Orlistat pauma

Orlistat Powder wikiō-AASraw

Orlistat Powder Nā Kiʻi Kumu

He aha ka Orlistat Powder?

ʻO Orlistat ka pauka he lāʻau lapaʻau i hoʻohana ʻia no ka mālama ʻana i nā maʻi obesity a i ʻole ke kaumaha. Ua hoʻomohala mua ʻia e Roche a hoʻokuʻu ʻia ma ʻAmelika Hui Pū ʻIa i ka makahiki 1999. ʻO ia wale nō ka lāʻau hoʻēmi kaumaha ma luna o ka counter i ʻae ʻia e FDA, CFDA, a Ema i ka honua. Hana ia ma ke kāohi ʻana i ka pancreatic a me ka gastric lipases, nā enzymes kuleana no ka wāwahi ʻana i nā momona meaʻai i ka ʻōpū o ka ʻōpū. ʻO kēia ke kumu e hoʻokuʻu ʻia ai ka momona ʻaʻole i hoʻoheheʻe ʻia i loko o ka feces, ka hopena i ka liʻiliʻi o nā calorie i lawe ʻia mai ka momona.

Ma ʻAmelika Hui Pū ʻIa, ua ʻae ʻia ka orlistat no ka mālama ʻana i ka helu kino kino (BMI, Body Mass Index, unit kg/㎡) hiki a ʻoi aku paha ma mua o 30 (ke kūlana obesity US). Ma waho aʻe, ʻo ka poʻe me ka helu kino kino ma waena o 27 a me 30 a me nā mea pilikia olakino e like me ke koko kiʻekiʻe a i ʻole ka maʻi diabetes.

Pehea e hana ai ka Orlistat Powder?

Hoʻohana ka Orlistat pauka ma ke kāohi ʻana i ka ʻōpū a me ka pancreatic lipases, ʻo ia nā enzyme e kuleana no ka wāwahi ʻana i nā triglycerides i loko o nā waikawa momona liʻiliʻi e hiki ke hoʻopili ʻia e ke kino. Ma ke kāohi ʻana i kēia mau enzymes, pale ʻo AASraw orlistat i ka hydrolysis o nā triglycerides i loko o ka ʻōpū, kahi e hoʻemi ai i ka nui o ka momona meaʻai.

No ka mea ʻaʻole i wāwahi ʻia nā triglycerides i loko o nā ʻakika momona manuahi, ua hoʻokuʻu ʻia lākou me ka loli ʻole i nā feces. ʻO kēia kaʻina hana e alakaʻi i ka hoʻemi ʻana i ka caloric intake a hoʻoikaika i ka pohō kaumaha. Ua hōʻike ʻia ʻo Orlistat e pale i ka 30% o ka momona meaʻai mai ka lawe ʻana.

Ma waho aʻe o ka pale ʻana i nā lipases, ʻaʻole hoʻi ka orlistat i ka thioesterase domain o fatty acid synthase (FAS). Hoʻopili ʻia kēia enzyme i ka hoʻonui ʻana o nā maʻi kanesa akā ʻaʻole nā ​​​​pūnaewele maʻamau. Eia nō naʻe, hiki i nā hopena ʻaoʻao o ka orlistat, e like me ke kāohi ʻana i nā mea kelepona ʻē aʻe a i ʻole bioavailability maikaʻi ʻole, hiki ke hoʻopilikia i kāna noi ʻana ma ke ʻano he lāʻau antitumor kūpono.

Ma ke ʻano holoʻokoʻa, ʻo ka hana o ka orlistat e pili ana i ka pale ʻana i nā enzyme e pili ana i ka hoʻoheheʻe ʻana i ka momona, e alakaʻi ana i ka hōʻemi ʻana i ka nui o ka momona meaʻai i hoʻopaʻa ʻia a hoʻonui i ke kaumaha.

Nā pōmaikaʻi o ka hoʻohana ʻana i ka Orlistat Powder

ʻO Orlistat ka pauka he lāʻau lapaʻau i hoʻohana nui ʻia e mālama i ka momona, ma mua o ka pale ʻana i ka absorption o nā momona mai ka ʻai kanaka. Eia hou, hiki iā ia ke hōʻemi haʻahaʻa i ke koko a ʻike ʻia e pale i ka hoʻomaka ʻana o ka maʻi maʻi type 2, inā mai ka pohō kaumaha a i ʻole nā ​​hopena ʻē aʻe.

· Hana i ka nui

Hoʻohana mua ʻia ka pauka Orlistat no ka mālama ʻana i ka momona i hui pū ʻia me kahi meaʻai hoʻemi-calorie mālama mālama olakino. ʻO kāna hana nui,ʻo ia ka paleʻana i ka laweʻana i nā momona meaʻai ma ka hanaʻana ma keʻano he lipase inhibitor, a laila e ho'ēmi ana i ka caloric intake.AASraw Orlistat pauka e hana ana ma ke kāohiʻana i nā lipases gastric a me ka pancreatic, nā enzymes kuleana no ka wāwahiʻana i nā triglycerides i loko o ka'ōpū. Ke paʻa ʻia ka hana lipase, ʻaʻole hydrolyzed nā triglycerides mai ka meaʻai i loko o nā ʻakika momona manuahi a hiki ke hoʻokuʻu ʻia me ka loli ʻole.

Hōʻike ʻia nā ʻikepili i hui ʻia mai nā hoʻokolohua lapaʻau i ka poʻe i hāʻawi ʻia i ka orlistat me ka hoʻololi ʻana i ke ʻano o ka nohona, e like me ka ʻai a me ka hoʻoikaika kino, e nalowale ma kahi o 2-3 kilokani (4-7 lb) ʻoi aku ka nui o ka poʻe i lawe ʻole i ka lāʻau i ka makahiki. Ma waena o 35.5% a me 54.8% o nā kumuhana i loaʻa i ka 5% a i ʻole ka emi ʻana o ka nui o ke kino, ʻoiai ʻaʻole i momona kēia mau mea āpau. Ma waena o 16.4% a me 24.8% i loaʻa ma ka liʻiliʻi he 10% ka emi ʻana o ka momona o ke kino. Pono e hoʻomaopopo ʻia ma hope o ka pau ʻana o ka orlistat, ua loaʻa hou ka nui o nā kumuhana i ke kaumaha - a hiki i ka 35% o ke kaumaha i nalowale.

· Hoemi i ke koko

Ma waho aʻe o ke kōkua ʻana i ka pohō kaumaha, ua hōʻike nā haʻawina e hiki i ka pauka orlistat ke alakaʻi i kahi hoʻohaʻahaʻa haʻahaʻa o ke kahe koko. Hōʻike ʻia nā ʻikepili i hui ʻia mai nā hoʻokolohua lapaʻau e hōʻemi ana ka orlistat i ke koko systolic a me ka diastolic ma ka awelika o 2.5 a me 1.9 mmHg, kēlā me kēia. ʻO ka mīkini ma hope o kēia hoʻemi ʻana i ke kahe koko e manaʻo ʻia e pili ana i ka pohō kaumaha i loaʻa ma o ka hoʻohana ʻana i ka orlistat, no ka mea, ʻo ka momona ka mea i ʻike ʻia no ka hypertension. Eia nō naʻe, he mea nui e hoʻomaopopo i ka emi ʻana o ke kahe koko i loaʻa ma o ka hoʻohana ʻana i ka orlistat he liʻiliʻi a ʻaʻole pono e hilinaʻi ʻia ma ke ʻano he lapaʻau hoʻokahi no ka hypertension. Pono ka poʻe me ka hypertension e hoʻomau i ka ʻōlelo aʻo a kā lākou mea mālama ola a hoʻohana i ka lāʻau lapaʻau e like me ka mea i kuhikuhi ʻia.

· Kāohi i ka hoʻomaka ʻana o ka maʻi diabetes type 2

Ua hōʻike ʻia ka pauka Orlistat i ka hopena pale i ka hoʻomaka ʻana o ka maʻi maʻi type 2, ʻokoʻa i kona kaumaha kaumaha a me nā hopena hoʻohaʻahaʻa koko. ʻO kēia paha ma muli o ka nui o ka nui o ka momona no ka hoʻomohala ʻana i ka maʻi maʻi type 2, a hiki i Orlistat ke kōkua i ka pohō kaumaha i nā poʻe momona. Ua hōʻike nā haʻawina e hiki i ka orlistat ke hōʻemi i ka nui o ka maʻi maʻi type 2 i ka poʻe i paʻa i ka nui o ka nui o nā loli ola. ʻAʻole ʻike maopopo ʻia ke ʻano kūpono o ka orlistat e pale ai i ka hoʻomaka ʻana o ka maʻi diabetes type 2, akā manaʻo ʻia e pili ana i ka hiki o ka lāʻau lapaʻau e hōʻemi i ka caloric intake ma ke kāohi ʻana i ka lawe ʻana o ka momona meaʻai, hiki ke alakaʻi i ka hoʻomaikaʻi ʻana i ka metabolism glucose a me ka insulin. ka naʻau. He mea nui e hoʻomaopopo i ka orlistat ʻaʻole ia he pani no ke ola olakino, a pono e hui pū ʻia kona hoʻohana ʻana me ka meaʻai hoʻemi-calorie a me ka hoʻomaʻamaʻa no ka maikaʻi loa.

Nānā: No ka hoʻonuiʻana i nā pono o ka pauka Orlistat, he mea koʻikoʻi ke kūʻaiʻana mai kahi mea hilinaʻi. Ke kūʻai aku ʻoe i ka pauka Orlistat mai AASraw, hiki iā ʻoe ke hilinaʻi e loaʻa iā ʻoe kahi huahana maʻemaʻe, kiʻekiʻe kiʻekiʻe e pili ana i nā koi koʻikoʻi.

ʻO ka hopena o ka Orlistat Powder?

ʻO Orlistat ka pauka, e like me nā lāʻau lapaʻau, loaʻa nā hopena ʻaoʻao. ʻOiai e pili wale ana i ka ʻōpū o ka ʻōpū a ʻaʻole i nā ʻōnaehana cardiovascular a i ʻole ke kikowaena, ʻaʻole hiki ke mālama ʻia nā hopena ʻaoʻao.

Nā hopena piliʻaoʻao

ʻO nā ʻili ʻaila a i ʻole nā ​​​​stools ʻaila hinu

• Ke ahi
• Hōʻoluʻolu ʻōpū
• ʻO ka wikiwiki o ka pahu
• Hoʻonui ʻia ka nui o ka wai
• Kūleʻaʻole ka manaʻo
• ʻO nā meaʻala
• Hoʻonui ʻia ka ʻōpū o ka ʻōpū
• Moʻa momona (ʻaila) stools
• ʻO Steatorrhea

I ka piʻi ʻana o ka momona o ka meaʻai, piʻi pū ka nui o ka hopena. Hiki i ka hapa nui o nā maʻi ke hoʻomaikaʻi ma hope o ka lawe ʻana i ka lāʻau no kekahi manawa.

ʻO nā hopena ʻeha o ka ʻōpū

• ʻEha ʻōpū/ ʻehaʻeha
• Ka wai wai
• Nā mea hoʻonaniʻoluʻolu
• ʻeha ʻeha/ka ʻehaʻeha,
• ʻO ka ʻeha niho
• ʻO ka ʻeha ʻeha

Nānā: He mea pono e hoʻomaopopo i ka maikaʻi o ka pauka orlistat e pili kokoke ana i nā hopenaʻaoʻao, a hiki i ka pauka orlistat kiʻekiʻe ke hoʻemi i ka hopena o nā hopena. ʻO ka kūʻaiʻana mai kahi mea hoʻolako i ka pauka maka e like me AASraw hiki ke kōkua i ka ho'ēmiʻana i ka hopena o ka hopena o ka hopena. Eia nō naʻe, he mea nui e nīnau mau i kahi ʻoihana mālama ola ma mua o ka hoʻomaka ʻana i kekahi lāʻau lapaʻau hou a i ʻole ka regimen hoʻohui.

ʻO ka Dosage a me ka Administration of Orlistat Powder no ka Hoʻomaopopo

ʻO Orlistat ka pauka he lāʻau lapaʻau i hoʻohana ʻia no ka mālama ʻana i ka pohō kaumaha a me ka mālama ʻana i ke kaumaha ke hoʻohana pū ʻia me ka meaʻai hoʻemi-calorie. ʻO ka mea i manaʻo ʻia a me ka lawelawe ʻana o Orlistat pauka e like me kēia.

Hoʻoponopono

ʻO ka mea i manaʻo ʻia o Orlistat pauka ʻo 120 mg i lawe waha ʻia i ka manawa 3 i ka lā me kēlā me kēia pāʻina nui i loaʻa ka momona. ʻAʻole pono ka nui o ka nui o kēlā me kēia lā ma mua o 360 mg.

hooponopono

Pono e lawe waha ʻia ka pauka Orlistat i ka wā, a i ʻole hoʻokahi hola ma hope, kēlā me kēia pāʻina nui i loko o ka momona. Inā hala ʻole kahi meaʻai a ʻaʻohe momona, hiki ke hoʻokuʻu ʻia ka nui o ka pauka Orlistat. Pono e aʻo ʻia nā maʻi e lawe i kahi multivitamin i loaʻa nā huaora momona-soluble ma kahi o ʻelua mau hola ma mua a ma hope paha o ka lawe ʻana i ka pauka Orlistat.

Hoʻololi i ka hoʻoponopono

ʻAʻole pono ka hoʻoponopono ʻana i ka dose no nā poʻe maʻi me ka maʻi renal a i ʻole ka ate. Eia nō naʻe, hiki i nā poʻe maʻi me ka maʻi diabetes mellitus ke koi aku i ka hoʻoponopono ʻana i kā lākou mau lāʻau maʻi diabetes, a pono e nānā pono ʻia ka mana glycemic.

kaiapuni

He mea nui e hoʻomaopopo ʻaʻole pono e hoʻohana ʻia ka pauka Orlistat i ka wā hāpai a i ʻole e ka poʻe me ka maʻi malabsorption maʻi, cholestasis, a i ʻole hypersensitivity i ka mea hana a i ʻole nā ​​​​mea hoʻohana huahana. Pono paha nā poʻe maʻi me ka maʻi diabetes e hoʻoponopono i kā lākou mau lāʻau maʻi diabetes a nānā pono i ka mana glycemic.

Notes

ʻO ka ʻikepili a me ka ʻike hoʻokele i hāʻawi ʻia e pili ana i ka pauka Orlistat no ka ʻike ʻike wale nō a ʻaʻole pono e hoʻohana ʻia i mea pani no ka ʻōlelo aʻoaʻo olakino. E kūkākūkā mau me kahi mea mālama ola ma mua o ka hoʻomaka ʻana i kekahi lāʻau lapaʻau a mea hoʻohui paha, me ka pauka Orlistat. Pono e hoʻoholo ʻia ka dosage a me ka hoʻokele ʻana o ka pauka Orlistat e pili ana i ka mōʻaukala olakino pilikino, nā lāʻau lapaʻau o kēia manawa, a me nā mea pili ʻē aʻe. Eia kekahi, ʻo ke kūʻai ʻana i ka pauka Orlistat me ke kiʻekiʻe kiʻekiʻe mai kahi mea kūʻai aku Orlistat pauka a mea kūʻai aku paha he mea nui loa.

ʻO ka hui ʻana o Orlistat me nā lāʻau ʻē aʻe

• Hiki i ka Orlistat ke ho'ēmi i ka laweʻana o nā huaora A, D, a me E. No laila, inā e lawe anaʻoe i nā mea hoʻomākaukau i loaʻa nā huaora A, D, a me E (e like me kekahi mau hoʻomākaukau multivitamin), ponoʻoe e lawe i nā huaora 2 mau hola ma hope o ka laweʻana i ka orlistat.
• ʻO nā mea maʻi me ka maʻi maʻi type 2 pono paha e hoʻemi i ka nui o nā lāʻau hypoglycemic waha (e like me ka sulfonylureas).
• ʻO ka hui pū ʻana o ka orlistat me ka cyclosporine hiki ke hoʻohaʻahaʻa i ka pae plasma o ka hope.
• Ke hoʻohana ʻia ka orlistat me ka amiodarone, hiki ke hōʻemi i ka absorption o ka hope a hōʻemi i ka hopena curative.
• Inā hoʻohana pū ʻia me nā lāʻau ʻē aʻe i ka manawa like, hiki ke hoʻopili ʻia ka lāʻau lapaʻau, e ʻoluʻolu e nīnau i kāu kauka a lāʻau lapaʻau paha no nā kikoʻī.

Ma hea e kūʻai ai i ka Orlistat Powder?

He mea koʻikoʻi ka ʻimi ʻana i kahi mea hoʻolako pauka Orlistat hilinaʻi a kaulana no ka poʻe i ka lāʻau lapaʻau a i ʻole ʻoihana mālama ola e pono ai kēia lāʻau lapaʻau no kā lākou huahana a i ʻole nā ​​​​mea maʻi. He mea nui e koho i kahi mea hoʻolako e hiki ke hāʻawi i ka pauka Orlistat kiʻekiʻe e kū ana i nā kūlana a me nā lula i koi ʻia. Pono e loaʻa i ka mea hoʻolako kahi moʻolelo maikaʻi e pili ana i ka mana o ka maikaʻi, ka hoʻopili, ka hoʻouna ʻana, a me ka lawelawe mea kūʻai aku. Ma ke koho ʻana i kahi mea hoʻolako hilinaʻi, hiki i nā mea kūʻai ke hōʻoia e loaʻa iā lākou kahi huahana palekana a kūpono hoʻi no kā lākou pono.

KANAKA he mea hoʻolako maikaʻi i nā mea lāʻau lapaʻau, me ka pauka Orlistat. He ʻōnaehana koʻikoʻi koʻikoʻi ko lākou e hōʻoia i ka maikaʻi o kā lākou huahana a hoʻokō i nā kūlana i koi ʻia. Hāʻawi pū lākou i nā mea kūʻai aku i kahi palapala hōʻoia no kēlā me kēia pahu o Orlistat pauka a lākou e kūʻai aku ai, no laila hiki iā ʻoe ke hōʻoia i ka maʻemaʻe a me ka maikaʻi o ka huahana. Eia kekahi, hāʻawi ʻo AASraw i ka uku hoʻokūkū a me ka hāʻawi pono ʻana, ʻo ia nā mea nui e noʻonoʻo ai i ke koho ʻana i kahi mea hoʻolako. Ma keʻano holoʻokoʻa, ʻo AASraw kahi mea hoʻolako kaulana o Orlistat pauka e hāʻawi ana i nā huahana kiʻekiʻe, ka uku hoʻokūkū, a me ka hāʻawi pono ʻana.

Orlistat Powder Hoike Hoao-HNMR

He aha ka HNMR a he aha ka HNMR spectrum e haʻi iā ʻoe? ʻO H Nuclear Magnetic Resonance (NMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā huila i loaʻa nā pūhui i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR e hoʻohālikelike i nā hale waihona puke spectral a i ʻole e kuhi pololei i ke ʻano kumu. Ke ʻike ʻia ke ʻano kumu, hiki ke hoʻohana ʻia ka NMR no ka hoʻoholo ʻana i ka conformation molecular i ka hopena a me ke aʻo ʻana i nā waiwai kino ma ka pae molekala e like me ka hoʻololi conformational, nā hoʻololi ʻana, ka solubility, a me ka diffusion.

Orlistat pauka (96829-58-2) -COA

Orlistat pauka (96829-58-2) -COA

Pehea e kūʻai Pauka Orlistat mai AASraw?

❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu WhatsApp iā mākou, e hoʻopili aku kā mākou mea kūʻai aku (CSR) iā ʻoe i loko o 12 mau hola.

❷E hāʻawi iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.

❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala lawe, a me ka lā i manaʻo ʻia e hiki mai ai (ETA).

❹E uku ʻia a hoʻouna ʻia nā waiwai i loko o 12 mau hola.

❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.

Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine

Mea kākau moʻolelo puke moʻolelo ʻepekema:
1. Xiongcai Feng
Keʻena o Gastroenterology, Ka Halemai Hoʻohui Mua, Ke Kulanui ʻo Sun Yat-sen, Guangzhou, Guangdong, Kina
2. Jovana V. Jovankić
Ke Kulanui o Kragujevac, Kumu o ka ʻEpekema, Keʻena o Biology a me Ecology, Radoja Domanovića 12, 34000, Kragujevac, Serbia
3. Sandhya R. Bassin MD
ʻO ke Kula Lapaʻau ʻo Icahn ma mauna ʻo Sinai, ke Keʻena ʻo Endocrine, Diabetes, a me ka maʻi iwi
4. Vian Ahmed Wasta Esmail
Keʻena o ka lāʻau lapaʻau lapaʻau, ke kulanui o ka lāʻau lapaʻau, ke Kulanui o Sulaimani, Sulaimani, Iraq
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.

E hoʻomaopopo '

[1] Siebenhofer A, Winterholer S, Jeitler K, Horvath K, Berghold A, Krenn C, Semlitsch T (Ianuali 2021). "Nā hopena lōʻihi o nā lāʻau hoʻohaʻahaʻa kaumaha i ka poʻe me ka hypertension". ʻO ka Cochrane Database of Systematic Reviews. 1 (1):CD007654.

[2] Mancini MC, Halpern A (ʻApelila 2006). "Pharmacological mālama o ka momona". ʻO Arquivos Brasileiros de Endocrinologia a me Metabologia. 50 (2):377–389.

[3] Heck AM, Yanovski JA, Calis KA (Malaki 2000). "Orlistat, kahi mea hoʻopiʻi lipase hou no ka mālama ʻana i ka momona". Pharmacotherapy. 20 (3):270–279.

[4] Garcia SB, Barros LT, Turatti A, Martinello F, Modiano P, Ribeiro-Silva A, et al. (ʻAukake 2006). ”. Nā leka maʻi maʻi. 240 (2):221–224.

[5] "Apono ʻo FDA iā Orlistat no ka hoʻohana ʻana ma luna o ka counter" (Press release).USFood and Drug Administration (FDA).7 February 2007.Archived from ka mea kumu ma ka lā 13 o Mei 2009. Kiʻi ʻia i ka lā 7 Pepeluali 2007.

E kiʻi i kahi hōʻaiʻē nui