IDFP

ʻO ka AASraw me ka hōʻailona a me ka hana hana mai gram i ka kauoha nui o IDFP (615250-02-7), ma lalo o ke kānāwai CGMP a me ke kamepiula maikaʻi.

IDFP he huiʻanohosphorus ka mea nāna i kālua MAGL a me FAAH me nā IC50 o 0.8 a me 3 nM, ma muli o kēia .1 Ma 10 mg / kg, hoʻonui ka IDFP i ka nui o ka 2-AG a me ka AEA ma mua o 10, a emi iho ka nui o ka waichichikika like ka nui o keʻano. ʻO ka endocannabinoids,ʻo ka 2-arachidonoyl glycerol (2-AG) a me ka arachidonoyl ethanolamide (AEA), he lipid olaola e hoʻoponopono ai i nāʻano neurological a me nā hana i ka hopena ma ka hoʻololiʻana i nā hakepili cannabinoid, cannabinoid central (CB1) a me cannabinoid āpau (CB2). ʻO ka Monoacylglycerol lipase (MAGL) a me ka waikawa fatty amidehydrolase (FAAH) e hoʻoulu i ka 2-AG a me ka AEA, no laila e hoʻopau ai i kā lākou hana ola.

Product Description

ʻO ka wiki IDFP


I.IDFP nā Pūʻulu Pūʻulu:

Name: IDFP
CAS: 615250-02-7
Nā Kaulike Molecular: C15H32FO2P
Molecular Weight: 294.391
Wahi Manaʻo:
Hōʻoia Kōkua: -20 ° C
kala like 'ole:


II. Kaʻina IDFP

1.Names:

Nā inoa inoa: ISOPROPYL DODECYLFLUOROPHOSPHONATE
Synonym:
IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE; P-DODECYL-1-METHYLETHYL ESTER-PHOSPHONOFLUORIDIC ACID

2. Hoʻohana hoʻohana iā IDFP:

ʻO ka IDFP he mea organophosphorus e pili ana i ka sarinʻelele. E like me sarin, he mea hikiʻole ke hoʻololi i ka nezytransmitters, no ka mea,ʻo ka chain alyl length of IDFP ka mea i hoʻonāwaliwali loa i mea hoʻonāukiuki o ka acetylcholinesterase (AChE), me IC50 o 6300nM wale nō, oiai He mana hoʻokiʻekiʻe ia o nā enzymes monoacylglycerol lipase (MAGL), ka enzyme mua e hoʻopau ai i ka Xocuma-XINX-arachidonoylglycerol endocannabinoid (2-AG), a me ka waikawa fatty amide hydrolase (FAAH), ka enzyme mua e hoʻohaʻahaʻa ai i ka mea anandamide endocannabinoid nui . ʻO ka IC2 o IDFP he 50nM ma MAGL, a me 0.8nM ma FAAH. ʻO ka pāpāʻana o kēia mau enzymesʻelua e hoʻonui ana i ka nui o ka anandamide a me ka 3.0-AG ma ka lolo, e hiki ai ke hōʻailona hōʻailona cannabinoid a me nā hopena o ka hana cannabinoid maʻamau i nā haʻawina holoholona, ​​aʻo kona hemahema ma AChE,ʻaʻole ia e hōʻoia i nā hōʻailona choicergic [2 ] [1] [2] [3] Ma muli o konaʻano hana likeʻole i nā mea hana nerve i pāpāʻia,ʻo ka chain alyl length of IDFP ka mea e hāʻule ai ma waho o ka ho'ākāka o "nā meaʻawaʻawa" ma lalo o ka Convention Weapons Convention, [4] a mai ka manawa mai ʻAʻole ia e hōʻike i ka hanaʻana o AChE i nā pūhui organophosphorus e pili ana,ʻaʻole hiki ke hoʻohālikeʻia ka IDFP i nā mana hana likeʻole.

3.Wai keʻano o IDFP?

No ka mālamaʻana i ka wā lōʻihi, manaʻo mākou e mālama i ka IDFP e like me ka hāʻawiʻia i -20 ℃. Pono e kūpaʻa no ka makahiki hoʻokahi.
Hoʻomoheʻia ka IDFP e like me ka hopena ma ka methyl acetate. No ka hoʻololiʻana i ka mea pale, hoʻokuʻu wale i ka methyl acetate ma lalo o ke kahawai o ka hauʻona a hoʻololi koke i ka pa'ū o nā koho koho. E like me ke ethanol, DMSO, a me ka dimethyl formamide i hoʻomaʻemaʻeʻia me ka'ōmole inerā. ʻO ka solubility o ka IDFP ma kēia mau mea pale e like me 10mg / ml.
Inā makemakeʻia nā'eneke waikiki no nā hoʻokolohua olaola, hiki iā lākou ke hoʻomākaukau maikaʻiʻia ma ka diluʻuʻana i ka solvent organic i loko o ka mea kānana a me ka saline oototona.E hoʻomaopopo i ka nui o ke koena o keʻano o ka meaola, no ka mea, hiki i nā mea hoʻolālā kino ke loaʻa nā hopena physiological i nā haʻahaʻa haʻahaʻa. ʻaʻoleʻoe e'ōlelo i ke kākoʻo o ka waiwai aqueous no ka lā hoʻokahi.

4.How hoʻohana ka IDFP?

ʻO ka IDFP he mea hoʻoluhi hikiʻole ke hoʻololi i nā nezytransmitters, akā,ʻo ka chain alive lōʻihi o ka IDFP he palupalu ia e like me keʻano hōʻailona o ka acetylcholinesterase (AChE),ʻoiai he mea hana pono ia o nā enzymesʻelua monoacylglycerol lipase ( MAGL), ka enzyme mua e hoʻoponopono ai i ka 2-arachidonoylglycerol endocannabinoid (2-AG), a me ka waikawa momona amide hydrolase (FAAH), ka enzyme mua e hoʻohaʻahaʻa ai i ka mea'ē aʻe o ke anandamide mainendocannabinoid. ʻO ka mea organophosphorus ka mea hana i ka MAGL a me ka FAAH me nā IC50 o 0.8 a me 3 nM, ma kēia .1 Ma 10 mg / kg, hoʻonui ka IDFP i ka nui o ka 2-AG a me ka AEA ma mua o 10, a hoʻemi i ke kiʻekiʻe o ka waichidonic acid 10-hāmu.

5.Warning:

ʻAʻole kēia huahana no ka hoʻohanaʻana o ke kanaka a iʻole ka lāʻau ola, akā, e hoʻomanaʻo hou nei i ka loiloi. E mālama i ka pilina kūikawā me kaʻili, nā maka, ka'ōpū o ka'ōpū, nā pilikiaʻole, e kāhea koke i kāu kauka.

6.IDFP Māla Pāla:

ʻOiwi kauohaʻo 10grams.
Hiki ke hoʻouna i ka nīnau no ka mea maʻamau (Ma waena o 1kg) i nā hola 12 ma hope o ka uku.
No ke kauoha nui aku hiki ke hoʻokuʻuʻia i ka 3 mau lā hana ma hope o ka uku.

7.IDFP Pāʻani Pālolo Lā:

No ka nīnauʻana i ko mākou mea hōʻailona kōkua (CSR) no nā kiko'ī, no kāu'ōlelo.

8.IDFP Hoʻolālā:

E hoʻolakoʻia i ka wā e hiki mai ana.

9.Does kahi o ka IDFP i kekahi mauʻaoʻao?

ʻO ka medal medulla, i manaʻoʻia he mea koʻikoʻi no ka hoʻoponoponoʻana i ka paʻakai a me ka wai a me ke kaohiʻana i ke kaohi wā lōʻihi, ua hoʻonuiʻia i ka anandamide a meʻelua o kāna mau enzymes metabolizing nui, cyclooxygenase-2 (COX-2) a me kaʻaila momona amide hydrolase (FAAH) . ʻO ka waipū o anandamide (15, 30, a me 60 nmol · min-1 · kg-1) i loko o ka medal medulla o C57BL / 6J mice hoʻonāukiuki i nā diuresis a me ka paʻakai paʻakai i loko o ka COX-2- akā,ʻaʻole ke COX-1-kūpaʻa. No ka hoʻoholo inā loaʻa ka endocannabinoids hopena ma loko o ka medal medal, e like me ka hopena o ka intramedullary isopropyl dodecyl fluorophosphate (IDFP), e hoʻoneʻe ai i nā endocannabinoid hydrolases nui, i aʻoʻia. Ua hoʻopiʻi ka IDFP maʻamau i ka mea hoʻonui a me ka sodium excretion i loko o kahi COX-2- akā,ʻaʻole ka COX-1-i ka hilinaʻi. ʻAʻole nō ka anandamide a iʻole ka IDFP i hoʻopili i ka helu hoʻopili penihana. ʻAʻohe pūnaewele (0.625 mg · kg-1 · 30 min-1 iv)ʻaʻole intramedullary (15 nmol · min-1 · kg-1 · 30 min-1) Hōʻai'ē IDFP ma mua o ka anandamide intramedullary (15-30 nmol · min-1 · kg-1) ka hopena o ka anandamide, e'ōlelo anaʻaʻole pono ka waihīpī o ka anandamide no kona hana diuretic. ʻAʻole ka hopena o ka IDFP Intramedullary i ke kahe o ke koko akā hoʻoikaika i ke kahe o ke koko. ʻO nā hopena o ka IDFP ma ka'ōmiko a me ke kaheʻana o ke kalapona e pili ana iā FAAH e like me ka hoʻohanaʻana i nā mice FAAH knockout. ʻO kaʻikeʻana o ka nui o ka mīkini PGE2 o ka HPLC-electrospray ionization a me ka spectrometry kahe i hōʻikeʻia e ka emiʻana o ka IDFP i ka PGE2 urinary E kūlike kēia mauʻikepili me kahi hana FAAH a me ke anandamide e hana ana ma o ka metabolite COX-2 e hoʻoholo i diuresis a me ka haukale paʻakai ma ka ka mousekidney.


III. IDFP HNMR

ʻO mākou nā mea e hoʻopiliʻia ai ka momona, ka momona'āpana kūʻai, Raw Aprepitant Powder (170729-80-3) hplc≥98% | Nā R & D Hoʻokiʻekiʻe AASraw


IV. Pehea e kūʻai ai i IDFP mai AASraw?

1.E hōʻike mai iā mākou ma o mākou leka uilapūnaewele noiʻi, aiʻole skype pūnaeweleka hoʻonohonoho hoʻonohonoho kanaka (CSR).
2.Ke hāʻawi mai i kāu helu a me kāu helu wahi.
3.OUR CSR e hāʻawi iāʻoe i ka helu, ka manawa uku, helu helu, nā puka puka a me ka lā i hōʻea muaʻia (ETA).
4.E ukuʻia a hoʻokuʻuʻia nā waiwai i nā hola 12 (No ke kauoha ma loko o 10kg).
Ua loaʻaʻo 5.Goods a hāʻawi i nā manaʻo.


Eʻike i kāu moʻomanaʻo pūnaewele punahele:

Pehea e hoʻohana ai i ka Clenbuterol no ka pohō kaumaha He aha ka nandrolone kalo e hoʻohanaʻia no nā koina nandrolone?


Nāʻike hou aku e pili ana i nā huahana kūpono,pōmaikaʻi e kaomi maʻaneʻi.


=

Reviews

'Aʻohe hōʻike manaʻo hou.

E lilo i mua e nānā i "IDFP"

Ko oukou mail aae? E, aole e paʻiʻia. I kauoha ia mahinaʻai, ua hoailono aku la *

Captcha *