Product Description
He aha ka PT-141 (Bremelanotide)?
PT-141, i ʻike ʻia he bremelanotide,he inoa maʻamau no kahi papa hou o nā peptides e aʻo ʻia nei e kōkua i ka hoʻomaikaʻi ʻana i ka hana ʻino (erectile dysfunction, a i ʻole impotence) i loko o nā kāne a kōkua i ka hoʻomaikaʻi ʻana i ka hana ʻino (sexual arousal disorder) i nā wahine.141 ʻaʻole hana i ka ʻōnaehana vascular e like me nā pūhui ʻelua i hala, akā ua ʻike ʻia a ua hōʻike ʻia e kōkua i ka hoʻonui ʻana i ka hana moekolohe i nā mammals kāne a me nā wahine. 141 pūnaewele, nui nā kumu, e like me ka PT 141 mea hana a me ka mea hoʻolako, hiki ke maʻalahi.
Pehea ka hana ʻana o PT-141(Bremelanotide)?
ʻO PT-141 (Bremelanotide) ka mea mua o kahi papa lāʻau ʻē aʻe i ʻike ʻia he melanocortin agonists no ka therapeutic pathology. ʻO nā ala o nā hana hoʻomalu ma mua o ka pololei o ka ʻōnaehana. Hōʻike ka ʻikepili clinical e hiki ke mālama pono ʻia ka PT-141 (Bremelanotide) i nā maʻi maʻi ʻole. ʻoluʻolu hoʻomanawanui i ka hoʻohālikelike ʻia me nā lāʻau invasive e like me ka injections a me nā pellets transurethral, a ʻike ʻia he wikiwiki ka hoʻomaka ʻana o ka hana.
'Ōleloʻiaʻo Bremelanotide PT-141 e hana ma ka hoʻouluʻana i nā melanocortin receptors i loko o ka lolo, ma laila e kōkua ai i ka hoʻonuiʻana i ka moe kolohe. e like me ka 1-2 mg, aʻo ka hapa nui o nāʻiole wahine i hōʻike i nā pane maikaʻi ma nā doses e like me 2-3 mg. Uaʻoi aku ka kiʻekiʻe o nā koi no nāʻiole wahine, akā, uaʻikeʻia nā hopena ikaika i nāʻiole wahine.
He mea nui e hoʻomaopopo i ke ʻano o ka hana o ka huahana e pili ana i kona ʻano. kumu.AASraw, ka mea hana kaulana a me ka mea hoʻolako o PT-141, hāʻawi i nā huahana peptide kiʻekiʻe no ka noiʻi kūʻokoʻa a me nā kikowaena hoʻomohala a me nā hale hana.
Nā pōmaikaʻi o ka hoʻohana ʻana i ka peptide PT-141 (Brelanotide)
Hāʻawi ʻo PT-141 (Bremelanotide) i nā pōmaikaʻi nui i ka mālama ʻana i ka male ʻana i nā kāne a me nā wahine. libido haʻahaʻa, a me ka impotence.
Hoʻonui i ka makemake moekolohe
ʻO kekahi o nā pōmaikaʻi nui o PT-141 ʻo ia ka hiki ke hoʻonui i ka makemake i ka wahine ma o ka ʻōnaehana nerve waena me ka ʻole o ka hoʻopilikia ʻana i ka ʻōnaehana vascular. profile. ʻAʻole ia e hoʻopilikia nui i ke olakino holoʻokoʻa.
I ka mālama ʻana i ka hana ʻino, ua hōʻike ʻia ʻo PT-141 e hoʻoikaika pono i ka makemake i ka wahine, a hiki i nā hopena ke lōʻihi.
Hoʻonui i ka ikehu
Ma waho aʻe o kāna kuleana i ka hoʻoponopono ʻana i ka moe kolohe, ua hōʻike ʻo PT-141 i ka hiki ke hoʻonui maoli i nā pae ikehu. Hoʻohana pū nā keʻena hormone kāne i ka PT-141 e hoʻoponopono i nā hōʻailona pili i ka testosterone haʻahaʻa. ʻike pinepine i ka lethargy, ka luhi, a i ʻole ka nele o ka ikehu.
Hoʻopaʻa i nā maʻi pigmentation o ka ʻili.
Eia kekahi, ua ʻimi ʻia ʻo PT-141 no kona hiki ke mālama i nā maʻi pigmentation o ka ʻili a ua hoʻohana ʻia ma ke ʻano he ʻano kūlohelohe, sunless tanning agent. Pono e hoʻomaopopo ʻia ʻo ke kumu nui o ka hoʻohana ʻana i ka PT-141 e hoʻomau i ka mālama ʻana i nā ʻano hana like ʻole a me ka hoʻonui ʻana i ka makemake wahine i nā kāne a me nā wahine.
He kī ia i ke kūʻai ʻana i ka PT-141 mai nā kumu kaulana; ināʻaʻole,ʻaʻole hiki iāʻoe ke loaʻa ka hopena maikaʻi loa mai ka PT-141. Ma keʻano he mea hana a me ka mea hoʻolako PT-141, manaʻoʻo AASraw e hoʻolako i ka PT-141 maʻemaʻe ma ka honua holoʻokoʻa.
Nā hopena ʻaoʻao o ka peptide PT-141 (Brelanotide)
ʻOiai ʻo PT-141 (Bremelanotide) e ʻae maikaʻi ʻia, he mea nui e makaʻala i nā hopena ʻaoʻao e hiki mai ana.
'O Nausea: ʻO ka nausea kekahi o nā hopena ʻaoʻao maʻamau i hōʻike ʻia o PT-141. Hiki iā ia ke hoʻoulu i nā manaʻo o ka queasiness a i ʻole ka ʻōpū ʻeha.
Heʻeha: Hiki i kekahi poʻe ke loaʻa i ke poʻo poʻo ma ke ʻano he hopena ʻaoʻao o ka PT-141. ʻO kēia mau maʻi poʻo he maʻamau maʻamau a hoʻoholo iā lākou iho.
Nā wahi hoʻolālā pūnaeweleMa muli o ka lawelawe ʻia ʻana o PT-141 ma o ka injection, aia ka hiki ke ʻike i nā hopena o ka wahi injection e like me ka ʻeha, ka ʻulaʻula, a i ʻole ka pehu ʻana ma ka pūnaewele injection.
Hoʻoponopono: Hiki i ka no'ono'o a i'ole ka na'au māmā ma ke 'ano he hopena o ka PT-141. He mea nui e pale i nā hana e pono ai ka maka'ala inā loa'a iā'oe ka no'ono'o.
'Oloke: Loaʻa paha i kekahi poʻe ka luhi a i ʻole ka luhi ma hope o ka lawe ʻana i ka PT-141.
ʻO ka'ākau Nasal: Inā lawelawe ʻia ʻo PT-141 ma ke ʻano hoʻoheheʻe ihu, hiki i ka ʻāʻī ʻana a i ʻole nā mea ʻona paha ma ke ʻano he hopena ʻaoʻao.
He mea nui e hoʻomaopopo ʻaʻole e ʻike nā kānaka a pau i kēia mau hopena ʻaoʻao, a ʻokoʻa paha ka paʻakikī a me ka pinepine o nā hopena ʻaoʻao i waena o kēlā me kēia kanaka. . Eia kekahi, i ka wā e kūʻai ai i ka PT-141, pono ʻoe e koho pono i ka mea hoʻolako PT-141 e hōʻoia i ka maikaʻi o ka huahana. Ma ka manawa like, pono e hoʻohana ʻia ma lalo o ke alakaʻi ʻana o nā poʻe loea e pale i nā hopena ʻino.
PT-141 vs Melanotan II (MT-2)
ʻO ka PT-141 (Bremelanotide) a me Melanotan II (MT-2) kekahi mau ʻokoʻa i kā lākou hopena a me nā ʻano hana i ka wā e pili ana i ka mālama ʻana i ka erectile dysfunction (ED). Eia ka hoʻohālikelike ma waena o PT-141 a me MT-2 nā hopena ma ED.
①Mechanism o ka hana
PT-141
Hana nui ʻo PT-141 i ka ʻōnaehana o ke kikowaena ma ka huli ʻana i nā melanocortin receptors, ʻoi aku ka melanocortin 4 receptor (MC4R) i loko o ka lolo. hoʻomaikaʻi i ka hana erectile.
Melanotan II
Hana nui ʻia ʻo Melanotan II ma ka huli ʻana i ka melanocortin receptors, ʻoi aku ka melanocortin 1 receptor (MC1R). ʻAʻole pololei ka hana erectile i ka PT-141.
②E nānā i ka Erectile Dysfunction
PT-141
Ua aʻo pono ʻia a hoʻomohala ʻia ʻo PT-141 no ka mālama ʻana i ka moe kolohe, me ka erectile dysfunction, i nā kāne a me nā wahine.
Melanotan II
ʻOiai ua hōʻike ʻia ʻo Melanotan II e loaʻa i kekahi mau hopena i ka hana moe kolohe a me ka libido, ʻaʻole i kālele ʻia kāna kumu nui i ka mālama ʻana i ka erectile dysfunction.
③Hōʻike Kauka
PT-141
Ua ho'āʻo ka PT-141 i nā ho'āʻo hoʻokolohua e loiloi pono ana i kona pono i ka mālamaʻana i ka erectile dysfunction.Ua hōʻike kēia mau ho'āʻo i nā hopena maikaʻi, e hōʻike ana i kona kūpono ma keʻano he koho lapaʻau no ED.
Melanotan II
ʻO Melanotan II he mau hōʻike hōʻike hōʻike liʻiliʻi e kākoʻo ana i kona pono i ka mālama ʻana i ka maʻi erectile.
I ka hōʻuluʻulu manaʻo, ua aʻo nui ʻia a hoʻomohala ʻia ʻo PT-141 no ka mālama ʻana i ka erectile dysfunction a me ka male ʻana i nā kāne a me nā wahine. lima, ʻo Melanotan II ka mea nui i ka ʻeleʻele o ka ʻili a he liʻiliʻi ka hōʻike pololei no kona pono i ka mālama ʻana i ka erectile dysfunction.
Ma hea e kūʻai aku ai i ka PT-141(Bremelanotide)?
I ka hiki ʻana i ka PT-141 (Bremelanotide), he mea koʻikoʻi ia e hoʻokumu i ka palekana a me ka ʻoiaʻiʻo i ka wā e noʻonoʻo ai i kahi kūʻai mai nā mea hoʻolako pūnaewele. He mea nui ka inoa o ka mea hoʻolako, e like me kā lākou mālama ʻana i nā kūlana mana maikaʻi a me ka hāʻawi ʻana i nā palapala e pono ai e like me kahi palapala hōʻoia.
Ināʻoe eʻimi ana i kahi kumu hilinaʻi no ke kūʻaiʻana i ka PT-141, hiki i ka AASraw ke koho kūpono. ka hoʻomohala ʻana a me ka hana ʻana i nā huahana olakino like ʻole.
PT-141 Hōʻike Hōʻike-HNMR
He aha ka HNMR a He aha ka HNMR spectrum e haʻi aku iā ʻoe? ʻO H Nuclear Magnetic Resonance (NMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā hui pū ʻia i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR e hoʻohālikelike i nā hale waihona puke spectral a i ʻole e kuhi pololei i ke ʻano kumu. Ke ʻike ʻia ke ʻano kumu, hiki ke hoʻohana ʻia ka NMR no ka hoʻoholo ʻana i ka conformation molecular i ka hopena a me ke aʻo ʻana i nā waiwai kino ma ka pae molekala e like me ka hoʻololi conformational, nā hoʻololi ʻana, ka solubility, a me ka diffusion.
Pehea e kūʻai ai i ka PT-141 mai AASraw?
❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu whatsapp iā mākou, e hoʻopili aku kā mākou mea kūʻai aku (CSR) me ʻoe i 12 mau hola.
❷E hāʻawi mai iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.
❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala hoʻouna a me ka lā i manaʻo ʻia (ETA).
❹E uku ʻia a hoʻouna ʻia nā waiwai i loko o 12 mau hola.
❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.
Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine
Mea kākau moʻolelo puke moʻolelo ʻepekema:
1. Anita H. Clayton MD
Keʻena o ka Psychiatry a me Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia
2. François Giuliano MD, PhD
ʻO ka Halemai ʻo Raymond Poincaré—Keʻena o ka lāʻau lapaʻau kino a me ka hoʻoponopono hou ʻana, Garches, Farani
3. Mohammad Reza Safarinejad
Urology and Nephrology Research Center, Shaheed Modarress Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
4. Raymond C. Rosen PhD
Keʻena o ka Psychiatry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, USA
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.
E hoʻomaopopo '
[1]. Simon JA, Kingsberg SA "Ka palekana a me ka maikaʻi o Bremelanotide no ka Hypoactive Sexual Desire Disorder." Obstet Gynecol.2019 Nov.PMID:31599847.
[2] Diamond LE, Earl DC, Heiman JR, Rosen RC, Perelman MA, Harning R. J Sex Med.141 Jul; PMID:2006.
[3] ʻO Ückert S, Bannowsky A, Albrecht K, Kuczyk MA (November 2014). "Melanocortin receptor agonists i ka mālama ʻana i nā male kāne a me ka wahine: nā hopena mai ka noiʻi kumu a me nā noiʻi lapaʻau". 23):11–1477.doi:83/10.1517.PMID 13543784.2014.934805.
[4] Pfaus J, Giuliano F, Gelez H. "Bremelanotide: he hiʻohiʻona o nā hopena CNS preclinical ma ka hana moe wahine." J Sex Med.2007 Nov.PMID:17958619.
[5] Mintzes B, Tiefer L, Cosgrove L. "Bremelanotide a me flibanserin no ka makemake haʻahaʻa i ka wahine: ka hewa o ka precedent hoʻoponopono. "Drug Ther Bull.2021 Dec;PMID:34642243.
[6] Molinoff PB, Shadiack AM, Earl D, Diamond LE, Quon CY.
ʻO Rosen RC, Diamond LE, Earl DC, Shadiack AM, Molinoff PB. pane iā Viagra. "Int J Impot Res.7 Apr.PMID:141.
[8] Diamond LE, Earl DC, Garcia WD, Spana C. 141 ʻApelila;PMID:2005.
