Product Description
He aha Selank?
ʻO Selank peptide kahi peptide synthetic i loaʻa mai ka tuftsin, kahi peptide kūlohelohe i loaʻa i loko o ke kino kanaka. Ua hoʻomohala ʻia me ka hui pū ʻana me ka VVZakusov Research Institute of Pharmacology ma ke Institute of Molecular Genetics, Russian Academy of Medical Sciences. Ma Rūsia, ua ʻae ʻia no ka mālama ʻana i ka maʻi ʻehaʻeha ākea (GAD) a hoʻohana ʻia hoʻi i ka leʻaleʻa e like me ka nootropic.
ʻO ke kaʻina kikoʻī o ka peptide Selank ʻo Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). Hoʻolālā ʻia kēia kaʻina e hoʻohālike i nā hana a tuftsin, kahi i komo i ka hoʻoponopono immune a loaʻa nā waiwai anxiolytic. Ua aʻo nui ʻia ʻo Selank no kāna mau hopena therapeutic, me ka hoʻomaikaʻi ʻana i nā hōʻailona hopohopo a me ke kaumaha, ka hoʻonui ʻana i ka hoʻomanaʻo a me ka cognition, a me ka hoʻoikaika ʻana i ke ʻano o ka mālie.
Ke manaʻo nei ka hoʻomohala ʻana o Selank e hoʻoponopono i nā palena o ka peptide tuftsin kūlohelohe, he pōkole ke ola o ke kino. Ma ka synthesizing Selank, ʻimi nā ʻepekema e hana i kahi ʻano paʻa a lōʻihi o ka tuftsin, e ʻae ana i nā noi therapeutic ʻoi aku ka maikaʻi a hilinaʻi.
Pehea ka hana a Selank?
Hoʻohana ʻo Selank i kona hopena ma ke kino ma o nā ʻano hana like ʻole. ʻOiai ʻaʻole ʻike ʻia nā hana pololei o ka hana, eia kekahi mau hypotheses e pili ana i ka hana a Selank.
ʻO ka modulation Neurotransmitter: Manaʻo ʻia ʻo selank ka hopena o ka neʻe ʻana o nā neurotransmitters monoamine e like me ke serotonin, dopamine, a me nā norepinephrine. Hiki ke kōkua ʻo Selank i ka hoʻoponopono ʻana i ke ʻano, cognition, a me nā kūlana naʻau ma o ka hoʻohuli ʻana i ka metabolism a me nā pae o kēia mau neurotransmitters.
Ka launa pū me ka ʻōnaehana pale: ʻo selank kahi analog tuftsin synthetic e hōʻike ana he mau waiwai immunomodulatory paha. Manaʻo ʻia e hoʻopili i ke koena o nā cytokines helper cell T a hoʻololi i ka hōʻike ʻana o Interleukin-6 (IL-6), ʻo ia mau mea ʻelua he mea nui i ka pane a me ka hoʻoponopono.
Ka hopena ma ka brain-derived neurotrophic factor (BDNF): Ua hōʻike ʻia ʻo selank e hoʻoikaika i ka hōʻike BDNF i ka hippocampus, kahi ʻāpana o ka lolo no ke aʻo ʻana a me ka hoʻomanaʻo.
ʻO ka enzyme inhibition: selank a me kāna lāʻau peptide like ʻo Semax i hōʻike ʻia e kāohi i nā enzyme i komo i ka haki ʻana o nā enkephalins a me nā peptides regulatory endogenous. Hiki i kēia hana ke kōkua i ka hoʻoponopono ʻana i nā pae peptide a me ka hana, hiki ke hoʻopilikia i ka ʻike ʻeha a me nā kaʻina hana physiological ʻē aʻe.
He mea nui e kūʻai i ka selank mai kahi mea hoʻolako kaulana i hiki ke hōʻoia i ka maikaʻi o ka selank peptide. Hiki i ka mea hana selankʻoihana a me ka mea hoʻolako AASraw ke hoʻolako i ka selank me ke kūlana kiʻekiʻe no ke kākoʻo o ke kikowaena R&D kūʻokoʻa a me ka hale hana. Inā loaʻa iā ʻoe nā mea e pono ai, ʻo selank wholesale mai AASraw kahi koho maikaʻi loa.
Nā pōmaikaʻi o Selank
Ua aʻo ʻia ʻo Selank peptide no kāna mau pono therapeutic kūpono a ua hōʻike i nā hopena maikaʻi like ʻole. Eia kekahi mau pono kūpono o Selank.
Nā hopena anxiolytic
Ua hōʻike ʻo Selank i nā hopena anti-anxiety i nā hoʻokolohua lapaʻau a me nā haʻawina holoholona. Hiki ke kōkua i ka hōʻemi ʻana i nā hōʻailona hopohopo, hoʻomaikaʻi i ka maikaʻi o ke ola, a hoʻēmi i ka hopohopo pili i nā maʻi like ʻole.
Hoʻonui noʻonoʻo
Ua ʻike ʻia ʻo Selank e hoʻomaikaʻi i ka hana cognitive a hoʻomaikaʻi i ka hiki ke aʻo a me ka hoʻomanaʻo. Hiki iā ia ke hoʻoikaika i ka noʻonoʻo maikaʻi, ke aʻo ʻana, a me nā kaʻina hoʻomanaʻo, hiki ke hoʻopōmaikaʻi i nā poʻe me nā hemahema o ka naʻau a i ʻole ka poʻe e nānā ana e hoʻokō i kā lākou hana cognitive.
Hoʻoponopono manaʻo
Loaʻa paha iā Selank nā waiwai hoʻoponopono naʻau, hiki ke hāʻawi i kāna hopena anxiolytic. Ua aʻo ʻia no kona hiki ke hoʻololi i ka ʻōlelo o ka brain-derived neurotrophic factor (BDNF), kahi mea koʻikoʻi i ka hoʻoponopono ʻana i ke ʻano a me ka ulu ʻana a me ka mālama ʻana i nā neurons.
Ka hoʻololi ʻana i ka ʻōnaehana pale
Ua hōʻike ʻia ʻo Selank i nā hopena immunomodulatory, me ka hoʻoulu ʻana i ka hoʻokuʻu ʻana o nā interferon a me ka hoʻonui ʻana i ka hana ʻana o nā mea kōkua T helper type 1 (Th1). Hiki i kēia mau hopena ke kōkua i kāna mau waiwai hoʻoikaika kino.
Ke pale pale
Ua hōʻike ʻo Selank i ka hana antioxidant a ua hōʻike ʻia e hoʻemi i nā pae o nā radical manuahi i loko o ke ake. Hiki iā ia ke kōkua i ka hoʻihoʻi ʻana i ke ʻano o nā pūnaʻi ate, hiki ke kōkua i ke olakino ate.
Ma mua o ka hoʻohana ʻana i ka selank, e like me kekahi peptide a i ʻole therapeutic intervention, ʻoi aku ka maikaʻi e kūkākūkā me kahi loea olakino. Hiki iā lākou ke hāʻawi i ka ʻōlelo aʻoaʻo, loiloi i nā pōʻino e hiki mai ana, a nānā i kāu holomua e hōʻoia i ka hoʻohana palekana a kūpono. Eia kekahi, he mea koʻikoʻi ke kūʻai ʻana i nā peptides mai ke kumu kūpono. Mālama ʻo AASraw i ka mana koʻikoʻi koʻikoʻi a ua hana ʻo ia i kahi pūʻulu selank kiʻekiʻe no ke kūʻai aku. Inā pono, ʻoluʻolu ʻoe e kūʻai i ka peptide selank.
ʻO Selank vs Semax
ʻO Selank lāua ʻo Semax nā peptides synthetic i hoʻomohala ʻia no kā lākou hopena therapeutic hiki. ʻOiai kaʻana like lākou i kekahi mau mea like, loaʻa iā lākou nā ʻokoʻa like ʻole i kā lākou peptide sequences, nā kumu i loaʻa, nā hoʻohana therapeutic, a me nā ʻano hoʻokele. Eia kahi hoʻohālikelike ma waena o Selank a me Semax:
· Kaʻina peptide
Selank: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
Semax: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
· Loaʻa mai
Selank: Loaʻa ʻia ʻo Selank mai tuftsin, kahi peptide kūlohelohe i komo i ka hoʻoponopono immune a me nā waiwai anxiolytic.
Semax: Loaʻa ʻia ʻo Semax mai kahi ʻāpana ACTH, kahi hormone peptide i komo i ka hoʻoponopono ʻana i ka hana cortisol.
· Hoʻohana lāʻau lapaʻau
Selank: Ua ʻae ʻia ʻo Selank ma Rūsia no ka mālama ʻana i ka maʻi hopohopo nui (GAD). Hoʻohana ʻia ia no ke kaumaha, anhedonia (nalo o ka leʻaleʻa), ka hoʻololi ʻana i ka immune, nā hōʻailona wehe ʻana i ka waiʻona, a me ka hoʻonui ʻana i ka naʻau.
Semax: Hoʻohana mua ʻia ʻo Semax no ka hoʻonui ʻana i ka cognitive, me ka hoʻomaikaʻi ʻana i ka nānā, hoʻomanaʻo, a me nā hana cognitive. Ua aʻo pū ʻia no nā hopena neuroprotective a loaʻa iā ia nā noi kūpono i ka mālama ʻana i ka maʻi ʻeha, ka ʻeha o ka lolo traumatic, a me nā maʻi maka e like me ka optic nerve neuropathy a me ka glaucoma.
· Nā hopena ʻaoʻao
Selank: ʻO nā hopena ʻaoʻao ʻokoʻa a maʻamau ʻole e pili ana me Selank hiki ke komo i ka dizziness, ka luhi, ka lauoho lauoho, ke poʻo poʻo, ka ʻeha o ka ihu, ka nausea, a me ka ʻeha ʻeha. Eia naʻe, ʻaʻole i hōʻike pinepine ʻia kēia mau hopena ʻaoʻao.
Semax: Manaʻo ʻia ʻo Semax he palekana a ʻae ʻia, me nā hopena ʻaoʻao ʻokoʻa ʻole i hōʻike ʻia.
· Nā hopena noʻonoʻo
Selank: Ua aʻo ʻia ʻo Selank no kona hiki ke hoʻonui i ka cognition, hoʻomanaʻo, a me nā hiki ke aʻo.
Semax: Ua ʻike ʻia ʻo Semax no kāna mau hopena cognitive-hoʻonui, ʻoi loa i ka hoʻomaikaʻi ʻana i ka nānā, hoʻomanaʻo, a me nā hana cognitive.
· Nā hopena anxiolytic
Selank: Ua hōʻike ʻo Selank i nā hopena anti-anxiety a hoʻohana ʻia no ka mālama ʻana i nā maʻi hopohopo.
Semax: ʻOiai ʻo Semax ka mea nui i ka hoʻonui ʻana i ka cognitive, loaʻa paha kekahi mau hopena anxiolytic, ʻoiai ʻaʻole ia ka hoʻohana therapeutic mua.
· Nā hopena neuroprotective
Selank: Ua hōʻike ʻo Selank i nā hopena neuroprotective i nā haʻawina.
Semax: Ua aʻo ʻia ʻo Semax no kāna mau neuroprotective waiwai, ʻoi loa i ka pōʻaiapili o ka hahau a me ka hōʻeha ʻeha o ka lolo.
He mea nui e hoʻomaopopo he ʻike ākea ka ʻike i hāʻawi ʻia, a ʻokoʻa paha nā waiwai kikoʻī a me ka hoʻohana ʻana iā Selank a me Semax e pili ana i nā kūlana pilikino a me ka loaʻa ʻana o ka ʻāina. Manaʻo mau ʻia e kūkākūkā me kahi ʻoihana mālama ola no ka ʻike pololei a pilikino e pili ana i kēia mau peptides.
Ma hea e kūʻai ai iā Selank?
Aia nā ʻano mea kūʻai aku a me nā mea kūʻai aku e kūʻai aku i nā peptides a me nā huahana pili. Hiki i kēia mau pūnaewele pūnaewele ke hāʻawi iā Selank no ke kūʻai aku. He mea nui e hōʻoia e koho ʻoe i kahi mea kūʻai kaulana a hilinaʻi i ke kūʻai ʻana ma ka pūnaewele. E heluhelu i nā loiloi o nā mea kūʻai aku, e nānā i nā palapala hōʻoia, a e hōʻoia i ka ʻoiaʻiʻo a me ka maikaʻi o ka huahana.
ʻO AASraw he mea hoʻolaha kaulana aʻoihana a me ka mea hoʻolako i mea kūikawā i ka hāʻawiʻana i ka nui o ka peptide raw powders a me nā hue. Me ko mākou akamai a me ka ʻike i ka ʻoihana, hāʻawi mākou i nā huahana kiʻekiʻe e hoʻokō i nā pono o nā mea noiʻi, nā hui lāʻau lapaʻau, a me nā poʻe i komo i ka peptide synthesis a me ka hoʻomohala ʻana. Inā makemake ʻoe e ʻimi i kahi mea hoʻolako Selank hilinaʻi, ʻo AASraw kahi koho maikaʻi.
Hōʻike hoʻāʻo Selank-HNMR
He aha ka HNMR a he aha ka HNMR spectrum e haʻi iā ʻoe? ʻO H Nuclear Magnetic Resonance (NMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā huila i loaʻa nā pūhui i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR e hoʻohālikelike i nā hale waihona puke spectral a i ʻole e kuhi pololei i ke ʻano kumu. Ke ʻike ʻia ke ʻano kumu, hiki ke hoʻohana ʻia ka NMR no ka hoʻoholo ʻana i ka conformation molecular i ka hopena a me ke aʻo ʻana i nā waiwai kino ma ka pae molekala e like me ka hoʻololi conformational, nā hoʻololi ʻana, ka solubility, a me ka diffusion.
Pehea e kūʻai ai iā Selank mai AASraw?
❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu WhatsApp iā mākou, e hoʻopili aku kā mākou mea kūʻai aku (CSR) me ʻoe i loko o 12 mau hola.
❷E hāʻawi iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.
❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala lawe, a me ka lā i manaʻo ʻia e hiki mai ai (ETA).
❹E uku ʻia a hoʻouna ʻia nā waiwai i loko o 12 mau hola.
❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.
Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine
Mea kākau moʻolelo puke moʻolelo ʻepekema:
1.Timur Kolomin
ʻO ka Laboratory of Molecular Genetics of Hereditary Diseases, Keʻena o ka Molecular Basis of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Russia.
2.T. ʻO Syunyakov
Keʻena o ka Borderline Psychiatry, FSBI "Serbsky National Research Center for Social and Forensic Psychiatry", Moscow, Russia
3.TN Sollertinskaja
IMSechenov Institute of Evolutionary Physiology a me Biochemistry o RAS, Rusia
4.Marina Morozova
Ke Keʻena o Biomedical and Pharmaceutical Technology, Faculty of Biotechnology and Organic Synthesis, Lomonosov Moscow University of Fine Chemical Technology, Russia
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.
Reference
[1] Inozemtseva LS, Karpenko EA, Dolotov OV, Levitskaya NG, Kamensky AA, Andreeva LA, Grivennikov IA (2008). ʻEpekema Biological Doklady. 421:241–243.
[2] SEMAX: kahi lāʻau lapaʻau ākea ākea e hoʻoikaika i ka ʻōnaehana nerve. Institute of Molecular Genetics (ma ka Lūkini).
[3] Solov'ev VB, Gengin MT, Sollertinskaia TN, Latynova IV, Zhivaeva LV (2012). Zhurnal Evoliutsionnoi Biokhimii I Fiziologii (ma Rusia). 48 (3):254–257.
[4] Uchakina ON, Uchakin PN, Miasoedov NF, Andreeva LA, Shcherbenko VE, Mezentseva MV, et al. (2008). Zhurnal Nevrologii I Psikhiatrii Imeni SSKorsakova. 108 (5):71–75.
[5] Kost NV, Sokolov OI, Gabaeva MV, Grivennikov IA, Andreeva LA, Miasoedov NF, Zozulia AA (2001) . "Semax a selank inhibit the enkephalin-degrading enzymes from human serum". Bioorganicheskaia Khimiia (ma Lūkini). 27 (3):180–183.
[6] Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM (ʻAukake 2010). ʻO ka Experimental'naia a me Klinicheskaia Farmakologiia. 73 (8):2–5.
