Product Description
He aha ka Semax?
ʻO Semax kahi peptide neuroprotective hou, i loaʻa mai ka molecular structure o adrenocorticotropic hormone (ACTH), he mea maoli i loaʻa i loko o ke kino kanaka, i ʻike ʻia ʻo MEHFPGP. Ua hoʻomohala ʻia e kahi hui noiʻi Lūkini mai ka Institute of Molecular Genetics, i ka wā mua, ua alualu ʻia ʻo ia ma ke ʻano he lapaʻau no ka poʻe i hōʻeha ʻia i ka lolo. Eia nō naʻe, loaʻa iā Semax ka moʻolelo like, potency, a me ka makeup chemical i ka pauka Noopept. Ma Rusia a me Ukraine, ua ʻae ʻia ʻo Semax e hoʻohana e pale a mālama i nā maʻi circulatory, pinepine kūʻai ʻia ma ke ʻano he "nootropic" a i ʻole "lāʻau lapaʻau akamai" a ua manaʻo ʻia e hoʻomaikaʻi i ka hana cognitive a me ka hoʻomanaʻo. Eia nō naʻe, ma USA, lawelawe ʻo Semax ma ke ʻano he kumu kumu no ka nui o nā huahana pharmacological, e hoʻohana ai e mālama i ka hoʻomaʻamaʻa lapaʻau no ka mālama ʻana i nā maʻi CNS (ischemic brain stroke, dys-circulatory encephalopathy, optic nerve atrophy, etc.).
Hoʻohana pinepine ʻia ʻo Semax ma ke ʻano he nasal spray a i ʻole subcutaneous injection a loaʻa ʻole ka bioavailability waha. Kona hoʻohana a me ka dosage ʻokoʻa ka regimen ma muli o ke kūlana kūikawā no ka mālama ʻana. Inā ʻoe e noʻonoʻo nei e kūʻai i kahi peptide o ka pauka Semax a i ʻole i hoʻopau ʻia nā hue ma ka pūnaewele, kahi mea hoʻolako kaulana he koho koʻikoʻi nui ia, hiki ke hōʻoia e loaʻa iā ʻoe ka maikaʻi o ka peptide Semax. A, Hiki iā AASraw ke hāʻawi i nā peptides kiʻekiʻe me ke kākoʻo o ke kikowaena R&D kūʻokoʻa a me ka hale hana, ʻae ʻia nā kauoha wholesale Semax.[1][2]
Pehea e hana ai ʻo Semax
Ke hana nei ʻo Semax ma o nā mīkini he nui e hoʻolaha i nā ʻano like ʻole o ka hana o ka lolo a me ke olakino, eia kekahi o nā ala i manaʻo ʻia e hoʻokō ai ʻo Semax i kāna mau hopena:
(1) ʻO ka hoʻololi ʻana o nā mea neurotrophic
Hoʻonui ʻo Semax i nā pae a me ka hana o ka brain-derived neurotrophic factor (BDNF) a hiki ke hoʻoikaika i ka ulu, hoʻomohala, a me ke ola ʻana o nā neurons, e kōkua i ka aʻo a hoʻomaikaʻi i ka hoʻomanaʻo.
(2) Hoʻololi ʻōnaehana dopaminergic
Hoʻopili ʻo Semax i ka ʻōnaehana dopamine i loko o ka lolo, hiki ke hoʻoikaika i ka hoʻokuʻu ʻana i ka dopamine, a hoʻonui i ka naʻau dopamine receptor, e alakaʻi ana i ka hoʻomaikaʻi. hana paʻa a me ka hooponopono ana.
(3) Nā hopena anti-inflammatory a antioxidant
Hōʻike ʻo Semax i nā waiwai anti-inflammatory ma o ka hoʻohaʻahaʻa ʻana i ka hana ʻana o nā molekole pro-inflammatory a me ka hoʻolaha ʻana i ka hoʻokuʻu ʻana i nā mea anti-inflammatory. Hoʻohana pū ia ma ke ʻano he antioxidant, e pale ana i nā neurons mai ke kaumaha oxidative a me ka pōʻino i hoʻokumu ʻia e nā radical manuahi.[6][3]
(4) Neuropeptide modulation
Hiki i Semax ke hoʻoikaika i nā pae a me nā hana o nā neuropeptides like ʻole, hiki ke kōkua i ka hōʻeha ʻana i ka ʻeha, nā hopena anti-inflammatory, a me ka hoʻololi ʻana i ka ʻōnaehana pale ma ka hoʻoponopono ʻana i kēia mau neuropeptides.
(5) Nā hopena neuroprotective
Ua hōʻike ʻo Semax i nā waiwai neuroprotective ma o ka hoʻonui ʻana i ke ola neuronal, e hōʻemi ana i ka apoptosis neuronal (make cell), a me ka hoʻolaha ʻana i ka hoʻihoʻi ʻana a me ka hana hou. Kōkua ia i ka pale ʻana i nā neurons mai ka pōʻino a kākoʻo i ko lākou olakino holoʻokoʻa a me ka hana.
(6) Hoʻonui hoʻonui ʻike
Hiki iā Semax ke hoʻonui i ka synaptic plasticity, kōkua e hoʻoikaika a nāwaliwali paha i ka pane ʻana i ka hana neural a alakaʻi i ka hoʻomaikaʻi ʻana i ka hana cognitive.
He mea nui e hoʻomaopopo i ka hoʻomau ʻana o ka noiʻi ʻo Semax, aia ka nui o kāna mau hana pololei a ʻaʻole maopopo ka hopena.[1][6] Akā, i ka mākeke o kēia manawa, kūʻai nui ʻia ʻo Semax ma ke ʻano he "cognitive enhancer" a me "neuroprotective agent", ʻo ia kekahi o nā mea hoʻohui nootropics maikaʻi loa.[7]
ʻO nā pono kūpono ke hoʻohana ʻoe iā Semax
ʻO Semax kahi nootropic ʻO ka lāʻau lapaʻau i hōʻike ʻia e hāʻawi i nā pono kūpono a me ka hoʻohana ʻana i nā wahi like ʻole, eia ka mea noiʻi i hōʻike ʻia nā pōmaikaʻi:
①E hoʻomaikaʻi i ka nānā a me ka hoʻomanaʻo: Ua hōʻike kekahi mau mea hoʻohana i ka hoʻomaikaʻi ʻana i ka nānā ʻana a me ka hoʻomanaʻo ʻana i ka wā e hoʻohana ana iā Semax.
② Hoʻemi ʻia nā hōʻailona hopohopo a me ke kaumaha: Ua hōʻike ʻia ʻo Semax i nā hopena hoʻoponopono i ke ʻano, hiki ke hōʻemi i nā hōʻailona o ka hopohopo a me ke kaumaha.
③I hoʻomaikaʻi i ka noʻonoʻo a me ka nānā ʻana: Ua wehewehe nā mea hoʻohana i ka hoʻonui ʻana o ka noʻonoʻo a me ka nānā ʻana me ka hoʻohana Semax.
④ Nā hopena i hōʻemi ʻia mai ke kaumaha: Loaʻa iā Semax ka hiki ke hoʻohaʻahaʻa i nā hopena maikaʻi ʻole o ke kaumaha ma ke kino a hoʻoikaika i kahi ʻano mālie.
No nā kūlana Lapaʻau ke hoʻohana ʻo Semax no ka mālama ʻana
①Maʻi hopohopo: Ua kuhikuhi ʻia ʻo Semax no ka lapaʻau o nā maʻi hopohopo, ʻoiai ʻoi aku ka nui o ka noiʻi ʻana e hoʻokumu i kona pono.
② Nā hanana Ischemic a me ka hahau ʻana: Ua noiʻi ʻia ʻo Semax no kona hiki ke kōkua i ka hoʻihoʻi ʻana i ka hahau a hōʻemi i ka pōʻino i hoʻokumu ʻia e nā hanana ischemic.
③Hoʻoulu hou ʻana i ke aʻalolo: Ua hōʻike ʻo Semax i ka hiki ke hoʻoikaika i ka hana hou a me ka hoʻoponopono.
④ADHD: Ua hoʻohana ʻia ʻo Semax ma ke ʻano he lāʻau lapaʻau ʻē aʻe no ADHD, ʻoiai ʻo kona pono i kēia mea e pono ai ka hoʻokolokolo hou.
⑤Opioid withdrawal: Ua ʻimi ʻia ʻo Semax ma ke ʻano he kōkua kūpono i ka hoʻokele ʻana i nā hōʻailona withdrawal i ka wā o ka mālama ʻana i ka opioid.
⑥ʻO nā maʻi maʻi e like me ALS, Parkinson's Disease, a me Alzheimer's: Ua aʻo ʻia ʻo Semax i nā hiʻohiʻona preclinical a hōʻike i ka hoʻohiki i ka hoʻomaikaʻi ʻana i nā hōʻailona a me ka piʻi ʻana o ka maʻi i kēia mau kūlana, akā pono ka noiʻi hou.
⑦Thrombosis: Ua noiʻi ʻia ʻo Semax no kona hiki ke pale a mālama i ka thrombosis, ʻoiai ʻoi aku ka nui o ka noiʻi e hoʻokumu i kona pono.
⑧ Nā pilikia ʻōpū: Ua ʻimi ʻia ʻo Semax no kona hiki ke mālama i nā maʻi pili i ka ʻōpū, akā ua kaupalena ʻia nā hōʻike lapaʻau.
He aha ka hopena ʻaoʻao o Semax?
E like me ka hōʻike ʻana o kekahi mau noiʻi a me nā mea hoʻohana, ʻike ʻia ʻo Semax he palekana a ʻae ʻia. Eia nō naʻe, e like me kekahi mea, hiki ke loaʻa iā Semax aoao waiwai. He mea nui e hoʻomaopopo he ʻokoʻa nā pane o kēlā me kēia iā Semax, ʻaʻole hiki i nā mea āpau ke ʻike i kēia aoao waiwai. Eia kekahi mau mea hiki aoao waiwai pili me Semax:
▪ Lilo ka lauoho
▪ Nausea
▪ Ka luaʻi
▪ ʻEha poʻo
▪ Ka luhi mālie
▪ Hoʻomaha
▪ ʻO ka ihu ihu
▪ Nā hopena maʻi
▪ Nā pilikia moe
▪ Hoʻololi i ka ʻai
▪ Hoʻonui i ke kō koko
He mea pono ke hoʻomaopopo ʻia ua aʻo nui ʻia ʻo Semax ma Rūsia a hoʻohana ʻia i ka hoʻomaʻamaʻa lapaʻau no kekahi mau makahiki, me kahi kūlana palekana maikaʻi. Akā, inā he mea hoʻohana hou ʻoe me Semax, ʻaʻole maʻamau ʻoe e aʻo i ka hana Semax stack me nā nootropics a i ʻole nā mea hoʻohui ʻē aʻe, hiki ke hoʻonui i ka hopena o ka pōʻino. aoao waiwai. Inā hoʻomau ʻoe e hana i kēia mea, ʻoi aku ka maikaʻi o ke kamaʻilio ʻana me ke kauka mālama ola ma mua o ka hoʻohana ʻana.
Semax VS Selank: Nā mea like a me nā ʻokoʻa
Semax a ʻo Selank nā lāʻau peptide ʻelua me nā hopena noʻonoʻo a hoʻonui i ka naʻau, akā loaʻa iā lākou nā ʻano hana like ʻole a me nā noi. Eia kahi hoʻohālikelike ma waena o Semax a me Selank:
(1) Mechanism o ka hana:
Semax: Ua loaʻa iā Semax mai kahi peptide i kapa ʻia he hormone adrenocorticotropic (ACTH). Hana ia ma ka hoʻololi ʻana i nā pae o nā neurotransmitters e like me dopamine, serotonin, a me nā norepinephrine i loko o ka lolo. Hana nui ʻo Semax ma ke ʻano he neuroprotective a me ka cognitive-enhancing agent.
Selank: He mea synthetic ka Selank ʻakika'amino i hoʻokumu ʻia ma kahi ʻāpana o ka peptide Tuftsin. Hana ʻo ia ma ke ʻano he anxiolytic a me ka antidepressant ma ka hoʻoponopono ʻana i nā pae o ke kaumaha hormones, e like me ka cortisol. Hoʻopili pū ʻo Selank i nā pae o nā neurotransmitters, me ke serotonin.
(2) Nā hopena a me nā pono
Semax: Ua ʻike ʻia ʻo Semax no kāna pono kūpono i ka hoʻomaikaʻi ʻana i nā hana cognitive e like me ka nānā, hoʻomanaʻo, a me ka nānā ʻana. Hiki ke kōkua i ka ho'ēmiʻana i nā hōʻailona o ka hopohopo, ke kaumaha, a me ke kaumaha. Ua aʻo ʻia ʻo Semax i nā kūlana e like me ka stroke, ADHD, a me nā maʻi neurodegenerative.
Selank: Hoʻohana mua ʻia ʻo Selank no kāna mau anxiolytic a me nā hopena antidepressant. Hiki ke kōkua i ka hōʻemi ʻana i nā hōʻailona hopohopo, hoʻoikaika i ka hoʻomaha, a hoʻomaikaʻi i ke ʻano. Ua aʻo ʻia ʻo Selank i nā maʻi hopohopo, ke kaumaha, a me ka maʻi post-traumatic stress (PTSD).
(3) Hooponopono
Semax: Loaʻa ʻia ʻo Semax ma ke ʻano he nasal spray a lawelawe ʻia i loko o ka intranasally.
Selank: Loaʻa ʻia ʻo Selank ma ke ʻano he nasal spray, akā hiki ke hoʻopili ʻia ma lalo o ka ʻili.
(4) Palekana Palekana
Semax: Manaʻo ʻia ʻo Semax he palekana a ʻae ʻia, me nā hopena ʻaoʻao i hōʻike ʻia. ʻO nā hopena ʻaoʻao i hōʻike pinepine ʻia e pili ana i ka ʻeha ʻeha o ka ihu, ke poʻo poʻo, a me ka huhū liʻiliʻi.
Selank: Ua manaʻo ʻia ʻo Selank he ʻano palekana maikaʻi, me ka liʻiliʻi i hōʻike ʻia aoao waiwai. Hiki i kekahi mau mea hoʻohana ke loaʻa ka ʻehaʻeha o ka ihu a i ʻole ke poʻo.
He mea nui e hoʻomaopopo i ka nā hopena a me nā pōmaikaʻi o Semax a me Selank ke aʻo ʻia nei, a ua kaupalena ʻia nā hōʻike i loaʻa. Hiki ke ʻokoʻa ka maikaʻi a me ka hoʻohana pono ʻana o kēia mau peptides i waena o nā kānaka. Manaʻo ʻia e kūkākūkā me kahi ʻoihana mālama olakino ma mua o ka noʻonoʻo ʻana i ka hoʻohana ʻana iā Semax, Selank, a i ʻole nā lāʻau lapaʻau peptide ʻē aʻe, no ka mea hiki iā lākou ke hāʻawi i nā ʻōlelo aʻo pilikino e pili ana i kāu mau pono kikoʻī a me ka mōʻaukala olakino.
Ma hea e kūʻai ai iā Semax online,?
He mea koʻikoʻi ia e makaʻala inā makemake ʻoe e kūʻai iā Semax a i ʻole nā mea hoʻohui nootropic ʻē aʻe ma ka pūnaewele, e like me ka hoʻopunipuni. huahana hiki ke pilikia. No ka hōʻoia ʻana e kūʻai aku nei ʻoe i ka Semax kiʻekiʻe e palekana a ikaika hoʻi, ʻoi aku ka maikaʻi o ke kūʻai pololei ʻana mai kahi hale hana Semax kaulana, mea kūʻai aku ʻo Semax, a i ʻole ʻoihana Semax me nā loiloi mea kūʻai aku. Ma mua o ke kauoha ʻana iā Semax, pono ʻoe e hana hou i ka noiʻi e pili ana i nā mea kūʻai aku ʻo Semax, nā kaʻina hana hana, a me nā ana hoʻokele maikaʻi.
Manaʻo nui mākou iā AASraw, he mea hana kaulana a ʻoihana a me ka mea hoʻolako e hoʻolako i kahi ākea o ka peptide. pauda maka a me na hue. Me ko mākou akamai a me ka ʻike i ka ʻoihana, hāʻawi mākou i nā huahana kiʻekiʻe e hoʻokō i nā pono o nā mea noiʻi, nā hui lāʻau lapaʻau, a me nā poʻe i komo i ka peptide synthesis a me ka hoʻomohala ʻana. Inā makemake ʻoe e ʻimi i kahi mea hoʻolako Semax pono, ʻo AASraw kahi koho maikaʻi loa.[3][4]
Hōʻike hoʻāʻo Semax-HNMR
He aha ka HNMR a he aha ka HNMR spectrum e haʻi iā ʻoe? ʻO H Nuclear Magnetic Resonance (NMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā hui pū ʻia i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR e hoʻohālikelike i nā hale waihona puke spectral a i ʻole e kuhi pololei i ke ʻano kumu.[1][6] Ke ʻike ʻia ke ʻano kumu, hiki ke hoʻohana ʻia ka NMR no ka hoʻoholo ʻana i ka conformation molecular i ka hopena a me ke aʻo ʻana i nā waiwai kino ma ka pae molekala e like me ka hoʻololi conformational, nā hoʻololi ʻana, ka solubility, a me ka diffusion.
Pehea e kūʻai ai iā Semax mai AASraw?
❶I Hoʻokaʻaʻike iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu WhatsApp iā mākou, e hoʻopili aku kā mākou mea kūʻai aku (CSR) iā ʻoe i nā hola 12.
❷E hāʻawi iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.
❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala lawe, a me ka lā i manaʻo ʻia e hiki mai ai (ETA).
❹E uku ʻia a hoʻouna ʻia nā waiwai i loko o 12 mau hola.
❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.
Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine
Mea kākau moʻolelo puke moʻolelo ʻepekema:
1.Nataliya Yu.Glazova
Institute of Molecular Genetics,RAS,2 Akademika Kurchatova square,Moscow 123182,Russia
2.D.Khukhareva
Lomonosov Moscow State University, Biological- Human and Animal physiology, Moscow, Russian Federation
3. ʻO Antonio Magrì
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche (CNR),Via P.Gaifami 18,95126 Catania,Italy
4.TYagapova
ʻO ka Laboratory of Molecular Genetics of Hereditary Diseases, Keʻena o ka Molecular Basis of Human Genetics, Institute of Molecular Genetics RAS, 2 Kurchatov Sq., Moscow 123182, Russia
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi ʻana a me ka hoʻomaikaʻi ʻana i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.
Reference
[1] Sciacca MFM, Naletova I, Giuffrida ML, Attanasio F. ACS Chem Neurosci.2022 Feb 16;13(4):486-496.PMID: 35080861.
[2] Sudarkina OY, Pilippenkov IB"Brain Protein Expression Profile hōʻoia i ka hopena pale o ka ACTH(4-7)PGP Peptide (Semax) i loko o kahi Model Rat o Cerebral Ischemia-Reperfusion".Int J Mol Sci.2021 Jun 8;22(12). ):6179.PMID: 34201112
[3] Dergunova LV, Dmitrieva VG”The Peptide Drug ACTH(4-7)PGP (Semax) Kāohi i nā mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain”.Mol Biol (Mosk).2021 Mei-Iun;55 (3): 402-411.PMID: 34097675.
[4] Panikratova YR, Lebedeva IS”Functional Connectomic Approach to Studying Selank and Semax Effects”.Dokl Biol Sci.2020 Jan;490(1):9-11.PMID: 32342318.
[5] Slominsky PA, Shadrina MI”Peptides semax a me selank pili i ka hana o na iole me 6-OHDA i hookomoia PD-like parkinsonism.Dokl Biol Sci.2017 Mei;474(1):106-109.PMID: 28702721.
[6] Kaplan AY, Kochetova AG, Nezavibathko VN, Rjasina TV, Ashmarin IP (Sepatemaba 1996). :19.
[7] Tabbì G, Magrì A"Semax, he ACTH4-10 peptide analog me ka pili kiʻekiʻe no ka copper(II) ion a me ka hiki ke pale aku i ka metala i hoʻokomo ʻia i ka meaʻawaʻawa cell"J Inorg Biochem.2015 Jan;142:39-46.doi: 10.1016.PMID: 25310602.
