Product Description
1. J147 Powder wikiō-AASraw
2. J147 Powder Nā Kiʻi Kumu
| Name: | ʻO J 147 ka pauma |
| CAS: | 1146963-51-0 |
| Kaulike Molecular: | C18H17F3N2O2 |
| Kaumaha Molecular: | 350.3349896 |
| Wahi Manaʻo: | 177-178 ° C |
| Hōʻoia Kōkua: | 4 ° C |
| kala like 'ole: | Paleʻeleʻele aʻeleʻele paha |
He aha ka J147 Powder?
ʻO ka pauka J147 kahi mea hoʻoheheʻe synthetic o curcumin, kahi ʻāpana o ka curry spice turmeric. ʻO ka J147 Powder he Curcumin a me Cyclohexyl-Bisphenol A (CBA) derivative ʻo ia ka neurogenic a me ka neuroprotective.
Ua hōʻike ʻia ʻo J147 Powder i ka hoʻomaikaʻi maikaʻi ʻana i ka hōʻino cognitive i nā maʻi maʻi Alzheimer kahiko. Hoʻokumu ʻia kēia mau ʻike i nā hiʻohiʻona holoholona ʻelemakule wikiwiki. ʻO ka J147 Powder kahi lāʻau neurotrophic waha e hoʻohuli i ka hōʻino naʻau.
ʻO Curcumin kahi polyphenol i loaʻa i loko o ka turmeric a me ka ginger.
He nui nā pōmaikaʻi i hōʻike ʻia e Curcumin i ka mālama ʻana i nā maʻi like ʻole, akā naʻe aia nā palena ma muli o kona nāwaliwali hiki ke hele i ke koko-Brain Barrier (BB).
Hiki i ka J147 ka pauka ke hele i ka BBB i loko o ka lolo (ikaika) a hoʻoulu i ka hana ʻana o ka neuronal stem cell.
ʻO ka pauka J147, ʻaʻole like me nā lāʻau lapaʻau o ka maʻi Alzheimer o kēia manawa, ʻaʻole ia he acetylcholinesterase inhibitor a ʻaʻole hoʻi he inhibitor phosphodiesterase, akā hoʻomaikaʻi ia i ka cognition me kahi mālama pōkole.
Ke kaulana nei kēia nootropic ma ke ʻano he lapaʻau no ka maʻi o Alzheimer. Ua loaʻa pū i ka J-147 Powder ka hoihoi o nā mea hoʻohana olakino ma muli o kona hiki ke hoʻonui i ka hoʻomanaʻo, hoʻonui i ka hiki ke aʻo, a me ke olakino lolo holoʻokoʻa. ʻO ka mea hoʻohana e ʻimi nei i ke kūʻai ʻana i ka pauka J147, pono e kūʻai me ka mea hana mua, i hiki iā ʻoe ke kiʻi i ka hale kūʻai J-147 pauka uku e mālama i ke kālā.
Pehea ka hana a J-147?
ʻAʻole ʻike ʻia ka hopena o J-147 i nā cell a hiki i ka Salk Institute neurobiologists i hoʻoponopono i ka puzzle ma 2018. Hana ʻo J-147 ma ka hoʻopaʻa ʻana i ka ATP synthase. Mālama kēia pūmua mitochondrial i ke kaʻina hana kahiko ma o ka hoʻololi ʻana i ka hana o ka ikehu cellular. ʻO ka heleʻana o ka J-147 Powder i loko o ka pūnaewele kanaka e pale i nā meaʻawaʻawa e pili ana i ka makahiki i hanaʻia e ka mitochondria dysfunctional a me ka hoʻonuiʻana i ka ATP.
ʻO ka hana o ka hana a J-147 Powder e hoʻonui i nā pae o nā neurotransmitters like ʻole e like me NGF a me BDNF. Eia kekahi, hoʻemi ia i nā pae beta-amyloid, i hoʻokiʻekiʻe mau ʻia i nā maʻi maʻi Alzheimer a me dementia. ʻO nā hopena J-147 ka hoʻemi ʻana i ka piʻi ʻana o ka maʻi o Alzheimer, ka hoʻohaʻahaʻa ʻana i ka nalowale hoʻomanaʻo, a me ka hoʻonui ʻana i ka hana ʻana o nā cell neuronal.
Ua mālama ʻia kekahi mau haʻawina me J-147 Powder i nā ʻiole. Ua hoʻokō ʻia kahi hoʻokolokolo kanaka ma 2020, akā naʻe, ʻaʻole i hōʻike ʻia nā hopena piha.
maika of J147 Pauda
①Hoʻonui i ka hana Mitochondrial A ʻO ke ola manawa
He mea maikaʻi loa ka J147 Powder i ka hōʻemi ʻana i ke kaumaha oxidative a me ka hoʻonui ʻana i ka hana mitochondrial.
No ka laʻana, hoʻonui ka J147 Powder i ka hana mitochondrial ma ka hoʻomaikaʻi ʻana i nā pae ATP (inhibiting ATP synthase, kikoʻī ATP5A).
Hiki i ka J147 Powder ke hoʻemi i nā metabolites ʻino e alakaʻi ai i ka excitotoxicity ma ke kāohi ʻana i ka ATP synthase.
Ma kahi pae biochemical, hoʻolaha kēia i ka mitochondria ʻōpio / olakino (ma ka hoʻololi ʻana i ke ala AMPK/mTOR).
② Kāohi i ka maʻi o Alzheimer
Hoʻōla ʻo J147 Powder i ka hōʻino ʻana i ka naʻau i loko o kahi kumu ʻiole maʻi Alzheimer (AD).
Hiki i ka J147 Powder ke hoʻoikaika i ka metabolism Amyloid-Beta (A) a hoʻemi i nā pae i ka lolo ma ka hoʻohaʻahaʻa -Secretase protein pae (BACE).
Hiki i ka J147 Powder ke pale i ka homeostasis permeability BBB a hoʻomaikaʻi i ka hana vascular i nā ʻano holoholona o ka maʻi o Alzheimer.
Hiki i ka J147 Powder ke hoʻonui nui i nā pae Docosahexaenoic Acid (DHA) i ka lolo.
Hiki iā ia ke kōkua i ka hoʻihoʻi ʻana i nā pae Glutamate i ka lolo (i hana ʻia mai ka TCA intermediate -ketoglutarate).
③Hoʻomaikaʻi i ka hoʻomanaʻo
Hoʻomaikaʻi ia i ka cognition i nā ʻiole maʻi Alzheimer a me nā hiʻohiʻona holoholona maʻamau.
Hiki i ka J147 Powder ke hoʻihoʻi i nā hemahema cognitive koʻikoʻi i nā hiʻohiʻona holoholona kahiko loa.
Hiki iā J-147 ke kōkua me ka hoʻomanaʻo spatial a me ka Long-Term Potentiation (LTP).
④Ulu lolo
Hiki i ka J 147 Powder ke hoʻonui a hoʻoulu i ka synaptic plasticity i ka lolo.
Hoʻokumuʻo J 147 Powder i ka synaptic plasticity ma ka mālamaʻana i ka'ōlelo Synaptophysin (kahi protein synaptic vesicle i ho'ēmiʻia i kaʻelemakule a me AD a ua manaʻoʻia he biomarker no ka poho synapse).
Hoʻonui ka J-147 Powder i ka ulu o ka lolo ma o ka hoʻonui ʻana i nā pae o ka Nerve Growth Factor (NGF) a me Brain-Derived Neurotrophic Factor (BDNF) (BDNF).
⑤Mālama i nā Neurons
ʻAʻole koi ʻo J 147 Powder i ka BDNF i neuroprotective.
Mālama pū ka J 147 Powder i nā neurons mai ka glutathione (GSH) deficiency.
Mālama ʻo J-147 Powder i ka lolo mai ka nele o ka glucose.
I loko o ka lolo AD, 5-Lipoxygenase (5-LOX) e hoʻoulu hou i nā cell immune e hoʻoulu i kahi pane inflammatory, a ʻo Heme Oxygenase 1 (HO-1) hana ma ke ʻano he pro-oxidant ma mua o ka antioxidant.
Hiki i ka Curcumin derivative J147 Powder ke hoʻohaʻahaʻa i nā pae HO-1 a me ke kāohi ʻana i ka 5-LOX.
⑥Hiki ke hoʻomaikaʻi i ka maʻi diabetes
I nā hiʻohiʻona holoholona, ua hōʻike ʻo J147 Powder i ka emi ʻana o ke koko Glucose a me ka pae HbA1c ma ka hoʻonui ʻana i ka AMPK.
ʻOiai ʻaʻole koʻikoʻi, hiki i ka J147 Powder ke hoʻonui i ka hana o ke koena beta cell i ka maʻi diabetes.
⑦Paipai i ka ʻeha a me ka neuropathy
Ua hōʻoia ʻia ʻo J-147 Powder i ka mālama ʻana i ka Diabetic Neuropathy i kahi ʻano holoholona me ka maʻi diabetes type 1.
Hiki ke kōkua i ka hōʻemi ʻana i ka maʻi diabetes-induced motor nerve dysfunction, peripheral sensitivity, a me nā pae ʻeha.
⑧ Hiki ke hoʻomaikaʻi i ka hopohopo
Hiki i ka J147 Powder ke hōʻemi i nā pae hopohopo.
Ua hiki iā J147 Powder ke hōʻemi i nā pae hopohopo i ka wā o nā hoʻokolohua maze i nā ʻano holoholona me AD.
J147 Pauda dose a ahu iho
Ua hoʻohana nā haʻawina ʻokoʻa i nā lāʻau ʻokoʻa ma nāʻiole, akā ʻo kekahi o nā loiloi i loiloi hou ʻia i hāʻawi ʻia nāʻiole 10 mg / kg o ke kaumaha o ke kino i kēlā me kēia lā. Ua hoʻohana ʻia kahi noiʻi ʻē aʻe i nā lāʻau ʻana o 1, 3 a i ʻole 9 mg / kg, a loaʻa nā hopena pili i ka lāʻau, me nā dute ʻoi aku ka maikaʻi.
Eia nō naʻe, ʻo ka unuhi ʻana i kēia i nā mea hana kanaka e pono ai e hoʻoponopono no ka ʻilikai o ka ʻili. Wahi a ke ʻano hoʻololi hoʻololi i hoʻohana mau ʻia, pono ka mahele lāʻau like kanaka me ka mahele o ka ʻiole i hoʻokaʻawale ʻia e 12.3 – a i ʻole .81 mg i kg o ke bodyweight o ka lā.
E ʻike ʻia kekahi o nā pōmaikaʻi ke hoʻomaka ʻoe e hoʻohana. ʻOiai me ka lāʻau lapaʻau pōkole, loaʻa ʻo J-147 i nā hopena antidepressant-like wikiwiki i nā ʻiole ma kahi o 3 mau lā me ka hoʻokumu ʻole ʻana i ka lāʻau lapaʻau a i ʻole ka hoʻonui ʻana i ka cognition. Nui nā J147 Powder no ke kūʻai aku ma ka pūnaewele, he mea nui e kūʻai i ka huahana maoli a kiʻekiʻe. Hiki iā ʻoe ke kūʻai aku iā J147 Powder Wholesale me ka mea hoʻolako AASRAW.
ʻAʻole kaulana ʻo J147 i waena o nā poʻe olakino no ka lōʻihi no mākou e ʻōlelo wiwo ʻole i nā waihona. ʻAʻole hiki i nā nootropics a pau ke 'hui a hoʻohālikelike' me ka palekana.
J147 Pauda hkanaka trials and user experiences
Ua hoʻopaʻa inoa ʻia ka noiʻi kanaka J147 Powder mua a ua manaʻo ʻia e hoʻopau ʻia i ka makahiki 2020. Ua ʻike ʻia ua hana ʻia ma ke ʻano he 1 hoʻokolohua ma 64 mau kānaka olakino, me ka pahuhopu nui o ka nānā ʻana i ka palekana a me nā pharmacokinetics (half-life, side nā hopena, nā kiko kiko) o J147 Powder, ma mua o kona pono i ka mālama ʻana i kekahi ʻano.
ʻOiai ʻaʻole i hoʻolaha ʻia nā ʻike o kēia noiʻi ʻana, ʻike mākou ua ʻike ʻia ua hoʻopau ʻia me ka pilikia ʻole.
ʻOiai ʻo J147 Powder kahi mea noiʻi noiʻi a ua kūkākūkā ʻia ma nā kaiāulu nootropics, ʻaʻole i nui nā hōʻike mea hoʻohana i hāʻawi ʻia a hiki i kēia manawa, a nui ka poʻe e kali nei e ʻike hou aʻe ma mua o ka hoʻohana ʻana. Wahi a nā mea hoʻohana o J-147 Powder, He mea maʻalahi ke kūʻai aku i ka pauka J147 ma ka pūnaewele, e loaʻa ana kahi mea kūʻai aku ʻo J147 Powder i kekahi mau manawa. Hāʻawi ka mea hoʻolako AASRAW i ka pauka J-147 kiʻekiʻe. Inā hana ʻoe i nā mea hoʻohui J-147, hiki iā ʻoe ke kūʻai i ka J147 Powder bulk e hauʻoli i ke kumukūʻai maikaʻi.
ʻAʻole ʻike ka hapa nui o ka poʻe i nā hopena i ʻike ʻia mai nā ʻike mea hoʻohana liʻiliʻi i hōʻike ʻia. ʻOiai ʻoi aku ka ʻōpio a me ke olakino o nā mea hoʻohana a ʻoi aku ka pōkole o ka manawa o ka hoʻohana ʻana ma mua o nā haʻawina, ʻaʻole i loaʻa i ka curcumin derivative J147 Powder nā hopena nootropic koʻikoʻi i nā ʻōpio olakino.
Hiki iā mākou ke hana i nā manaʻo hoʻonaʻauao e pili ana i ka pono o ka J147 Powder i ka nele o ka noiʻi kanaka a i ʻole nā anecdotes kaulana. Ma ke kumumanaʻo, ʻo nā mea a pau e hoʻonui ai i ka ikehu neuronal pono e loaʻa nā hopena nootropic, akā naʻe, ʻaʻole i kaupalena ʻia kāu hana cognitive e ka hoʻohana ʻana i ka ikehu. Hiki ke hilinaʻi i ka hikiwawe o nā meaʻai ke komo a puka i waho o kou lolo a i ʻole ka maikaʻi o kou mau manaʻo.
ʻO ka Curcumin derivative J147 Powder hoʻi e hoʻopuka i nā mea neurotrophic nui aʻe, ʻo ia ka mea hiki ke kōkua i kou lolo e hoʻomohala i nā synapses a me nā cell lolo. Akā, e hoʻomanaʻo i hiki ke hoʻonui i nā synapses a me nā cell lolo.
ʻAʻohe kumu e manaʻoʻiʻo ai e loaʻa i ka J147 Powder ka hopena nootropic koʻikoʻi i nā ʻōpio, nā mākua olakino. No ka poʻe i loaʻa i ka dementia, ʻoi aku ka maikaʻi. I nā poʻe ʻelemakule liʻiliʻi i ʻike e holo ana ka dementia i loko o ko lākou ʻohana, hiki ke kōkua ʻia ma ke ʻano he nootropic no ka mea hiki ke hoʻōki a hoʻohuli paha i ka nalo cognitive ma mua o ka ulu ʻana i ka dementia clinical. ʻO kēlā me kēia hihia, e liʻiliʻi ka manawa ma mua o ka maopopo ʻana.
ʻO J-147 Pauda risks a side ehelehelena
Ua nānāʻia ka J147 Powder a uaʻikeʻia he palekana no ka hoʻohana lōʻihi e nā labs kūʻokoʻa. Ua hala i ka ho'āʻo toxicological i nā noiʻi holoholona i koi ʻia e ka Food and Drug Administration (FDA), a ʻaʻohe hopena maikaʻi ʻole i kākau ʻia i loko o ke kanaka ke lawe ʻia ma ke ʻano i ʻōlelo ʻia (e kūkākūkā ʻia ma hope).
kahi e kūʻai aku i ka pauka J-147?
Ke hoʻopaʻapaʻa ʻia nei ke kānāwai o kēia nootropic, akā ʻaʻole ia e pale iā ʻoe mai ke kūʻai ʻana i nā mea kūpono. Ma hope o nā mea a pau, ke hoʻomaka nei nā hoʻokolohua lapaʻau no J-147 Alzheimer. Hiki iā ʻoe ke kūʻai i ka pauka mai nā hale kūʻai pūnaewele mai hiki iā ʻoe ke hoʻohālikelike i nā kumukūʻai J-147 Powder mai nā mea kūʻai aku. Eia nō naʻe, pono ʻoe e mākaʻikaʻi a puni no kahi mea hana kaulana me ka hoʻāʻo ʻana i nā keʻena kūʻokoʻa.
Inā makemake ʻoe i kahi J-147 Powder no ke kūʻai aku, e nānā me kā mākou hale hana. Hāʻawi mākou i kahi ākea o nā nootropics ma lalo o ka mana koʻikoʻi. Ma muli o kāu pahuhopu psychonautic, hiki iā ʻoe ke kūʻai i ka nui a i ʻole hoʻokahi. E hoʻomaopopo ʻoe, ʻoluʻolu ke kumukūʻai ʻo J-147 Powder ke kūʻai ʻoe i ka nui kūʻai nui.
J147 Powder Hoike Hoao-HNMR
He aha ka HNMR a He aha ka HNMR spectrum e haʻi aku iā ʻoe? ʻO H Nuclear Magnetic Resonance (NMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā hui pū ʻia i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR e hoʻohālikelike i nā hale waihona puke spectral a i ʻole e kuhi pololei i ke ʻano kumu. Ke ʻike ʻia ke ʻano kumu, hiki ke hoʻohana ʻia ka NMR no ka hoʻoholo ʻana i ka conformation molecular i ka hopena a me ke aʻo ʻana i nā waiwai kino ma ka pae molekala e like me ka hoʻololi conformational, nā hoʻololi ʻana, ka solubility, a me ka diffusion.
J-147 Pauka(1146963-51-0)-COA
Pehea e kūʻai J147 Powder mai AASraw?
❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu whatsapp iā mākou, e hoʻopili kā mākou mea kūʻai aku (CSR) me ʻoe i loko o 12 mau hola.
❷E hāʻawi mai iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.
❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala hoʻouna a me ka lā i manaʻo ʻia (ETA).
❹E uku ʻia a hoʻouna ʻia nā waiwai i loko o 12 mau hola.
❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.
Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine
Mea kākau moʻolelo puke moʻolelo ʻepekema:
1. Paul A. Lapchak
He kanaka ʻepekema a me ka mea noiʻi ma ke kahua o ka neurology a me ka noiʻi stroke.
2. David Schubert
ʻO ka Salk Institute for Biological Studies, Cellular Neurobiology Laboratory, La Jolla, Kaleponi, USA
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.
E hoʻomaopopo '
[1] Pan X, Chen L, Xu W, Bao S, Wang J, Cui X, Gao S, Liu K, Avasthi S, Zhang M, Chen R. nā hopena o J147. Hoʻoponopono i ka lolo. 2021 ʻAukake 6;411:113374. doi: 10.1016/j.bbr.2021.113374. Epub 2021 Mei 21. PMID: 34023306
[2] Li J, Chen L, Li G, Chen X, Hu S, Zheng L, Luria V, Lv J, Sun Y, Xu Y, Yu Y. Ma o 147-HT5A-Mediated cAMP Signaling. "Front Neurosci. 1 Iulai 2020;8:14. doi: 701/fnins.10.3389. eCollection 2020.00701.PMID: 2020
[3] ʻO Jin R, Wang M, Zhong W, Kissinger CR, Villafranca JE, Li G. "J147 Ho'ēmi i ka TPA-Induced Brain Hemorrhage in Acute Experimental Stroke in Rats."Front Neurol. 2022 Mar 2;13:821082. doi: 10.3389/fneur.2022.821082. eCollection 2022. PMID: 35309561
[4] Emmanuel IA, Olotu FA, Agoni C, Soliman MES. "I ka Silico Repurposing o J147 no ka Neonatal Encephalopathy Treatment: Ke ʻimi nei i nā Molecular Mechanisms of Mutant Mitochondrial ATP Synthase." Curr Pharm Biotechnol. 2020;21(14):1551-1566. doi: 10.2174/1389201021666200628152246. PMID: 32598251
[5] Lian L, Xu Y, Zhang J, Yu Y, Zhu N, Guan X, Huang H, Chen R, Chen J, Shi G, Pan J. 147-HT5A loaʻa. Neuropharmacology. 1 Iun;2018:135-506. doi: 513/j.neuropharm.10.1016. Epub 2018.04.003 Apr 2018. PMID: 5
