ʻO ka Isotretinoin ka pau

Isotretinoin Pauda wikiō-AASraw

Isotretinoin Pauda Nā Kiʻi Kumu

He aha ka Isotretinoin Powder?

ʻO Isotretinoin kahi lāʻau lapaʻau i hoʻohana ʻia e mālama i ka ʻeha nodular koʻikoʻi. Pono e hoʻohana wale ʻia inā ʻaʻole kōkua nā lāʻau ʻē aʻe a i ʻole nā ​​​​antibiotic i ke kōkua ʻana i ka haki. E like me ka mea i hoʻoholo ʻia e kāu kauka, hiki ke hoʻohana ʻia ka isotretinoin e mālama i nā maʻi ʻili ʻē aʻe.

ʻO Isotretinoin kahi lāʻau lapaʻau waha i ʻae ʻia e ka FDA e mālama i ka haki. Hoʻohana ʻia ia no ka mālama ʻana i ka ʻekene nodular koʻikoʻi i hiki ʻole ke pane aku i nā lāʻau ʻē aʻe a i ʻole nā ​​lāʻau lapaʻau. ʻO ka ʻekene nodular kahi ʻano o ka ʻeha ʻeha kahi i hana ʻia ai nā puʻupuʻu a me nā puʻupuʻu ma lalo o ka ʻili. Hiki ke hoʻohana ʻia ka Isotretinoin i waho-label no nā kūlana e like me ka ʻili ʻaila a me ka rosacea.

Hiki paha iā ʻoe ke lohe i ka isotretinoin Powder i ʻōlelo ʻia e nā inoa ʻē aʻe. ʻO Accutane kahi inoa inoa kaulana i loaʻa ʻole. Loaʻa ka Isotretinoin ma ke ʻano he lāʻau lapaʻau maʻamau a i ʻole ma lalo o kekahi mau inoa inoa e like me:

Absorica

Absorica LD

Amnesty

ʻO Claravis

Myorisan

Zenatan

ʻO ka Isotretinoin Powder kahi huaʻai A derivative. Hoʻohana ia ma ka hōʻemi ʻana i nā ʻili ʻaila o kou ʻili. Hiki iā ia ke kōkua i ka hoʻemi ʻana i ka nui o ka aila i hana ʻia e kou ʻili.

Pehea e hana ai ka Isotretinoin Powder?

Hoʻokumu ka Isotretinoin Powder i nā kumu kumu o ka haki. Hoʻokumu ʻia ka ʻeʻe ma muli o ka paʻa ʻana o kou ʻili me ka aila a me nā ʻili ʻili make, e hana ana i wahi kono no ka ulu ʻana o ka maʻi bacteria a ma hope e alakaʻi ai i kahi hopena inflammatory a me ke ʻano "zit" a i ʻole comedones.

Kōkua ʻo Isotretinoin Powder i ka mālama ʻana i ka huehue ma ka hōʻemi ʻana i ka ʻaila hinu (sebaceous glands), pale i nā pores clogged, hoʻemi i ka ulu ʻana o ka ʻili bacteria, a me nā hopena anti-inflammatory. I ka wā o ka mālama ʻana, hoʻemi pū ka Isotretinoin Powder i ka hana ʻaila (sebum). Hoʻomau ka hapa nui o ka poʻe i ka mālama ʻana a hiki i ka hemo ʻana o ko lākou haki; akā naʻe, loaʻa i kekahi poʻe ka hoʻi hou ʻana o ka haki a pono e hahai i kahi papa ʻelua o Isotretinoin Powder.

Pehea ka maikaʻi o ka Isotretinoin Powder no ka hakihaki?

Wahi a nā haʻawina, ma hope o 5 mau mahina o ka mālama ʻana, 80 a 90% o ka poʻe e ʻike i ka hoʻomaikaʻi ʻana o 95% i kā lākou helu inflammatory acne (Straus 1984). He aha ke ʻano o kēia?

No laila, inā he 20 mau wahi ʻeha (hoʻokiʻekiʻe a ʻulaʻula) ma ka maka i ka hoʻomaka ʻana o ka mālama ʻana, pono lākou e manaʻo e loaʻa iā ia he 1 a i ʻole 2 mau kiko ma ka hopena o 5 mau mahina.

Ma hope o 5 mau mahina o ka mālama ʻana, pono e manaʻo kekahi e loaʻa iā ia he 20 mau wahi hou i kēlā me kēia pule e loaʻa i 1 a i ʻole 2 mau wahi hou i kēlā me kēia pule.

ʻOiai e loaʻa i kekahi poʻe ka mana piha o ko lākou mau kiko, nui nā mea ʻē aʻe e loaʻa i kekahi manawa i ka wā e lawe ana i ka Isotretinoin Powder - akā ʻoi aku ka liʻiliʻi o kēia mau helu, liʻiliʻi, a pōkole ke ola. No ka hoʻonuiʻana i nā pono o ka Isotretinoin Powder, ponoʻoe e kūʻai mau i ka Isotretinoin Powder mai kahi mea hana kūpono. Nui nā Isotretinoin Powder no ke kūʻai aku ma ka pūnaewele, ʻaʻole maʻalahi ka loaʻa ʻana o kahi mea hoʻolako Isotretinoin Powder maikaʻi. Eia naʻe, mai kūʻai i nā huahana liʻiliʻi i mea e mālama ai i ke kālā. Inā makemake ʻoe e mālama i kekahi kumukūʻai, hiki iā ʻoe ke kūʻai nui aku i ka Isotretinoin Powder e loaʻa i kahi kumukūʻai maikaʻi aʻe.

imua o tknʻu

Pono nā poʻe maʻi i kahi papa lipid e nānā i kā lākou mau triglyceride a me nā triglycerides a me nā hoʻāʻo koko e hoʻoholo ai i kā lākou hana ate ma mua o ka hoʻomaka ʻana i ka lāʻau isotretinoin. Pono e lawe ʻia nā hoʻokolohua hāpai e nā wahine o ka makahiki hānau keiki. Hoʻoponopono hou ʻia kēia mau labs i ka wā o ka mālama ʻana, akā i ka mahina mua.

Ka pilikia o ka hānau ʻana

He kumu hoʻopaʻapaʻa nā hopena ʻaoʻao o ka lāʻau. ʻO ka Teratogenicity ka hopena ʻike a weliweli loa. Hōʻike kēia inā hoʻohana nā wahine i ka Isotretinoin Powder i ka wā hāpai, e hoʻoulu ai i ka hānau ʻana. ʻO ka Isotretinoin Powder ke kumu o ka hānauʻana i nā pōʻino i loko o ke kikowaena pūnaewele, ka maka, ka puʻuwai, a me ka thymus gland.

Ma hope o hoʻokahi mahina o ka lāʻau isotretinoin, hiki i ka wahine ke hāpai me ka makaʻu ʻole i ka hānau ʻana. ʻAʻohe hopena o ka Isotretinoin Powder i ka momona a paʻakikī paha i ka hāpai ʻana.

Isotretinoin Pauda side ehelehelena

I ka pau ʻana o nā koho ʻē aʻe a pau, ua hōʻoia ʻo Isotretinoin Powder i ka maikaʻi loa i ka mālama ʻana i ka haki. ʻAʻole pinepine nā kauka i ke kuhikuhi ʻana i ka isotretinoin ma muli o nā hopena koʻikoʻi i hiki ke loaʻa i kou kino. Eia naʻe, no ka mea ua aʻo maikaʻi ʻia ka Isotretinoin Powder, ʻike ʻia nā hopena ʻaoʻao āpau a hiki ke mālama ʻia. Inā hiki iā ʻoe ke kūʻai i ka huahana mai kahi mea hana Isotretinoin Powder hilinaʻi, hiki iā ia ke kōkua iā ʻoe e pale i nā hopena ʻaoʻao pono ʻole.

Nā hopena kino:

①ʻAneʻe hou aku

Aneane e hoʻomāinoino ʻia ka ʻekene i nā hana mua o ka mālama ʻana. ʻO ka lāʻau lapaʻau, ʻike ʻia ʻo ka hoʻomaʻemaʻe ʻana, e hoʻokuke aku i nā ʻili ʻili make a pau, ka aila, a me nā ʻōpala mai lalo o ka ʻili, e hoʻoulu ai i ka ʻeha a me ka nui o ka haki. E hoʻomaka ana ka ʻāʻī ma hope o ka pau ʻana o kēia hana.

②Kanaka paʻaka

Ke kāohi ʻo Isotretinoin Powder i ka hana ʻaila i loko o ka ʻili, lilo ia i maloʻo loa a hiki i ka ʻili, ʻili, a me ka ʻili. No ka hoʻoponopono ʻana i kēia, ʻōlelo ʻia kahi moisturizer ikaika.

③ʻIke Lā

E hoʻolilo ʻo Isotretinoin Powder i kou ʻili i kiʻi paʻi kiʻi. E ʻaʻahu i ka pale lā a pale aku i ka hoʻohana ʻana i nā mīkini hoʻomaʻemaʻe i loko.

④Lehelehe ʻAha

Eia hou, e ʻike ʻia ka hopena maloʻo o Isotretinoin Powder ma kou lehelehe. E mālama mau i ka Chapstick ma ka lima e pale i ke koko a me nā lehelehe mahā.

⑤ʻO Retinoid Dermatitis

I nā manawa kakaikahi, hiki i ka pauka isotretinoin ke hopena i ka ʻili ʻili. E kelepona i kāu kauka dermatologist inā loaʻa iā ʻoe ka maʻi dermatitis i hiki iā lākou ke ʻōlelo aku i kahi cream topical e mālama ai.

⑥ʻO ka Teratogenicity

No nā keiki i hānau ʻole ʻia, ʻo ka isotretinoin ka mea ʻino loa. Hiki ke hopena i ka hāʻule ʻana, ka hānau mua ʻana, a i ʻole ke ʻano o ka hānau ʻana. ʻO nā ʻino o ka hānau ʻana e hiki mai ana, ʻo ia hoʻi ka ʻāʻī ʻāʻī, nā kīnā o ka naʻau, nā pepeiao nalo, ka lohe ʻole, nā maka nalo, a me nā maka nalo. Inā he wahine ʻoe e ʻimi nei e hoʻomaka i ka mālama ʻana iā Accutane, pono ʻoe e hoʻohana i ka mana hānau a ʻaʻohe manaʻo e hāpai i ka wā e mālama ana. A he mea nui loa e kūʻai aku ʻoe i ka Isotretinoin Powder mai kahi mea hoʻolako hilinaʻi.

'Oʻonoʻo

①Headaches

Hiki i ka Isotretinoin Powder ke hoʻoikaika i kou lolo e hiki ke alakaʻi i ke poʻo poʻo, dizziness, blurred vision, a me ka luhi.

②Hiki ke hoʻololi i ka loli

ʻIke kekahi mau maʻi i ka huhū, hopohopo, huhū, a me ke kaumaha i ka lawe ʻana i ka Isotretinoin Powder.

③kaumaha

I kekahi manawa, hōʻike kekahi mau maʻi i nā manawa kaumaha a i ʻole manaʻo suicidal. Inā hoʻomaka ʻoe e ʻike i nā loli koʻikoʻi i kou olakino noʻonoʻo, e kelepona koke i kāu kauka.

ʻO nā kumukūʻai o Isotretinoin Powder

ʻO kēia nā kumukūʻai e noʻonoʻo ai i ka wā e hoʻomaka ai i kahi papa o Isotretinoin. Hiki i kēia mau mea ke hāʻawi i kahi manaʻo koʻikoʻi o nā kumukūʻai:

ʻO ke kumukūʻai o ka lāʻau lapaʻau e hilinaʻi ʻia ma ke ʻano i kuhikuhi ʻia iā ʻoe. Hiki ke loaʻa kēia mai ka £35 i kēlā me kēia mahina no ka poʻe ma kahi haʻahaʻa haʻahaʻa a i ka £ 135 i kēlā me kēia mahina no ka poʻe ma kahi kiʻekiʻe. E ʻokoʻa ke kumukūʻai o nā lāʻau lapaʻau e like me ka ikaika o ka mākeke i ka manawa o kāu papa.

Inā loaʻa iā ʻoe ka ʻike waiwai i ka lawe ʻana iā Accutane (mea hana Isotretinoin Powder), hiki iā ʻoe ke hoʻāʻo e kūʻai i ka Isotretinoin Powder mai kahi mea hoʻolako pūnaewele. E kūʻai i ka Isotretinoin Powder i ka nui o ka kauoha hiki ke loaʻa ke kumu kūʻai maikaʻi.

Ke hoʻāʻo ʻoe e lawe i ka Isotretinoin Powder, he mea nui ia e hōʻoia i ke ʻano kūpono. Pono ʻoe e loaʻa i kekahi ʻike me ka poʻe ʻoihana.

Nā ʻōlelo aʻoaʻo koʻikoʻi

ʻAʻole pono nā maʻi e hāpai a hāpai paha i ka isotretinoin. He pilikia nui ka Isotretinoin no ka lilo ʻana o ka hāpai ʻana, ka hānau mua ʻana, ka make neonatal, a i ʻole nā ​​​​mea ʻino o ka hānau ʻana i ke keiki i hānau ʻole ʻia (nā pilikia kino i ka hānau ʻana).

Ua hoʻokumu ʻia ka papahana iPLEDGE e hōʻoia i ka hoʻohana ʻole ʻana o nā wahine hāpai i ka isotretinoin a ʻaʻole e hāpai nā wahine i ka hoʻohana ʻana i ka isotretinoin. ʻO nā maʻi āpau, me nā wahine hiki ʻole ke hāpai a me nā kāne, hiki ke loaʻa i ka isotretinoin wale nō inā i kākau inoa ʻia lākou me iPLEDGE, loaʻa iā lākou ka palapala kauoha mai ke kauka i kākau inoa ʻia iPLEDGE, a hoʻopau i ka palapala kauoha ma kahi lāʻau lapaʻau i hoʻopaʻa inoa ʻia iPLEDGE. ʻAʻole pono ke kūʻai ʻia ʻo Isotretinoin ma ka Pūnaewele.

He aha ka nānā ʻana e pono ai no ka mālama ʻana iā Isotretinoin?

Manaʻo ʻia kahi hoʻāʻo koko ma mua a i ka wā o ka mālama ʻana i ka isotretinoin. Nānā nā hoʻāʻo koko i ka helu koko, ka hana o ka ate, a me nā pae momona o ke koko (cholesterol a me triglycerides). Hiki i ka Isotretinoin ke hoʻonui i ka triglyceride (momona koko) a i ʻole nā ​​pilikia o ka hana ate ma nā hihia kakaʻikahi.

I nā wahine, hana ʻia kahi hoʻāʻo hāpai ma mua o ka mālama ʻana a hiki ke hana hou ʻia i kēlā me kēia manawa i ka wā o ka mālama ʻana.

Isotretinoin Pauda Hoike Hoao-HNMR

He aha ka HNMR a he aha ka HNMR spectrum e haʻi iā ʻoe? ʻO H Nuclear Magnetic Resonance (NMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā huila i loaʻa nā pūhui i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR e hoʻohālikelike i nā hale waihona puke spectral a i ʻole e kuhi pololei i ke ʻano kumu. Ke ʻike ʻia ke ʻano kumu, hiki ke hoʻohana ʻia ka NMR no ka hoʻoholo ʻana i ka conformation molecular i ka hopena a me ke aʻo ʻana i nā waiwai kino ma ka pae molekala e like me ka hoʻololi conformational, nā hoʻololi ʻana, ka solubility, a me ka diffusion.

Isotretinoin pauka(4759-48-2)-COA

Isotretinoin pauka(4759-48-2)-COA

Pehea e kūʻai Isotretinoin Pauda mai AASraw?

❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu WhatsApp, e hoʻopili aku kā mākou mea kūʻai aku (CSR) iā ʻoe i nā hola 12.

❷E hāʻawi iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.

❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala lawe, a me ka lā i manaʻo ʻia e hiki mai ai (ETA).

❹Hoʻopau ʻia ka uku a hoʻouna ʻia nā waiwai i nā hola 12.

❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.

Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine

Mea kākau moʻolelo puke moʻolelo ʻepekema:
1. Matthew T. Taylor BA
Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania
2. E. Mahé
Service de dermatologie et médecine vasculaire, Hôpital Victor-Dupouy, 69 rue du Lieutenant-Colonel-Prud'hon, 95107 Argenteuil, Palani
3. Khalaf Kridin MD PhD
Lűbeck Institute of Experimental Dermatology, Kulanui o Lübeck, Lübeck, Kelemānia
4. Ethan D. Borre
Keʻena ʻepekema Ola Ola, Duke University School of Medicine, Durham, North Carolina, USA
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.

E hoʻomaopopo '

[1] Huang YC, Cheng YC. "Hoʻomaʻamaʻa Isotretinoin no ka haki a me ka pilikia o ke kaumaha: He loiloi ʻōnaehana a me ka meta-analysis." J Am Acad Dermatol. 2017 Iun;76(6):1068-1076.e9. doi: 10.1016/j.jaad.2016.12.028. Epub 2017 Mar 11. PMID: 28291553

[2] Polokalamu iPLEDGE, Loaʻa hope loa iā Kekemapa 2021.

[3] Lee SY, Jamal MM, et al. "Ke hoʻonui nei paha ka ʻike ʻana i ka isotretinoin i ka pilikia no ka ulu ʻana o ka maʻi ʻeha? He meta-analysis. Eur J Gastroenterol Hepatol. 2016 Feb;28(2):210-6.

[4] Racine A, Cuerq A, et al. "Isotretinoin a me ka pilikia o ka maʻi ʻeha o ka ʻōpū: kahi haʻawina ʻāina Farani." Am J Gastroenterol. 2014;109(4):563-9.

[5] Rashtak S, Khaleghi S, et al. "Ka hōʻike ʻana o Isotretinoin a me ka pilikia o ka maʻi ʻeha ʻeha." JAMA Dermatol. 2014;150(12):1322-6.

[6] Lee YH, Scharnitz TP, Muscat J, Chen A, Gupta-Elera G, Kirby JS. "Ka nānā ʻana o ka Laboratory i ka wā o ka Isotretinoin Therapy for Acne: He Systematic Review and Meta-analysis." JAMA Dermatol. 2016 Jan;152(1):35-44. doi: 10.1001/jamadermatol.2015.3091. PMID: 26630323

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