ʻO ka pauka Tamoxifen Citrate

ʻO Tamoxifen Citrate (Nolvadex) wikiō pauka

ʻO Tamoxifen Citrate (Nolvadex) ka pauka maʻamau

He aha ka Tamoxifen Citrate Powder?

ʻO ka pauka Tamoxifen Citrate he lāʻau lapaʻau i hoʻohana ʻia e mālama i kekahi mau ʻano o ka maʻi maʻi umauma i nā wahine a me nā kāne, e pale i ka maʻi maʻi umauma invasive i nā wahine i loaʻa i ka ductal carcinoma in situ (nā ʻano ʻē aʻe i loko o nā ducts o ka umauma), a no ka pale ʻana i ka maʻi kanesa o ka umauma. nā wahine i pilikia nui i ka ulu ʻana i ka maʻi. Ke aʻo ʻia nei hoʻi i ka mālama ʻana i nā ʻano maʻi maʻi ʻē aʻe. Hoʻopaʻa ʻo Tamoxifen citrate i nā hopena o ka hormone estrogen i loko o ka ʻiʻo o ka umauma, hiki ke kōkua i ka mālama ʻana i nā maʻi kanesa o ka umauma mai ka ulu ʻana. He ʻano ia o ka estrogen receptor modulator (SERM). ʻO Tamoxifen ka mea hana o ka tamoxifen citrate. Ua kapa ʻia ʻo Soltamox.

Pehea e hana ai ʻo Tamoxifen Citrate?

Pono e hoʻopili ʻia ʻo Tamoxifen Citrate powder (Nolvadex) i nā mea loaʻa estrogen i kekahi wahi o ke kino. Ke pau ka paʻa ʻana o ka estrogen, e emi ana kona hopena ma nā ʻiʻo o ka umauma. No laila ua emi ka hopena o ka estrogen ma nā ʻiʻo o ka umauma no ka mea ʻaʻole paʻa ka estrogen. I mea e pale ai i ka hoʻonui ʻana i ka hana estrogen i ka wā e hoʻohana ana i nā steroid anabolic, ke ʻimi nei nā mea kūʻai aku i kēia hopena kikoʻī.

ʻAʻole naʻe e hoʻohaʻahaʻa koke ʻo Tamoxifen i nā pae estrogen o ke kino. ʻO ka mea likeʻole, pili ia i kekahi mau estrogen receptors, e pale ana i kēia mau estrogens mai ka ho'āʻoʻana e hoʻopili, a ua pau ka hana ma muli o ka hopena.

ʻOiai ua hoʻohana ʻia kēia lāʻau lapaʻau ma ke ʻano he ʻāpana o ka hoʻomaʻamaʻa post-cycle, ʻaʻole ia he steroid anabolic, ʻoiai kona inoa. Ma hope o ka pōʻaiapuni steroid, kōkua kēia lāʻau lapaʻau i ka poʻe e hoʻihoʻi hou i nā pae hormone maʻamau o ke kino. Kōkua ia i ka pale ʻana i nā hopena ʻaoʻao makemake ʻole, me ka gynecomastia a me ka hoʻopau ʻana i ka testosterone, a hiki paha ke hoʻopakele i ke ola.

Nā pōmaikaʻi o Tamoxifen Citrate Powder no ke kino

❶ Hoʻonui i ka Testosterone

Ua ʻike ʻia ka noiʻi i paʻi ʻia ma ka Journal of Clinical Endocrinology & Metabolism ua hoʻonui nui ʻo Nolvadex i nā pae testosterone manuahi i ke kino. Ua hōʻike pū ʻia nā hopena o ka haʻawina ʻoi aku ka nui o ka piʻi ʻana o ka testosterone me Nolvadex ma mua o nā lāʻau PCT ʻē aʻe.

Hana kēia i ka Nolvadex PCT i mea e pono ai no nā mea hoʻohana steroid anabolic. ʻAneʻane lākou a pau e ʻike i ka hana testosterone haʻahaʻa i ka wā a ma hope o ke kaʻina. Hiki i kēia ke hōʻeha i ko lākou olakino a hoʻohuli i nā mea i loaʻa i ka wā o ka pōʻai. A laila, hiki i kahi Nolvadex PCT ke kōkua i nā mea hoʻohana steroid e mālama i kā lākou holomua.

❷ Hana i ka Gynecomastia

Hōʻike nā hopena mai kahi hoʻokolohua hoʻokolohua kanaka he 7 o 10 mau kāne makua i hōʻemi i ka nui o ko lākou gynecomastia ma hope o hoʻokahi mahina o ka Nolvadex (Tamoxifen Citrate). Ua ʻike hou ka poʻe noiʻi e hana ana i ka noiʻi ʻana i ka hoʻohana ʻana i ka Nolvadex ʻaʻohe mea ʻona i waena o nā maʻi.

E hoʻomanaʻo ʻaʻole nā ​​bodybuilders i loaʻa i ka gynecomastia. Hoʻomaopopo ka manaʻo i ke kiʻi o nā kāne a me nā keikikāne e ʻike ana i ka 'man boobs' i ka hoʻomaka ʻana o ka wā ʻōpio a hiki i ka 70%. ʻO ia ke ʻano o ka hoʻopiʻi ʻana o ka gynecomastia e ʻoi aku ma mua o ka lehulehu e hele mau ana.

❸ Kūkulu ʻia ka wehewehe ʻana i ka ʻiʻo

Wahi a kahi hōʻike a The Guardian, ua hoʻohana ka poʻe gym-goers ma UK i ka Nolvadex e kūkulu i ka wehewehe ʻana i nā ʻiʻo no nā makahiki. ʻAʻole pono kēia e kahaha. Ua hōʻike ʻia nā haʻawina mua e pili ana i nā ʻiole hoʻohālike e hoʻonui ana kēia estrogen blocker i ka ikaika muscular i waena o nā mea hoʻohana.

❹ Kahukula 'ino' ʻO Cholesterol

ʻElua ʻano cholesterol i loko o kou kino. Manaʻo ʻia ka cholesterol kiʻekiʻe he 'maikaʻi' no ka mea pili ia me ka haʻahaʻa o ka maʻi puʻuwai. ʻO ka cholesterol haʻahaʻa haʻahaʻa, aka cholesterol maikaʻi ʻole, hiki ke hoʻoulu i nā maʻi like ʻole o ka puʻuwai, ka hahau ʻana, a me ka ʻeha o ka umauma ma nā pae kiʻekiʻe.

Ma laila e pau ai ka lono ʻino. Ua loaʻa i kahi noiʻi kanaka ua hoʻohaʻahaʻa nui ʻo Nolvadex i ka 'cholesterol, hiki ke hoʻopakele iā ʻoe mai nā maʻi puʻuwai a me ka hahau. Ua ʻike ka poʻe i komo i ka haʻawina he 16 pakeneka ka emi ʻana o ko lākou mau pae LDL ma hope o 12 mau mahina o ka mālama ʻana iā Nolvadex.

ʻO nā hopena ʻaoʻao o ka Tamoxifen Citrate Powder

❶ Piʻipiʻi ʻōpū

Ke ʻōlelo nei kekahi poʻe hoʻohana i ka hoʻohana ʻana iā Nolvadex i hōʻeha ko lākou ʻōpū. Hiki i kēia ke hāʻawi i nā pilikia e like me ka ʻōpū o ka ʻōpū, ka ʻeha o ka ʻōpū, ka ʻōpū, ka ʻōpū, a me ka constipation. ʻAʻole nā ​​kānaka a pau e hoʻohana ana iā Nolvadex e ʻike i kēia mau pilikia.

❷ Puhi wela

ʻO ka wela wela ke hoʻopuni koke i kou maka a me kou kino holoʻokoʻa. Inā hoʻomau mau, hiki i nā wela wela o ka pō ke hoʻopilikia i kou hiamoe. Inā ʻoe e kū nei i kēia pilikia, e hoʻāʻo e holo i ka peʻahi kaupaku e mālama i kou lumi moe e like me ka hiki.

❸ Headaches

ʻO ka maʻi poʻo kekahi o nā hopena maʻamau o ka hoʻohana ʻana iā Nolvadex. ʻO ka hapa nui o ka manawa, e maʻalahi ke poʻo me ka hoʻohana ʻana iā Nolvadex. Hiki paha iā ʻoe ke ʻike iā ia me kahi papa hoʻomaha ʻeha. Eia naʻe, hiki i kekahi poʻe ke loaʻa i nā mea koʻikoʻi.

ʻO ka hoʻohana ʻana o Tamoxifen Citrate Powder

①No nā kāne

ʻO Gynecomastia, i ʻike pinepine ʻia ʻo ka ʻiʻo o ka umauma kāne, ʻaʻole nui ʻia ka hoʻohana ʻana i ka tamoxifen i loko o ka pōʻai steroid. ʻAʻole wale ia, akā ʻoi aku ka maʻalahi o ka poʻe i kēia pilikia inā hoʻohana lākou i kekahi steroid anabolic-androgenic i loaʻa nā ʻano aromatizing. ʻO Nolvadex ka lāʻau lapaʻau kūpono e pale aku ai i ka gyno me ka maʻalahi, maʻalahi, a me ka palekana.

Eia hou, pono lākou e hoʻomaka i kā lākou PCT pōʻai me kahi haʻahaʻa haʻahaʻa o tamoxifen-ma kahi o 10mg-ma mua o ka hoʻomau. Inā maikaʻi nā kānaka, hiki iā lākou ke hoʻonui i ka nui i 20 mg. Hoʻomaka ia e hana ma ka launa pū ʻana me nā mea loaʻa i nā ʻiʻo o ka umauma a me ka pale ʻana i nā hopena o ka estrogen.

Ma ka ʻaoʻao ʻē aʻe, hiki i nā kāne ke koi i nā lāʻau lapaʻau aromatase inhibitor inā ʻike lākou he ikaika loa ka hana ʻala o ka steroid no ka Nolvadex e hoʻokō pono i kēia ʻano.

②No nā wāhine

Hoʻohana pinepine ʻia ʻo Tamoxifen e nā mea pāʻani wahine no ka pahuhopu hoʻokahi - e hoʻoikaika i ka hana ma muli o ka piʻi ʻana o nā pae testosterone.

Hiki paha i kēia lāʻau lapaʻau ke hoʻololi i nā wahine i koi ʻole i nā hopena ikaika o nā steroids, ʻoi aku ka nui o nā hopena ʻaoʻao kāne.

Hiki i nā wāhine ke lawe i ka tamoxifen e hoʻonui i ko lākou kino me ka hoʻonui ʻana i ka hana no ka mea ʻoi aku ka paʻakikī, ʻoi aku ka ʻoi aʻe o ke kino me ka ʻole o nā pilikia e pili ana i ka hoʻohana ʻana i ka steroid.

ʻO nā wahine e koi ana i kēia mau pono āpau e pono e lawe i kahi mea liʻiliʻi loa o ka tamoxifen i kēlā me kēia lā-ʻo 10 mg wale nō ma ke ʻano o ka post-cycle therapy.

I ka wā o ka PCT, hoʻohana ke kino i ka tamoxifen ma nā pae kiʻekiʻe aʻe e paipai i ke kino e hoʻokuʻu maoli i ka testosterone. Ma hope o ka manawa o ke kaohi ʻana i ka hana kūlohelohe i ka wā a ma hope o ka pōʻai steroid, hoʻokuʻu maoli ʻia ka testosterone.

Eia kekahi, ʻōlelo ʻia e hoʻomau no hoʻokahi a ʻelua mau mahina ma hope o ke kaʻina. E hoʻohana ʻia ʻo Tamoxifen me nā lāʻau lapaʻau ʻē aʻe, e like me ka mea hoʻokae aromatase a i kekahi manawa hCG.

No ka hapa mua o ka pōʻai Nolvadex PCT, ʻōlelo ʻia e lawe nā kāne i 40 mg i kēlā me kēia lā. E ʻike ʻia ka hapa lua o Tamoxifen post-cycle therapy i ka hōʻemi ʻana i ka dosage i 20 mg i kēlā me kēia lā. ʻO ka hope, aia i nā mea hoʻohana inā koho lākou i kahi kaʻina hana ʻewalu pule, ʻehā pule ʻehā, a i ʻole kekahi mea ma waena.

ʻO Tamoxifen Citrate Powder vs. Clomid no PCT

ʻO ka pauka Tamoxifen a me ka pauka Clomid he mau mea like loa. ʻO nā meaʻelua nā mea hoʻopaneʻe aromatase nonsteroidal a ua makemakeʻia nā meaʻelua e nā mea hoʻohana steroid anabolic e pale i nā hopena o ka estrogenic. Loaʻa i nā lāʻau ʻelua ke ʻano like ʻole o ka hopena hopena. Lawe ʻo Tamoxifen i ke alakaʻi ma ke ʻano he mea hoʻohana nui ʻia e nā bodybuilders akā hiki ke iho i lalo i nā kumu he nui e pili ana i ka loaʻa, ke kumukūʻai, a me ka makemake e hahai i ke ala o ka mea a nā hoaaloha a me nā hoa pili pūnaewele e ʻōlelo ai.

ʻOiai hiki i kēia mau AI ʻelua ke kōkua i ka hoʻoulu ʻana i ka hana testosterone kūlohelohe, ʻaʻole i manaʻo ʻia e ka hapa nui o nā kāne ke koho kūpono no PCT ke hoʻohana wale ʻia; ʻoiaʻiʻo, ʻaʻole nui ka poʻe e hoʻohana i kahi AI ikaika like Arimidex or Letrozole i ka wā o ka PCT i nā mea a pau, a ma kahi e hele ai i kahi lāʻau SERM me Nolvadex kahi koho kaulana, me Clomid a me HCG pinepine pū kekahi.

Clomid (clomiphene citrate) ka pauka kekahi lāʻau lapaʻau i hoʻohana pinepine ʻia e nā mea hoʻohana steroid. ʻAʻole like me ka Letrozole Powder he mea hoʻomakeʻa aromatase, ʻo Clomid kahi mea koho estrogen receptor modulator (SERM). He maikaʻi loa nā lāʻau ʻelua akā ʻokoʻa ka hana, no laila ʻaʻole hiki ke ʻōlelo ʻia ʻoi aku ka maikaʻi ma mua o kekahi.

Hoʻohana pinepine ʻia ʻo Tamoxifen a me Clomid i ka wā PCT. Eia naʻe, ʻoi aku ka maikaʻi o ka Tamoxifen (Nolvadex) ma mua o Clomid. Eia naʻe, ua hui pū ʻia kēia mau lāʻau lapaʻau i kekahi manawa a hoʻohana ʻia ma ke ʻano he ʻāpana o ka pōʻai PCT. Kūʻai pinepine lākou i ka pauka tamoxifen e hoʻopiha i kekahi i kekahi a hāʻawi i ka mea hoʻohana i ka hopena nui loa.

Ma hea e kūʻai ai i ka Tamoxifen Citrate Powder?

ʻO Tamoxifen Citrate (Nolvadex) kahi Selective Estrogen Receptor Modulator (SERM) i hoʻohana mau ʻia ma ke ʻano he Cycle Therapy ke hoʻopau kekahi bodybuilder i ka holo ʻana i kahi pōʻai steroid. ʻO Nolvadex kekahi manawa i kapa ʻia a hoʻokaʻawale ʻia ma ke ʻano he Estrogen antagonist. ʻO kāna kuleana koʻikoʻi e hōʻole i nā hopena ʻino o ka estrogen i kou kino.

ʻO AASraw kahi mea hana loea no ka hoʻolako ʻana i ka pauka tamoxifen nona kahi lab kūʻokoʻa a me kahi hale hana nui e like me ke kākoʻo, e hoʻokō ʻia nā hana āpau ma lalo o ka hoʻoponopono CGMP a me kahi ʻōnaehana mālama maikaʻi. Paʻa ka ʻōnaehana hoʻolako pauka tamoxifen, a ua ʻae ʻia nā kauoha kūʻai a me nā mea kūʻai nui. Inā makemake ʻoe e kūʻai i ka pauka tamoxifen ma ka pūnaewele, hoʻokipa e kipa i kā mākou pūnaewele (kino makemaka.com).

Raw Tamoxifen Citrate Powder Testing Report-HNMR

He aha ka HNMR a he aha ka HNMR spectrum e haʻi iā ʻoe? ʻO H Nuclear Magnetic Resonance (NMR) spectroscopy kahi ʻenehana kemika analytical i hoʻohana ʻia i ka hoʻokele maikaʻi a me ka noiʻi no ka hoʻoholo ʻana i ka ʻike a me ka maʻemaʻe o kahi laʻana a me kona ʻano molekala. No ka laʻana, hiki i ka NMR ke hoʻokaʻawale i nā huila i loaʻa nā pūhui i ʻike ʻia. No nā pūhui i ʻike ʻole ʻia, hiki ke hoʻohana ʻia ka NMR e hoʻohālikelike i nā hale waihona puke spectral a i ʻole e kuhi pololei i ke ʻano kumu. Ke ʻike ʻia ke ʻano kumu, hiki ke hoʻohana ʻia ka NMR no ka hoʻoholo ʻana i ka conformation molecular i ka hopena a me ke aʻo ʻana i nā waiwai kino ma ka pae molekala e like me ka hoʻololi conformational, nā hoʻololi ʻana, ka solubility, a me ka diffusion.

ʻO Tamoxifen Citrate Powder(54965-24-1)-COA

ʻO Tamoxifen Citrate Powder(54965-24-1)-COA

Pehea e kūʻai ʻO ke kāpili kūmole Pauka mai AASraw?

❶E hoʻokaʻaʻike mai iā mākou ma kā mākou ʻōnaehana nīnau leka uila, a i ʻole e waiho i kāu helu WhatsApp, e hoʻopili aku kā mākou mea kūʻai aku (CSR) iā ʻoe i nā hola 12.

❷E hāʻawi iā mākou i kāu helu a me kāu helu wahi i nīnau ʻia.

❸Na kā mākou CSR e hāʻawi iā ʻoe i ka ʻōlelo ʻōlelo, ka manawa uku, ka helu ʻimi, nā ala lawe, a me ka lā i manaʻo ʻia e hiki mai ai (ETA).

❹Hoʻopau ʻia ka uku a hoʻouna ʻia nā waiwai i nā hola 12.

❺ Loaʻa nā waiwai a hāʻawi i nā manaʻo.

Mea kākau o kēia ʻatikala:
Kauka Monique Ua puka 'o Hong mai ke Kula Nui o UK Imperial College London Faculty of Medicine

Mea kākau moʻolelo puke moʻolelo ʻepekema:
1. Samira Mohebbi
Keʻena ʻOihana Kimia, Ke Kulanui ʻo Shahid Beheshti, Tehran, Iran
2. Nuttawadee Sittisanguanphan
ʻO ke Koleke Petroleum a me Petrochemical, Chulalongkorn University, Bangkok 10330, Thailand
3. Amit Sharma
Keʻena ʻOihana Lapaʻau, ISF College of Pharmacy, Moga, Punjab, 142001, India
4. Stefano Barbieri
Keʻena ʻOihana Lapaʻau, Kulanui o Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italia
5. Yosra SR Elnaggar
Keʻena o ka lāʻau lapaʻau, ke kumu o ka lāʻau lapaʻau, ke Kulanui o Alexandria, 1 Khartoum Square, Azarita, Messalla Post Office, PO Box 21521, Alexandria, Egypt
ʻAʻole ʻae kēia kauka/ ʻepekema i ke kūʻai, kūʻai ʻana, a hoʻohana paha i kēia huahana no kekahi kumu. ʻAʻohe pili a pili ʻole ʻo Aasraw, i hōʻike ʻia a i ʻole, me kēia kauka. ʻO ke kumu o ka haʻi ʻana i kēia kauka, ʻo ia ka hoʻomaikaʻi, hoʻomaikaʻi a hoʻomaikaʻi i ka hana noiʻi a me ka hoʻomohala piha i hana ʻia e nā ʻepekema e hana nei i kēia mea.

Reference

[1] Quirke VM.Tamoxifen mai Failed Contraceptive Pill to Best-Selling Breast Cancer Medicine:A Case-Study in Pharmaceutical Innovation.Front Pharmacol.2017;8:620.

[2] Brufsky AM, Dickler MN.Estrogen Receptor-Positive Breast Cancer: Exploiting Signaling Pathways Implicated in Endocrine Resistance.Oncologist.2018 Mei;23(5):528-539.

[3] Eggemann H, Altmann U, Costa SD, Ignatov A. Ka pōmaikaʻi ola o tamoxifen a me ka mea hoʻopaneʻe aromatase i ka maʻi maʻi umauma kāne a wahine.J Cancer Res Clin Oncol.2018 Feb;144(2):337-341.

[4] Staley H,McCallum I,Bruce J.Postoperative Tamoxifen no ka ductal carcinoma in situ:Cochrane systematic review and meta-analysis.Breast.2014 Oct;23(5):546-51.

[5] Hansmann A, Adolph C, Vogel T, Unger A, Moeslein G. High-dose tamoxifen a me sulindac ma ke ʻano he lāʻau lapaʻau mua no nā maʻi maʻi desmoid. Cancer.2004 Feb 01;100(3):612-20.

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