URB597

ʻO ka AASraw me ka hōʻano a me ka hana hana mai ka gram a ka kauoha nui o URB597 (546141-08-6), ma lalo o ke kānāwai CGMP a me ke kikowaena o ka mana o ka mana.

URB597, ka mea i kapaʻiaʻo KDS-4103, he mea hoʻokiʻekiʻe loa a he koho i ka fatty-acid amide hydrolase (FAAH), he mea enzyme e hoʻohaunaele i ka hydrolysis intracellular o ka anandamide endocannabinoid, me nā helu o 50% concentration concentration inhibition IC50 o 4.6 nM a me 0.5 nM ma ka lolo a me ka'ōpū microsomes o ke kanaka. Mālie ka URB597 i ke kaumaha, antidepressant, antinociceptive a analgesic hopena ma vivo me ka wahoʻole i nā hōʻailona e pili ana i nā pūnaewele cannabinoid.

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Product Description

URB597 wikiō


I.URB597 mau mea kumu:

Name: URB597
CAS: 546141-08-6
Purity: ≥99% (HPLC)
Nā Kaulike Molecular: C20H22N2O3
Molecular Weight: 338.4
EINECS: 1312995-182-4
Hōʻuluʻulu Manaʻo: N-Cyclohexylcarbamic acid 3 '- (aminocarbonyl) [1,1'-biphenyl] -3-yl ester; 3'-CarbaMoyl- [1,1'-biphenyl] -3-yl cyclohexylcarbaMate; 3- (3-carbaMoylphenyl) phenyl N-cyclohexylcarbaMate CarbaMic acid, N-cyclohexyl, 3 '- (aMinocarbonyl) [1,1'-biphenyl] -3-yl ester; KDS 4103 N-Cyclohexylcarbamic acid 3' - (aminocarbonyl) [1,1'-biphenyl] -3-yl ester ; N-Cyclohexylcarbamic acid 3 '- (aminocarbonyl) [1,1'-biphenyl] -3-yl ester URB 597 KDS 4103; URB 597,> = 98%; APD597 (URB597)
Wahi Manaʻo: 155-157 ° C
Alpha: D + 5 ° (c = 0.437 ma chloroform)
Hōʻoia Kōkua: 2-8 ° C
DMSO kūpaʻa: soluble2mg / mL, hoʻomaʻemaʻe (warmed)
kala like 'ole: Kūleʻa paʻa


II. Ke hoʻohana nei ka URB597 ma ke kaʻina:

1.Name:

URB597

2.How kahi hana no URB597?

NĀ KULA:ʻO kahi pilikino koʻikoʻi nui me ka hoʻohanaʻana i ka 1 (CB1) hoʻopuka pono cannabinoidʻo ka hoʻohuiʻana i kēia mau mea i ka inuʻona lama a me ka piliʻana i ka lāʻau lapaʻau. Ma keʻanoʻokoʻa'ē aʻe, hiki ke hoʻokōʻia ka hoʻouluʻana o CB1-receptor i ka hoʻonuiʻana i nā anandamide me ka hoʻohanaʻana i hydrolase fatty acids amide hydrolase (FAAH) inhibitors. Nń Pahuhopu: Ke hoʻohana nei i ka mea hoʻonāukiʻI FAAH URB597, uaʻimi mākou i ka hoʻonāʻana o ke kani cannabinoid e pili ana i ka hoʻonui i ka hoʻohanaʻana i ka waiʻino, e like me ka mea e hana me ka agonists CB1. Nā mea hana a me nāʻano: Ua ho'āʻoʻiaʻo URB597 ma luna o ka hoʻonāʻauʻana i ka waipiro ma nāʻiole Wistar a ma ka inuʻawaʻawa homecage e koho ai i nāʻiole inu lama (SPS). Ma nāʻiole Wistar, ua loiloiʻia ka hopena o ka URB597 ma muli o ka hopohopo i ka waiʻona a me kaʻilihune, ka'ohimhimine-a me ka hoʻokomo houʻiaʻana o kaʻaha inu wai. No ka hoʻohālikelike, ua ho'āʻoʻia hoʻi ka hopena o ka hoʻopiʻi o ka CB1 rimonabant ma ka hoʻolāʻauʻanaʻo ethanol. Nā hualoaʻa: Ma lalo o ko mākou hoʻokolohua, hoʻokele o intraperitoneal (IP) o URB597 (0.0, 0.3 a me 1.0 mg / kg)ʻaʻole hoʻonui i ka inu wai inu ma ka MSP aʻaʻole hoʻi i hoʻonohonohoʻia ka lakenekaō 1 a me ka holomua o ka waiʻona i loko o nā Wistars iʻole i kohoʻia. I nā hoʻouka houʻana,ʻaʻole i loaʻa ka hopena o ka pūpū ma kahi e hōʻikeʻia ai - ka hopena o ka pilikia - a me ka hoʻohuli houʻana i nā yohimbine. Ma ka hoʻololiʻana, ua hoʻopau loaʻo URB597 i ka pane o ka anxigenic i ka manawa o ka hoʻoihoʻana ma hope o ka hoʻoponopono IP liʻiliʻi o ka waiʻona (3.0 g / kg). ʻO Rimonabant (0.0, 0.3, 1.0, a me 3.0 mg / kg) ke emi nui aku i ke kahanol-administration. Nń hopena: Nā hopena e hōʻike ana i ka hoʻonāukiukiʻana o ka pūnaehana anandamide endocannabinoid ma ke kohoʻana i ka pāʻaniʻole o ka FAAHʻaʻole hoʻonui i ka hopena o ka hoʻohana i ka lāʻauʻawaʻawa akā hoʻoemi i ka hopohopo e pili ana i ka weheʻana o ka wai. Hiki iā mākou ke noʻonoʻo i kēlā lāʻau lāʻau e pili ana i ka hoʻohanaʻana i nā modulators systemocococanabinoid e like me URB597 hiki ke hāʻawi aku i nā mea kūpono kūpono i ka hoʻohālikelikeʻana me nā mea ho'ōla ho'ōla CB1.

3.I hana i ka URB597?

ʻO nā hopena o ka URB 597 wale nō a i hui pū me ka anandamide iʻimiʻia ma kahi hui hoʻokahi (n = 4) i hoʻohālikeʻia ka Δ9-THC (0.1 mg · kg-1 iv) mai ka kaʻa, a ma kahi hui (n = 5) e loaʻa ʻo ka Δ9-THC mau loa (1 mg · kg-112 h-1 sc) i hoʻohālike i ka rimonabant kalaika cannabinoid (1 mg · kg-1 iv).

4.Further kuhikuhi:

Ua hoʻonuiʻia ka URB 597 i nā hopena halihali o ka anandamide akāʻaʻole i kekahi CB1 agonists. Eia naʻe,ʻaʻole i hoʻonui maikaʻiʻo URB 597 i ke kahakahaʻana o ka hōʻailona o ka Δ9-THC i hoʻokomoʻia e ka anandamide. ʻO nā hui, hōʻikeʻia kēia mauʻike e ka'āpana anandamide ma ke kōpō primate hikiʻole ke hoʻomaʻamaʻa i nā hopena o ka hana o kaʻoihana anandamide.

ʻO ka'āpana momona a me ke kohoʻana i ka amethy acid amide hydrolase (FAAH) inhibitor (ʻo nā helu o ke IC50ʻo 3 a me 5 nM i loko o ke akepaʻa a me ka lolo kuhi). ʻAʻole kahi hana hoʻonāukiuki e kū'ē i nāʻano he nui o nā mea loaʻa, nāʻohana ion a me nā enzymes, e like me nā haipena cannabinoid a me ka ratio monoacylglycerol lip. Hōʻikeʻia ka'āpana antiallodynic a me ka antihyperalgesic i loko o kahi hōʻailona o ke ahi. Ma loko o ka vitio,ʻo KDS-4103 ka mea e hana ai i ka hana FAAH me nā hāʻina o ka pākuʻi waena (IC (50)) o 5 nM ma nā membrane o ka lolo a me ka 3 nM i nā hua likeʻole o ke kino kanaka. I loko o ka olaola, KDS-4103 ka mea i loko o ka hana i ka lolo a me ka lolo a me ka median inhibitory (ID (50)) o 0.15 mg / kg. ʻAʻole pili maikaʻi loa ka pūnaewele me nā mea i pili i nā cannabinoid, me nā hōʻailona cannabinoid a me ka halihali anandamide, aiʻole me kahi lehulehu o nā mea loaʻa, nā mea kelepona, nāʻeke a me nā enzymes. Ma o ka lawelaweʻana i nāʻiole a me nāʻiole KDS-4103 e hoʻopiʻi i nā mea nui, nā noʻonoʻo-like, nā antidepressant-like a me nā analgesic, nā mea i paleʻia ma ke kāohiʻana me nā mea hōʻailona CB1. I ka likeʻana, ma nā paʻi hiki i ka pāʻani i ka hana FAAH a hoʻonui i ka nui o ka neʻabinoid,ʻaʻoleʻo KDS-4103 e hoʻoneʻe i nā hopena o nāʻano cannabinoid (pēnei i, catalepsy, hypothermia, hyperphagia),ʻaʻole i kumu kahi koho, nā hopena o nā mea hana o ka cannabis, Delta9-tetrahydrocannabinol (Delta9-THC). ʻO kēia mau hualoaʻa e hōʻike ana i ka hana a KDS-4103 ma o ka hoʻonuiʻana i nā hana tonic o ka anandamide ma kekahi hapa o nā mea loaʻa CB (1), hiki ke hoʻohanaʻia i ka hoʻoholoʻana i nā manaʻo a me kaʻeha. Loaʻaʻia ke KDS-4103 ma nāʻiole a me nā kēne cynomolgus. ʻO nā haʻawina kāʻili haʻahaʻa haʻahaʻa (1,500 mg / kg, ma ke os) i loko o kēia mauʻanoʻeluaʻaʻole i hōʻike i ka lāʻauʻino. Pēlā nō,ʻaʻole iʻikeʻia nā meaʻawaʻawa ma nā hōʻailona cytotoxicity bacteria i loko o ka vitro a ma ka hōʻoia Ames. Eia kekahi,ʻaʻole iʻikeʻia nāʻaha i nāʻiole ma ka ho'āʻo rotarod ma hope o ka mālamaʻana i ka ip a me ke KDS-4103 ma nā doses a hiki i ka 5 mg / kg aiʻole ma kahi papa hanaʻike maʻamau ma hope o nā oopa hiki i ka 1,500 mg / kg. ʻO nā hopena e hōʻike ana e hāʻawi aku anaʻo KDS-4103 i kahi kiʻi hou me kahi puka kūpono maikaʻi no ka mālamaʻana i ka hopohopo, ke kaumaha a me kaʻeha.

5. URB597:

ʻOiwi kauohaʻo 10grams.
Hiki ke hoʻouna i ka nīnau no ka mea maʻamau (Ma waena o 1kg) i nā hola 12 ma hope o ka uku.
No ka hoʻonohonoho nui (Ma waena o 1kg) hiki ke hoʻounaʻia i ka 3 workingdays ma hope o ka uku.

6. Uihana URB597:

No ka nīnauʻana i ko mākou mea hōʻailona kōkua (CSR) no nā kiko'ī, no kāu'ōlelo.

7. URB597 Marketing:

E hoʻolakoʻia i ka wā e hiki mai ana.


III. URB597 HNMR

ʻO mākou nā mea e hoʻopiliʻia ai ka momona, ka momona'āpana kūʻai, Raw Aprepitant Powder (170729-80-3) hplc≥98% | Nā R & D Hoʻokiʻekiʻe AASraw


IV. Pehea e kūʻai ai i URB597 mai AASraw?

1.E hōʻike mai iā mākou ma o mākou leka uilapūnaewele noiʻi, aiʻole skype pūnaeweleka hoʻonohonoho hoʻonohonoho kanaka (CSR).
2.Ke hāʻawi mai i kāu helu a me kāu helu wahi.
3.OUR CSR e hāʻawi iāʻoe i ka helu, ka manawa uku, helu helu, nā puka puka a me ka lā i hōʻea muaʻia (ETA).
4.E ukuʻia a hoʻokuʻuʻia nā waiwai i nā hola 12 (No ke kauoha ma loko o 10kg).
Ua loaʻaʻo 5.Goods a hāʻawi i nā manaʻo.


Eʻike i kāu moʻomanaʻo pūnaewele punahele:

Pehea e hoʻohana ai i ka Clenbuterol no ka pohō kaumaha He aha ka nandrolone kalo e hoʻohanaʻia no nā koina nandrolone?


Nāʻike hou aku e pili ana i nā huahana kūpono,pōmaikaʻi e kaomi maʻaneʻi.


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