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MMAD (Demethyldolastatin 10)

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SKU: 203849-91-6. Māhele:

ʻO ka AASraw me ka hōʻano a me ka hana hana mai ka gram a ka papa hana nui o MMAD (Demethyldolastatin 10) (CAS 203849-91-6), ma lalo o ke kānāwai CGMP a me ke kikowaena o ka mana.

Eia kekahi, MMAD 'ōleloʻia e hoʻohanaʻia i ka hoʻokumuʻana i nā hōʻailona kūikawā e kū'ē i nā mea hōʻailona lāʻau (NDCs). I ka NDCs, hui pūʻiaʻo MMAD me ka anti-5T4 antibody a me ka anti-Her2. Hōʻikeʻia ka hōʻikeʻana o nā NDC i nāʻoihana maikaʻi loa a me nā pharmacokinetics.

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Product Description

ʻO MMAD (Demethyldolastatin 10) wikiō


MMAD (Demethyldolastatin 10) mau mea pono

Name: MMAD (Demethyldolastatin 10)
CAS: 203849-91-6
Nā Kaulike Molecular: C41H66N6O6S
Molecular Weight: 771.06
Wahi Manaʻo: N / A
Hōʻoia Kōkua: Powder -20 ° C 3 makahiki
4 ° C 2 makahiki
I ka hoʻouluʻana -80 ° C 6 mahina
-20 ° C 1 mahina
kala like 'ole: 'Ola i keʻokeʻo-keʻokeʻo (paʻakikī)


MMAD (Demethyldolastatin 10) (203849-91-6) hoʻohanaʻia i ka holomua steroid

Nā inoa

Hō'ālua: Demethyldolastatin 10 (203849-91-6); Monomethylauristatin D; Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

Pākuʻi ma MMAD (Demethyldolastatin 10)

ʻAʻole i paʻa ponoʻia nā huahana no nā noi lāʻau. No ka noiʻi noiʻi wale nō

No ka loaʻaʻana o kahi haʻahaʻa kiʻekiʻe, e hoʻomahaʻoe i ka pahu i 37 ℃ a lulu i loko o ka ultrasonic bath no kekahi manawa. E hiki ke mālama ponoʻia nāʻenehana i lalo -20 ℃ no kekahi mau mahina.

Nā kuhikuhi hou aku

In Vitro: MMB (Demethyldolastatin 10) (203849-91-6) i hui pūʻia ma o ka hana hana kaulike oxime-ligation e hāʻawi ai i kekahi mau pūhui pili i ka lāʻau hōʻailona (ADCs) kokoke-homogenous me ka ratio anti-to-antibody o ~ 2.0. ʻO nā hopena hopena e hōʻike ana i nā waiwai pharmacokinetic maikaʻi, ka hanaʻoihana cytotoxic iʻoi aku i vitro e pili ana i nā pūnaewele maʻi HER2. Inā hoʻohālikelikeʻia me ADCs i hoʻomākaukauʻia e cysteine ​​alkylation ma hope o ka hoʻohaʻahaʻa disulfide ka waena, hōʻikeʻia nāʻano ADC ma kahi kūlohelohe-kūikawā-kahi-kūpono-i ka hanana i loaʻa ka nui o ka cytotoxicity i vitro

I Vivi:ʻO ka hopena o nā'āpana anti anti-drug drug (ADCs) hōʻike i ka hoʻohālike o ka tumo a pau i nā koʻi. Loaʻa lākou i kaʻike loxicology maikaʻi i nāʻiole.


Pehea e kūʻai ai MMAD; e kūʻai i Demethyldolastatin 10 mai AASraw

1.E hōʻike mai iā mākou ma o mākou leka uila pūnaewele noiʻi, aiʻole skype pūnaeweleka hoʻonohonoho hoʻonohonoho kanaka (CSR).
2.Ke hāʻawi mai i kāu helu a me kāu helu wahi.
3.OUR CSR e hāʻawi iāʻoe i ka helu, ka manawa uku, helu helu, nā puka puka a me ka lā i hōʻea muaʻia (ETA).
4.E ukuʻia a hoʻokuʻuʻia nā waiwai i nā hola 12 (No ke kauoha ma loko o 10kg).
Ua loaʻaʻo 5.Goods a hāʻawi i nā manaʻo.


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