gland pituitary, pane kou kino ma ka hana ʻana i ka hormone luteinizing liʻiliʻi (LH) a me ka follicle-stimulating hormone (FSH).

ʻO ka LH (luteinizing hormone) a me ka FSH (follicle-stimulating hormone) he hana koʻikoʻi i ka hana ʻana o ka testosterone e nā testicles i nā kāne. Hiki i ka Testosterone replacement therapy (TRT) ke kōkua i ka hoʻonui ʻana i nā pae testosterone i nā kāne me ka hypogonadism kiʻekiʻe, akā hiki ke loaʻa i nā hopena lōʻihi i ka fertility a me ka hana testosterone endogenous. ʻO kēia no ka mea hiki i ka TRT ke kāohi i ka hana o LH a me FSH, e alakaʻi ana i ka emi ʻana o ka hana ʻana o ka testosterone endogenous a me ka emi ʻana o ka helu sperm. No laila, hiki i nā kāne i loaʻa iā TRT ke loaʻa i ka emi ʻana o ka momona a pono paha ke kākoʻo o waho, e like me nā lāʻau lapaʻau a i ʻole nā ​​ʻenehana hānau keiki kōkua, i ka makua kāne.

ʻO ia hoʻi, ʻoiai inā he olakino kāu mau testicles ma mua o kou hoʻomaka ʻana i ka TRT, hiki iā ʻoe ke hilinaʻi mau loa i ka testosterone exogenous ke hoʻomaka ʻoe. E emi loa ana kāu mau testosterone a me ka momona inā haʻalele ʻoe i ka hoʻohana ʻana ia mea ma mua o kou hoʻomaka ʻana i ka TRT.

ʻO Encomiphene Citrate Powder kahi palekana palekana i ka mālama ʻana i ka TRT, he mau pilikia mai ka hōʻemi ʻana o ka testicular a me ka ʻeʻe i ka emi ʻana o ka hana sperm. ʻOiai ua manaʻo ʻia nā lāʻau ʻelua e hoʻonui i ka pae testosterone, Encomiphene Citrate Powder e hoʻoulu i ke kino e hana i kāna testosterone ponoʻī, ʻoiai ʻo ka testosterone replacement therapy maʻamau e hoʻololi i nā pae testosterone haʻahaʻa i nā kāne me ka exogenous, synthetic testosterone.

Nā ʻokoʻa ma waena o Encomiphene Citrate a me Clomid (clomiphene citrate)

ʻO Encomiphene Citrate a me clomiphene citrate nā mea koho estrogen receptor modulators (SERMs) a hoʻohana ʻia e mālama i ka infertility i nā kāne me nā pae haʻahaʻa testosterone. Eia naʻe, aia kekahi mau ʻokoʻa ma waena o nā lāʻau ʻelua.

ʻO ka ʻokoʻa nui ma waena o Encomiphene Citrate a me clomiphene citrate ʻo ia ʻo Encomiphene Citrate ka transisomer o clomiphene citrate, he isomer hoʻokahi me ka antagonism estrogen maʻemaʻe. ʻOiai aia ka clomiphene citrate i kahi hui o nā isomers. Ua manaʻo kekahi mau haʻawina e liʻiliʻi paha nā hopena ʻaoʻao o Encomiphene Citrate a ʻoi aku ka maikaʻi ma mua o ka clomiphene citrate i kekahi mau maʻi.

Ma ke ʻano o kā lākou hoʻohana ʻana, hoʻohana ʻia ʻo Encomiphene Citrate a me clomiphene citrate e mālama i ka infertility i nā kāne me nā pae haʻahaʻa testosterone. Hana lākou ma ka hoʻonui ʻana i ka hana o ka hormone luteinizing (LH) a me ka follicle-stimulating hormone (FSH), ʻo ia hoʻi ka mea e hoʻoulu ai i nā testicles e hoʻonui i ka testosterone.

Ma keʻano holoʻokoʻa, ʻoiai ʻo Encomiphene Citrate a me clomiphene citrate nā lāʻau lapaʻau like, ʻo Encomiphene Citrate paha he ʻano maʻemaʻe a ʻoi aku ka maikaʻi o ka lāʻau lapaʻau, ʻoiai ʻoi aku ka nui o ka noiʻi e hoʻomaopopo pono i nā ʻokoʻa ma waena o nā lāʻau ʻelua.

Hoʻohana i ka Encomiphene Citrate Powder ma ke ʻano he lāʻau hoʻoikaika hana

ʻO Encomiphene Citrate kahi lāʻau lapaʻau i hoʻohana mua ʻia e mālama i ka hypogonadism kāne a me ka infertility. ʻOiaiʻaʻole i'āponoʻia no ka hoʻohanaʻana ma keʻano he lāʻau lapaʻau e hoʻonui ai i ka hana, ua hōʻikeʻia kekahi mau mea pāʻani a me nā bodybuilders i ka Encomiphene Citrate Powder e hoʻonui i kā lākou mau testosterone a hoʻonui i kā lākou hana. I nā ʻāina he nui, ʻaʻole kānāwai ka hoʻohana ʻana a me ka hāʻawi ʻana i ka lāʻau Encomiphene Citrate (nā inoa inoa tentative brand Androxal a me EnCyzix) me ka ʻole o ke kau ʻana. Eia naʻe, hiki iā ʻoe ke kūʻai i ka Encomiphene Citrate Powder. ʻO ka hoʻohanaʻana i ka Encomiphene Citrate Powder hoʻopunipuni hiki ke pilikia a hiki ke hana i nā hopena maikaʻiʻole, He mea nui e kūʻai i ka maʻemaʻe kiʻekiʻe Encomiphene Citrate Powder mai kahi mea kūʻai pono.ʻO AASRAW ka mea hoʻolako i ka hilinaʻi.

He aha nā hopena ʻaoʻao o ka lawe ʻana i ka Encomiphene Citrate?

ʻO Encomiphene Citrate kahi lāʻau lapaʻau i kuhikuhi pinepine ʻia i nā kāne me ka hypogonadism (mau haʻahaʻa testosterone haʻahaʻa). E like me nā lāʻau lapaʻau, hiki i ka Encomiphene Citrate ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole nā ​​​​mea a pau e ʻike iā lākou. ʻO kekahi mau hopena maʻamau o ka lawe ʻana i ka Encomiphene Citrate Powder e komo pū me:

Hoʻopihaʻia ke kukū

Heʻeha

'O Nausea

'Oloke

Hoʻoponopono

Kanikani'āʻula.

Hiki ke hoʻololi i ka loli

Pau

Hoʻonui i ka ulu lauoho

I nā hihia koʻikoʻi, hiki ke loaʻa nā hopena ʻaoʻao koʻikoʻi, e like me ka haʻalulu ʻike, ke koko koko, a i ʻole nā ​​pilikia ate. Inā ʻike ʻoe i kekahi o kēia mau hōʻailona, ​​​​pono ʻoe e kelepona koke i kāu mea mālama ola.

He mea nui e hoʻomaopopo i ka lawe ʻia ʻana o nā papa Encomiphene Citrate ma lalo o ka nānā ʻana o kahi mea mālama olakino a ʻOiai inā e kūʻai ʻoe i ka Enclomiphene Powder, pono e lawe ʻia i ka dosage i kuhikuhi ʻia. ʻO ka lawe nui ʻana i kēia lāʻau lapaʻau a i ʻole ka hoʻohana ʻana iā ia no nā kumu ʻē aʻe ma mua o ka mea i kuhikuhi ʻia e hiki ke hoʻonui i ka hopena o nā hopena ʻaoʻao.

Pehea e loaʻa ai iaʻu ka Encomiphene Citrate Powder?

Ua hōʻike nā hoʻokolohua lapaʻau ma Encomiphene Citrate Powder i nā hopena hoʻohiki i ka hoʻomaikaʻi ʻana i nā pae testosterone a me nā hōʻailona o ka hypogonadism (haʻahaʻa testosterone) i nā kāne. Eia naʻe, pono ka noiʻi hou aʻe e hoʻomaopopo pono i kona palekana a me ka pono.

Inā hoʻopau ʻoe i ka loaʻa ʻana o kahi maʻi hypogonadism lua, a laila kūpono ʻo Encomiphene Citrate Powder i kāu noʻonoʻo ʻana ma ke ʻano he lapaʻau no kou kūlana.

Nui nā koho e kūʻai aku i ka Enclomiphene Citrate Powder bulk no ka mea he nui ka Encomiphene Citrate Powder no ke kūʻai aku ma ka pūnaewele. Inā ʻaʻole ʻoe i hana pēlā, ʻo ia ka manawa e hoʻi ai i ka mea hana Encomiphene Citrate Powder a nānā iā AASRAW. Eia nō naʻe, hāʻawi ʻo AASRAW i ka Encomiphene Citrate Powder ma ke kumukūʻai hale kūʻai.

Enclomiphene Citrate Powder Testing Report-HNMR

He aha ka HNMR a he aha ka HNMR spectrum e haʻi iā ʻoe? ʻO H Nuclear Magnetic Resonance (NMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā huila i loaʻa nā pūhui i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR e hoʻohālikelike i nā hale waihona puke spectral a i ʻole e kuhi pololei i ke ʻano kumu. Ke ʻike ʻia ke ʻano kumu, hiki ke hoʻohana ʻia ka NMR no ka hoʻoholo ʻana i ka conformation molecular i ka hopena a me ke aʻo ʻana i nā waiwai kino ma ka pae molekala e like me ka hoʻololi conformational, hoʻololi i ka pae, solubility, a me ka diffusion.

Pehea e kūʻai ai i ka Enclomiphene Citrate Powder mai AASraw?

❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu WhatsApp, e hoʻopili aku kā mākou mea kūʻai aku (CSR) iā ʻoe i nā hola 12.

❷E hāʻawi iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.

❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala lawe, a me ka lā i manaʻo ʻia e hiki mai ai (ETA).

❹Hoʻopau ʻia ka uku a hoʻouna ʻia nā waiwai i nā hola 12.

❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.

Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine

Mea kākau moʻolelo puke moʻolelo ʻepekema:
1. Jed Kaminetsky MD
University Urology Associates New York, NY, USA
2. AW Pastuszak
Baylor College of Medicine, USA
3. Greg Fontenot
ʻO ke Kaiʻula, TX
4. RD Wiehle
Zonagen, Inc., The Woodlands, TX; Noiʻi Biomedical Kiʻekiʻe, Pennington, NJ
5. Andrew McCullough
Albany, NY
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.

Reference

[1] Rodriguez KM, Pastuszak AW, Lipshultz LI. "Encomiphene Citrate no ka mālamaʻana i ka hypogonadism kāne lua". Expert Opin Pharmacother.2016 Aug;17(11):1561-7.doi:10.1080/14656566.2016.1204294. PMID:2016.

[2] Earl JA, Kim ED.”Encomiphene Citrate:He lapaʻau e mālama ai i ka momona i nā kāne me ka lua o ka hypogonadism”.Expert Rev Endocrinol Metab.2019 Mei;14(3):157-165.doi:10.1080/17446651.2019.1612239.Epub2019. 7.PMID:31063005.

[3] Kim ED, McCullough A, Kaminetsky J.” Hoʻonui ka Oral Encomiphene Citrate i ka testosterone a mālama i ka helu sperm i nā kāne hypogonadal obese, ʻaʻole like me ka testosterone topical: hoʻihoʻi ma mua o ka hoʻololi ʻana ".BJU Int.2016 Apr;117(4):677-85.doi :10.1111/bju.13337.Epub 2015 Okatoba 23.PMID:26496621 Hoao Hoao.

[4] Kaminetsky J, Hemani ML. "Clomiphene citrate a me ka enclomiphene no ka mālamaʻana i ka hypogonadal androgen deficiency".

[5] Wiehle R, Cunningham GR, Pitteloud N, Wike J, Hsu K, Fontenot GK, Rosner M, Dwyer A, Podolski J. ;2013(12):112-8.doi:1188/bju.200.Online ma mua o ka paʻi ʻana.PMID:10.1111.

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