ʻO J 147 ka pauma

 

ʻO J 147 kaona wikiō

 

 

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Ka Raw J 147 kaomi mau mea Characters

 

Name:	ʻO J 147 ka pauma
CAS:	1146963-51-0
Kaulike Molecular:	C18H17F3N2O2
Kaumaha Molecular:	350.3349896
Wahi Manaʻo:	177-178 ° C
Hōʻoia Kōkua:	4 ° C
kala like 'ole:	Paleʻeleʻele aʻeleʻele paha

 

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Mālamaʻo Raw J 147 e hoʻonui i ka hana o ka lolo a me kahi wikiwiki hou aʻe

 

Nā inoa

ʻO J 147 ka pauma

 

J 147 (1146963-51-0) Nānā hoʻohana

Ke hoʻohana nei i kahi papa hana ʻike lāʻau no ka maʻi ʻo Alzheimer (AD) e pili ana i nā pathologies he nui o ka wā ʻelemakule, ua ʻike mākou i kahi hui pū me ka pono i ka hoʻomanaʻo rodent a me nā ʻano holoholona AD. ʻOiai ʻo kēia hui, ʻo J-147 pauma, he phenyl hydrazide, aia kahi hopohopo e hiki ke hoʻopili ʻia i nā amine / hydrazines ʻaʻaleʻa e carcinogenic paha. No ka ʻimi ʻana i kēia hiki, ua nānā mākou i nā metabolites o ka pauka J 147 i ka microsome kanaka a me ka iole a me ka plasma iole. Hōʻike ʻia ʻaʻole i hoʻopili ʻia ka pauma J-147 (1146963-51-0) i nā amine a me nā hydrazine ʻala, i kūpaʻa mau ʻia ka scaffold, a ʻo nā metabolites oxidative pū kekahi me neuroprotective. Hoʻoholo ʻia e hāʻawi ʻia nā metabolites nui o J 147 (1146963-51-0) pauka i kāna hana olaola i nā holoholona.
ʻO J 147, i loaʻa mai i ka curcumin mea ʻala curry, haʻahaʻa haʻahaʻa a hoʻohuli maoli i ka poino i nā neurons e pili ana me Alzheimer.

ʻO J 147 (1146963-51-0) ka pūmole mitochondrial i kapaʻiaʻo ATP synthase,ʻo ia hoʻiʻo ATP5A, kahi hapa o kēlā pūmua. Hoʻokomoʻia ka ATP synthase ma ka hanauna mitochondrial o ATP, kahi pūnaewele e hoʻohana ai no ka ike.

Ua hōʻike nā mea noiʻi ma ka hoʻohaʻahaʻaʻana i ka hana o ATP synthase, hiki iā lākou ke pale i nā pūnaewele neuronal mai kekahi mau maʻi e pili ana i kaʻelemakule o ka lolo. ʻO kekahi kumu no kēia hana neuroprotective i manaʻoʻiaʻo ka hopena o ka hopena i loko o ka pōʻino neuronal cell.

ʻO kaʻole ka hopena o ka hopena e hana ai i nā neurons a pepehiʻia e ka overactivation o nā leka uila no ka neurotransmitter glutamate excitation. E noʻonoʻo e like me ka hoʻololiʻana o ke kukui a hemo a hiki i ka pauʻana o ke kukui.

Ma muli koke iho nei, ua hōʻikeʻia ka hana o ATP synthase hana no ka neuroprotection e pili ana i ka pōʻino o nā mea e hoʻopukaʻia ai i kahi hoʻonaʻauaoʻoʻoleʻa [4]. ʻO ka lua o nā haʻawina i hōʻikeʻia ai nā hiʻohiʻona mouse e hōʻike ana i keʻano o ke kanakaʻano MAPPP 1 (hIF1), ka mea i hoʻomau i ke kāohiʻana o ATP synthase, uaʻoi aku ka ikaika o ka make ma hope o ka pōʻino excitotoxic. Ke kuhi nei kēiaʻikepili me kēia aʻo J 147 hou maʻemaʻe, kahi i hoʻonuiʻia ai ka IF1 ma nāʻiole i hoʻemiʻia ka hana o ATP synthase (ʻoiaiʻo ATP5A) a he neuroprotective.

 

Ka'ōlelo aʻoʻana ma luna o ka huhū J 147 pauma

Hōʻikeʻia nāʻikepili i hōʻikeʻia maʻaneʻi e hiki i kaʻehu J-147 ke hiki i ka hoʻopakeleʻana i nā hemahema iʻikeʻia i ka manawa hopena o ka maʻi. Hiki ke pilikinoʻia ka hikiʻana o ka mīkini J-147 i mea e hoʻonui ai i ka hoʻomanaʻoʻana i nā miole AD i hoʻohuiʻia i nā mea neurotropic NGF (ke kumu hānai nerve) a me ka BDNF (kekona neurotrophic factor) a me nāʻano proteins BDNF e pane mai ana he mea nui ia e aʻo ai a me ka hoʻomanaʻo. ʻO ka hoʻohālikelikeʻana ma waena o ka hanana J-147 (1146963-51-0) a me ka hanapezil i loko o ka model scopolamine ua hōʻikeʻoiai ua like nā mea likeʻelua i ka hoʻopakeleʻana i ka hoʻomanaʻo no ka wā liʻiliʻi, uaʻoi aku ka nui o ka pāʻani Spatial i ka hoʻopakeleʻana i ka hoʻomanaʻo spatial a me ka hui pūʻana o nā meaʻelua. maikaʻi loa no kaʻikepili o kaʻikepili a me kaʻike.

 

Nā kuhikuhi hou aku

ʻO ka maʻi o Alzheimer kahi maʻi o ka lolo e holomua, ua kohoʻiaʻo ia ke kumu nuiʻekolu o ka make maʻAmelika Huipūʻia a uaʻoi aku i ka elima milionaʻAmelika. ʻO ia ke kumu nui loa o ka diamentia i nā mākua, e like me nā National Institute of Health. ʻOiaiʻo nā lāʻau lapaʻau i hoʻouluʻia i nā 20 mau makahiki i hala iho nei, ke kau nei i ka waihona amyloid i loko o ka lolo (kahi hoʻomanaʻo o ka maʻi), he mau mea i hōʻoiaʻiʻoʻia ma ke keʻena.

"ʻOiaiʻo ka hoʻohanaʻana o nā lāʻau lapaʻau i nā makahiki 20 i hala iho nei, e kau ana i ka waihoʻana o ka amyloid plaque deposits ma ka lolo (kahi hoʻomanaʻo o ka maʻi),ʻaʻohe mea i hōʻoia maikaʻi ma ke keʻena kino," wahi a Schubert, ka mea kākau nui o ka noi.

I nā makahiki i hala aku nei, ua hoʻomakaʻo Schubert a me kona mau hoa e hoʻokō i ka maʻi mai kahi kihi hou. Ma mua o ka amyloid i hoʻoholoʻia, ua hoʻoholo kaʻawa e pale i ka pilikia nui no ka makahiki maʻi. Me ka hoʻohanaʻana i nā pale e pili ana i nā pūnaewele e pili ana i nā maʻi o ka loloho o kaʻelemakule, ua hōʻano hou lākou i ka paukū X XUMUM (147-1146963-51).

I ka wā ma mua, ua ʻike ka hui e hiki i ka pauka J-147 ke pale a pale i ka nalo ʻana o ka hoʻomanaʻo ʻana a me ka pathology o Alzheimer i nāʻiole i loaʻa kahi mana o ke ʻano hoʻoilina o ʻO Alzheimer's, ke kumu hoʻohālikelike iole i hoʻohana mau ʻia. Eia nō naʻe, ʻo kēia ʻano o ka maʻi ma kahi o ka 1 pākēneka wale nō o nā hihia Alzheimer. No nā mea ʻē aʻe āpau, ʻo ka ʻelemakule ka mea nui makaʻu, wahi a Schubert. Ua makemake ka kime e ʻimi i nā hopena o ka moho lāʻau i ka lāhui o nāʻiole i kēlā makahiki me ka wikiwiki a ʻike i kahi mana o dementia e like me ke ʻano o ka maʻi kanaka e pili ana i ka makahiki.

 

J 147 Kaheʻe Pow

ʻOiwi kauohaʻo 10grams.
Hiki ke hoʻouna i ka nīnau no ka mea maʻamau (Ma waena o 1kg) i nā hola 12 ma hope o ka uku.
No ka hoʻonohonoho nui (Ma waena o 1kg) hiki ke hoʻounaʻia i ka 3 workingdays ma hope o ka uku.

 

Raw J 147 kaheʻe Marketing

E hoʻolakoʻia i ka wā e hiki mai ana.

 

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Pehea e kūʻai ai i ka X XUMUM kalo mai AASraw

 

1.E hōʻike mai iā mākou ma o mākou leka uila ʻōnaehana nīnau, a i ʻole skype pūnaeweleka hoʻonohonoho hoʻonohonoho kanaka (CSR).
2.Ke hāʻawi mai i kāu helu a me kāu helu wahi.
3.OUR CSR e hāʻawi iāʻoe i ka helu, ka manawa uku, helu helu, nā puka puka a me ka lā i hōʻea muaʻia (ETA).
4.E ukuʻia a hoʻokuʻuʻia nā waiwai i nā hola 12 (No ke kauoha ma loko o 10kg).
Ua loaʻaʻo 5.Goods a hāʻawi i nā manaʻo.

 

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