ʻO J 147 ka pauma

1. J147 Powder wikiō-AASraw

J147 Powder Nā Kiʻi Kumu

He aha ka J147 Powder?

ʻO ka pauka J147 kahi mea hoʻoheheʻe synthetic o curcumin, kahi ʻāpana o ka curry spice turmeric. ʻO ka J147 Powder he Curcumin a me Cyclohexyl-Bisphenol A (CBA) derivative ʻo ia ka neurogenic a me ka neuroprotective.

Ua hōʻike ʻia ʻo J147 Powder i ka hoʻomaikaʻi maikaʻi ʻana i ka hōʻino cognitive i nā maʻi maʻi Alzheimer kahiko. Hoʻokumu ʻia kēia mau ʻike i nā hiʻohiʻona holoholona ʻelemakule wikiwiki. J147 He waha waha ka pauda lāʻau neurotrophic ikaika e hoʻohuli i ka pōʻino o ka naʻau.

ʻO Curcumin kahi polyphenol i loaʻa i loko o ka turmeric a me ka ginger.

He nui nā pono i hōʻike ʻia ʻo Curcumin i ka mālama ʻana i nā maʻi like ʻole, akā naʻe, aia nā palena ma muli o kona nāwaliwali hiki ke hele i ka Blood-Brain Barrier (BB).

Hiki i ka J147 ka pauka ke hele i ka BBB i loko o ka lolo (ikaika) a hoʻoulu i ka hana ʻana o ka neuronal stem cell.

ʻO ka pauka J147, ʻaʻole like me nā lāʻau lapaʻau o ka maʻi Alzheimer o kēia manawa, ʻaʻole ia he acetylcholinesterase inhibitor a ʻaʻole hoʻi he inhibitor phosphodiesterase, akā hoʻomaikaʻi ia i ka cognition me kahi mālama pōkole.

Ke kaulana nei kēia nootropic ma ke ʻano he lapaʻau no ka maʻi o Alzheimer. Ua loaʻa pū ʻo J-147 Powder i ka hoihoi o nā mea hoʻohana olakino ma muli o kona hiki ke hoʻonui i ka hoʻomanaʻo, hoʻonui i ka hiki ke aʻo, a me ke olakino lolo holoʻokoʻa. ʻO ka mea hoʻohana e ʻimi nei e kūʻai iā J147 Powder e kūʻai me ka mea hana mua i hiki iā lākou ke kiʻi i ka hale kūʻai J-147 pauka kumukūʻai e mālama i ke kālā.

Pehea ka hana a J-147?

ʻAʻole ʻike ʻia ka hopena o J-147 i nā cell a hiki i ka Salk Institute neurobiologists i hoʻoponopono i ka puzzle ma 2018. Hana ʻo J-147 ma ka hoʻopaʻa ʻana i ka ATP synthase. Mālama kēia pūmua mitochondrial i ke kaʻina hana kahiko ma o ka hoʻololi ʻana i ka hana o ka ikehu cellular. ʻO ka heleʻana o ka J-147 Powder i loko o ka pūnaewele kanaka e pale i nā meaʻawaʻawa e pili ana i ka makahiki i hanaʻia e ka mitochondria dysfunctional a me ka hoʻonuiʻana i ka ATP.

ʻO ka hana o ka hana a J-147 Powder e hoʻonui i nā pae o nā neurotransmitters like ʻole e like me NGF a me BDNF. Eia kekahi, hoʻemi ia i nā pae beta-amyloid, i hoʻokiʻekiʻe mau ʻia i nā maʻi maʻi Alzheimer a me dementia. ʻO nā hopena J-147 ka hoʻemi ʻana i ka piʻi ʻana o ka maʻi o Alzheimer, ka hoʻohaʻahaʻa ʻana i ka nalowale hoʻomanaʻo, a me ka hoʻonui ʻana i ka hana ʻana o nā cell neuronal.

Ua mālama ʻia kekahi mau haʻawina me J-147 Powder i nā ʻiole. Ua hoʻokō ʻia kahi hoʻokolokolo kanaka ma 2020, akā naʻe, ʻaʻole i hōʻike ʻia nā hopena piha.

maika of J147 Pauda

①Hoʻonui i ka hana Mitochondrial A ʻO ke ola manawa

J147 He maikaʻi loa ka pauka i ka hōʻemi ʻana i ke kaumaha oxidative a me ka hoʻonui hana mitochondrial.

No ka laʻana, hoʻonui ka J147 Powder i ka hana mitochondrial ma ka hoʻomaikaʻi ʻana i nā pae ATP (inhibiting ATP synthase, kikoʻī ATP5A).

Hiki i ka J147 Powder ke hoʻemi i nā metabolites ʻino e alakaʻi ai i ka excitotoxicity ma ke kāohi ʻana i ka ATP synthase.

Ma kahi pae biochemical, hoʻolaha kēia i ka mitochondria ʻōpio / olakino (ma ka hoʻololi ʻana i ke ala AMPK/mTOR).

② Kāohi i ka maʻi o Alzheimer

J147 Hoʻōla ka pauka i ka hōʻino ʻana i ka naʻau ma kahi Alzheimer kumu hoʻohālike ʻiole maʻi (AD).

Hiki i ka J147 Powder ke hoʻoikaika i ka metabolism Amyloid-Beta (A) a hoʻemi i nā pae i ka lolo ma ka hoʻohaʻahaʻa -Secretase protein pae (BACE).

Hiki i ka J147 Powder ke pale i ka homeostasis permeability BBB a hoʻomaikaʻi i ka hana vascular i nā ʻano holoholona o ka maʻi o Alzheimer.

J147 Hiki i ka pauda ke hoʻonui nui i ka Docosahexaenoic Acid (DHA) pae ma ka lolo.

Hiki iā ia ke kōkua i ka hoʻihoʻi ʻana i nā pae Glutamate i ka lolo (i hana ʻia mai ka TCA intermediate -ketoglutarate).

③Hoʻomaikaʻi i ka hoʻomanaʻo

Hoʻomaikaʻi ia i ka cognition i nā ʻiole maʻi Alzheimer a me nā hiʻohiʻona holoholona maʻamau.

Hiki i ka J147 Powder ke hoʻihoʻi i nā hemahema cognitive koʻikoʻi i nā hiʻohiʻona holoholona kahiko loa.

Hiki iā J-147 ke kōkua me ka hoʻomanaʻo spatial a me ka Long-Term Potentiation (LTP).

④Ulu lolo

Hiki i ka J 147 Powder ke hoʻonui a hoʻoulu i ka synaptic plasticity i ka lolo.

Hoʻokumuʻo J 147 Powder i ka synaptic plasticity ma ka mālamaʻana i ka'ōlelo Synaptophysin (kahi protein synaptic vesicle i ho'ēmiʻia i kaʻelemakule a me AD a ua manaʻoʻia he biomarker no ka poho synapse).

ʻO J-147 Hoʻoikaika ka pauka i ka ulu ʻana o ka lolo ma ka hoʻonui ʻana i nā pae o Nerve Growth Factor (NGF) a me Brain-Derived Neurotrophic Factor (BDNF) (BDNF).

⑤Mālama i nā Neurons

ʻAʻole koi ʻo J 147 Powder i ka BDNF i neuroprotective.

Mālama pū ka J 147 Powder i nā neurons mai ka glutathione (GSH) deficiency.

Mālama ʻo J-147 Powder i ka lolo mai ka nele o ka glucose.

I loko o ka lolo AD, 5-Lipoxygenase (5-LOX) e hoʻoulu hou i nā cell immune e hoʻoulu i kahi pane inflammatory, a ʻo Heme Oxygenase 1 (HO-1) hana ma ke ʻano he pro-oxidant ma mua o ka antioxidant.

Hiki i ka Curcumin derivative J147 Powder ke hoʻohaʻahaʻa i nā pae HO-1 a me ke kāohi ʻana i ka 5-LOX.

⑥Hiki ke hoʻomaikaʻi i ka maʻi diabetes

I nā hiʻohiʻona holoholona, ​​ua hōʻike ʻia ʻo J147 Powder e hoʻemi i ka pae koko Glucose a me HbA1c ma o ka hoʻonui ʻana i ka AMPK.

ʻOiai ʻaʻole koʻikoʻi, J147 Hiki ke hoʻonui i ka pauka ka hana o ke koena beta cell i ka maʻi diabetes.

⑦Paipai i ka ʻeha a me ka neuropathy

Ua hōʻike ʻia ʻo J-147 pauda i ka pono ka mālama ʻana i ka Diabetic Neuropathy i kahi ʻano holoholona me ke ʻano 1 diabetes.

Hiki ke kōkua i ka hōʻemi ʻana i ka maʻi diabetes-induced motor nerve dysfunction, peripheral sensitivity, a me nā pae ʻeha.

⑧ Hiki ke hoʻomaikaʻi i ka hopohopo

Hiki i ka J147 Powder ke hōʻemi i nā pae hopohopo.

J147 Ua hiki i ka pauda ke hoʻemi i nā pae hopohopo i ka wā o nā hoʻāʻo maze i nā hiʻohiʻona holoholona me AD.

J147 Pauda dose a ahu iho

Ua hoʻohana nā haʻawina ʻokoʻa i nā lāʻau ʻokoʻa ma nāʻiole, akā ʻo kekahi o nā loiloi i loiloi hou ʻia i hāʻawi ʻia nāʻiole 10 mg / kg o ke kaumaha o ke kino i kēlā me kēia lā. Ua hoʻohana ʻia kahi noiʻi ʻē aʻe i nā lāʻau ʻana o 1, 3 a i ʻole 9 mg / kg, a loaʻa nā hopena pili i ka lāʻau, me nā dute ʻoi aku ka maikaʻi.

Eia nō naʻe, ʻo ka unuhi ʻana i kēia i ke ʻano o ke kanaka pono e hoʻoponopono i ka ʻili o ke kino. Ma muli o ke kumu hoʻololi maʻamau i hoʻohana ʻia, pono e like ka nui o ke kanaka me ka nui o ka ʻiole i puʻunaue ʻia e 12.3–a i ʻole .81 mg no ke kilo o ke kaumaha o ke kino i kēlā me kēia lā.

E ʻike ʻia kekahi o nā pōmaikaʻi ke hoʻomaka ʻoe e hoʻohana. ʻOiai me ka lāʻau lapaʻau pōkole, J-147 elicits nā hopena antidepressant wikiwiki i nā ʻiole ma kahi o 3 mau lā me ka hoʻokumu ʻole ʻana i ka lāʻau lapaʻau a i ʻole ka hoʻonui ʻana i ka cognition. Nui nā J147 ʻO ka pauda no ke kūʻai aku ma ka pūnaewele, he mea nui e kūʻai i nā huahana maoli a me nā huahana kiʻekiʻe. Hiki iā ʻoe ke kūʻai iā J147 Powder Wholesale me mea hoʻolako AASRAW.

ʻAʻole kaulana ʻo J147 i waena o nā poʻe olakino no ka lōʻihi no mākou e ʻōlelo wiwo ʻole i nā waihona. ʻAʻole hiki i nā nootropics a pau ke 'hui a hoʻohālikelike' me ka palekana.

J147 Pauda hkanaka trials and user experiences

Ua hoʻopaʻa inoa ʻia ka noiʻi kanaka J147 Powder mua a ua manaʻo ʻia e hoʻopau ʻia i ka makahiki 2020. Ua ʻike ʻia ua hana ʻia ma ke ʻano he 1 hoʻokolohua ma 64 mau kānaka olakino, me ka pahuhopu mua o ka nānā ʻana i ka palekana a me nā pharmacokinetics (half-life, aoao waiwai, nā kiko kiko) o J147 Powder, ma mua o kona pono i ka mālama ʻana i kekahi ʻano.

ʻOiai ʻaʻole i hoʻolaha ʻia nā ʻike o kēia noiʻi ʻana, ʻike mākou ua ʻike ʻia ua hoʻopau ʻia me ka pilikia ʻole.

ʻOiai ʻo J147 Powder kahi mea noiʻi noiʻi a ua kūkākūkā ʻia ma kekahi mau kaiaulu nootropics, ʻaʻole i nui nā hōʻike hoʻohana i hāʻawi ʻia a hiki i kēia manawa, a nui ka poʻe e kali nei e ʻike hou i ka noiʻi ma mua o ka hoʻohana ʻana. Wahi a nā mea hoʻohana J-147 Powder, He mea maʻalahi ia kuai J147 pauda ma ka pūnaewele, e ʻimi ana i kahi mea kūʻai aku ʻo J147 Powder i kekahi manawa. AASRAW hoʻolako ka mea hoʻolako i ka pauka J-147 kiʻekiʻe. Inā hana ʻoe i nā mea hoʻohui J-147, hiki iā ʻoe kuai J147 Pauda nui e lealea i ke kumukuai maikai.

ʻAʻole ʻike ka hapa nui o ka poʻe i nā hopena i ʻike ʻia mai nā ʻike mea hoʻohana liʻiliʻi i hōʻike ʻia. ʻOiai ʻoi aku ka ʻōpio a me ke olakino o nā mea hoʻohana a ʻoi aku ka pōkole o ka manawa o ka hoʻohana ʻana ma mua o nā haʻawina, curcumin derivative J147 ʻAʻole paha he hopena nootropic koʻikoʻi ka pauka ma nā ʻōpio olakino olakino.

Hiki iā mākou ke hana i nā manaʻo hoʻonaʻauao e pili ana i ka pono o ka J147 Powder i ka nele o ka noiʻi kanaka a i ʻole nā ​​​​anecdotes kaulana. Ma ke kumumanaʻo, ʻo nā mea a pau e hoʻonui ai i ka ikehu neuronal pono e loaʻa i nā hopena nootropic, akā naʻe, kāu hana ʻano akamai ʻaʻole hiki ke kaupalena ʻia e ka hoʻohana ʻana i ka ikehu. Hiki ke hilinaʻi i ka hikiwawe o nā meaʻai ke komo a puka i waho o kou lolo a i ʻole ka maikaʻi o kou mau manaʻo.

ʻO ka Curcumin derivative J147 Powder hoʻi e hoʻopuka i nā mea neurotrophic nui aʻe, ʻo ia ka mea hiki ke kōkua i kou lolo e hoʻomohala i nā synapses a me nā cell lolo. Akā, e hoʻomanaʻo i hiki ke hoʻonui i nā synapses a me nā cell lolo.

ʻAʻohe kumu e manaʻoʻiʻo ai ʻo J147 E loaʻa i ka pauka kahi nootropic koʻikoʻi hopena i nā ʻōpio, nā mākua olakino. No ka poʻe i loaʻa i ka dementia, pono paha ia. I nā poʻe ʻelemakule liʻiliʻi i ʻike e holo ana ka dementia i loko o ko lākou ʻohana, hiki ke kōkua ʻia ma ke ʻano he nootropic no ka mea hiki ke hoʻōki a hoʻohuli paha i ka nalo cognitive ma mua o ka ulu ʻana i ka dementia clinical. ʻO kēlā me kēia hihia, e liʻuliʻu ana mākou ma mua o ka maopopo.

ʻO J-147 Pauda risks a side ehelehelena

Ua nānāʻia ka J147 Powder a uaʻikeʻia he palekana no ka hoʻohana lōʻihi e nā labs kūʻokoʻa. Ua hala i ka ho'āʻo toxicological i nā noiʻi holoholona i koi ʻia e ka Food and Drug Administration (FDA), a ʻaʻohe hopena maikaʻi ʻole i kākau ʻia i loko o ke kanaka ke lawe ʻia ma ke ʻano i ʻōlelo ʻia (e kūkākūkā ʻia ma hope).

kahi e kūʻai aku i ka pauka J-147?

Ke hoʻopaʻapaʻa ʻia nei ke kānāwai o kēia nootropic, akā naʻe, ʻaʻole ia e pale iā ʻoe mai ke kūʻai ʻana i nā mea kūpono. Ma hope o nā mea a pau, ke hoʻomaka nei nā hoʻokolohua lapaʻau no J-147 Alzheimer. Hiki iā ʻoe kūʻai i ka pauda mai nā hale kūʻai pūnaewele no ka mea hiki iā ʻoe ke hoʻohālikelike i nā kumukūʻai J-147 Powder mai nā mea kūʻai aku. Eia naʻe, pono ʻoe e ʻimi a puni no kahi kaulana mea hana me ka ho'āʻo hoʻokolohua kūʻokoʻa.

Inā makemake ʻoe i kahi J-147 kuai pauda, e nānā me kā mākou hale hana. Hāʻawi mākou i kahi ākea o nā nootropics ma lalo o ka mana koʻikoʻi. Ma muli o kāu pahuhopu psychonautic, hiki iā ʻoe kūʻai kūʻai ʻekahi a pakahi. E hoʻomaopopo, ʻo ka J-147 ʻO ke kumu kūʻai o ka pauda he hoaaloha wale nō ke kūʻai ʻoe ma ka nui kuai nui.

J147 Powder Hoike Hoao-HNMR

He aha ka HNMR a he aha ka HNMR spectrum e haʻi iā ʻoe? ʻO H Nuclear Magnetic Resonance (INMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā hui pū ʻia i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR (a i ʻole e hoʻohālikelike ʻia i nā hale waihona puke spectral a i ʻole e hoʻokaʻawale pololei i ke ʻano kumu. e like me ka hoʻololi conformational, hoʻololi i ka pae, solubility, a me ka diffusion.

J-147 Pauka(1146963-51-0)-COA

J-147(1146963-51-0)-COA

Pehea e kūʻai J147 Powder mai AASraw?

❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu WhatsApp iā mākou, e hoʻopili aku kā mākou mea kūʻai aku (CSR) me ʻoe i loko o 12 mau hola.

❷E hāʻawi iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.

❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala lawe, a me ka lā i manaʻo ʻia e hiki mai ai (ETA).

❹E uku ʻia a hoʻouna ʻia nā waiwai i loko o 12 mau hola.

❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.

Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine

Mea kākau moʻolelo puke moʻolelo ʻepekema:
1. Paul A. Lapchak
He kanaka ʻepekema a me ka mea noiʻi ma ke kahua o ka neurology a me ka noiʻi stroke.
2. David Schubert
ʻO ka Salk Institute for Biological Studies, Cellular Neurobiology Laboratory, La Jolla, Kaleponi, USA
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi ʻana a me ka hoʻomaikaʻi ʻana i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.

E hoʻomaopopo '

[1] Pan X, Chen L, Xu W, Bao S, Wang J, Cui X, Gao S, Liu K, Avasthi S, Zhang M, Chen R. nā hopena o J147. Hoʻoponopono i ka lolo. 2021 ʻAukake 6;411:113374. doi: 10.1016/j.bbr.2021.113374. Epub 2021 Mei 21. PMID: 34023306

[2] Li J, Chen L, Li G, Chen X, Hu S, Zheng L, Luria V, Lv J, Lā Y, Xu Y, Yu Y. Sub-Acute Lapaʻau ʻana o Curcumin Derivative Hoʻomaikaʻi ʻo J147 i ke ʻano hoʻohaʻahaʻa e like me ke kaumaha ma o 5-HT1A-Mediated cAMP Signaling. "Front Neurosci. 2020 Iulai 8;14:701. doi: 10.3389/fnins.2020.00701. eCollection 2020.PMID: 32733195

[3] ʻO Jin R, Wang M, Zhong W, Kissinger CR, Villafranca JE, Li G. "J147 Ho'ēmi i ka TPA-Induced Brain Hemorrhage in Acute Experimental Stroke in Rats."Front Neurol. 2022 Mar 2;13:821082. doi: 10.3389/fneur.2022.821082. eCollection 2022. PMID: 35309561

[4] Emmanuel IA, Olotu FA, Agoni C, Soliman MES. "I ka Silico Repurposing o J147 no ka Neonatal Encephalopathy Treatment: Ke ʻimi nei i nā Molecular Mechanisms of Mutant Mitochondrial ATP Synthase." Curr Pharm Biotechnol. 2020;21(14):1551-1566. doi: 10.2174/1389201021666200628152246. PMID: 32598251

[5] Lian L, Xu Y, Zhang J, Yu Y, Zhu N, Guan X, Huang H, Chen R, Chen J, Shi G, Pan J. 147-HT5A loaʻa. Neuropharmacology. 1 Iun;2018:135-506. doi: 513/j.neuropharm.10.1016. Epub 2018.04.003 Apr 2018. PMID: 5

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