Product Description
He aha ka PT-141 (Bremelanotide)?
PT-141, i ʻike ʻia he bremelanotide, he inoa maʻamau no ka papa hou o nā peptides e aʻo ʻia nei e kōkua i ka hoʻomaikaʻi ʻana i ka hana ʻino (erectile dysfunction, a impotence) i loko o nā kāne a e kōkua i ka hoʻomaikaʻi ʻana i ka hana ʻino (sexual arousal disorder) i nā wahine.141 ʻaʻole hana i ka ʻōnaehana vascular e like me nā pūhui ʻelua ma mua, akā ua ʻike ʻia a ua hōʻike ʻia e kōkua i ka hoʻonui ʻana i ka hana moe kolohe i nā mammals kāne a me nā wahine. Eia kekahi, ua ʻae ʻia ʻo peptide PT 141 i ka FDA i kēia manawa e mālama i ka hana ʻino i nā wahine. Inā makemake ka poʻe e kūʻai i ka peptide PT 141 ma ka pūnaewele, hiki ke loaʻa maʻalahi nā kumu, e like me ka mea hana PT 141 a me ka mea hoʻolako.
Pehea ka hana ʻana o PT-141(Bremelanotide)?
ʻO PT-141 (Bremelanotide) ka mea mua o kahi papa lāʻau ʻē aʻe i ʻike ʻia he melanocortin agonists no ka maʻi therapeutic pathology. Hiki i ke ʻano o ka hana o PT-141 (Bremelanotide) ke hāʻawi i nā pono palekana a me ka maikaʻi e hoʻohālikelike ʻia i nā huahana i loaʻa i kēia manawa no ka mea e hana ia ma nā ala o nā hana hoʻomalu ma mua o ka ʻōnaehana. Hōʻike ka ʻikepili maʻi i ka PT-141 (Bremelanotide) hiki ke mālama pono i nā maʻi maʻi maʻi ʻole. ʻO ka hoʻokumu ʻana o ka ihu o PT-141 (Bremelanotide) ma lalo o ka hoʻomohala ʻana he mea maʻalahi ia e like me ka lāʻau lapaʻau waha, ʻoluʻolu loa ka hoʻomanawanui i ka hoʻohālikelike ʻia me nā lāʻau invasive e like me nā injections a me nā pellets transurethral, a ʻike ʻia he wikiwiki ka hana.
'Ōleloʻiaʻo Bremelanotide PT-141 e hana ma ka hoʻouluʻana i nā mea hoʻokipa melanocortin i loko o ka lolo, e kōkua ai i ka hoʻonuiʻana i ka moe kolohe. He peptide i hoʻokumu ʻia melanocortin i hōʻike i ka maikaʻi i nā noiʻi lapaʻau i nā ʻiole kāne a me nā wahine. Ua hōʻike nā ʻiole kāne i nā pane erectile ma nā kumu haʻahaʻa e like me ka 1-2 mg, aʻo ka hapa nui o nā ʻiole wahine i hōʻike i nā pane maikaʻi i ka nui o ka 2-3 mg. ʻOi aku ka nui o nā koi no nā ʻiole wahine, akā ua ʻike ʻia nā hopena ikaika i nā ʻiole wahine.
He mea nui e hoʻomaopopo i ke ʻano o ka hana o ka huahana e pili ana i kona maikaʻi. ʻO nā huahana kiʻekiʻe wale nō ke loaʻa kahi hana kūpono o ka hana. No ka hōʻoiaʻana i ka maikaʻi o ka PT-141, he mea koʻikoʻi ka loaʻaʻana mai kahi kumu hilinaʻi. nā koi kūikawā, koho i ka PT-141 kūʻai nui mai AASraw he koho maikaʻi loa.
Nā pōmaikaʻi o ka hoʻohana ʻana i ka peptide PT-141 (Brelanotide)
Hāʻawi ʻo PT-141 (Bremelanotide) i nā pōmaikaʻi mua i ka mālama ʻana i ka maʻi ʻino i nā kāne a me nā wahine. Ke hoʻohana ʻia ma o ka injection, ua hōʻike ʻia nā hopena maikaʻi loa i nā kumuhana hoʻāʻo wahine. Eia nō naʻe, he mea maikaʻi nō ia no nā kāne e ʻike nei i nā pilikia e like me ka erectile dysfunction, libido haʻahaʻa, a me ka impotence.
Hoʻonui i ka makemake moekolohe
ʻO kekahi o nā pōmaikaʻi koʻikoʻi o PT-141 ʻo ia ka hiki ke hoʻonui i ka makemake i ka wahine ma o ka ʻōnaehana nerve waena me ka ʻole e hoʻopilikia i ka ʻōnaehana vascular. I ka hoʻohālikelikeʻana i nā lāʻau lapaʻau'ē aʻe, ua manaʻoʻiaʻo AASraw PT-141 iʻoi aku ka ikaika i ka mālamaʻana i kahi kūlana palekana maikaʻi. ʻAʻole ia e hoʻopilikia nui i ke olakino holoʻokoʻa.
I ka mālama ʻana i ka hana ʻino, ua hōʻike ʻia ʻo PT-141 i ka hoʻoikaika ʻana i ka makemake i ka wahine, a hiki i nā hopena ke lōʻihi. ʻIke kekahi poʻe i nā pōmaikaʻi a hiki i 72 mau hola ma hope o ka hoʻokomo ʻana o PT-141.
Hoʻonui i ka ikehu
Ma kahi o kāna kuleana i ka hoʻoponopono ʻana i ka moe kolohe, ua hōʻike ʻo PT-141 i ka hiki ke hoʻonui maoli i nā pae ikehu. Hoʻohana pū nā keʻena hormone kāne i ka PT-141 e hoʻoponopono i nā hōʻailona pili i ka testosterone haʻahaʻa. Hiki i ka hui peptide o PT-141 ke pōmaikaʻi i nā poʻe i ʻike pinepine i ka lethargy, luhi, a i ʻole ka nele o ka ikehu.
Hoʻopaʻa i nā maʻi pigmentation o ka ʻili.
Eia kekahi, ua ʻimi ʻia ʻo PT-141 no kona hiki ke mālama i nā maʻi pigmentation o ka ʻili a ua hoʻohana ʻia ma ke ʻano he lāʻau tanning kūlohelohe. Eia naʻe, ʻo ka propensity o PT-141 e hoʻoulu i ka moekolohe i nā mea hoʻohana ua kaupalena ʻia kāna noi i nā huahana tanning. He mea nui ia e hoʻomaopopo i ke kumu nui o ka hoʻohana ʻana i ka PT-141 e hoʻomau i ka mālama ʻana i nā hana like ʻole a me ka hoʻonui ʻana i ka makemake wahine i nā kāne a me nā wahine.
He kī nui e kūʻai i ka PT-141 mai nā kumu kaulana; a i ʻole, ʻaʻole hiki iā ʻoe ke kiʻi i ka hopena maikaʻi loa mai PT-141. Ma ke ʻano he mea hana a me ka mea hoʻolako PT-141, manaʻo ʻo AASraw e hoʻolako i ka PT-141 maʻemaʻe ma ka honua holoʻokoʻa. Inā he pono kāu, ʻo ka peptide PT-141 o AASraw kahi koho maikaʻi loa iā ʻoe.
Nā hopena ʻaoʻao o ka peptide PT-141 (Brelanotide)
ʻOiai ʻo PT-141 (Bremelanotide) e ʻae maikaʻi ʻia, pono e makaʻala i nā hopena ʻaoʻao e hiki mai ana. ʻO kekahi o nā hopena ʻaoʻao o PT-141 e komo pū ana:
'O Nausea: ʻO ka nausea kekahi o nā hopena ʻaoʻao maʻamau i hōʻike ʻia o PT-141. Hiki ke hoʻoulu i nā manaʻo o ka queasiness a i ʻole ka ʻōpū ʻeha.
Heʻeha: Hiki i kekahi poʻe ke loaʻa i ke poʻo poʻo ma ke ʻano he hopena ʻaoʻao o ka PT-141. ʻO kēia mau poʻo poʻo maʻamau ka maʻalahi a hoʻoholo iā lākou iho.
Nā wahi hoʻolālā pūnaewele: Ma muli o ka lawelawe ʻia ʻana o ka PT-141 ma o ka ʻinikua, hiki ke ʻike ʻia nā hopena o ka wahi i hoʻopaʻa ʻia e like me ka ʻeha, ʻulaʻula, a i ʻole ka pehu ʻana ma ka wahi i hoʻopaʻa ʻia.
Hoʻoponopono: Hiki i ka no'ono'o a i'ole ka pu'uwai māmā ma ke 'ano he hopena o ka PT-141. He mea nui e pale i nā hana e pono ai ka maka'ala inā loa'a iā'oe ka no'ono'o.
'Oloke: Loaʻa paha i kekahi poʻe ka luhi a luhi paha ma hope o ka lawe ʻana i ka PT-141.
ʻO ka'ākau Nasal: Inā lawelawe ʻia ʻo PT-141 ma ke ʻano o ka nasal spray, hiki mai ka nasal congestion a stuffiness ma ke ʻano he hopena ʻaoʻao.
He mea nui e hoʻomaopopo ʻaʻole e ʻike nā kānaka a pau i kēia mau hopena ʻaoʻao, a ʻokoʻa paha ka paʻakikī a me ka pinepine o nā hopena ʻaoʻao i waena o kēlā me kēia kanaka. Inā ʻike ʻoe i nā hopena ʻaoʻao e pili ana a i ʻole nā hopena hoʻomau, pono ʻoe e nīnau me ke kauka olakino no ke alakaʻi hou aku. Eia kekahi, i ke kūʻai ʻana i ka PT-141, pono ʻoe e koho pono i ka mea hoʻolako PT-141 e hōʻoia i ka maikaʻi o ka huahana. I ka manawa like, pono e hoʻohana ʻia ma lalo o ke alakaʻi a nā poʻe loea e pale i nā hopena ʻino.
PT-141 vs Melanotan II (MT-2)
ʻO ka PT-141 (Bremelanotide) a me Melanotan II (MT-2) he mau ʻokoʻa ko lākou hopena a me nā hana o ka hana i ka wā e pili ana i ka mālama ʻana i ka erectile dysfunction (ED). Eia kahi hoʻohālikelike ma waena o PT-141 a me MT-2 e pili ana i kā lākou hopena ma ED.
①Mechanism o ka hana
PT-141
Hana nui ʻo PT-141 i ka ʻōnaehana nūnū waena ma o ka huli ʻana i nā mea loaʻa melanocortin, ʻoi aku ka melanocortin 4 receptor (MC4R) i ka lolo. Hoʻoulu ia i ka hoʻokuʻu ʻana o ka nitric oxide, e kōkua ana i ka hoʻomaha ʻana i nā ʻiʻo maʻemaʻe i loko o ka penis a hoʻonui i ke kahe koko, e alakaʻi ana i ka hana erectile.
Melanotan II
Hana nui ʻo Melanotan II ma ka huli ʻana i nā mea loaʻa melanocortin, ʻoi aku ka melanocortin 1 receptor (MC1R). ʻO kāna kumu nui e hoʻoulu i ka hana ʻana o ka melanin i loko o ka ʻili, ka hopena i ka pōʻeleʻele o ka ʻili. ʻOiai he hopena paha ia i ka hana moe kolohe, ʻoi aku ka liʻiliʻi o kona hopena i ka hana erectile e hoʻohālikelike ʻia me PT-141.
②E nānā i ka Erectile Dysfunction
PT-141
Ua aʻo ʻia a hoʻomohala ʻia ʻo PT-141 no ka mālama ʻana i ka maʻi maʻi, me ka erectile dysfunction, i nā kāne a me nā wahine. Ua hōʻike nā hoʻokolohua lapaʻau i nā hopena hoʻohiki i ka hoʻomaikaʻi ʻana i ka hana erectile a me ka makemake moe.
Melanotan II
ʻOiai ua hōʻike ʻia ʻo Melanotan II me ka anecdotally e loaʻa kekahi mau hopena i ka hana moe kolohe a me ka libido, ʻaʻole i kālele kāna kumu nui i ka mālama ʻana i ka erectile dysfunction. Hoʻohana nui ʻia ia no nā hopena tanning a ua kaupalena ʻia nā hōʻike lapaʻau e kākoʻo ana i kona hoʻohana ʻana i ka mālama ʻana iā ED.
③Hōʻike Kauka
PT-141
Ua hana ʻo PT-141 i nā hoʻokolohua lapaʻau e loiloi pono ana i kona pono i ka mālama ʻana i ka erectile dysfunction. Ua hōʻike kēia mau ho'āʻo i nā hopena maikaʻi, e hōʻike ana i kona hiki ke koho i ka lāʻau lapaʻau no ED.
Melanotan II
ʻO Melanotan II ka palena o nā hōʻike lapaʻau e kākoʻo ana i kona pono i ka mālama ʻana i ka erectile dysfunction. ʻO ka hapa nui o nā ʻikepili i loaʻa e pili ana i kona hopena i ka hana moe kolohe e hoʻokumu ʻia ma nā hōʻike anecdotal ma mua o nā noiʻi lapaʻau koʻikoʻi.
I ka hōʻuluʻulu manaʻo, ua aʻo nui ʻia a hoʻomohala ʻia ʻo PT-141 no ka mālama ʻana i ka erectile dysfunction a me ka male ʻana i nā kāne a me nā wahine. ʻO kāna hana o ka hana e kuhikuhi pololei i ka ʻōnaehana nerve waena a ua hōʻike i nā hopena hoʻohiki i nā hoʻokolohua lapaʻau. Ma ka ʻaoʻao ʻē aʻe, ʻo Melanotan II ka mea nui i ka ʻeleʻele o ka ʻili a ʻoi aku ka liʻiliʻi o nā hōʻike pololei no kona pono i ka mālama ʻana i ka erectile dysfunction.
Ma hea e kūʻai aku ai i ka PT-141(Bremelanotide)?
I ka hiki ʻana iā PT-141 (Bremelanotide), he mea koʻikoʻi ia e hoʻokumu i ka palekana a me ka ʻoiaʻiʻo i ka wā e noʻonoʻo ai i kahi kūʻai mai nā mea hoʻolako pūnaewele. Pono e ʻimi ʻia nā kumu ʻoiaʻiʻo a hilinaʻi e hōʻoia i ka maikaʻi a me ka maikaʻi o ka huahana no kāna mau noi olakino. He mea nui ka hōʻoia ʻana i ka inoa o ka mea hoʻolako, e like me kā lākou mālama ʻana i nā kūlana mana maikaʻi a me ka hāʻawi ʻana i nā palapala e pono ai e like me ka Certificate of Analysis.
Ināʻoe eʻimi ana i kahi kumu hilinaʻi no ke kūʻaiʻana i ka PT-141, hiki i ka AASraw ke koho kūpono. ʻO AASraw kahi hui e hāʻawi ana i ka nui o nā peptides, me ka PT-141. Hoʻohana pinepine ʻia kā lākou huahana e nā laboratories a me nā keʻena noiʻi no ka hoʻomohala ʻana a me ka hana ʻana i nā huahana olakino.
PT-141 Hōʻike Hōʻike-HNMR
He aha ka HNMR a he aha ka HNMR spectrum e haʻi iā ʻoe? ʻO H Nuclear Magnetic Resonance (NMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā huila i loaʻa nā pūhui i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR e hoʻohālikelike i nā hale waihona puke spectral a i ʻole e kuhi pololei i ke ʻano kumu. Ke ʻike ʻia ke ʻano kumu, hiki ke hoʻohana ʻia ka NMR no ka hoʻoholo ʻana i ka conformation molecular i ka hopena a me ke aʻo ʻana i nā waiwai kino ma ka pae molekala e like me ka hoʻololi conformational, nā hoʻololi ʻana, ka solubility, a me ka diffusion.
Pehea e kūʻai ai i ka PT-141 mai AASraw?
❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu WhatsApp iā mākou, e hoʻopili aku kā mākou mea kūʻai aku (CSR) iā ʻoe i loko o 12 mau hola.
❷E hāʻawi iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.
❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala lawe, a me ka lā i manaʻo ʻia e hiki mai ai (ETA).
❹E uku ʻia a hoʻouna ʻia nā waiwai i loko o 12 mau hola.
❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.
Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine
Mea kākau moʻolelo puke moʻolelo ʻepekema:
1. Anita H. Clayton MD
Keʻena o ka Psychiatry a me Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia
2. François Giuliano MD, PhD
ʻO ka Halemai ʻo Raymond Poincaré—Keʻena o ka lāʻau lapaʻau kino a me ka hoʻoponopono hou ʻana, Garches, Farani
3. Mohammad Reza Safarinejad
Urology and Nephrology Research Center, Shaheed Modarress Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
4. Raymond C. Rosen PhD
Keʻena o ka Psychiatry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, USA
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.
E hoʻomaopopo '
[1]. Simon JA, Kingsberg SA "Ka palekana a me ka maikaʻi o Bremelanotide no ka Hypoactive Sexual Desire Disorder." Obstet Gynecol.2019 Nov.PMID:31599847.
[2] Diamond LE, Earl DC, Heiman JR, Rosen RC, Perelman MA, Harning R. J Sex Med.141 Jul; PMID:2006.
[3] ʻO Ückert S, Bannowsky A, Albrecht K, Kuczyk MA (November 2014). "Melanocortin receptor agonists i ka mālama ʻana i nā male kāne a me ka wahine: nā hopena mai ka noiʻi kumu a me nā noiʻi lapaʻau". 23):11–1477.doi:83/10.1517.PMID 13543784.2014.934805.
[4] Pfaus J, Giuliano F, Gelez H. "Bremelanotide: he hiʻohiʻona o nā hopena CNS preclinical ma ka hana moe wahine." J Sex Med.2007 Nov.PMID:17958619.
[5] Mintzes B, Tiefer L, Cosgrove L. "Bremelanotide a me flibanserin no ka makemake haʻahaʻa i ka wahine: ka hewa o ka precedent hoʻoponopono. "Drug Ther Bull.2021 Dec;PMID:34642243.
[6] Molinoff PB, Shadiack AM, Earl D, Diamond LE, Quon CY.
ʻO Rosen RC, Diamond LE, Earl DC, Shadiack AM, Molinoff PB. pane iā Viagra. "Int J Impot Res.7 Apr.PMID:141.
[8] Diamond LE, Earl DC, Garcia WD, Spana C. 141 ʻApelila;PMID:2005.
