Hana ʻo AASraw i nā pauka NMN a me NRC i ka nui!

TAK-438

Rating: Māhele:

ʻO TAK438, i ʻike ʻia ʻo Vonoprazan Fumarate, kahi lāʻau hou no ka mālama ʻana i nā maʻi e pili ana i ka waikawa me kahi ʻano hana o ka hana i kapa ʻia he potassium-hoʻokūkū acid blockers (P-CABs) e hoʻokūkū hoʻokūkū ana i ka hoʻopaʻa ʻana o nā iʻa potasiuma iā H +, K + -ATPase ( ʻike pū ʻia ʻo ka proton pump) i ke kaʻina hope loa o ka waiū gastric secretion i nā cellet gastric parietal, kaohi i ka waiʻona gastric acid. Hāʻawi ia i kahi hopena acid acid paʻa ikaika a hoʻomau ʻia.

Product Description

Nā ʻano kikoʻī

Product Name TAK-438 pauka
Kāleka CAS 1260141-27-2
Ka Lā Molecular C21H20FN3O6S
Kaumaha Kaumaha 461.46
'O Synonyms Vonoprazan Fumarate;
TAK-438 pauka;
1260141-27-2;
Vonoprazan fumurate;
TAK438.
Keʻano ʻO ka'ōmaʻomaʻo i ka paukūʻeleʻele
Ka mālama a me ka lima lima Maloʻo, ʻeleʻele a ma 0 - 4 C no ka wā pōkole (mau lā a i mau pule) a i ʻole -20 C no ka wā lōʻihi (mau mahina i mau makahiki).

 

TAK-438 pauka wehewehe

ʻO TAK438, i ʻike ʻia ʻo Vonoprazan Fumarate, kahi lāʻau hou no ka mālama ʻana i nā maʻi e pili ana i ka waikawa me kahi ʻano hana o ka hana i kapa ʻia he potassium-hoʻokūkū acid blockers (P-CABs) e hoʻokūkū hoʻokūkū ana i ka hoʻopaʻa ʻana o nā iʻa potasiuma iā H +, K + -ATPase ( ʻike pū ʻia ʻo ka proton pump) i ke kaʻina hope loa o ka waiū gastric secretion i nā cellet gastric parietal, kaohi i ka waiʻona gastric acid. Hāʻawi ia i kahi hopena acid acid paʻa ikaika a hoʻomau ʻia.

I nā ʻōpū o ka ʻōpū i hoʻomaʻamaʻa ʻia, ʻo TAK-438 paukū lapaʻau i hopena i kahi hana ʻoi aku ka lōʻihi o ka ikaika a me ka ikaika. ʻO ka hopena pāpā o TAK-438 paukū ma ka huna acid e like me ka pili o ka gastric parietal cell physiology.

 

TAK-438 pauka Ka hana hana

TAK-438 pauka (Vonoprazan fumarate) kahi pyrole derivative a me ka potassium-hoʻokūkū acid blocker (P-CAB) e hoʻokūkū hoʻokūkū i ka pūnaewele paʻa potassium o gastric H (+), K (+) - ATPase, kahi enzyme kī i ka kaʻina hana o ka gastric acid hoʻokaʻa. Hiki i ka hui ke hōʻiliʻili i nā wahi acid a pono e hāʻawi i kahi lōʻihi o ka pāpā ma muli o kahi alkaline pKa o 9.06.

I nā ʻōpū o ka ʻōpū i hoʻomaʻamaʻa ʻia, ʻo TAK-438 paukū lapaʻau i hopena i kahi hana ʻoi aku ka lōʻihi o ka ikaika a me ka ikaika. ʻO ka hopena pāpā o TAK-438 paukū ma ka huna acid e like me ka pili o ka gastric parietal cell physiology.

 

TAK-438 paukū noi

ʻO TAK-438 pauka (Vonoprazan fumarate a i ʻole Vonoprazan) kahi lāʻau hou no ka mālama ʻana i nā maʻi e pili ana i ka waikawa me kahi ʻano hana o ka hana i kapa ʻia he potassium-hoʻokūkū acid blockers (P-CABs) e hoʻokūkū hoʻokūkū ana i ka paʻa ʻana o nā iʻa potasiuma iā H +, K + - ʻO ATPase (i ʻike ʻia ʻo ka paukū proton) i ka hopena hope loa o ka huna ʻana o ka acidic gastric i loko o nā cell gastric parietal. Ua ʻae ʻia ka lāʻau i Iapana no ka mālama ʻana i nā maʻi e pili ana i ka acid, e like me gastric ulcer, duodenal ulcer, reflux esophagitis and Adjunct to Helicobacter pylori eradication in the case of Helicobacter pylori gastritis.

 

TAK-438 pauka Nā ʻaoʻao ʻaoʻao a me ka ʻōlelo aʻoaʻo

Hoʻopili pū ʻia nā hopena ʻaoʻao maʻamau:

▪ ʻōpū,

▪ nausea a me ka luaʻi,

▪ ka paʻa paʻa,

▪ ʻeha o ka ʻōpū,

▪ ʻeha ka ʻili,

▪ ʻeha puʻuwai.

 

ʻAʻole kēia nā hopena āpau o TAK438. No ka ʻike hou aku, e nīnau i kāu kauka a kauka paha. Kāhea i kāu kauka no ka ʻōlelo aʻoaʻo olakino e pili ana i nā hopena. Hiki paha iā ʻoe ke hōʻike i nā hopena i FDA ma 1-800-FDA-1088.

 

Reference

[1] Arikawa Y, Nishida H, Kurasawa O, Hasuoka A, Hirase K, Inatomi N, Hori Y, Matsukawa J, Imanishi A, Kondo M, Tarui N, Hamada T, Takagi T, Takeuchi T, Kajino M. Discovery o he puke pyrrole derivative 1- [5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e fumarate (TAK-438 pauka) ma ke ʻano he potassium-hoʻokūkū blocker waikawa (P-CAB). ʻO J Med Chem. 2012 Mei 10; 55 (9): 4446-56. hana: 10.1021 / jm300318t. Epub 2012 Apr 30. PubMed PMID: 22512618.

[2] Kondo M, Kawamoto M, Hasuoka A, Kajino M, Inatomi N, Tarui N. Ke nānā pono kiʻekiʻe ʻana o nā mea pale potassium-hoʻokūkū. Ka Papa J Biomol. 2012 Pepeluali; 17 (2): 177-82. hana: 10.1177 / 1087057111421004. Epub 2011 Sep 22. PubMed PMID: 21940711.

[3] Shin JM, Inatomi N, Munson K, Strugatsky D, Tokhtaeva E, Vagin O, Sachs G. Hoʻohālikelike i kahi blocker acid potassium-hoʻokūkū hou o ka gastric H, K-ATPase, 1- [5- (2- fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 pauka). ʻO J Pharmacol Exp Ther. 2011 Nov; 339 (2): 412-20. hana: 10.1124 / jpet.111.185314. Epub 2011 Aug 9. PubMed PMID: 21828261; PubMed Central PMCID: PMC3199995.

[4] Hori Y, Matsukawa J, Takeuchi T, Nishida H, Kajino M, Inatomi N. He noi e hoʻohālikelike ana i ka hopena antisecretory o ka pauka TAK-438, kahi blocker acid potassium-hoʻokūkū hou, me lansoprazole i nā holoholona. ʻO J Pharmacol Exp Ther. 2011 Jun; 337 (3): 797-804. hana: 10.1124 / jpet.111.179556. Epub 2011 Malaki 16. PubMed PMID: 21411494.

[5] Matsukawa J, Hori Y, Nishida H, Kajino M, Inatomi N. A like hoʻohālikelike e pili ana i ke ʻano o ka hana o ka TAK-438 pauka, kahi puke potassium-hoʻokūkū waikawa blocker, a me lansoprazole i ka mua moʻomeheu ʻōpelu gastric glands. ʻO Biochem Pharmacol. 2011 Mei 1; 81 (9): 1145-51. hana: 10.1016 / j.bcp.2011.02.009. Epub 2011 Mar 1. PubMed PMID: 21371447.

[6] Hori Y, Imanishi A, Matsukawa J, Tsukimi Y, Nishida H, Arikawa Y, Hirase K, Kajino M, Inatomi N. 1- [5- (2-Fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 pauka), kahi puke a me ka potassium-hoʻokūkū waikiki ikaika no ka mālama ʻana i nā maʻi e pili ana i ka waikawa. ʻO J Pharmacol Exp Ther. 2010 ʻOkakopa; 335 (1): 231-8. hana: 10.1124 / jpet.110.170274. Epub 2010 Jul 12. PubMed PMID: 20624992.


  • ʻO GefitinibFree heluhelu hou
  • ʻO ErlotinibFree heluhelu hou
  • Sunitinib MalateFree heluhelu hou