Product Description
He aha ka Melanotan II?
Melanotana ʻO II (i kapa ʻia ʻo Melanotan 2,MT2,MT-2,MT-II) he ʻano ʻano synthetically i hana ʻia o kahi hormone peptide i hana maoli ʻia i loko o ke kino e hoʻoulu ai i ka melanogenesis, kahi kaʻina hana no ka pigmentation o ka ʻili.Alpha-Melanocyte Stimulating ʻO ka Hormone, i ʻike pinepine ʻia ʻo MSH, e hana ma ka hoʻāla ʻana i nā mea loaʻa melanocortin kikoʻī e hana i kāna mau hopena. 2 he mau hopena ma mua o ka hoʻoulu ʻana i ka ʻili, e like me ke kāohi ʻana i ka pōloli, ka hoʻoulu ʻana i ka lipolysis, a me ka hoʻonui ʻana i ka libido.
ʻO ka hoʻomohala ʻana o Melanotan 2
ʻO ka hana mua ʻana o ka Melanotan 2 peptide synthetic hiki ke hāʻawi ʻia i ke Kulanui o Arizona. I ka wā o ka noiʻi e pili ana i ka hoʻomohala ʻana i ka pale ʻana i ka maʻi maʻi ʻili, ua kau ʻia ka manaʻo i ka hoʻomohala ʻana i kahi ala e hoʻoulu ai i ka melanogenesis kūlohelohe, a i ʻole ka hana kūlohelohe o ka melanin. i loko o ka ʻili, me ka ʻole o ka ʻike pono ʻana i ka radiation ultraviolet i ka lā. I ka wā mua, ua hoʻāʻo nā mea noiʻi o ke Kulanui o Arizona e lawelawe pololei i ka hormone alpha-MSH kūlohelohe i mea e loaʻa ai kēia hopena i makemake ʻia. Ua hoʻoholo ʻo ka MSH kūlohelohe i ka hapalua o ke ola o ka hoʻohana maoli ʻana ma ke ʻano he lāʻau lapaʻau. Loaʻa i ka hapalua o ke ola no ka hoʻohana therapeutic hana.
He aha ka Melanin?
ʻO ka Melanin ka puaʻa ʻili i hana ʻia e pale ai i ko mākou ʻili mai ka lā a me ka pōʻino o ka lā. a ʻo kona pale ʻana i ka radiation UV, ʻo ia ka mea hiki i kēlā poʻe me ka ʻili maikaʻi ke puhi a hoʻoweliweli i ka pōʻino DNA hou aʻe.
ʻO ka loaʻa ʻana o ka lako o ka huaora D mai ka lā me ka pilikia ʻole o ka ulu ʻana i ka melanoma he ʻano hana kaulike ia. o nā ʻili puaʻa ʻili i kapa ʻia he melanocytes.
Pehea ka hana ʻana o Melanotan II?
Hana ʻo Melanotan II (MT2) ma ka launa pū ʻana me nā mea loaʻa kikoʻī o ke kino i kapa ʻia he melanocortin receptors.
ʻO ka hoʻopaʻa ʻana i ka melanocortin receptors
Hoʻopaʻa ʻia ʻo Melanotan II a hoʻōla i nā mea loaʻa melanocortin, ʻoi aku ka nui o ka MC1R a me ka MC4R receptors.
Hoʻoulu i ka hana melanin
Ke hoʻopaʻa ʻia ʻo Melanotan II i ka melanocortin receptors, hoʻoulu ia i kahi ʻano o nā hopena biochemical i loko o nā melanocytes. ʻO kēia hoʻoulu ʻana e alakaʻi i ka hoʻonui ʻana o ka melanin, ka puaʻa e pili ana i ka hoʻoholo ʻana i ka ʻili, ka lauoho, a me ka waihoʻoluʻu maka.
Hoʻoulu i nā ala melanin
Hoʻolaʻa ʻo Melanotan II i nā ala hōʻailona e pili ana i ka melanogenesis, ke kaʻina hana o ka melanin synthesis. Aia kēia me ke ala cyclic adenosine monophosphate (cAMP), kahi mea koʻikoʻi i ka hoʻoponopono ʻana i ka hana a me ka hāʻawi ʻana i ka melanin.
Hoʻonui i ka hana melanocyte
Hoʻoikaika ka Melanotan II i ka hoʻonui a me ka hana o nā melanocytes, e alakaʻi ana i ka hoʻonui ʻana i ka hana melanin.
Nā hopena pale lā
Ma ka hoʻonui ʻana i ka hana melanin, hiki i ka Melanotan II ke hāʻawi i kahi pae o ka pale ʻana i ka radiation UV. Hoʻopili ʻo Melanin i nā kukuna UV, pale iā lākou mai ke komo hohonu ʻana i nā ʻili o ka ʻili a hoʻopōʻino i ka DNA, sunburn, a me nā hopena pōʻino ʻē aʻe e pili ana i ka nui o ka lā.
He mea nui e hoʻomaopopo he ʻokoʻa ka hopena a me ka lōʻihi o ka hopena tanning o Melanotan II i waena o nā poʻe ma muli o nā kumu e like me genetics, doseage, a me ka pinepine o ka hoʻohana. no nā hana palekana o ka lā, e like me ke kau ʻana i ka pale lā a me ka hoʻopaʻa ʻana i ka ʻike UV.
ʻO Melanotan II (MT2) nā pōmaikaʻi peptide tanning
Loaʻa iā Melanotan II (MT2) kekahi mau hiʻohiʻona kūikawā e hoʻokaʻawale iā ia mai nā ʻano hana tanning a me nā ʻano pigmentation ʻili. Eia kekahi mau hiʻohiʻona kaulana:
Hoʻonui i ka hana melanin
Hoʻolālā ʻia ʻo Melanotan II e hoʻoulu i ka hana ʻana o ka melanin, ka puaʻa e pili ana i ka ʻili, ka lauoho, a me ka waihoʻoluʻu maka. Hoʻopili kēia peptide i nā melanocortin receptors, e hoʻoulu ai i ka hoʻokuʻu ʻana o ka melanin, kahi e alakaʻi ai i ka ʻili ʻeleʻele.
Hiki ke hoʻemi ʻia ka lā (Melanotan II no ka tanning)
ʻO kekahi o nā pōmaikaʻi koʻikoʻi o Melanotan II ʻo ia ka hiki ke hōʻemi i ka nui o ka ʻike ʻana o ka lā e pono ai e hoʻokō i kahi tan. pōʻino ʻili.
Melanotan II 'ae i ka po'e 'a'ole 'a'a'a a 'a'a mau i ka lā e loa'a i ka tan.Synthetic melanotropin peptide supplements e hā'awi i ka hiki ke ho'ololi i ke ola no nā po'e ma'i me ka lā allergies / mutated receptors.'O ka tan maoli e ulu a'e i ka manawa, 'o ia ka pale ma'i 'a'ai ikaika loa. Hiki i kēlā ʻili maikaʻi ke loaʻa i kēia lā. Ua hana ʻia ʻo Melanotan me ka pahuhopu e hoʻohaʻahaʻa i ka nui o ka maʻi maʻi a lilo paha i mea hoʻomaʻemaʻe lā ʻole.
Hoʻohana ka poʻe haʻuki a me ka poʻe hoʻoikaika kino i ka Melanotan 2 no ka hoʻonui ʻana i ka tanning, ka piʻi ʻana o ka libido a me ka hoʻopau ʻana i ka makemake. Ke hoʻomau nei ʻo Melanotan II i ka peptide tanning maikaʻi loa i kūʻai ʻia ma ka pūnaewele.
Nā noi lapaʻau kūpono
Ma waho aʻe o ka tanning cosmetic, hōʻike ʻo Melanotan II i ka ʻōlelo hoʻohiki i kekahi mau kūlana olakino. No ka laʻana, hiki ke hoʻohana ʻia i kahi koho lapaʻau no ka poʻe me ka vitiligo, kahi maʻi ʻili i ʻike ʻia e nā ʻāpana o ka ʻili depigmented. ka mālama ʻana i ka erythropoietic protoporphyria (EPP), kahi maʻi i hoʻoili ʻole ʻia e hōʻeha i ka naʻau nui i ka lā.
Hōʻike ʻia ka hoʻonui libido
ʻO kahi hiʻohiʻona hoihoi e pili ana me Melanotan 2 ka hopena i hōʻike ʻia ma ka libido a me ka hana pili kino. e ʻike ʻia e nā mea hoʻohana a pau.
Melanotan II poho kaumaha
ʻOiai ʻaʻole kāna kumu nui, ua manaʻo kekahi mau haʻawina e hiki ke kōkua ʻo Melanotan II i ka hoʻopau ʻana i ka ʻai a me ka poho kaumaha.
ʻO ke ʻano o Melanotan II (MT2) i loaʻa ma ka mākeke
Nui nā Melanotan II no ke kūʻai aku ma ka pūnaewele, ʻoi aku ka nui o ka lako o MT2. Loaʻa i ka MT2 ke ʻano i loko o ka Nasal sprays, pre-mixed Melanotan 2, nā pila, melanotan2 waha a me Melanotan II injections. Akā naʻe, loaʻa mua ka peptide Melanotan II (MT2). ma ka mākeke ma ke ʻano o ka pauka lyophilized no ka hoʻoponopono hou ʻana a me ka hoʻoponopono ʻana ma hope. Eia nā ʻano maʻamau o Melanotan II i loaʻa:
Pepa Pauka
Kūʻai pinepine ʻia ʻo Melanotan II e like me ka pauka lyophilized, ʻo ia kahi ʻano maloʻo maloʻo o ka peptide. ʻO ka mea maʻamau e hele mai i loko o nā hue a i ʻole nā mea liʻiliʻi.
Hana hou
Ma mua o ka hoʻohana ʻana, pono e hoʻopili hou ʻia ka pauka me kahi solvent kūpono, maʻamau ka wai sterile a i ʻole ka wai bacteriostatic. Hiki ke hoʻololi ʻia nā ʻōlelo kuhikuhi ma muli o ka huahana kikoʻī a me ka mea hana MT2, no laila he mea nui e hahai pono i nā kuhikuhi i hāʻawi ʻia.
Injection
Ke hana hou ʻia ka pauka, hoʻohana pinepine ʻia ʻo Melanotan II ma o ka injection subcutaneous. Hoʻohana ʻia kahi nila liʻiliʻi e hoʻoheheʻe i ka hopena ma lalo o ka ʻili, maʻamau i loko o ka momona momona o ka ʻōpū a i ʻole ka ʻūhā. e mālama i ke kālā iā ia e kūʻai i ka pauka lyophilized o Melanotan 2 e hana i kā lākou MT2 injection.Buy Melanotan 2 wholesale e loaʻa i kahi kumukūʻai kūpono.
He mea koʻikoʻi ia e hōʻoia i ka maikaʻi a me ka pono o ka huahana i ke kūʻai ʻana iā Melanotan II, no ka mea, hiki i nā mana hoʻopunipuni a i hana ʻole ʻia ke kau i nā pilikia hou aʻe.
Nā hopena ʻaoʻao o Melanotan II
ʻO ka peptide Melanotan II i hāʻawi ʻia ma lalo o ka ʻili i hōʻike ʻia he palekana a maikaʻi hoʻi i nā dosage i ʻōlelo ʻia. ʻO nā hopena ʻaoʻao i hōʻike ʻia me ka melanotan II penei
'O Nausea
ʻEha ka ʻōpū
ua hoʻemi ikaika loa ka makemake
ʻO Yawning
ʻili ʻeleʻele
ʻO ka hoʻopaʻa kino penile
Hoʻololi i nā ʻano mole
I nā hihia koʻikoʻi, aia nā pilikia no kēia mau hopena koʻikoʻi loa, me:
He ʻano koʻikoʻi o ka maʻi maʻi ʻili (melanoma)
Ka hana ʻana i nā mole hou a me ka naevi melanocytic atypical
Rhabdomyolysis (ka luku ʻana i nā ʻiʻo ʻiʻo i hiki ke make)
ʻO ka maʻi encephalopathy
Hoʻolilo maikaʻi
He mea koʻikoʻi nō hoʻi ka hoʻomaopopo ʻana inā e hoʻokaʻawale ʻia nā nila a ʻaʻole hoʻomaʻemaʻe pono ʻia ma mua o ka hoʻohana ʻana, aia ka pilikia o ka haumia. E like me kekahi injection, ʻulaʻula a me ka ʻeha ma ka wahi i hoʻopaʻa ʻia. kiʻekiʻe.
ʻAʻole ʻōlelo ʻia e hoʻohana i ka PT-141 injection concurrently me ka PDE5 inhibitor i nā kāne ma muli o ka pilikia o ka priapism.
ʻAʻole pono e hoʻohana ʻia kēia huahana inā hāpai ʻoe a hānai paha. ʻAʻole lawa nā hōʻike e hōʻike ai i ka palekana o ka poʻe o kēia ʻano. ʻOi aku ka koʻikoʻi inā ʻoe ma nā lāʻau lapaʻau ʻē aʻe. I kēia manawa, ʻaʻohe mea i ʻike ʻia e pili ana i ka lāʻau lapaʻau, akā ʻoi aku ka maikaʻi o ka makaʻala ma mua o ka minamina.
Hiki paha i nā mea noiʻi makemake i ka noiʻi ʻana i nā hopena ʻaoʻao Melanotan 2 e pili ana i kahi e kūʻai ai i kēia kemika noiʻi ma ka pūnaewele.
Melanotan II Hōʻike Hōʻike-HNMR
He aha ka HNMR a He aha ka HNMR spectrum e haʻi aku iā ʻoe? ʻO H Nuclear Magnetic Resonance (NMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā hui pū ʻia i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR e hoʻohālikelike i nā hale waihona puke spectral a i ʻole e kuhi pololei i ke ʻano kumu. Ke ʻike ʻia ke ʻano kumu, hiki ke hoʻohana ʻia ka NMR no ka hoʻoholo ʻana i ka conformation molecular i ka hopena a me ke aʻo ʻana i nā waiwai kino ma ka pae molekala e like me ka hoʻololi conformational, nā hoʻololi ʻana, ka solubility, a me ka diffusion.
Pehea e kūʻai ai iā Melanotan II mai AASraw?
❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu whatsapp iā mākou, e hoʻopili aku kā mākou mea kūʻai aku (CSR) me ʻoe i 12 mau hola.
❷E hāʻawi mai iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.
❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala hoʻouna a me ka lā i manaʻo ʻia (ETA).
❹E uku ʻia a hoʻouna ʻia nā waiwai i loko o 12 mau hola.
❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.
Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine
Mea kākau moʻolelo puke moʻolelo ʻepekema:
1. Mariël P Ter Laak
Keʻena o ka Lapaʻau Lapaʻau, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht
2. Chase W. Mallory BHS
ʻO Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA
3. Miia Kilpeläinen
Kula Lapaʻau Lapaʻau, Lapaʻau ʻenehana, University of Eastern Finland, Kuopio, Finland
4. Ryouichi Banno
Keʻena o nā maʻi Metabolic, Field of Internal Medicine, Nagoya University Graduate School of Medicine, Iapana
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.
E hoʻomaopopo '
[1] Gilhooley E, Daly S, McKenna D. "Melanotan II Mea hoʻohana ʻike: He Qualitative Study of Online Discussion Forums." Dermatology. 2021;237(6):995-999. doi: 10.1159/000514492. Epupa 2021 ʻAukake 31.PMID: 34464955
[2] Peters B, Hadimeri H, Wahlberg R, Afghahi H. "Melanotan II: kahi kumu o ka renal infarction: loiloi o ka palapala a me ka hōʻike hihia." CEN Case Rep. 2020 Mei; 9(2):159-161. doi: 10.1007/s13730-020-00447-z. Epub 2020 Jan 18.PMID: 31953620
[3] Tomassi S, Dimmito MP, Cai M, D'Aniello A, Del Bene A, Messere A, Liu Z, Zhu T, Hruby VJ, Stefanucci A, Cosconati S, Mollica A, Di Maro S.”CLIPSing Melanotan-II to Discover ʻO nā Agonists hMCR koho he nui. "J Med Chem. 2022 Mar 10;65(5):4007-4017. doi: 10.1021/acs.jmedchem.1c01848. Epub 2022 Feb 21.PMID: 35188390
[4] Giuliano F, Clément P, Droupy S, Alexandre L, Bernabé J. "Melanotan-II: Ke noiʻi ʻana i ka hopena o ka mea hoʻoulu a me ka mea hoʻoikaika i ka penile i ka ʻiole anesthetized."Neuroscience. 2006;138(1):293-301. doi: 10.1016/j.neuroscience.2005.11.008. Epub 2005 Dec 19.PMID: 16360286
[5] Hjuler KF, Lorentzen HF. "Melanoma pili me ka hoʻohana ʻana i ka melanotan-II." Dermatology. 2014;228(1):34-6. doi: 10.1159/000356389. Epub 2013 Dec 18.PMID: 24355990
[6] Jain S, Panyutin A, Liu N, Xiao C, Piñol RA, Pundir P, Girardet C, Butler AA, Dong X, Gavrilova O, Reitman ML. nā mea loaʻa." Am J Physiol Endocrinol Metab. 1 Sep 2018;1(315):E3-E357. doi: 366/ajpendo.10.1152. Epub 00024.2018 Mei 2018.PMID: 29
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